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  1. Article: [MALT lymphoma/ Waldenström macroglobulinemia].

    Kobayashi, Yukio

    Rinsho ketsueki] The Japanese journal of clinical hematology

    2019  Volume 60, Issue 3, Page(s) 238–239

    MeSH term(s) Humans ; Lymphoma, B-Cell, Marginal Zone ; Waldenstrom Macroglobulinemia
    Language Japanese
    Publishing date 2019-05-26
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 390900-1
    ISSN 0485-1439
    ISSN 0485-1439
    DOI 10.11406/rinketsu.60.238
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1175: Show issues Location:
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    Zs.MO 535: Show issues

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  2. Article ; Online: JSH practical guidelines for hematological malignancies, 2018: II. Lymphoma-3. Lymphoplasmacytic lymphoma/Waldenström's macroglobulinemia (LPL/WM).

    Kobayashi, Yukio

    International journal of hematology

    2019  Volume 110, Issue 5, Page(s) 524–528

    MeSH term(s) Humans ; Immunoglobulin M/metabolism ; Lymphoma, B-Cell/diagnosis ; Lymphoma, B-Cell/drug therapy ; Lymphoma, B-Cell/physiopathology ; Prognosis ; Waldenstrom Macroglobulinemia/diagnosis ; Waldenstrom Macroglobulinemia/drug therapy ; Waldenstrom Macroglobulinemia/genetics ; Waldenstrom Macroglobulinemia/physiopathology
    Chemical Substances Immunoglobulin M
    Language English
    Publishing date 2019-09-07
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 1076875-0
    ISSN 1865-3774 ; 0917-1258 ; 0925-5710
    ISSN (online) 1865-3774
    ISSN 0917-1258 ; 0925-5710
    DOI 10.1007/s12185-019-02730-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  3. Article ; Online: JSH practical guidelines for hematological malignancies, 2018: II. Lymphoma-2. Marginal zone lymphoma (MALT lymphoma/extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue and splenic marginal zone lymphoma).

    Kobayashi, Yukio

    International journal of hematology

    2019  Volume 110, Issue 4, Page(s) 393–405

    MeSH term(s) Hematologic Neoplasms/therapy ; Humans ; Lymphoma, B-Cell, Marginal Zone/pathology ; Lymphoma, B-Cell, Marginal Zone/therapy ; Practice Guidelines as Topic ; Splenic Neoplasms
    Language English
    Publishing date 2019-08-19
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 1076875-0
    ISSN 1865-3774 ; 0917-1258 ; 0925-5710
    ISSN (online) 1865-3774
    ISSN 0917-1258 ; 0925-5710
    DOI 10.1007/s12185-019-02719-6
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  4. Article: [Strategy for treatment of acute lymphoblastic leukemia].

    Kobayashi, Yukio

    Rinsho ketsueki] The Japanese journal of clinical hematology

    2018  Volume 59, Issue 10, Page(s) 2019–2027

    Abstract: The treatment outcomes of adult acute lymphoblastic leukemia (ALL) have improved. Furthermore, the introduction of pediatric specific therapies has enhanced ALL treatment results in adolescents and young adult (AYAs). Age-related molecular signatures ... ...

    Abstract The treatment outcomes of adult acute lymphoblastic leukemia (ALL) have improved. Furthermore, the introduction of pediatric specific therapies has enhanced ALL treatment results in adolescents and young adult (AYAs). Age-related molecular signatures have also been identified, such as Philadelphia chromosome (Ph)-like ALL and DUX4/ERG gene-associated ALL. The measurement of minimal residual disease (MRD) has enabled the early detection of patients susceptible to relapse, and they become candidates for hematopoietic stem cell transplantation (HSCT). However, new generation tyrosine kinase inhibitor (TKI) therapy has enabled the avoidance of HSCT in Ph-positive ALL cases. Novel agents targeting CD19 and CD22 molecules will be available in the near future that should improve treatment outcomes in patients newly diagnosed with ALL.
    MeSH term(s) Hematopoietic Stem Cell Transplantation ; Humans ; Molecular Targeted Therapy ; Neoplasm, Residual ; Philadelphia Chromosome ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/therapy ; Protein Kinase Inhibitors/therapeutic use ; Protein-Tyrosine Kinases/antagonists & inhibitors ; Transplantation, Homologous ; Treatment Outcome
    Chemical Substances Protein Kinase Inhibitors ; Protein-Tyrosine Kinases (EC 2.7.10.1)
    Language Japanese
    Publishing date 2018-10-10
    Publishing country Japan
    Document type Journal Article ; Review
    ZDB-ID 390900-1
    ISSN 0485-1439
    ISSN 0485-1439
    DOI 10.11406/rinketsu.59.2019
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 535: Show issues

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  5. Article ; Online: Design of a new self-assembling antioxidant nanomedicine to ameliorate oxidative stress in zebrafish embryos.

    Shashni, Babita / Tamaoki, Junya / Kobayashi, Makoto / Nagasaki, Yukio

    Acta biomaterialia

    2023  Volume 159, Page(s) 367–381

    Abstract: Oxidative stress, which is a persistent state of elevated reactive oxygen species (ROS), is implicated in the pathogeneses of several diseases, making antioxidant-based therapeutics the aptest intervention. Nevertheless, the clinical failure of ... ...

    Abstract Oxidative stress, which is a persistent state of elevated reactive oxygen species (ROS), is implicated in the pathogeneses of several diseases, making antioxidant-based therapeutics the aptest intervention. Nevertheless, the clinical failure of conventional low-molecular-weight (LMW) antioxidants in oxidative stress-related diseases to yield favorable therapeutic outcomes and an increased mortality rate attributable to their poor pharmacokinetic characteristics, necessitates the development of alternative therapeutics. In light of this, we designed and synthesized a new amphiphilic polymer functionalized with a clinically safe base polymer of poly(styrene-co-maleic anhydride) copolymer conjugated with the LMW pleiotropic antioxidant TEMPO (a potent antioxidant) and biocompatible poly(ethylene glycol) (TEMPO-installed PSMA-g-PEG), which self-assembles into nano-sized micelles (SMAPo
    MeSH term(s) Animals ; Antioxidants/pharmacology ; Reactive Oxygen Species ; Zebrafish ; Nanomedicine ; Oxidative Stress ; Polymers ; Polyethylene Glycols
    Chemical Substances Antioxidants ; tempol (U78ZX2F65X) ; poly(styrene-co-maleic anhydride) ; Reactive Oxygen Species ; Polymers ; Polyethylene Glycols (3WJQ0SDW1A)
    Language English
    Publishing date 2023-01-12
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2173841-5
    ISSN 1878-7568 ; 1742-7061
    ISSN (online) 1878-7568
    ISSN 1742-7061
    DOI 10.1016/j.actbio.2023.01.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Current diagnosis and treatment for acute myeloid leukemia.

    Kobayashi, Yukio

    Rinsho ketsueki] The Japanese journal of clinical hematology

    2017  Volume 58, Issue 4, Page(s) 364–372

    Abstract: Genomic studies of acute myeloid leukemia have been extensively in progress. In patients with therapy-related myeloid neoplasms, peripheral blood before chemotherapy was found to have a minute clone with mutated oncogenes and tumor suppressor genes. ... ...

    Abstract Genomic studies of acute myeloid leukemia have been extensively in progress. In patients with therapy-related myeloid neoplasms, peripheral blood before chemotherapy was found to have a minute clone with mutated oncogenes and tumor suppressor genes. Patients who were in complete remission showed a fraction of mutated genes. This status involves clonal hematopoiesis of indeterminate potential and demonstrates that a fraction of cells with mutated genes cannot result in leukemia. Regarding treatment, the results of two phase 3 studies have shown efficacy; midostaurin is effective in combination with the standard 7+3 therapy, and another mixed compound comprising micellized cytarabine and daunorubicin at a mixing molar ratio of 5 : 1 is more effective than the standard 7+3 therapy. Emerging novel agents include those that inhibit SMO, IDH2, and chromatin modifying enzymes. These treatments are still in the early phase of clinical trials, but some of them have shown remarkable effects.
    MeSH term(s) Epigenesis, Genetic ; Genome, Human ; Humans ; Leukemia, Myeloid, Acute/diagnosis ; Leukemia, Myeloid, Acute/drug therapy ; Leukemia, Myeloid, Acute/genetics ; Molecular Targeted Therapy ; Prognosis
    Language Japanese
    Publishing date 2017
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 390900-1
    ISSN 0485-1439
    ISSN 0485-1439
    DOI 10.11406/rinketsu.58.364
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Successful Treatment of ALK-Positive Large-Cell Neuroendocrine Carcinoma of the Lung With Sequential ALK Inhibitors: A Case Report.

    Kobayashi, Takayuki / Uehara, Yuji / Watanabe, Kageaki / Hishima, Tsunekazu / Hosomi, Yukio

    JTO clinical and research reports

    2023  Volume 4, Issue 7, Page(s) 100538

    Abstract: ALK-positive large-cell neuroendocrine carcinoma (LCNEC) is an exceptionally rare form of lung cancer. The efficacy of ALK inhibitors in treating ALK-positive LCNEC remains unclear. Here, we report a case of ALK-positive LCNEC of the lung, which revealed ...

    Abstract ALK-positive large-cell neuroendocrine carcinoma (LCNEC) is an exceptionally rare form of lung cancer. The efficacy of ALK inhibitors in treating ALK-positive LCNEC remains unclear. Here, we report a case of ALK-positive LCNEC of the lung, which revealed a sustained clinical benefit (24+ mo of overall survival) after treatment with sequential ALK inhibitors and local therapies. This remarkable improvement in survival underscores the importance of testing metastatic LCNEC for biomarkers, such as
    Language English
    Publishing date 2023-06-15
    Publishing country United States
    Document type Case Reports
    ISSN 2666-3643
    ISSN (online) 2666-3643
    DOI 10.1016/j.jtocrr.2023.100538
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  8. Article ; Online: Effect of wearing masks on odor detection and recognition.

    Kato, Taiga / Suzuki, Jun / Kobayashi, Yuta / Oishi, Tetsuya / Ikushima, Hiroyuki / Yamauchi, Yasunari / Katori, Yukio

    Acta oto-laryngologica

    2024  , Page(s) 1–5

    Abstract: Background: The effect of wearing masks on olfaction remains unclear.: Objectives: This study aimed to clarify the differences between the effects of no masks, surgical masks, and N95 respirator masks by conducting both identification and threshold ... ...

    Abstract Background: The effect of wearing masks on olfaction remains unclear.
    Objectives: This study aimed to clarify the differences between the effects of no masks, surgical masks, and N95 respirator masks by conducting both identification and threshold olfaction tests.
    Methods: Young, healthy volunteers aged ≥ 18 years and < 30 years without awareness of apparent olfactory disorder were included. All participants filled out a questionnaire on olfaction and completed an acuity smell identification test (Open Essence test) and an olfactory threshold test (T&T olfactometry) while wearing no masks, surgical masks, or N95 respirator masks.
    Results: In the Open Essence tests, the no-mask group score was significantly higher than those of the surgical- and N95-mask groups. Using T&T olfactometry, the median-detection threshold of the no-mask group was significantly lower than that of the surgical-mask group, and the surgical-mask group threshold was significantly lower than that of the N95-mask group. Similar patterns were observed for the median-recognition threshold.
    Conclusions: Wearing masks, especially an N95 mask, reduces the ability to detect and identify odors. This disadvantage should be considered by professionals such as healthcare workers, who require proper olfaction to perform appropriate tasks.
    Language English
    Publishing date 2024-03-12
    Publishing country England
    Document type Journal Article
    ISSN 1651-2251
    ISSN (online) 1651-2251
    DOI 10.1080/00016489.2024.2325047
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Statistical mechanics of protein structural transitions: Insights from the island model.

    Kobayashi, Yukio

    Biophysics and physicobiology

    2016  Volume 13, Page(s) 251–262

    Abstract: The so-called island model of protein structural transition holds that hydrophobic interactions are the key to both the folding and function of proteins. Herein, the genesis and statistical mechanical basis of the island model of transitions are reviewed, ...

    Abstract The so-called island model of protein structural transition holds that hydrophobic interactions are the key to both the folding and function of proteins. Herein, the genesis and statistical mechanical basis of the island model of transitions are reviewed, by presenting the results of simulations of such transitions. Elucidating the physicochemical mechanism of protein structural formation is the foundation for understanding the hierarchical structure of life at the microscopic level. Based on the results obtained to date using the island model, remaining problems and future work in the field of protein structures are discussed, referencing Professor Saitô's views on the hierarchic structure of science.
    Language English
    Publishing date 2016-11-18
    Publishing country Japan
    Document type Journal Article ; Review
    ISSN 2189-4779
    ISSN 2189-4779
    DOI 10.2142/biophysico.13.0_251
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Interstitial lung changes and persistent COVID-19 in a patient with follicular lymphoma: A case report.

    Yomota, Makiko / Tanaka, Masaru / Kobayashi, Takayuki / Kitano, Masatake / Ikeda, Saori / Kanemasa, Yusuke / Yanagawa, Noriyo / Hosomi, Yukio

    Respirology case reports

    2024  Volume 12, Issue 2, Page(s) e01298

    Abstract: We herein report a case of interstitial lung changes in a patient with prolonged coronavirus disease 2019 (COVID-19) with follicular lymphoma receiving rituximab and bendamustine who recovered after treatment with a combination therapy consisting of ... ...

    Abstract We herein report a case of interstitial lung changes in a patient with prolonged coronavirus disease 2019 (COVID-19) with follicular lymphoma receiving rituximab and bendamustine who recovered after treatment with a combination therapy consisting of corticosteroids and immunosuppressive agents. There is currently no treatment strategy for prolonged pneumonitis following COVID-19, which can be life-threatening for immunocompromised patients. Thus, further investigation is warranted.
    Language English
    Publishing date 2024-02-20
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2750180-2
    ISSN 2051-3380
    ISSN 2051-3380
    DOI 10.1002/rcr2.1298
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