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  1. Article ; Online: m

    Tsuchiya, Kazuo / Yoshimura, Katsuhiro / Iwashita, Yuji / Inoue, Yusuke / Ohta, Tsutomu / Watanabe, Hirofumi / Yamada, Hidetaka / Kawase, Akikazu / Tanahashi, Masayuki / Ogawa, Hiroshi / Funai, Kazuhito / Shinmura, Kazuya / Suda, Takafumi / Sugimura, Haruhiko

    Cancer gene therapy

    2022  Volume 29, Issue 10, Page(s) 1355–1372

    Abstract: The modification of ... ...

    Abstract The modification of N
    MeSH term(s) Humans ; AlkB Homolog 5, RNA Demethylase/genetics ; AlkB Homolog 5, RNA Demethylase/metabolism ; Carcinoma, Non-Small-Cell Lung/genetics ; Carcinoma, Non-Small-Cell Lung/metabolism ; Cell Proliferation/genetics ; Lung Neoplasms/pathology ; Prognosis ; RNA, Messenger/genetics ; RNA-Binding Proteins/metabolism
    Chemical Substances AlkB Homolog 5, RNA Demethylase (EC 1.14.11.-) ; ALKBH5 protein, human (EC 1.14.11.-) ; RNA, Messenger ; RNA-Binding Proteins
    Language English
    Publishing date 2022-03-22
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1212513-1
    ISSN 1476-5500 ; 0929-1903
    ISSN (online) 1476-5500
    ISSN 0929-1903
    DOI 10.1038/s41417-022-00451-8
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4125: Show issues Location:
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  2. Article ; Online: m

    Nagaki, Yushi / Motoyama, Satoru / Yamaguchi, Tomokazu / Hoshizaki, Midori / Sato, Yusuke / Sato, Teruki / Koizumi, Yukio / Wakita, Akiyuki / Kawakita, Yuta / Imai, Kazuhiro / Nanjo, Hiroshi / Watanabe, Hiroyuki / Imai, Yumiko / Minamiya, Yoshihiro / Kuba, Keiji

    Genes to cells : devoted to molecular & cellular mechanisms

    2020  Volume 25, Issue 8, Page(s) 547–561

    Abstract: Esophageal squamous cell carcinoma (ESCC) is one of the most fatal types of malignant tumors worldwide. Epitranscriptome, such as ... ...

    Abstract Esophageal squamous cell carcinoma (ESCC) is one of the most fatal types of malignant tumors worldwide. Epitranscriptome, such as N
    MeSH term(s) Adenosine/analogs & derivatives ; Adenosine/genetics ; Adenosine/metabolism ; Adult ; Aged ; AlkB Enzymes/metabolism ; AlkB Homolog 5, RNA Demethylase/genetics ; AlkB Homolog 5, RNA Demethylase/metabolism ; Alpha-Ketoglutarate-Dependent Dioxygenase FTO/metabolism ; Animals ; Cell Cycle/genetics ; Cell Line, Tumor ; Cell Proliferation/genetics ; Cyclin-Dependent Kinase Inhibitor p21/genetics ; Cyclin-Dependent Kinase Inhibitor p21/metabolism ; Disease Progression ; Esophageal Neoplasms/genetics ; Esophageal Neoplasms/metabolism ; Esophageal Neoplasms/pathology ; Esophageal Squamous Cell Carcinoma/genetics ; Esophageal Squamous Cell Carcinoma/metabolism ; Esophageal Squamous Cell Carcinoma/pathology ; Female ; Gene Expression/genetics ; Gene Expression Regulation, Neoplastic/genetics ; Humans ; Male ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Middle Aged ; Prognosis ; RNA Stability/genetics ; RNA, Messenger/genetics ; RNA, Messenger/metabolism
    Chemical Substances CDKN1A protein, human ; Cyclin-Dependent Kinase Inhibitor p21 ; RNA, Messenger ; N-methyladenosine (CLE6G00625) ; ALKBH5 protein, human (EC 1.14.11.-) ; AlkB Homolog 5, RNA Demethylase (EC 1.14.11.-) ; AlkB Enzymes (EC 1.14.11.33) ; Alpha-Ketoglutarate-Dependent Dioxygenase FTO (EC 1.14.11.33) ; FTO protein, human (EC 1.14.11.33) ; Adenosine (K72T3FS567)
    Language English
    Publishing date 2020-07-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 1330000-3
    ISSN 1365-2443 ; 1356-9597
    ISSN (online) 1365-2443
    ISSN 1356-9597
    DOI 10.1111/gtc.12792
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4539: Show issues Location:
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  3. Article: EBV Exploits RNA m

    Yanagi, Yusuke / Watanabe, Takahiro / Hara, Yuya / Sato, Yoshitaka / Kimura, Hiroshi / Murata, Takayuki

    Frontiers in microbiology

    2022  Volume 13, Page(s) 870816

    Abstract: N6-methyladenosine (m ...

    Abstract N6-methyladenosine (m
    Language English
    Publishing date 2022-06-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2022.870816
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  4. Article ; Online: Photocatalytic solar hydrogen production from water on a 100-m

    Nishiyama, Hiroshi / Yamada, Taro / Nakabayashi, Mamiko / Maehara, Yoshiki / Yamaguchi, Masaharu / Kuromiya, Yasuko / Nagatsuma, Yoshie / Tokudome, Hiromasa / Akiyama, Seiji / Watanabe, Tomoaki / Narushima, Ryoichi / Okunaka, Sayuri / Shibata, Naoya / Takata, Tsuyoshi / Hisatomi, Takashi / Domen, Kazunari

    Nature

    2021  Volume 598, Issue 7880, Page(s) 304–307

    Abstract: The unprecedented impact of human activity on Earth's climate and the ongoing increase in global energy demand have made the development of carbon-neutral energy sources ever more important. Hydrogen is an attractive and versatile energy carrier (and ... ...

    Abstract The unprecedented impact of human activity on Earth's climate and the ongoing increase in global energy demand have made the development of carbon-neutral energy sources ever more important. Hydrogen is an attractive and versatile energy carrier (and important and widely used chemical) obtainable from water through photocatalysis using sunlight, and through electrolysis driven by solar or wind energy
    Language English
    Publishing date 2021-08-25
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/s41586-021-03907-3
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 26: Show issues Location:
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    Zs.MG 9: Show issues
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  5. Article: Reference Values of M-mode Echocardiographic Parameter in Adult Toy Breed Dogs.

    Isayama, Noriko / Uchimura, Yusuke / Sasaki, Kenta / Maeda, Erika / Takahashi, Toshihisa / Watanabe, Megumi

    Frontiers in veterinary science

    2022  Volume 9, Page(s) 918457

    Abstract: ... The association between BW and echocardiographic parameters was assessed by linear regression analyses. M-mode ... The LVIDDN value for 95% of dogs weighing <5 kg was achieved by dividing the M-mode measurement by BW raised ...

    Abstract Introduction: Myxomatous mitral valve disease (MMVD) is one of the most common heart diseases in dogs, and there is a dearth of reports that have investigated reference values for left ventricular end-diastolic internal diameter corrected for body weight (LVIDDN) exclusively in toy breeds.
    Animals: Eighty-six client-owned healthy dogs weighing <5 kg, including Toy Poodles, Chihuahuas, Yorkshire Terriers, Papillon, and other small breeds or small mixed breeds (mixed breed, Pomeranian, dachshund, Shih Tzu, and Maltese). In this retrospective single-center study, data were collected from dogs attending clinic for annual checkup between April 2014 and March 2021.
    Materials and methods: Experienced echocardiographers performed transthoracic echocardiography, with reference ranges established using healthy dogs. Measurements of body weight (BW), heart rate, and several echocardiographic variables were obtained. The association between BW and echocardiographic parameters was assessed by linear regression analyses. M-mode measurements were obtained and normalized using equations developed from the regression analyses.
    Results: The LVIDDN value for 95% of dogs weighing <5 kg was achieved by dividing the M-mode measurement by BW raised to the power 0.332. The upper limit of the prediction interval for breeds weighing <5 kg was much lower than the value currently applied.
    Conclusions: We propose a reference LVIDDN value of ≥1.6 for the diagnosis of stage B2 MMVD in toy breed dogs. The results of our study will guide clinicians in deciding when to start treatment for MMVD in small breed dogs.
    Language English
    Publishing date 2022-06-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2834243-4
    ISSN 2297-1769
    ISSN 2297-1769
    DOI 10.3389/fvets.2022.918457
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  6. Article ; Online: Heterogeneous localization of muscarinic cholinoceptor M

    Rawangwong, Atsara / Khrongyut, Suthankamon / Chomphoo, Surang / Konno, Kohtaro / Yamasaki, Miwako / Watanabe, Masahiko / Kondo, Hisatake / Hipkaeo, Wiphawi

    Archives of oral biology

    2019  Volume 100, Page(s) 14–22

    Abstract: ... of muscarinic cholinergic receptor M ...

    Abstract We hypothesize variation in expression and localization, along the course of the glandular tubule, of muscarinic cholinergic receptor M
    MeSH term(s) Acinar Cells/metabolism ; Animals ; Mice ; Microscopy, Immunoelectron ; Receptor, Muscarinic M1/metabolism ; Salivary Ducts/metabolism
    Chemical Substances Receptor, Muscarinic M1
    Language English
    Publishing date 2019-02-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 80227-x
    ISSN 1879-1506 ; 0003-9969
    ISSN (online) 1879-1506
    ISSN 0003-9969
    DOI 10.1016/j.archoralbio.2019.02.001
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    In stock of ZB MED Cologne/Königswinter

    Ul III Zs.151: Show issues Location:
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  7. Article ; Online: Comparison of 0.1 M Stable CsCl and 1 M NH

    Koshikawa, Masami K / Watanabe, Mirai / Tamaoki, Masanori / Ito, Shoko / Takamatsu, Takejiro / Murata, Tomoyoshi / Saito, Takashi / Hayashi, Seiji

    Analytical sciences : the international journal of the Japan Society for Analytical Chemistry

    2018  Volume 35, Issue 2, Page(s) 153–158

    Abstract: To evaluate the mobility and bioavailability ... ...

    Abstract To evaluate the mobility and bioavailability of
    MeSH term(s) Cesium/chemistry ; Cesium Radioisotopes/analysis ; Cesium Radioisotopes/isolation & purification ; Chemical Fractionation/methods ; Chlorides/chemistry ; Indicators and Reagents/chemistry ; Minerals/chemistry ; Nitrates/chemistry ; Soil/chemistry
    Chemical Substances Cesium Radioisotopes ; Chlorides ; Indicators and Reagents ; Minerals ; Nitrates ; Soil ; Cesium (1KSV9V4Y4I) ; Cesium-137 (4T2E65IAR7) ; cesium chloride (GNR9HML8BA) ; ammonium nitrate (T8YA51M7Y6)
    Language English
    Publishing date 2018-09-21
    Publishing country Japan
    Document type Comparative Study ; Journal Article
    ZDB-ID 1483376-1
    ISSN 1348-2246 ; 0910-6340
    ISSN (online) 1348-2246
    ISSN 0910-6340
    DOI 10.2116/analsci.18P325
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  8. Article ; Conference proceedings ; Online: CLONING, SEQUENCING AND REGULATION OF THE LIPASE GENE FROM PSEUDOMONASSP. M-12-33

    Nakanishi, Yuji / Watanabe, Hidemi / Washizu, Kinya / Narahashi, Yoshiko / Kurono, Yoshiaki

    2024  

    Abstract: Thelipase gene from Pseudomonas sp. M-12-33 was cloned. The cloned DNA was 2.9 Kb in length ...

    Abstract Thelipase gene from Pseudomonas sp. M-12-33 was cloned. The cloned DNA was 2.9 Kb in length, which was essential for production of the lipase and contained two open reading frames, lipA and lipX. The lipA gene was supposed to comprise 1092 nucleotides and give a preproprotein of 364 aminoacids which was then processed to a mature lipase protein of 320 amino acids. On the other hand, the lipX gene was assumedto code a protein of 344 amino acids concerned with someregulation of the enzyme production.
    Language English
    Publishing date 2024-03-27
    Publisher GBF Gesellschaft für Biotechnologische Forschung mbH, Braunschweig
    Publishing country de
    Document type Article ; Conference proceedings ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: CTX-M-55-type ESBL-producing fluoroquinolone-resistant Escherichia coli sequence type 23 repeatedly caused avian colibacillosis in Kagoshima Prefecture, Japan.

    Misumi, Wakako / Magome, Asami / Okuhama, Erina / Uchimura, Eriko / Tamamura-Andoh, Yukino / Watanabe, Yoichiro / Kusumoto, Masahiro

    Journal of global antimicrobial resistance

    2023  Volume 35, Page(s) 325–331

    Abstract: ... of adopting chicks were compared.: Results: Seven CTX-M-type ESBL genes, bla: Conclusions: APEC is often ... spread of high-risk APEC strains such as CTX-M-55-type ESBL-producing Og78-ST23. ...

    Abstract Objectives: The production of expanded-spectrum beta-lactamases (ESBLs) and fluoroquinolone resistance in Enterobacteriaceae has become a global concern. The aim of this study was to investigate the spread of ESBL-producing and fluoroquinolone-resistant avian pathogenic Escherichia coli (APEC) in Kagoshima, a prefecture with the largest amount of poultry in Japan.
    Methods: The antimicrobial susceptibility and genetic characteristics of 228 APEC strains isolated from 57 farms in Kagoshima Prefecture, Japan, between 2005 and 2017 were analysed. Information about the companies with hatcheries connected to the farms was also collected, and the epidemiologic relatedness of APEC strains and the processes of adopting chicks were compared.
    Results: Seven CTX-M-type ESBL genes, bla
    Conclusions: APEC is often transferred from hatcheries to farms via healthy chicks, and the prudent use of antimicrobials and careful monitoring of resistant strains on poultry farms and hatcheries are important in preventing the selection and spread of high-risk APEC strains such as CTX-M-55-type ESBL-producing Og78-ST23.
    MeSH term(s) Animals ; Humans ; Fluoroquinolones/pharmacology ; Japan/epidemiology ; Anti-Bacterial Agents/therapeutic use ; Escherichia coli ; Escherichia coli Infections/epidemiology ; Escherichia coli Infections/veterinary ; Escherichia coli Infections/drug therapy ; Chickens ; Poultry ; Ciprofloxacin
    Chemical Substances Fluoroquinolones ; Anti-Bacterial Agents ; Ciprofloxacin (5E8K9I0O4U)
    Language English
    Publishing date 2023-10-31
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2710046-7
    ISSN 2213-7173 ; 2213-7173
    ISSN (online) 2213-7173
    ISSN 2213-7173
    DOI 10.1016/j.jgar.2023.10.015
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  10. Article: Novel color M-mode echocardiography for non-invasive assessment of the intraventricular pressure in goats: Feasibility, repeatability, and the effect of sedation.

    Mandour, Ahmed S / Samir, Haney / Yoshida, Tomohiko / Matsuura, Katsuhiro / Hamabe, Lina / Shimada, Kazumi / Abdelmageed, Hend A / Elbadawy, Mohamed / Uemura, Akiko / Takahashi, Ken / Watanabe, Gen / Tanaka, Ryou

    Frontiers in veterinary science

    2022  Volume 9, Page(s) 935437

    Abstract: ... gradients (IVPG), estimated from color M-mode echocardiography (CMME) of the transmitral flow, have been ...

    Abstract Background: The intraventricular pressure difference (IVPD) and intraventricular pressure gradients (IVPG), estimated from color M-mode echocardiography (CMME) of the transmitral flow, have been introduced as novel indices for the evaluation of heart functions. Until now, no study demonstrated the feasibility of the CMME approach to measure IVPD and IVPG in any farm animals. The aim of this study was to assess the feasibility and repeatability of CMME-derived IVPD and IVPG variables in goats and explore the effect of sedation on the measured variables.
    Materials and methods: Sixteen male Shiba goats were included in this study and underwent conventional echocardiography. Eight goats were used in the repeatability of IVPD/IVPG variables. Another eight goats were used to evaluate the effect of sedation by xylazine on IVPD/IVPG measurements. CMME between the base and the apex of the left ventricle was carried out. The IVPD and IVPG were analyzed using in-house code software. The IVPD and IVPG were expressed as total, basal, mid-to-apical, mid, and apical segments. Data analysis including the imaging quality score (IQS), repeatability, variability, intraclass correlation coefficient (ICC), as well as the effect size of sedation on the measured variables was calculated.
    Results: IVPD and IVPG variables from CMME were feasible in all goats. Low to moderate variability of IVPD and IVPG variables was observed (CV 95% <25%) except for the apical IVPD and apical IVPG. The IVPD/IVPG measurements were repeatable without a significant effect of animal or time on the obtained measurements. The overall ICC was higher than 0.75 in all variables except for the apical segment. Xylazine administration reduced the total, basal, and mid parts of IVPD and IVPG with a large effect size (biserial ranked correlation; rc > 0.8).
    Conclusion: We reported, for the first time, IVPD and IVPG measurements by CMME in goats. The assessment of IVPD and IVPG by CMME is feasible in goats which can be evaluated in further cardiovascular or pharmacological studies in this species.
    Language English
    Publishing date 2022-10-06
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2834243-4
    ISSN 2297-1769
    ISSN 2297-1769
    DOI 10.3389/fvets.2022.935437
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