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Article ; Online: Utilization of point-of-care ultrasound to evaluate for enterovesical fistula.

VanFleet, Alexander X / Kinkead, Zoe / Daniel, Jeannez / Derr, Charlotte

2023 Volume 31, Issue 1, Page(s) 113–115

Abstract: Enterovesical fistula formation is a relatively rare disease process although a common complication for patients with inflammatory bowel disease (IBD), notably Crohn's disease. Enterovesical fistulas most commonly arise from diverticulitis (65-80%), ... ...

Abstract	Enterovesical fistula formation is a relatively rare disease process although a common complication for patients with inflammatory bowel disease (IBD), notably Crohn's disease. Enterovesical fistulas most commonly arise from diverticulitis (65-80%), cancer (10-20%), or Crohn's disease (5-7%). An increasing amount of evidence supports the use of ultrasonography as the primary imaging method for the monitoring of complications in individuals with a documented history of IBD. Our case report presents a 30-year-old female with a history of Crohn's disease who presented to the Emergency Department with concern for possible enterovesical fistula formation. Using bedside gray-scale ultrasonography, a fistulous tract clearly visualizing air bubbles and fecal matter actively moving from bowel to the bladder through the fistula was visualized confirming the diagnosis of an enterovesical fistula. While CT imaging is instrumental in identifying mural and extramural complications of IBD, performing ultrasonography in patients with IBD serves as an efficient, inexpensive, and noninvasive diagnostic aid for the diagnosis of enterovesical fistula.
MeSH term(s)	Female ; Humans ; Adult ; Crohn Disease/complications ; Crohn Disease/diagnostic imaging ; Point-of-Care Systems ; Urinary Bladder Fistula/diagnostic imaging ; Urinary Bladder Fistula/complications ; Intestinal Fistula/diagnostic imaging ; Intestinal Fistula/complications ; Ultrasonography
Language	English
Publishing date	2023-11-30
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	1425144-9
ISSN	1438-1435 ; 1070-3004
ISSN (online)	1438-1435
ISSN	1070-3004
DOI	10.1007/s10140-023-02192-z
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Zs.A 4880: Show issues

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Article ; Online: Data Linkages for Wildfire Exposures and Human Health Studies: A Scoping Review.

Barkoski, J / Van Fleet, E / Liu, A / Ramsey, S / Kwok, R K / Miller, A K

GeoHealth

2024 Volume 8, Issue 3, Page(s) e2023GH000991

Abstract: ... of wildfire exposures on health, and (c) identify gaps and opportunities to leverage exposure and health data ...

Abstract	Wildfires are increasing in frequency and intensity, with significant consequences that impact human health. A scoping review was conducted to: (a) understand wildfire-related health effects, (b) identify and describe environmental exposure and health outcome data sources used to research the impacts of wildfire exposures on health, and (c) identify gaps and opportunities to leverage exposure and health data to advance research. A literature search was conducted in PubMed and a sample of 83 articles met inclusion criteria. A majority of studies focused on respiratory and cardiovascular outcomes. Hospital administrative data was the most common health data source, followed by government data sources and health surveys. Wildfire smoke, specifically fine particulate matter (PM
Language	English
Publishing date	2024-03-13
Publishing country	United States
Document type	Journal Article ; Review
ISSN	2471-1403
ISSN (online)	2471-1403
DOI	10.1029/2023GH000991
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Article ; Online: Image Super-Resolution via Iterative Refinement.

Saharia, Chitwan / Ho, Jonathan / Chan, William / Salimans, Tim / Fleet, David J / Norouzi, Mohammad

IEEE transactions on pattern analysis and machine intelligence

2023 Volume 45, Issue 4, Page(s) 4713–4726

Abstract: We present SR3, an approach to image Super-Resolution via Repeated Refinement. SR3 adapts denoising diffusion probabilistic models (Ho et al. 2020), (Sohl-Dickstein et al. 2015) to image-to-image translation, and performs super-resolution through a ... ...

Abstract	We present SR3, an approach to image Super-Resolution via Repeated Refinement. SR3 adapts denoising diffusion probabilistic models (Ho et al. 2020), (Sohl-Dickstein et al. 2015) to image-to-image translation, and performs super-resolution through a stochastic iterative denoising process. Output images are initialized with pure Gaussian noise and iteratively refined using a U-Net architecture that is trained on denoising at various noise levels, conditioned on a low-resolution input image. SR3 exhibits strong performance on super-resolution tasks at different magnification factors, on faces and natural images. We conduct human evaluation on a standard 8× face super-resolution task on CelebA-HQ for which SR3 achieves a fool rate close to 50%, suggesting photo-realistic outputs, while GAN baselines do not exceed a fool rate of 34%. We evaluate SR3 on a 4× super-resolution task on ImageNet, where SR3 outperforms baselines in human evaluation and classification accuracy of a ResNet-50 classifier trained on high-resolution images. We further show the effectiveness of SR3 in cascaded image generation, where a generative model is chained with super-resolution models to synthesize high-resolution images with competitive FID scores on the class-conditional 256×256 ImageNet generation challenge.
Language	English
Publishing date	2023-03-07
Publishing country	United States
Document type	Journal Article
ISSN	1939-3539
ISSN (online)	1939-3539
DOI	10.1109/TPAMI.2022.3204461
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Article ; Online: Subcutaneous fentanyl for labour analgesia: a retrospective case note review.

Fleet, J / Sok, C / Randall, E R / Cyna, A M

International journal of obstetric anesthesia

2020 Volume 45, Page(s) 138–141

Abstract: Background: In 2017, a South Australia Perinatal Practice Guideline was introduced state-wide for the use of subcutaneous fentanyl for labour analgesia as a replacement for intramuscular pethidine. We retrospectively reviewed the implementation of this ... ...

Abstract	Background: In 2017, a South Australia Perinatal Practice Guideline was introduced state-wide for the use of subcutaneous fentanyl for labour analgesia as a replacement for intramuscular pethidine. We retrospectively reviewed the implementation of this practice change in our institution. Methods: A retrospective review of maternal and neonatal case notes for the first 100 women administered subcutaneous fentanyl in labour at a single tertiary referral centre for maternity care, between February and June 2017. Results: Of the 102 women administered subcutaneous fentanyl, the majority (55%) were primipara, with an average maternal age of 29 years and body mass index of 27 kg/m Conclusions: Subcutaneous fentanyl for labour analgesia appears effective and has a low incidence of adverse events.
MeSH term(s)	Adult ; Analgesia ; Analgesia, Epidural ; Analgesia, Obstetrical ; Analgesics ; Female ; Fentanyl ; Humans ; Infant, Newborn ; Maternal Health Services ; Pregnancy ; Retrospective Studies
Chemical Substances	Analgesics ; Fentanyl (UF599785JZ)
Language	English
Publishing date	2020-10-21
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1086024-1
ISSN	1532-3374 ; 0959-289X
ISSN (online)	1532-3374
ISSN	0959-289X
DOI	10.1016/j.ijoa.2020.10.009
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Zs.A 3311: Show issues

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Book ; Online: Major and trace element analyses from DSDP Hole 26-253 at the Ninetyeast Ridge in the Indian Ocean, supplementary data to: Fleet, A J; McKelvey, B C (1978): Eocene explosive submarine volcanism, Ninetyeast Ridge, Indian Ocean. Marine Geology, 26(1-2), 73-97

Fleet, A J / McKelvey, B C

1978

Abstract: A basaltic sequence of Eocene submarine-erupted pyroclastic sediments totals at least 388 m at DSDP Site 253 on the Ninetyeast Ridge. These fossiliferous hyaloclastic sediments have been erupted and fragmented by explosive volcanism (hydroexplosions) in ... ...

Abstract	A basaltic sequence of Eocene submarine-erupted pyroclastic sediments totals at least 388 m at DSDP Site 253 on the Ninetyeast Ridge. These fossiliferous hyaloclastic sediments have been erupted and fragmented by explosive volcanism (hydroexplosions) in shallow water. The occurrence of interbedded basaltic ash-fall tuffs within the younger horizons of the hyaloclastic sequence marks the emergence of some Ninetyeast Ridge volcanic vents above sea level. Considerable textural variation allows subdivision of the sequence into six informal lithostratigraphic units. Hydrothermal and diagenetic alteration has caused the complete replacement of all original glass by smectites, and the introduction of abundant zeolite and calcite cements. The major and trace element contents of the hyaloclastites vary due to the alteration, and the admixture of biogenous calcite. On a calcium carbonate-free basis systematic variations are recognisable. Mg, Ni, Cr and Cu are enriched, and Li and Zn depleted in the three older units relative to the younger three. The chemical variability is reflected by the development of saponite in the older part of the sequence and montmorillonite in the younger; and by the presence of a quartz-normative basalt flow occurring in Unit II, in contrast to the Mg-rich highly olivine-normative basalt at the base of the sequence. The younger and older parts of the sequence therefore appear to have been derived from magmas of different chemistry. The sequence, like other basaltic rocks recovered from the Ninetyeast Ridge, is enriched in the light relative to the heavy rare earth elements (REE) although the REE contents vary unsystematically with depth, probably because of the high-temperature subaqueous alteration and the presence of biogenous calcite. This REE data indicates that the Ninetyeast Ridge volcanism was different from that which produces mid-ocean ridge basalts.
Language	English
Dates of publication	1978-9999
Size	Online-Ressource
Publisher	PANGAEA - Data Publisher for Earth & Environmental Science
Publishing place	Bremen/Bremerhaven
Document type	Book ; Online
Note	This dataset is supplement to doi:10.1016/0025-3227(78)90047-6
DOI	10.1594/PANGAEA.762177
Database	Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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Article ; Online: The protein-specific activities of the transmembrane modules of Ptch1 and Ptch2 are determined by their adjacent protein domains.

Fleet, Andrew J / Hamel, Paul A

The Journal of biological chemistry

2018 Volume 293, Issue 43, Page(s) 16583–16595

Abstract: ... by the adjacent cytoplasmic and luminal domains. We first showed that individual N-terminal and C-terminal halves ...

Abstract	Signaling through the Hedgehog (Hh) pathway is mediated by the Patched (Ptch) family of proteins. Although the vertebrate Ptch proteins Ptch1 and Ptch2 harbor two closely related transmembrane modules related to sterol-sensing domains (SSDs), the role of these closely related receptors in the Hh pathway are not equivalent. Ptch1 is essential for development and appears to be the principal receptor mediating responses to Hh ligands, whereas Ptch2 is nonessential, and its role in Hh-signaling remains ambiguous. We hypothesized that the SSDs of the Ptch proteins function as generic modules whose protein-specific activities are determined by the adjacent cytoplasmic and luminal domains. We first showed that individual N-terminal and C-terminal halves of Ptch1 associated noncovalently to mediate ligand-dependent regulation of Hh signaling. The analogous regions of Ptch2 also interacted noncovalently but did not repress the Hh pathway. However, the SSD of Ptch2 were capable of repressing Hh signaling, as determined using chimeric proteins where the SSDs of Ptch1 were replaced by those from Ptch2. Replacement of the SSDs of Ptch1 with the analogous regions from the cholesterol transporter NPC1 failed to produce a chimeric protein capable of Hh repression. Further refinement of the specific regions in Ptch1 and Ptch2 revealed that specific cytoplasmic domains of Ptch1 were necessary but not sufficient for repression of Hh signaling and that the two principal luminal domains of Ptch1 and Ptch2 were interchangeable. These data support a model where the SSDs of the Ptch family proteins exhibit generic activities and that the adjacent cytoplasmic and luminal domains determine their protein-specific activities.
MeSH term(s)	Animals ; Cell Membrane/genetics ; Cell Membrane/metabolism ; Hedgehog Proteins/genetics ; Hedgehog Proteins/metabolism ; Humans ; Mice ; Mice, Knockout ; Patched-1 Receptor/chemistry ; Patched-1 Receptor/genetics ; Patched-1 Receptor/metabolism ; Patched-2 Receptor/chemistry ; Patched-2 Receptor/genetics ; Patched-2 Receptor/metabolism ; Protein Binding ; Protein Domains ; Signal Transduction
Chemical Substances	Hedgehog Proteins ; Patched-1 Receptor ; Patched-2 Receptor ; Ptch1 protein, mouse ; Ptch2 protein, mouse
Language	English
Publishing date	2018-08-30
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2997-x
ISSN	1083-351X ; 0021-9258
ISSN (online)	1083-351X
ISSN	0021-9258
DOI	10.1074/jbc.RA118.004478
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Article ; Online: Stable D-xylose ditriflate in divergent syntheses of dihydroxy prolines, pyrrolidines, tetrahydrofuran-2-carboxylic acids, and cyclic β-amino acids.

Balo, Rosalino / Fernández, Alberto G / Chopdat, Adam / Ayadi, Soufian El / Kato, Atsushi / Estévez, Ramón J / Fleet, George W J / Estévez, Juan C

Organic & biomolecular chemistry

2022 Volume 20, Issue 47, Page(s) 9447–9459

Abstract: Double nucleophilic displacement of D-xylo-ditriflate by amines, water and alkyl cyanoacetates, respectively, gave a series of bicyclic divergent intermediates for the synthesis of a wide range of highly functionalized targets, including hydroxylated ... ...

Abstract	Double nucleophilic displacement of D-xylo-ditriflate by amines, water and alkyl cyanoacetates, respectively, gave a series of bicyclic divergent intermediates for the synthesis of a wide range of highly functionalized targets, including hydroxylated prolines, pyrrolidines, furanoic acids, and cyclopentanes.
MeSH term(s)	Proline ; Pyrrolidines ; Xylose ; Carboxylic Acids
Chemical Substances	Proline (9DLQ4CIU6V) ; Pyrrolidines ; Xylose (A1TA934AKO) ; Carboxylic Acids
Language	English
Publishing date	2022-12-07
Publishing country	England
Document type	Journal Article
ZDB-ID	2097583-1
ISSN	1477-0539 ; 1477-0520
ISSN (online)	1477-0539
ISSN	1477-0520
DOI	10.1039/d2ob01255c
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: A retroviral link to vertebrate myelination through retrotransposon-RNA-mediated control of myelin gene expression.

Ghosh, Tanay / Almeida, Rafael G / Zhao, Chao / Mannioui, Abdelkrim / Martin, Elodie / Fleet, Alex / Chen, Civia Z / Assinck, Peggy / Ellams, Sophie / Gonzalez, Ginez A / Graham, Stephen C / Rowitch, David H / Stott, Katherine / Adams, Ian / Zalc, Bernard / Goldman, Nick / Lyons, David A / Franklin, Robin J M

Cell

2024 Volume 187, Issue 4, Page(s) 814–830.e23

Abstract: Myelin, the insulating sheath that surrounds neuronal axons, is produced by oligodendrocytes in the central nervous system (CNS). This evolutionary innovation, which first appears in jawed vertebrates, enabled rapid transmission of nerve impulses, more ... ...

Abstract	Myelin, the insulating sheath that surrounds neuronal axons, is produced by oligodendrocytes in the central nervous system (CNS). This evolutionary innovation, which first appears in jawed vertebrates, enabled rapid transmission of nerve impulses, more complex brains, and greater morphological diversity. Here, we report that RNA-level expression of RNLTR12-int, a retrotransposon of retroviral origin, is essential for myelination. We show that RNLTR12-int-encoded RNA binds to the transcription factor SOX10 to regulate transcription of myelin basic protein (Mbp, the major constituent of myelin) in rodents. RNLTR12-int-like sequences (which we name RetroMyelin) are found in all jawed vertebrates, and we further demonstrate their function in regulating myelination in two different vertebrate classes (zebrafish and frogs). Our study therefore suggests that retroviral endogenization played a prominent role in the emergence of vertebrate myelin.
MeSH term(s)	Animals ; Gene Expression ; Myelin Sheath/metabolism ; Oligodendroglia/metabolism ; Retroelements/genetics ; RNA/metabolism ; Zebrafish/genetics ; Anura
Chemical Substances	Retroelements ; RNA (63231-63-0)
Language	English
Publishing date	2024-02-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	187009-9
ISSN	1097-4172 ; 0092-8674
ISSN (online)	1097-4172
ISSN	0092-8674
DOI	10.1016/j.cell.2024.01.011
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Zs.A 1167: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 58: Show issues

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Article ; Online: Design, synthesis and glycosidase inhibition of DAB derivatives with C-4 peptide and dipeptide branches.

Zi, Dong / Shimadate, Yuna / Wang, Jun-Zhe / Kato, Atsushi / Li, Yi-Xian / Jia, Yue-Mei / Fleet, George W J / Yu, Chu-Yi

Organic & biomolecular chemistry

2023 Volume 21, Issue 13, Page(s) 2729–2741

Abstract: A series of DAB-peptide and DAB-dipeptide derivatives were synthesized from D-tartrate-derived nitrone 18. The DAB peptides 16 are derivatives ... ...

Abstract	A series of DAB-peptide and DAB-dipeptide derivatives were synthesized from D-tartrate-derived nitrone 18. The DAB peptides 16 are derivatives of
MeSH term(s)	Animals ; Cattle ; Glycoside Hydrolases ; Molecular Docking Simulation ; Dipeptides ; C-Peptide ; beta-Galactosidase ; Structure-Activity Relationship ; Molecular Structure
Chemical Substances	Glycoside Hydrolases (EC 3.2.1.-) ; Dipeptides ; C-Peptide ; beta-Galactosidase (EC 3.2.1.23)
Language	English
Publishing date	2023-03-29
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2097583-1
ISSN	1477-0539 ; 1477-0520
ISSN (online)	1477-0539
ISSN	1477-0520
DOI	10.1039/d3ob00097d
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Article ; Online: Through the big top: An exploratory study of circus-based artistic knowledge translation in rural healthcare services, Québec, Canada.

Théberge, Julie / Smithman, Mélanie Ann / Turgeon-Pelchat, Catherine / Tounkara, Fatoumata Korika / Richard, Véronique / Aubertin, Patrice / Léonard, Patrick / Alami, Hassane / Singhroy, Diane / Fleet, Richard

PloS one

2024 Volume 19, Issue 4, Page(s) e0302022

Abstract: Background: The conventional methods and strategies used for knowledge translation (KT) in academic research often fall short in effectively reaching stakeholders, such as citizens, practitioners, and decision makers, especially concerning complex ... ...

Abstract	Background: The conventional methods and strategies used for knowledge translation (KT) in academic research often fall short in effectively reaching stakeholders, such as citizens, practitioners, and decision makers, especially concerning complex healthcare issues. In response, a growing number of scholars have been embracing arts-based knowledge translation (ABKT) to target a more diverse audience with varying backgrounds and expectations. Despite the increased interest, utilization, and literature on arts-based knowledge translation over the past three decades, no studies have directly compared traditional knowledge translation with arts-based knowledge translation methods. Thus, our study aimed to evaluate and compare the impact of an arts-based knowledge translation intervention-a circus show-with two traditional knowledge translation interventions (webinar and research report) in terms of awareness, accessibility, engagement, advocacy/policy influence, and enjoyment. Methods: To conduct this exploratory convergent mixed method study, we randomly assigned 162 participants to one of the three interventions. All three knowledge translation methods were used to translate the same research project: "Rural Emergency 360: Mobilization of decision-makers, healthcare professionals, patients, and citizens to improve healthcare and services in Quebec's rural emergency departments (UR360)." Results: The findings revealed that the circus show outperformed the webinar and research report in terms of accessibility and enjoyment, while being equally effective in raising awareness, increasing engagement, and influencing advocacy/policy. Each intervention strategy demonstrates its unique array of strengths and weaknesses, with the circus show catering to a diverse audience, while the webinar and research report target more informed participants. These outcomes underscore the innovative and inclusive attributes of Arts-Based Knowledge translation, showcasing its capacity to facilitate researchers' engagement with a wider array of stakeholders across diverse contexts. Conclusion: As a relevant first step and a complementary asset, arts-based knowledge translation holds immense potential in increasing awareness and mobilization around crucial health issues.
MeSH term(s)	Humans ; Quebec ; Translational Science, Biomedical ; Delivery of Health Care ; Canada ; Emergency Service, Hospital
Language	English
Publishing date	2024-04-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0302022
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