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  1. Article ; Online: Melanoma development: stage-dependent cancer competence of the melanocytic lineage.

    Kunz, Manfred

    Signal transduction and targeted therapy

    2021  Volume 6, Issue 1, Page(s) 433

    MeSH term(s) Humans ; Melanocytes ; Melanoma
    Language English
    Publishing date 2021-12-20
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 2886872-9
    ISSN 2059-3635 ; 2095-9907
    ISSN (online) 2059-3635
    ISSN 2095-9907
    DOI 10.1038/s41392-021-00854-3
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  2. Article ; Online: Patient-derived melanoma models.

    Karras, Franziska / Kunz, Manfred

    Pathology, research and practice

    2024  , Page(s) 155231

    Abstract: Melanoma is a very aggressive, rapidly metastasizing tumor that has been studied intensively in the past regarding the underlying genetic and molecular mechanisms. More recently developed treatment modalities have improved response rates and overall ... ...

    Abstract Melanoma is a very aggressive, rapidly metastasizing tumor that has been studied intensively in the past regarding the underlying genetic and molecular mechanisms. More recently developed treatment modalities have improved response rates and overall survival of patients. However, the majority of patients suffer from secondary treatment resistance, which requires in depth analyses of the underlying mechanisms. Here, melanoma models based on patients-derived material may play an important role. Consequently, a plethora of different experimental techniques have been developed in the past years. Among these are 3D and 4D culture techniques, organotypic skin reconstructs, melanoma-on-chip models and patient-derived xenografts, Every technique has its own strengths but also weaknesses regarding throughput, reproducibility, and reflection of the human situation. Here, we provide a comprehensive overview of currently used techniques and discuss their use in different experimental settings.
    Language English
    Publishing date 2024-02-28
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 391889-0
    ISSN 1618-0631 ; 0344-0338
    ISSN (online) 1618-0631
    ISSN 0344-0338
    DOI 10.1016/j.prp.2024.155231
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    In stock of ZB MED Cologne/Königswinter

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  3. Article ; Online: Melanoma development

    Manfred Kunz

    Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-

    stage-dependent cancer competence of the melanocytic lineage

    2021  Volume 2

    Keywords Medicine ; R ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2021-12-01T00:00:00Z
    Publisher Nature Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Beidseitiges Pyoderma gangraenosum der äußeren Gehörgänge.

    Gora, Thomas / Zarnowski, Julia / Kunz, Manfred

    Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG

    2023  Volume 21, Issue 7, Page(s) 807–809

    Language German
    Publishing date 2023-04-30
    Publishing country Germany
    Document type Case Reports
    ZDB-ID 2093479-8
    ISSN 1610-0387 ; 1610-0379
    ISSN (online) 1610-0387
    ISSN 1610-0379
    DOI 10.1111/ddg.15035_g
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6148: Show issues Location:
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  5. Article ; Online: Großflächiger Lupus vulgaris durch Mycobacterium bovis.

    Zarnowski, Julia / Simon, Jan-Christoph / Kunz, Manfred

    Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG

    2023  Volume 21 Suppl 2, Page(s) 6–8

    MeSH term(s) Humans ; Lupus Vulgaris/diagnosis ; Lupus Vulgaris/microbiology ; Mycobacterium bovis
    Language German
    Publishing date 2023-04-25
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2093479-8
    ISSN 1610-0387 ; 1610-0379
    ISSN (online) 1610-0387
    ISSN 1610-0379
    DOI 10.1111/ddg.15100_g
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    Zs.A 6148: Show issues Location:
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  6. Article ; Online: Bilateral pyoderma gangraenosum of the external auditory canals.

    Gora, Thomas / Zarnowski, Julia / Kunz, Manfred

    Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG

    2023  Volume 21, Issue 7, Page(s) 807–809

    MeSH term(s) Humans ; Ear Canal ; Pyoderma
    Language English
    Publishing date 2023-05-01
    Publishing country Germany
    Document type Case Reports
    ZDB-ID 2093479-8
    ISSN 1610-0387 ; 1610-0379
    ISSN (online) 1610-0387
    ISSN 1610-0379
    DOI 10.1111/ddg.15035
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6148: Show issues Location:
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  7. Article: Current concepts of photosensitivity in cutaneous lupus erythematosus.

    Klein, Benjamin / Kunz, Manfred

    Frontiers in medicine

    2022  Volume 9, Page(s) 939594

    Abstract: Cutaneous lupus erythematosus (CLE) represents a complex autoimmune disease with a broad phenotypic spectrum ranging from acute to chronic destructive cutaneous lesions. Patients with CLE exhibit high photosensitivity and ultraviolet (UV) irradiation can ...

    Abstract Cutaneous lupus erythematosus (CLE) represents a complex autoimmune disease with a broad phenotypic spectrum ranging from acute to chronic destructive cutaneous lesions. Patients with CLE exhibit high photosensitivity and ultraviolet (UV) irradiation can lead to systemic flares in systemic lupus erythematosus. However, the exact mechanisms how UV irradiation enhances cutaneous inflammation in lupus are not fully understood. Recently, new molecular mechanisms of UV-driven immune responses in CLE were identified, offering potential therapeutic approaches. Especially the induction of type I interferons, central cytokines in lupus pathogenesis which are released by various skin cells, have become the focus of current research. In this review, we describe current pathogenic concepts of photosensitivity in lupus erythematosus, including UV-driven activation of intracellular nucleic acid sensors, cellular cytokine production and immune cell activation. Furthermore, we discuss activated pathways contributing to enhanced apoptosis as well as intracellular translocation of autoantigens thereby promoting CLE upon UV light exposure.
    Language English
    Publishing date 2022-08-25
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2022.939594
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  8. Article ; Online: Impact of Chronic Inflammation in Psoriasis on Bone Metabolism.

    Saalbach, Anja / Kunz, Manfred

    Frontiers in immunology

    2022  Volume 13, Page(s) 925503

    Abstract: Psoriasis is a chronic inflammatory disease of the skin and joints associated with several comorbidities such as arthritis, diabetes mellitus and metabolic syndrome, including obesity, hypertension and dyslipidaemia, Crohn's disease, uveitis and ... ...

    Abstract Psoriasis is a chronic inflammatory disease of the skin and joints associated with several comorbidities such as arthritis, diabetes mellitus and metabolic syndrome, including obesity, hypertension and dyslipidaemia, Crohn's disease, uveitis and psychiatric and psychological diseases. Psoriasis has been described as an independent risk factor for cardiovascular diseases and thus patients with psoriasis should be monitored for the development of cardiovascular disease or metabolic syndrome. However, there is mounting evidence that psoriasis also affects the development of osteoporosis, an important metabolic disease with enormous clinical and socioeconomic impact. At present, there are still controversial opinions about the role of psoriasis in osteoporosis. A more in depth analysis of this phenomenon is of great importance for affected patients since, until now, bone metabolism is not routinely examined in psoriatic patients, which might have important long-term consequences for patients and the health system. In the present review, we summarize current knowledge on the impact of psoriatic inflammation on bone metabolism and osteoporosis.
    MeSH term(s) Cardiovascular Diseases/etiology ; Humans ; Inflammation/complications ; Metabolic Syndrome ; Osteoporosis/etiology ; Psoriasis/complications
    Language English
    Publishing date 2022-06-23
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2022.925503
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  9. Book ; Thesis: Hypoxieinduzierte Genregulation und Signaltransduktion beim malignen Melanom und ihre Bedeutung für Tumorangiogenese und Apoptose

    Kunz, Manfred

    2000  

    Author's details vorgelegt von Manfred Kunz
    Language German
    Size 111 Bl., Ill., graph. Darst., 30 cm
    Edition [Mikrofiche-Ausg.]
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Rostock, Univ., Habil.-Schr., 2001
    HBZ-ID HT013289044
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2002 MB 1988 order for loan Magazin

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  10. Article ; Online: Gummatous Cutaneous Syphilis.

    Reschke, Robin / Kunz, Manfred / Ziemer, Mirjana

    Deutsches Arzteblatt international

    2022  Volume 119, Issue 26, Page(s) 457

    MeSH term(s) Humans ; Syphilis, Cutaneous ; Syphilis
    Language English
    Publishing date 2022-10-21
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2406159-1
    ISSN 1866-0452 ; 1866-0452
    ISSN (online) 1866-0452
    ISSN 1866-0452
    DOI 10.3238/arztebl.m2022.0050
    Database MEDical Literature Analysis and Retrieval System OnLINE

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