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  1. Book ; Thesis: Multidrug resistance protein 2

    Aubel, Raimundus Albertus Martinus Hermanus van

    transport properties of a drug efflux pump

    2000  

    Author's details door Raimundus Albertus Martinus Hermanus van Aubel
    Language Dutch
    Size 141 S. : graph. Darst.
    Publishing country Netherlands
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Nijmegen, Kath. Univ., Diss., 2000
    Note Zsfassung in niederländ. Sprache
    HBZ-ID HT012884210
    ISBN 90-901-3589-8 ; 978-90-901-3589-2
    Database Catalogue ZB MED Medicine, Health

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    2000 E 3331 order for loan Magazin

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  2. Article ; Online: Effect of KRAS codon 12 or 13 mutations on survival with trifluridine/tipiracil in pretreated metastatic colorectal cancer: a meta-analysis.

    Yoshino, T / Van Cutsem, E / Li, J / Shen, L / Kim, T W / Sriuranpong, V / Xuereb, L / Aubel, P / Fougeray, R / Cattan, V / Amellal, N / Ohtsu, A / Mayer, R J

    ESMO open

    2022  Volume 7, Issue 3, Page(s) 100511

    Abstract: Background: KRAS gene mutations can predict prognosis and treatment response in patients with metastatic colorectal cancer (mCRC).: Methods: We undertook a meta-analysis of three randomized, placebo-controlled trials (RECOURSE, TERRA and J003) to ... ...

    Abstract Background: KRAS gene mutations can predict prognosis and treatment response in patients with metastatic colorectal cancer (mCRC).
    Methods: We undertook a meta-analysis of three randomized, placebo-controlled trials (RECOURSE, TERRA and J003) to investigate the impact of KRAS mutations in codons 12 or 13 on overall survival (OS) and progression-free survival in patients receiving trifluridine/tipiracil (FTD/TPI) for refractory mCRC.
    Results: A total of 1375 patients were included, of whom 478 had a KRAS codon 12 mutation and 130 had a KRAS codon 13 mutation. In univariate analyses, the absence of a KRAS codon 12 mutation was found to significantly increase the OS benefit of FTD/TPI relative to placebo compared with the presence of the mutation {hazard ratio (HR), 0.62 [95% confidence interval (CI): 0.53-0.72] versus 0.86 (0.70-1.05), respectively; interaction P = 0.0206}. Multivariate analyses showed that taking confounding factors into account reduced the difference in treatment effect between the presence and the absence of KRAS codon 12 mutations, confirming that treatment benefit was maintained in patients with [HR, 0.73 (95% CI: 0.59-0.89)] and without [HR, 0.63 (95% CI: 0.54-0.74)] codon 12 mutations (interaction P = 0.2939). KRAS mutations in codon 13 did not reduce the OS benefit of FTD/TPI relative to placebo, and, furthermore, KRAS mutations at either codon 12 or codon 13 did not affect the progression-free survival benefit.
    Conclusions: Treatment with FTD/TPI produced a survival benefit, relative to placebo, regardless of KRAS codon 12 or 13 mutation status in patients with previously treated mCRC.
    MeSH term(s) Codon/therapeutic use ; Colonic Neoplasms/drug therapy ; Colorectal Neoplasms/drug therapy ; Colorectal Neoplasms/genetics ; Colorectal Neoplasms/pathology ; Frontotemporal Dementia/chemically induced ; Frontotemporal Dementia/drug therapy ; Frontotemporal Dementia/genetics ; Humans ; Mutation ; Proto-Oncogene Proteins p21(ras)/genetics ; Pyrrolidines ; Randomized Controlled Trials as Topic ; Thymine ; Trifluridine/pharmacology ; Trifluridine/therapeutic use ; Uracil/therapeutic use
    Chemical Substances Codon ; KRAS protein, human ; Pyrrolidines ; Uracil (56HH86ZVCT) ; Proto-Oncogene Proteins p21(ras) (EC 3.6.5.2) ; tipiracil (NGO10K751P) ; Thymine (QR26YLT7LT) ; Trifluridine (RMW9V5RW38)
    Language English
    Publishing date 2022-06-07
    Publishing country England
    Document type Journal Article ; Meta-Analysis ; Research Support, Non-U.S. Gov't
    ISSN 2059-7029
    ISSN (online) 2059-7029
    DOI 10.1016/j.esmoop.2022.100511
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  3. Article ; Online: Trifluridine/tipiracil plus bevacizumab in patients with untreated metastatic colorectal cancer ineligible for intensive therapy: the randomized TASCO1 study.

    Van Cutsem, E / Danielewicz, I / Saunders, M P / Pfeiffer, P / Argilés, G / Borg, C / Glynne-Jones, R / Punt, C J A / Van de Wouw, A J / Fedyanin, M / Stroyakovskiy, D / Kroening, H / Garcia-Alfonso, P / Wasan, H / Falcone, A / Kanehisa, A / Egorov, A / Aubel, P / Amellal, N /
    Moiseenko, V

    Annals of oncology : official journal of the European Society for Medical Oncology

    2020  Volume 31, Issue 9, Page(s) 1160–1168

    Abstract: Background: We designed an open-label, noncomparative phase II study to assess the safety and efficacy of first-line treatment with trifluridine/tipiracil plus bevacizumab (TT-B) and capecitabine plus bevacizumab (C-B) in untreated patients with ... ...

    Abstract Background: We designed an open-label, noncomparative phase II study to assess the safety and efficacy of first-line treatment with trifluridine/tipiracil plus bevacizumab (TT-B) and capecitabine plus bevacizumab (C-B) in untreated patients with unresectable metastatic colorectal cancer (mCRC) who were not candidates for combination with cytotoxic chemotherapies.
    Patients and methods: From 29 April 2016 to 29 March 2017, 153 patients were randomly assigned (1:1) to either TT-B (N = 77) or C-B (N = 76). The primary end point was progression-free survival (PFS). The primary PFS analysis was performed after 100 events (radiological progression or death) were observed. Secondary end points included overall survival (OS), quality of life (QoL; QLQ-C30 and QLQ-CR29 questionnaires), and safety.
    Results: Median (range) duration of treatment was 7.8 (6.0-9.7) months and 6.2 (4.1-9.1) months in the TT-B and C-B groups, respectively. Median (range) PFS was 9.2 (7.6-11.6) and 7.8 (5.5-10.1) months, respectively. Median (range) OS was 18 (15.2 to NA) and 16.2 (12.5 to NA) months, respectively. QoL questionnaires showed no relevant changes over time for either treatment. Therapies were well tolerated. Patients receiving TT-B had more grade ≥3 neutropenia (47% versus 5% with C-B). Patients receiving C-B had more grade ≥3 hand-foot syndrome (12% versus 0% with TT-B) and grade ≥3 diarrhea (8% versus 1% with TT-B), consistent with the known safety profiles of these agents.
    Conclusion: TT-B treatment showed promising clinical activity in untreated patients with unresectable mCRC ineligible for intensive therapy, with an acceptable safety profile and no clinically relevant changes in QoL.
    Clinical trial information: NCT02743221 (ClinicalTrials.gov).
    MeSH term(s) Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Bevacizumab/adverse effects ; Capecitabine/therapeutic use ; Colorectal Neoplasms/drug therapy ; Fluorouracil/therapeutic use ; Humans ; Pyrrolidines ; Quality of Life ; Thymine ; Trifluridine/adverse effects
    Chemical Substances Pyrrolidines ; Bevacizumab (2S9ZZM9Q9V) ; Capecitabine (6804DJ8Z9U) ; tipiracil (NGO10K751P) ; Thymine (QR26YLT7LT) ; Trifluridine (RMW9V5RW38) ; Fluorouracil (U3P01618RT)
    Language English
    Publishing date 2020-06-01
    Publishing country England
    Document type Clinical Trial, Phase II ; Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 1025984-3
    ISSN 1569-8041 ; 0923-7534
    ISSN (online) 1569-8041
    ISSN 0923-7534
    DOI 10.1016/j.annonc.2020.05.024
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  4. Article: Molecular pharmacology of renal organic anion transporters.

    Van Aubel, R A / Masereeuw, R / Russel, F G

    American journal of physiology. Renal physiology

    2000  Volume 279, Issue 2, Page(s) F216–32

    Abstract: Renal organic anion transport systems play an important role in the elimination of drugs, toxic compounds, and their metabolites, many of which are potentially harmful to the body. The renal proximal tubule is the primary site of carrier-mediated ... ...

    Abstract Renal organic anion transport systems play an important role in the elimination of drugs, toxic compounds, and their metabolites, many of which are potentially harmful to the body. The renal proximal tubule is the primary site of carrier-mediated transport from blood to urine of a wide variety of anionic substrates. Recent studies have shown that organic anion secretion in renal proximal tubule is mediated by distinct sodium-dependent and sodium-independent transport systems. Knowledge of the molecular identity of these transporters and their substrate specificity has increased considerably in the past few years by cloning of various carrier proteins. However, a number of fundamental questions still have to be answered to elucidate the participation of the cloned transporters in the overall tubular secretion of anionic xenobiotics. This review summarizes the latest knowledge on molecular and pharmacological properties of renal organic anion transporters and homologs, with special reference to their nephron and plasma membrane localization, transport characteristics, and substrate and inhibitor specificity. A number of the recently cloned transporters, such as the p-aminohippurate/dicarboxylate exchanger OAT1, the anion/sulfate exchanger SAT1, the peptide transporters PEPT1 and PEPT2, and the nucleoside transporters CNT1 and CNT2, are key proteins in organic anion handling that possess the same characteristics as has been predicted from previous physiological studies. The role of other cloned transporters, such as MRP1, MRP2, OATP1, OAT-K1, and OAT-K2, is still poorly characterized, whereas the only information that is available on the homologs OAT2, OAT3, OATP3, and MRP3-6 is that they are expressed in the kidney, but their localization, not to mention their function, remains to be elucidated.
    MeSH term(s) Animals ; Anion Transport Proteins ; Biological Transport/physiology ; Carrier Proteins/chemistry ; Carrier Proteins/genetics ; Carrier Proteins/physiology ; Cell Membrane/metabolism ; Humans ; Intracellular Membranes/metabolism ; Kidney/metabolism ; Kidney/physiology
    Chemical Substances Anion Transport Proteins ; Carrier Proteins
    Language English
    Publishing date 2000-08
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 603837-2
    ISSN 1522-1466 ; 1931-857X ; 0363-6127
    ISSN (online) 1522-1466
    ISSN 1931-857X ; 0363-6127
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  5. Conference proceedings: COS-OGA, a new oligosaccharidic elicitor that induces protection against a wide range of plant pathogens

    Aubel, G. van / Buonatesta, R. / Van, C. m / Bardin, M. / Mauch-Mani, B. / Mazzotta, S. / Nicot, P. / Pieterse, C. / Poessel, J. L. / Ponchet, M. / Schmitt, A.

    IOBC-WPRS Bulletin - Bulletin OILB-SROP

    2013  Volume 89, Page(s) 403–407

    Abstract: COS-OGA is a new elicitor that combines oligochitosan and oligopectates in presence of calcium ions. Elicitation of tomato plants with COS-OGA has been tested and resulted in leaf peroxidase activity increase, transcription of SA-associated defence genes ...

    Institution Unité de Recherche en Biologie Cellulaire Végétale, Université de Namur, Rue de Bruxelles 61, 5000 Namur, Belgium
    Event/congress Proceedings of the IOBC/WPRS Working Group "Induced resistance in plants against insects and diseases"; "Leaping from success in the lab to success in the field", Avignon, France, 10-13 June 2013
    Abstract COS-OGA is a new elicitor that combines oligochitosan and oligopectates in presence of calcium ions. Elicitation of tomato plants with COS-OGA has been tested and resulted in leaf peroxidase activity increase, transcription of SA-associated defence genes and overexpression of PR, heat-shock and DNA/RNA remodelling proteins. Greenhouse and field trials confirmed the efficacy of the elicitor against powdery mildew on cucumber and grapevine. [29937]
    Language English
    Document type Conference proceedings
    ISSN 978-92-9067-267-8
    Database Viticulture and Oenology Abstracts

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  6. Article ; Online: The temporal association between social isolation, distress, and psychotic experiences in individuals at clinical high-risk for psychosis.

    Akcaoglu, Zeynep / Vaessen, Thomas / Velthorst, Eva / Lafit, Ginette / Achterhof, Robin / Nelson, Barnaby / McGorry, Patrick / Schirmbeck, Frederike / Morgan, Craig / Hartmann, Jessica / van der Gaag, Mark / de Haan, Lieuwe / Valmaggia, Lucia / McGuire, Philip / Kempton, Matthew / Steinhart, Henrietta / Klippel, Annelie / Viechtbauer, Wolfgang / Batink, Tim /
    van Winkel, Ruud / van Amelsvoort, Thérèse / Marcelis, Machteld / van Aubel, Evelyne / Reininghaus, Ulrich / Myin-Germeys, Inez

    Psychological medicine

    2024  , Page(s) 1–9

    Abstract: Background: Psychotic experiences (PEs) and social isolation (SI) seem related during early stages of psychosis, but the temporal dynamics between the two are not clear. Literature so far suggests a self-perpetuating cycle wherein momentary increases in ...

    Abstract Background: Psychotic experiences (PEs) and social isolation (SI) seem related during early stages of psychosis, but the temporal dynamics between the two are not clear. Literature so far suggests a self-perpetuating cycle wherein momentary increases in PEs lead to social withdrawal, which, subsequently, triggers PEs at a next point in time, especially when SI is associated with increased distress. The current study investigated the daily-life temporal associations between SI and PEs, as well as the role of SI-related and general affective distress in individuals at clinical high risk (CHR) for psychosis.
    Methods: We used experience sampling methodology in a sample of 137 CHR participants. We analyzed the association between SI, PEs, and distress using time-lagged linear mixed-effects models.
    Results: SI did not predict next-moment fluctuations in PEs, or
    Conclusions: Our results suggest that SI and PEs are not directly related on a moment-to-moment level, but a negative emotional state when alone does contribute to the risk of PEs. These findings highlight the role of affective wellbeing during early-stage psychosis development.
    Language English
    Publishing date 2024-01-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 217420-0
    ISSN 1469-8978 ; 0033-2917
    ISSN (online) 1469-8978
    ISSN 0033-2917
    DOI 10.1017/S0033291723003598
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  7. Article ; Online: Efficacy of Acceptance and Commitment Therapy in Daily Life in Early Psychosis: Results from the Multi-Center INTERACT Randomized Controlled Trial.

    Myin-Germeys, Inez / van Aubel, Evelyne / Vaessen, Thomas / Steinhart, Henrietta / Klippel, Annelie / Lafit, Ginette / Viechtbauer, Wolfgang / Batink, Tim / van Winkel, Ruud / van der Gaag, Mark / van Amelsvoort, Therese / Marcelis, Machteld / Schirmbeck, Frederike / de Haan, Lieuwe / Reininghaus, Ulrich

    Psychotherapy and psychosomatics

    2022  Volume 91, Issue 6, Page(s) 411–423

    Abstract: Introduction/objective: This study aimed to investigate efficacy of Acceptance and Commitment Therapy in Daily Life (ACT-DL), combining face-to-face therapy with an Ecological Momentary Intervention (EMI), in addition to treatment as usual (TAU) for ... ...

    Abstract Introduction/objective: This study aimed to investigate efficacy of Acceptance and Commitment Therapy in Daily Life (ACT-DL), combining face-to-face therapy with an Ecological Momentary Intervention (EMI), in addition to treatment as usual (TAU) for psychotic distress, in comparison to TAU.
    Methods: Individuals aged 15-65 years with clinically established ultra-high risk or first episode of psychosis were randomly assigned to TAU or ACT-DL+TAU. ACT-DL+TAU consisted of 8 ACT-sessions augmented with an EMI-app. The primary outcome was psychotic distress assessed with the Comprehensive Assessment scale of At Risk Mental State (CAARMS) at post-intervention and 6- and 12-month follow-up. Secondary outcomes were functioning, symptom severity, and momentary psychotic distress. We performed multivariate mixed models according to intent-to-treat principles.
    Results: Between June 1, 2015 and December 31, 2018, 668 participants were referred, of whom 148 were randomized to ACT-DL+TAU (n = 71) or TAU (n = 77). One hundred and fifteen (78%) provided primary outcome data at least at one follow-up assessment. There was no evidence of greater reduction in the primary outcome measure CAARMS distress in ACT-DL+TAU compared to TAU (χ2(3) = 2.36; p = 0.50). However, out of the tested secondary outcomes, global functioning (χ2(3) = 9.05; p = 0.033), and negative symptoms (χ2(3) = 19.91; p<0.001) improved in ACT-DL+TAU compared to TAU, as did momentary psychotic distress (χ2(3) = 21.56; p < 0.001).
    Conclusions: INTERACT did not support a significant effect of ACT-DL over TAU on the primary outcome measure of psychotic distress as assessed with the CAARMS. Although significant improvements were found for some secondary outcome measures, further replication studies are needed to confirm the strength and specificity of these effects.
    MeSH term(s) Humans ; Acceptance and Commitment Therapy ; Psychotic Disorders/therapy ; Treatment Outcome
    Language English
    Publishing date 2022-03-18
    Publishing country Switzerland
    Document type Randomized Controlled Trial ; Journal Article
    ZDB-ID 209490-3
    ISSN 1423-0348 ; 0033-3190
    ISSN (online) 1423-0348
    ISSN 0033-3190
    DOI 10.1159/000522274
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  8. Article: Functional characterization of chicken TLR5 reveals species-specific recognition of flagellin.

    Keestra, A Marijke / de Zoete, Marcel R / van Aubel, Rémon A M H / van Putten, Jos P M

    Molecular immunology

    2008  Volume 45, Issue 5, Page(s) 1298–1307

    Abstract: Mammalian Toll-like receptor 5 (TLR5) senses flagellin of several bacterial species and activates the innate immune system. The avian TLR repertoire exhibits considerable functional diversity compared to mammalian TLRs and evidence of a functional TLR5 ... ...

    Abstract Mammalian Toll-like receptor 5 (TLR5) senses flagellin of several bacterial species and activates the innate immune system. The avian TLR repertoire exhibits considerable functional diversity compared to mammalian TLRs and evidence of a functional TLR5 in the avian species is lacking. In the present study we cloned and successfully expressed chicken TLR5 (chTLR5) in HeLa cells, as indicated by laser confocal microscopy. Infection of chTLR5 transfected cells with Salmonella enterica serovar Enteritidis activated NF-kappaB in a dose- and flagellin-dependent fashion. Similar NF-kappaB activation was observed with recombinant bacterial flagellin. Targeted mutagenesis of the proline residue at position 737 in the chTLR5-TIR domain was detrimental to chTLR5 function, confirming that the observed effects were conferred via chTLR5 and the MyD88 signaling pathway. Comparison of human, mouse and chicken TLR5 activation by flagellin of S. enterica serovar Typhimurium revealed that chTLR5 consistently yielded stronger responses than human but not mouse TLR5. This species-specific reactivity was not observed with flagellin of serovar Enteritidis. The species-specific TLR5 response was nullified after targeted mutagenesis of a single amino acid (Q89A) in serovar Typhimurium flagellin, while L415A and N100A substitutions had no effect. These results show that chickens express a functional TLR5 albeit with different flagellin sensing qualities compared to human TLR5. The finding that single amino acid substitutions in bacterial flagellin can alter the species-specific TLR5 response may influence the host range and susceptibility of infection.
    MeSH term(s) Animals ; Base Sequence ; Chickens ; Cloning, Molecular ; Flagellin/metabolism ; Genetic Predisposition to Disease ; HeLa Cells ; Humans ; Molecular Sequence Data ; Mutation, Missense ; NF-kappa B/metabolism ; Protein Binding/genetics ; Salmonella enteritidis/immunology ; Species Specificity ; Toll-Like Receptor 5/genetics ; Toll-Like Receptor 5/immunology ; Toll-Like Receptor 5/metabolism ; Transfection
    Chemical Substances NF-kappa B ; Toll-Like Receptor 5 ; Flagellin (12777-81-0)
    Language English
    Publishing date 2008-03
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 424427-8
    ISSN 1872-9142 ; 0161-5890
    ISSN (online) 1872-9142
    ISSN 0161-5890
    DOI 10.1016/j.molimm.2007.09.013
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  9. Article ; Online: Correction to: Efficacy of Acceptance and Commitment Therapy in Daily Life (ACT-DL) in early psychosis: study protocol for a multi-centre randomized controlled trial.

    Reininghaus, Ulrich / Klippel, Annelie / Steinhart, Henrietta / Vaessen, Thomas / van Nierop, Martine / Viechtbauer, Wolfgang / Batink, Tim / Kasanova, Zuzana / van Aubel, Evelyne / van Winkel, Ruud / Marcelis, Machteld / van Amelsvoort, Therese / van der Gaag, Mark / de Haan, Lieuwe / Myin-Germeys, Inez

    Trials

    2021  Volume 22, Issue 1, Page(s) 538

    Language English
    Publishing date 2021-08-16
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2040523-6
    ISSN 1745-6215 ; 1468-6694 ; 1468-6708
    ISSN (online) 1745-6215 ; 1468-6694
    ISSN 1468-6708
    DOI 10.1186/s13063-021-05513-0
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  10. Article: The central leucine-rich repeat region of chicken TLR16 dictates unique ligand specificity and species-specific interaction with TLR2.

    Keestra, A Marijke / de Zoete, Marcel R / van Aubel, Rémon A M H / van Putten, Jos P M

    Journal of immunology (Baltimore, Md. : 1950)

    2007  Volume 178, Issue 11, Page(s) 7110–7119

    Abstract: The ligand specificity of human TLR (hTLR) 2 is determined through the formation of functional heterodimers with either hTLR1 or hTLR6. The chicken carries two TLR (chTLR) 2 isoforms, type 1 and type 2 (chTLR2t1 and chTLR2t2), and one putative TLR1/6/10 ... ...

    Abstract The ligand specificity of human TLR (hTLR) 2 is determined through the formation of functional heterodimers with either hTLR1 or hTLR6. The chicken carries two TLR (chTLR) 2 isoforms, type 1 and type 2 (chTLR2t1 and chTLR2t2), and one putative TLR1/6/10 homologue (chTLR16) of unknown function. In this study, we report that transfection of HeLa cells with the various chicken receptors yields potent NF-kappaB activation for the receptor combination of chTLR2t2 and chTLR16 only. The sensitivity of this complex was strongly enhanced by human CD14. The functional chTLR16/chTLR2t2 complex responded toward both the hTLR2/6-specific diacylated peptide S-(2,3-bispalmitoyloxypropyl)-Cys-Gly-Asp-Pro-Lys-His-Pro-Lys-Ser-Phe (FSL-1) and the hTLR2/1 specific triacylated peptide tripalmitoyl-S-(bis(palmitoyloxy)propyl)-Cys-Ser-(Lys)(3)-Lys (Pam(3)CSK(4)), indicating that chTLR16 covers the functions of both mammalian TLR1 and TLR6. Dissection of the species specificity of TLR2 and its coreceptors showed functional chTLR16 complex formation with chTLR2t2 but not hTLR2. Conversely, chTLR2t2 did not function in combination with hTLR1 or hTLR6. The use of constructed chimeric receptors in which the defined domains of chTLR16 and hTLR1 or hTLR6 had been exchanged revealed that the transfer of leucine-rich repeats (LRR) 6-16 of chTLR16 into hTLR6 was sufficient to confer dual ligand specificity to the human receptor and to establish species-specific interaction with chTLR2t2. Collectively, our data indicate that diversification of the central LRR region of the TLR2 coreceptors during evolution has put constraints on both their ligand specificity and their ability to form functional complexes with TLR2.
    MeSH term(s) Amino Acid Sequence ; Animals ; Avian Proteins/chemistry ; Avian Proteins/genetics ; Avian Proteins/metabolism ; Avian Proteins/physiology ; Chickens ; Cloning, Molecular ; HeLa Cells ; Humans ; Leucine/chemistry ; Leucine/metabolism ; Ligands ; Molecular Sequence Data ; Protein Structure, Tertiary ; Repetitive Sequences, Amino Acid ; Sequence Analysis, DNA ; Species Specificity ; Toll-Like Receptor 1/physiology ; Toll-Like Receptor 2/chemistry ; Toll-Like Receptor 2/genetics ; Toll-Like Receptor 2/metabolism ; Toll-Like Receptor 2/physiology ; Toll-Like Receptor 6/physiology ; Toll-Like Receptors
    Chemical Substances Avian Proteins ; Ligands ; TLR2 protein, human ; Toll-Like Receptor 1 ; Toll-Like Receptor 2 ; Toll-Like Receptor 6 ; Toll-Like Receptors ; Leucine (GMW67QNF9C)
    Language English
    Publishing date 2007-04-27
    Publishing country United States
    Document type Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 3056-9
    ISSN 1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
    ISSN (online) 1550-6606
    ISSN 0022-1767 ; 1048-3233 ; 1047-7381
    DOI 10.4049/jimmunol.178.11.7110
    Database MEDical Literature Analysis and Retrieval System OnLINE

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