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  1. Book ; Online ; E-Book: School violence and primary prevention

    Miller, Thomas W.

    2023  

    Author's details edited by Thomas W. Miller
    Keywords Juvenile delinquents/Psychology
    Subject code 325
    Language English
    Size 1 online resource (734 pages)
    Edition 2nd ed.
    Publisher Springer
    Publishing place Cham, Switzerland
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 9783031131349 ; 9783031131332 ; 3031131347 ; 3031131339
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book: Handbook of stressful transitions across the lifespan

    Miller, Thomas W.

    2010  

    Author's details ed. by Thomas W. Miller
    Language English
    Size XXIII, 691 S. : graph. Darst.
    Publisher Springer Science+Business Media
    Publishing place New York u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT016203488
    ISBN 978-1-441-90747-9 ; 9781441907486 ; 1-441-90747-5 ; 1441907483
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2010 A 444 order for loan Magazin

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  3. Book ; Online: School Violence and Primary Prevention

    Miller, Thomas W.

    2008  

    Author's details edited by Thomas W. Miller
    Keywords Education ; Medicine ; Psychology, clinical ; Social work
    Language English
    Publisher Springer Science+Business Media, LLC
    Publishing place New York, NY
    Publishing country United States
    Document type Book ; Online
    HBZ-ID TT050386977
    ISBN 978-0-387-75660-8 ; 0-387-75660-4
    DOI 10.1007/978-0-387-77119-9
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

    Full text online

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  4. Article ; Online: AOA Critical Issues Symposium: The Dynamic Environment of Health Care.

    Lundy, Douglas W / Jevsevar, David S / Porter, Scott E / Miller, Thomas L

    The Journal of bone and joint surgery. American volume

    2024  

    Abstract: Abstract: The dynamic health-care environment continues to undergo disruptive change. As the health-care system emerges from the pandemic, underlying issues have progressively become critical. Private equity acquisition is dramatically increasing, and ... ...

    Abstract Abstract: The dynamic health-care environment continues to undergo disruptive change. As the health-care system emerges from the pandemic, underlying issues have progressively become critical. Private equity acquisition is dramatically increasing, and consolidation in the entire health-care system limits choice and access. Challenges in the workforce and supply chain persist, adding pressure on already strained health-care organizations. Innovative solutions are required to provide equitable value-based access to orthopaedic care.
    Language English
    Publishing date 2024-01-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 220625-0
    ISSN 1535-1386 ; 0021-9355
    ISSN (online) 1535-1386
    ISSN 0021-9355
    DOI 10.2106/JBJS.23.00809
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uk I Zs.58/1: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 464: Show issues

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  5. Article ; Online: Reply.

    Dellaripa, Paul F / Bush, Thomas / Miller, Frederick W / Feldman, Candace H

    Arthritis & rheumatology (Hoboken, N.J.)

    2023  Volume 75, Issue 8, Page(s) 1494

    Language English
    Publishing date 2023-06-14
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2756371-6
    ISSN 2326-5205 ; 2326-5191
    ISSN (online) 2326-5205
    ISSN 2326-5191
    DOI 10.1002/art.42488
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Degradation by Design: New Cyclin K Degraders from Old CDK Inhibitors.

    Thomas, Katie L / Bouguenina, Habib / Miller, Daniel S J / Sialana, Fernando J / Hayhow, Thomas G / Choudhary, Jyoti S / Rossanese, Olivia W / Bellenie, Benjamin R

    ACS chemical biology

    2024  Volume 19, Issue 1, Page(s) 173–184

    Abstract: Small molecules that induce protein degradation hold the potential to overcome several limitations of the currently available inhibitors. Monovalent or molecular glue degraders, in particular, enable the benefits of protein degradation without the ... ...

    Abstract Small molecules that induce protein degradation hold the potential to overcome several limitations of the currently available inhibitors. Monovalent or molecular glue degraders, in particular, enable the benefits of protein degradation without the disadvantages of high molecular weight and the resulting challenge in drug development that are associated with bivalent molecules like Proteolysis Targeting Chimeras. One key challenge in designing monovalent degraders is how to build in the degrader activity─how can we convert an inhibitor into a degrader? If degradation activity requires very specific molecular features, it will be difficult to find new degraders and challenging to optimize those degraders toward drugs. Herein, we demonstrate that an unexpectedly wide range of modifications to the degradation-inducing group of the cyclin K degrader CR8 are tolerated, including both aromatic and nonaromatic groups. We used these findings to convert the pan-CDK inhibitors dinaciclib and AT-7519 to Cyclin K degraders, leading to a novel dinaciclib-based compound with improved degradation activity compared to CR8 and confirm the mechanism of degradation. These results suggest that general design principles can be generated for the development and optimization of monovalent degraders.
    MeSH term(s) Proteolysis ; Cell Cycle Checkpoints ; Cyclins/metabolism
    Chemical Substances Cyclins
    Language English
    Publishing date 2024-01-09
    Publishing country United States
    Document type Journal Article
    ISSN 1554-8937
    ISSN (online) 1554-8937
    DOI 10.1021/acschembio.3c00616
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Open-Path Laser Absorption Sensor for Mobile Measurements of Atmospheric Ammonia.

    Shadman, Soran / Miller, Thomas W / Yalin, Azer P

    Sensors (Basel, Switzerland)

    2023  Volume 23, Issue 14

    Abstract: ... lightweight (~3.5 kg), battery-powered (<30 W) and operates autonomously. Details of the WMS setup and ...

    Abstract Anthropogenic emissions of ammonia to the atmosphere, particularly those from agricultural sources, can be damaging to the environment and human health and can drive a need for sensor technologies that can be used to detect and quantify the emissions. Mobile sensing approaches that can be deployed on ground-based or aerial vehicles can provide scalable solutions for high throughput measurements but require relatively compact and low-power sensor systems. This contribution presents an ammonia sensor based on wavelength modulation spectroscopy (WMS) integrated with a Herriott multi-pass cell and a quantum cascade laser (QCL) at 10.33 µm oriented to mobile use. An open-path configuration is used to mitigate sticky-gas effects and achieve high time-response. The final sensor package is relatively small (~20 L), lightweight (~3.5 kg), battery-powered (<30 W) and operates autonomously. Details of the WMS setup and analysis method are presented along with laboratory tests showing sensor accuracy (<~2%) and precision (~4 ppb in 1 s). Initial field deployments on both ground vehicles and a fixed-wing unmanned aerial vehicle (UAV) are also presented.
    Language English
    Publishing date 2023-07-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2052857-7
    ISSN 1424-8220 ; 1424-8220
    ISSN (online) 1424-8220
    ISSN 1424-8220
    DOI 10.3390/s23146498
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Visual outcomes of children undergoing penetrating keratoplasty in the US.

    Zhang, Lyvia J / Dana, Reza / Lorch, Alice C / Elze, Tobias / Miller, Joan W / Dohlman, Thomas H / Oke, Isdin

    The ocular surface

    2024  Volume 32, Page(s) 219–221

    Language English
    Publishing date 2024-02-24
    Publishing country United States
    Document type Letter
    ZDB-ID 2208578-6
    ISSN 1937-5913 ; 1542-0124
    ISSN (online) 1937-5913
    ISSN 1542-0124
    DOI 10.1016/j.jtos.2024.02.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6458: Show issues Location:
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  9. Article ; Online: Implementation of a minimally invasive cell culture system to measure the regulation of inflammation in a school-based sample of adolescents.

    McDade, Thomas W / Giletta, Matteo / Miller, Aaron A / Krause, Keegan C / Michels, Nathalie

    American journal of human biology : the official journal of the Human Biology Council

    2024  , Page(s) e24077

    Abstract: Dysregulated inflammation underlies many human diseases, and measures of responsiveness to activation, and sensitivity to inhibition, provide important information beyond baseline assessments of chronic inflammation. This study implements a simplified ... ...

    Abstract Dysregulated inflammation underlies many human diseases, and measures of responsiveness to activation, and sensitivity to inhibition, provide important information beyond baseline assessments of chronic inflammation. This study implements a simplified cell culture protocol in a school-based setting, using finger stick capillary blood collected from 333 adolescents (age 11.4-15.6 years) incubated with lipopolysaccharide (LPS). Median cytokine responses for IL6, IL1β, and TNFα were 61.9, 26.2, and 11.2 pg/mL, respectively. Samples were also incubated with LPS and glucocorticoid (GC) to measure GC sensitivity. Median responses were reduced in the presence of GC inhibition for IL6 (20.3 pg/mL), IL1β (10.5 pg/mL), and TNFα (3.3 pg/mL). Minimally invasive cell culture protocols provide novel opportunities for measuring inflammatory phenotypes in a wide range of non-clinical settings.
    Language English
    Publishing date 2024-03-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1025339-7
    ISSN 1520-6300 ; 1042-0533
    ISSN (online) 1520-6300
    ISSN 1042-0533
    DOI 10.1002/ajhb.24077
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2567: Show issues Location:
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  10. Article ; Online: From pregnancy to the postpartum: Unraveling the complexities of symptom profiles among trauma-exposed women.

    Miller, Michelle L / Laifer, Lauren M / Thomas, Emily B K / Grekin, Rebecca / O'Hara, Michael W / Brock, Rebecca L

    Journal of affective disorders

    2024  

    Abstract: Background: Many women experience new onset or worsening of existing posttraumatic stress disorder (PTSD) symptoms during pregnancy and the early postpartum period. However, perinatal PTSD symptom profiles and their predictors are not well understood.!## ...

    Abstract Background: Many women experience new onset or worsening of existing posttraumatic stress disorder (PTSD) symptoms during pregnancy and the early postpartum period. However, perinatal PTSD symptom profiles and their predictors are not well understood.
    Methods: Participants (N = 614 community adults) completed self-report measures across three methodologically similar longitudinal studies. Mixture modeling was used to identify latent subgroups of trauma-exposed women with distinct patterns of symptoms at pregnancy, 1-month, and 3-month postpartum.
    Results: Mixture modeling demonstrated two classes of women with relatively homogenous profiles (i.e., low vs. high symptoms) during pregnancy (n = 237). At 1-month postpartum (n = 391), results suggested a five-class solution: low symptoms, PTSD only, depression with primary appetite loss, depression, and comorbid PTSD and depression. At 3-months postpartum (n = 488), three classes were identified: low symptoms, elevated symptoms, and primary PTSD. Greater degree of exposure to interpersonal trauma and reproductive trauma, younger age, and minoritized racial/ethnic identity were associated with increased risk for elevated symptoms across the perinatal period.
    Limitations: Only a subset of potential predictors of PTSD symptoms were examined. Replication with a larger and more racially and ethnically diverse sample of pregnant women is needed.
    Conclusions: Results highlight limitations of current perinatal mental health screening practices, which could overlook women with elevations in symptoms (e.g., intrusions) that are not routinely assessed relative to others (e.g., depressed mood), and identify important risk factors for perinatal PTSD symptoms to inform screening and referral.
    Language English
    Publishing date 2024-04-23
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 135449-8
    ISSN 1573-2517 ; 0165-0327
    ISSN (online) 1573-2517
    ISSN 0165-0327
    DOI 10.1016/j.jad.2024.04.079
    Database MEDical Literature Analysis and Retrieval System OnLINE

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