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  1. Article ; Online: Ethnobotanical study on medicinal plants used by the Yi people in Xiaoliangshan, Yunnan Province, SW China.

    Addi, Yi-Won / Ren, Zong-Xin / Rutherford, Susan / Ding, Xiao-Yong / Guo, Chang-An / Zhang, Xiong / Zhang, Shuai / Liao, Heping / Wang, Yuhua

    Journal of ethnopharmacology

    2024  Volume 323, Page(s) 117683

    Abstract: Ethnopharmacological relevance: The Yi people in the Xiaoliangshan region in southwest China have ... of systematic documentation on the knowledge of traditional medicinal plants used by the Yi people ... the diversity of medicinal plants used by the Yi people and explore their therapeutic usages. 2. Evaluate and ...

    Abstract Ethnopharmacological relevance: The Yi people in the Xiaoliangshan region in southwest China have a unique practice of combining ritual treatment and traditional medicine to care for patients. Despite increasing urbanization in the area, they have managed to preserve their distinctive lifestyle and extensive knowledge of traditional medicinal plants, setting them apart from other regions. However, there is a lack of systematic documentation on the knowledge of traditional medicinal plants used by the Yi people in Xiaoliangshan.
    Aim of the study: This research aims to achieve the following objectives: 1. Document the diversity of medicinal plants used by the Yi people and explore their therapeutic usages. 2. Evaluate and analyze the main types of diseases with a high incidence in the local area and identify the types of medicinal plants used to treat these diseases. 3. Explore the underlying geographical and human factors influencing both disease prevalence and medicinal plant usage.
    Methods: Ethnobotanical research methods were used to record and analyze the medicinal plants used by the Yi in Xiaoliangshan. Experts identified all plant specimens collected during ethnobotanical field surveys. The types of diseases treated by medicinal plants were classified according to the International Classification of Primary Care -
    Results: A total of 125 medicinal plants were recorded after interviewing 193 participants. Of the medicinal plants identified, those with over 100 use reports were Paris polyphylla (202 use reports), Taxillus sutchuenensis (183), Artemisia indica (149), and Papaver somniferum (113). A total of 14 disease categories were recorded, with those related to the following categories having higher Informant Consensus factor values (ICF ≥0.85): Pregnancy, Childbearing, Family Planning, General and Unspecified, Urological, Respiratory, Musculoskeletal, and Skin. The highest quantity of medicinal plants is utilized to improve specific diseases and health problems, namely those related to Digestion, Skin, and Musculoskeletal. Fewer plant species were utilized for diseases or health issues associated with Eyes, Psychological, or Pregnancy, Childbearing, and Family Planning. The use reports from the informants also revealed how some medicinal plants are used to treat a variety of diseases or health issues. For instance, Malva pusilla is used for inducing abortion, treating postpartum hemorrhage, and joint sprains; Artemisia indica is used for treating malaria; Argentina lineata is used to remedy tuberculosis and malaria. Taxillus sutchuenensis is used for dealing with cold, pneumonia, and other ailments.
    Conclusions: The Yi people in Xiaoliangshan have a rich knowledge of traditional medicinal plants. Decoction and wine brewing are the most common processing methods used for these plants, which are utilized to treat a wide range of diseases. The characteristics of the medicinal use of the Yi people reflects the alpine mountainous environment in which they live, and their medical practices are closely related to traditional healing culture. This study enhances our understanding of the Yi traditional medicine via documentation and offers a valuable reference for future research and the development of new drugs.
    MeSH term(s) Humans ; China ; Ethnobotany ; Health Knowledge, Attitudes, Practice ; Malaria ; Phytotherapy ; Plants, Medicinal ; Southeast Asian People
    Language English
    Publishing date 2024-01-04
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 134511-4
    ISSN 1872-7573 ; 0378-8741
    ISSN (online) 1872-7573
    ISSN 0378-8741
    DOI 10.1016/j.jep.2023.117683
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Correction for: Jian-Pi-Yi-Shen decoction inhibits mitochondria-dependent granulosa cell apoptosis in a rat model of POF.

    Jiang, Xiao-Lin / Tai, He / Kuang, Jin-Song / Zhang, Jing-Yi / Cui, Shi-Chao / Lu, Yu-Xuan / Qi, Shu-Bo / Zhang, Shi-Yu / Li, Shun-Min / Chen, Jian-Ping / Meng, Xian-Sheng

    Aging

    2023  Volume 15, Issue 6, Page(s) 2358–2360

    Language English
    Publishing date 2023-03-30
    Publishing country United States
    Document type Journal Article ; Published Erratum
    ISSN 1945-4589
    ISSN (online) 1945-4589
    DOI 10.18632/aging.204637
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Identification of Active Compounds From Yi Nationality Herbal Formula

    Zhang, Ji-Zhong / Chen, Xiao-Yi / Wu, You-Jiao / Li, Li-Min / Huang, Li / Yin, Qiao-Zhi / Luo, Pei / Liu, Yuan

    Frontiers in pharmacology

    2020  Volume 11, Page(s) 568585

    Abstract: The Yi nationality herbal formula ...

    Abstract The Yi nationality herbal formula
    Language English
    Publishing date 2020-11-09
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2020.568585
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Clinical and whole exome sequencing findings in children from Yunnan Yi minority ethnic group with retinitis pigmentosa: two case reports.

    Xiao, Yi-Shuang / He, Wen-Ji / Jiang, Hong-Chao / Tan, Li / Ma, Jing / Zhang, Zhen

    Journal of medical case reports

    2023  Volume 17, Issue 1, Page(s) 226

    Abstract: ... of cases.: Case presentation: Two non-consanguineous Yi minority ethnic group families who have a 6.4 ... retinitis pigmentosa genes and give these two Yi minority ethnic group families from Yunnan more precise ...

    Abstract Background: Retinitis pigmentosa is a group of rare hereditary retinal dystrophy diseases that lead to difficulty seeing at night, progressive loss of peripheral field vision (tunnel vision), and eventual loss of central vision. However, a genetic cause cannot be determined in approximately 60% of cases.
    Case presentation: Two non-consanguineous Yi minority ethnic group families who have a 6.4-year-old boy and a 0.5-year-old boy, respectively, were recruited for genetic diagnosis. Here, we used whole-exome sequencing to detect mutations in the genes of the probands of the retinitis pigmentosa families, and Sanger sequencing to confirm the causal mutations identified by whole exome sequencing. In addition, we report two cases with retinitis pigmentosa caused by RDH12 (c.524C > T) and PRPF4 (c.1273G > A) pathogenic mutations.
    Conclusions: These results might extend the mutation spectrum of known retinitis pigmentosa genes and give these two Yi minority ethnic group families from Yunnan more precise genetic counseling and more specific prognoses.
    MeSH term(s) Male ; Humans ; Child ; Infant ; Exome Sequencing ; Ethnicity/genetics ; Exome/genetics ; DNA Mutational Analysis ; China ; Retinitis Pigmentosa/genetics ; Retinitis Pigmentosa/diagnosis ; Retinitis Pigmentosa/pathology ; Mutation ; Pedigree ; Alcohol Oxidoreductases/genetics
    Chemical Substances RDH12 protein, human (EC 1.1.1.105) ; Alcohol Oxidoreductases (EC 1.1.-)
    Language English
    Publishing date 2023-06-02
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 2269805-X
    ISSN 1752-1947 ; 1752-1947
    ISSN (online) 1752-1947
    ISSN 1752-1947
    DOI 10.1186/s13256-023-03830-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: A study of the plant folk nomenclature of the Yi people in Xiaoliangshan, Yunnan Province, China, and the implications for protecting biodiversity.

    Addi, Yi-Won / Zhang, Yu / Ding, Xiao-Yong / Guo, Chang-An / Wang, Yu-Hua

    Journal of ethnobiology and ethnomedicine

    2022  Volume 18, Issue 1, Page(s) 18

    Abstract: ... to distinguish plant species. This study aimed to document the folk botanical nomenclature of the Yi people ... of this study will assist in conserving biodiversity and the language of the Yi people and will promote ... the transmission of ethnobotanical knowledge.: Methods: An ethnobotanical survey of plants used by the Yi people ...

    Abstract Background: Folk plant nomenclature is a part of knowledge of indigenous people often used to distinguish plant species. This study aimed to document the folk botanical nomenclature of the Yi people in Xiaoliangshan, Yunnan Province, which has not been systematically investigated to date. The results of this study will assist in conserving biodiversity and the language of the Yi people and will promote the transmission of ethnobotanical knowledge.
    Methods: An ethnobotanical survey of plants used by the Yi people in Xiaoliangshan, Yunnan Province, was conducted from September 2019 to August 2021. Semi-structured interviews and key informant interviews were conducted to collect and document ethnobotanical information, which was then used to analyse the folk botanical nomenclature of the Yi people. In addition, the folk names of plants used by the Xiaoliangshan Yi community were compared with those of the Yi people living in the Daliangshan, where the environment is considerably different.
    Results: In this study, 266 informants were interviewed, and the names of 228 indigenous plants were extracted from 3088 use reports. The nomenclature used by the local Yi people is based on plant characteristics, plant habitat, plant use, and the local culture. By comparing the folk plant names of the Yi people in Xiaoliangshan with those of the Yi people in Daliangshan, we found that the plant names of the two places have some similarities and also with their own unique characters. The important folk plant names of the Yi people in Xiaoliangshan usually have a monosyllable non-binomial structure or have and "divine attributes" in their names.
    Conclusions: The Yi people in Xiaoliangshan have a rich and diverse knowledge of plant naming determined by cultural, and environmental factors. The botanical nomenclature of the Yi people has distinct rules and characteristics, and the plant naming directly includes important plants that they believe to be used and protected, which is of great significance to the protection of biodiversity.
    MeSH term(s) Biodiversity ; China ; Ethnobotany/methods ; Humans ; Knowledge ; Plants
    Language English
    Publishing date 2022-03-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 2202544-3
    ISSN 1746-4269 ; 1746-4269
    ISSN (online) 1746-4269
    ISSN 1746-4269
    DOI 10.1186/s13002-022-00504-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Yi Mai granule improve energy supply of endothelial cells in atherosclerosis via miRNA-125a-5p regulating mitochondrial autophagy through Pink1-Mfn2-Parkin pathway.

    Kong, De Zhao / Sun, Peng / Lu, Yi / Yang, Ye / Min, Dong Yu / Zheng, Si Cheng / Yang, Yi / Zhang, Zhe / Yang, Guan Lin / Jiang, Jun Wen

    Journal of ethnopharmacology

    2023  Volume 319, Issue Pt 1, Page(s) 117114

    Abstract: Ethnopharmacological relevance: Yi Mai granule (YMG) consists of two classic Chinese medicine ...

    Abstract Ethnopharmacological relevance: Yi Mai granule (YMG) consists of two classic Chinese medicine formulas used to treat cardiovascular disease for centuries. The Pink1-Mfn2-Parkin pathway, a well-recognized mechanism that mediates mitochondrial autophagy, plays a big part in mitochondrial quality control and the maintenance of heart function. However, the effects of YMG on endothelial dysfunction and mitochondrial autophagy remain unknown.
    Aim of the study: Here, we focused on the therapeutic effects of YMG in improving mitochondrial autophagy and the mechanism of YMG against cardiovascular disease.
    Materials and methods: In this study, rats were fed high-fat diet (HFD) for 21 weeks and were given high, medium, and low doses of YMG in stomach. The open field test was used to evaluate the rats' behavior. Atherosclerotic plaques, blood lipids, and cytokine levels were measured. Mitochondrial autophagy changes were observed by Transmission electron microscope (TEM). Human umbilical vein endothelial cells (HUVECs) were injured by angiotensinⅡ(AngⅡ) and were given high, medium, and low doses of YMG medicated serum in cell culture medium. Pink1-Mfn2-Parkin expression and miRNA 125a-5p expression were measured by RT-PCR and Western blot.
    Results: We demonstrated that the atherosclerosis model group tended to exhibit reduced vitality behaviors. We proved that the atherosclerosis model group showed obvious atherosclerotic plaques, endothelial cells destruction, and high level of blood lipid and cytokines (including hs-CRP, ET). Mitochondria were reduced, and mitophagy was inhibited in aortic cells of the model group. MiRNA-125a-5p was up-regulated; at the same time, Pink1-Mfn2-Parkin-mediated mitochondrial autophagy was prevented. We also proved that AngⅡinjured HUVEC showed obviously low mRNA levels of Pink1, Mfn2, and Parkin. Interestingly, we found that miRNA-125a-5p was significantly down regulated in Ang II-induced HUVECs. In addition, miRNA-125a-5p significantly reduced the protective effect of YiMai Granules against Ang II injury.
    Conclusion: Our finding indicated that Pink1-Mfn2-Parkin-mediated mitochondrial autophagy plays a crucial role in alleviating atherosclerosis. YMG alleviated atherosclerosis by potentially activating mitochondrial autophagy may via miRNA-125a-5p, regulating Pink1-Mfn2-Parkin pathway, and regulating proinflammatory factors, vasoconstriction cytokine, and blood lipids.
    MeSH term(s) Rats ; Humans ; Animals ; Endothelial Cells/metabolism ; Plaque, Atherosclerotic/metabolism ; Cardiovascular Diseases ; Protein Kinases/metabolism ; Autophagy ; Mitochondria ; Ubiquitin-Protein Ligases/genetics ; Ubiquitin-Protein Ligases/metabolism ; Atherosclerosis/drug therapy ; Atherosclerosis/genetics ; Atherosclerosis/metabolism ; Cytokines/metabolism ; Lipids/pharmacology ; MicroRNAs/genetics ; MicroRNAs/metabolism
    Chemical Substances Protein Kinases (EC 2.7.-) ; Ubiquitin-Protein Ligases (EC 2.3.2.27) ; Cytokines ; Lipids ; MicroRNAs
    Language English
    Publishing date 2023-09-09
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 134511-4
    ISSN 1872-7573 ; 0378-8741
    ISSN (online) 1872-7573
    ISSN 0378-8741
    DOI 10.1016/j.jep.2023.117114
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Chinese herbal decoction, Yi-Qi-Jian-Pi formula exerts anti-hepatic fibrosis effects in mouse models of CCl

    Yang, Shiyan / Cheng, Yajun / Wang, Xiaolong / Yue, Suyang / Wang, Xi / Tang, Li / Li, Hailun / Zhang, Jie / Xiong, Qingping / Tan, Shanzhong

    Heliyon

    2024  Volume 10, Issue 5, Page(s) e26129

    Abstract: Background: Yi-Qi-Jian-Pi Formula (YQJPF) is a herbal medicine that is used to treat patients ...

    Abstract Background: Yi-Qi-Jian-Pi Formula (YQJPF) is a herbal medicine that is used to treat patients with liver failure. However, scientific evidence supporting the treatment of hepatic fibrosis with YQJPF has not been forthcoming. The present study aimed to determine the mechanisms underlying the anti-fibrotic effects of YQJPF in mouse models of hepatic fibrosis.
    Methods: Mice were randomly assigned to control, hepatic fibrosis model, silymarin (positive treated), and low-, medium- and high-dose YQJPF (7.5, 15, and 30 g/kg, respectively) groups. Liver function, inflammatory cytokines, and oxygen stress were analyzed using ELISA kits. Sections were histopathologically stained with hematoxylin-eosin, Masson trichrome, and Sirius red. Macrophage polarization was measured by flow cytometry and immunofluorescence. Potential targets of YQJPF against hepatic fibrosis were analyzed by network pharmacology of Chinese herbal compound and the effects of YQJPF on the transforming growth factor-beta (TGF-β)/Suppressor of Mothers against Decapentaplegic family member 3 (Smad3) signaling pathway were assessed using qRT-PCR and immunohistochemical staining. Finally, metagenomics and LC-MS/MS were used to detect the intestinal flora and metabolites of the mice, and an in-depth correlation analysis was performed by spearman correlation analysis. The data were compared by one-way ANOVA and least significant differences (LSDs) or ANOVA-Dunnett's T3 method used when no homogeneity was detected.
    Results: We induced hepatic fibrosis using CCl
    Conclusions: YQJPF can reverse liver fibrosis by inhibiting inflammation, suppressing oxidative stress, regulating the immunological response initiated by macrophages, inhibiting TGF-β/Smad3 signaling and regulating intestinal flora homeostasis. Therefore, YQJPF may be included in clinical regimens to treat hepatic fibrosis.
    Language English
    Publishing date 2024-02-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2024.e26129
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Jian-Pi-Yi-Shen decoction inhibits mitochondria-dependent granulosa cell apoptosis in a rat model of POF.

    Jiang, Xiao-Lin / Tai, He / Kuang, Jin-Song / Zhang, Jing-Yi / Cui, Shi-Chao / Lu, Yu-Xuan / Qi, Shu-Bo / Zhang, Shi-Yu / Li, Shun-Min / Chen, Jian-Ping / Meng, Xian-Sheng

    Aging

    2022  Volume 14, Issue 20, Page(s) 8321–8345

    Abstract: As a widely applied traditional Chinese medicine (TCM), Jian-Pi-Yi-Shen (JPYS) decoction maybe ...

    Abstract As a widely applied traditional Chinese medicine (TCM), Jian-Pi-Yi-Shen (JPYS) decoction maybe applied in curing premature ovarian failure (POF) besides chronic kidney disease (CKD).
    MeSH term(s) Rats ; Female ; Humans ; Animals ; Primary Ovarian Insufficiency/metabolism ; Triptorelin Pamoate/metabolism ; Triptorelin Pamoate/pharmacology ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use ; Apoptosis ; Granulosa Cells/metabolism ; Mitochondria/metabolism
    Chemical Substances Triptorelin Pamoate (08AN7WA2G0) ; Drugs, Chinese Herbal
    Language English
    Publishing date 2022-10-27
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1945-4589
    ISSN (online) 1945-4589
    DOI 10.18632/aging.204320
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Bu Shen Yi Sui Capsule Promotes Myelin Repair by Modulating the Transformation of A1/A2 Reactive Astrocytes

    Zha, Zheng / Liu, Yi-Jiang / Liu, Si-Si / Zhang, Nan / Li, Jun-Ling / Qi, Fang / Jin, Liang-Yun / Xue, Bing / Yang, Tao / Fan, Yong-Ping / Zhao, Hui / Wang, Lei

    Oxidative medicine and cellular longevity

    2022  Volume 2022, Page(s) 3800004

    Abstract: Background/ ... ...

    Abstract Background/Aims
    MeSH term(s) Animals ; Astrocytes/metabolism ; Central Nervous System ; Complement C1q/metabolism ; Complement C1q/pharmacology ; Mice ; Mice, Inbred C57BL ; MicroRNAs/metabolism ; Multiple Sclerosis/drug therapy ; Multiple Sclerosis/metabolism ; Myelin Sheath ; Tumor Necrosis Factor-alpha/metabolism
    Chemical Substances MicroRNAs ; Tumor Necrosis Factor-alpha ; Complement C1q (80295-33-6)
    Language English
    Publishing date 2022-09-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2455981-7
    ISSN 1942-0994 ; 1942-0994
    ISSN (online) 1942-0994
    ISSN 1942-0994
    DOI 10.1155/2022/3800004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Clinical and whole exome sequencing findings in children from Yunnan Yi minority ethnic group with retinitis pigmentosa

    Yi-shuang Xiao / Wen-Ji He / Hong-chao Jiang / Li Tan / Jing Ma / Zhen Zhang

    Journal of Medical Case Reports, Vol 17, Iss 1, Pp 1-

    two case reports

    2023  Volume 6

    Abstract: ... of cases. Case presentation Two non-consanguineous Yi minority ethnic group families who have a 6.4-year ... retinitis pigmentosa genes and give these two Yi minority ethnic group families from Yunnan more precise ...

    Abstract Abstract Background Retinitis pigmentosa is a group of rare hereditary retinal dystrophy diseases that lead to difficulty seeing at night, progressive loss of peripheral field vision (tunnel vision), and eventual loss of central vision. However, a genetic cause cannot be determined in approximately 60% of cases. Case presentation Two non-consanguineous Yi minority ethnic group families who have a 6.4-year-old boy and a 0.5-year-old boy, respectively, were recruited for genetic diagnosis. Here, we used whole-exome sequencing to detect mutations in the genes of the probands of the retinitis pigmentosa families, and Sanger sequencing to confirm the causal mutations identified by whole exome sequencing. In addition, we report two cases with retinitis pigmentosa caused by RDH12 (c.524C > T) and PRPF4 (c.1273G > A) pathogenic mutations. Conclusions These results might extend the mutation spectrum of known retinitis pigmentosa genes and give these two Yi minority ethnic group families from Yunnan more precise genetic counseling and more specific prognoses.
    Keywords Mutation ; Retinitis pigmentosa ; Pediatric population ; Yunnan ; Medicine ; R
    Subject code 360
    Language English
    Publishing date 2023-06-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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