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  1. Book: Trockenrasen und Fließgewässer im UNESCO-Biosphärenreservat Rhön

    Görner, Martin

    Thüringer Teil

    (Mitteilungen aus dem Biosphärenreservat Rhön. Monografie ; 8. (2018))

    2018  

    Author's details Görner, Martin
    Series title Mitteilungen aus dem Biosphärenreservat Rhön. Monografie ; 8. (2018)
    Mitteilungen aus dem Biosphärenreservat Rhön
    Collection Mitteilungen aus dem Biosphärenreservat Rhön
    Language German
    Size 112 Seiten, Illustrationen, Karten, 30 cm
    Publisher Biosphärenreservat Rhön/Verwaltung Thüringen
    Publishing place Zella/Rhön
    Publishing country Germany
    Document type Book
    HBZ-ID HT020188933
    Database Catalogue ZB MED Nutrition, Environment, Agriculture

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    In stock of ZB MED Bonn / Germany

    Shelf markLoan statusLocation
    194/441 available for loan (reading room) Freihandmagazin (U1)

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  2. Book: Die Saale und ihre Aue im Raum Orlamünde

    Görner, Martin / Schmalz, Wolfgang / Schmidt, Karsten / Wagner, Falko

    2020  

    Author's details Görner, M. (Hrsg.) ; Autoren: Martin Görner, Wolfgang Schmalz, Karsten Schmidt, Dr. Falko Wagner
    Language German
    Size 48 Seiten, Illustrationen, Diagramme, Karten, 21 cm
    Publisher Verband für Angeln und Naturschutz Thüringen e.V ; Arbeitsgruppe Artenschutz Thüringen e.V
    Publishing place Jena
    Publishing country Germany
    Document type Book
    HBZ-ID HT020547099
    Database Catalogue ZB MED Nutrition, Environment, Agriculture

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    In stock of ZB MED Bonn / Germany

    Shelf markLoan statusLocation
    208/252 available for loan (reading room) Freihandmagazin (U1)

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  3. Book: Die Gewässer Thüringens

    Görner, Martin

    2011  

    Author's details hrsg. von Martin Görner
    Keywords Thüringen ; Stehendes Gewässer ; Fließgewässer
    Subject Fließendes Gewässer ; Wasserlauf ; Stillgewässer ; Standgewässer ; Stehgewässer
    Language German
    Size 351 S. : zahlr. Ill., graph. Darst., Kt.
    Publisher Arbeitsgruppe Artenschutz Thüringen
    Publishing place Jena
    Publishing country Germany
    Document type Book
    HBZ-ID HT017086255
    ISBN 978-3-00-035620-9 ; 3-00-035620-7
    Database Catalogue ZB MED Nutrition, Environment, Agriculture

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    In stock of ZB MED Bonn / Germany

    Shelf markLoan statusLocation
    134/363 available for loan (reading room) Freihandmagazin (U1)

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  4. Article ; Online: Hit and run oncogeneses in head and neck cancers requires greater investigation.

    Goon, Peter / Sudhoff, Holger / Goerner, Martin

    Journal of medical virology

    2022  Volume 95, Issue 1, Page(s) e28254

    Abstract: Head and neck cancers are unique in so far that two major oncogenic viruses, Epstein Barr virus (EBV) and Human papillomavirus (HPV) infect adjacent anatomy and cause nasopharyngeal and oropharyngeal cancers, respectively. Dominant recognized carcinogens ...

    Abstract Head and neck cancers are unique in so far that two major oncogenic viruses, Epstein Barr virus (EBV) and Human papillomavirus (HPV) infect adjacent anatomy and cause nasopharyngeal and oropharyngeal cancers, respectively. Dominant recognized carcinogens are alcohol and tobacco but some head and neck cancers have been found to have mixed carcinogens (including betel leaf, areca nuts, slaked lime, viruses, etc.) involved in their oncogenesis and conversely, groups of patients with unknown or less dominant carcinogens involved in their development. These cancers may have had viral involvement in the past but then lost most of their viral nucleic acids (be they DNA and/or RNA) below a detection threshold, thus rendering them virus-negative. Some of these virus-negative tumors appear to have mutagenic signatures associated with virus-positive cancers,  for example, from the APOBEC defense mechanism which is known to mutate viral nucleic acids as well as cause collateral damage to host DNA, with subsequent development of strongly viral prejudiced mutational signatures. These mechanisms are likely to be less efficient at oncogenesis than traditional EBV and HPV oncogenes directly driving mutagenesis, thus accounting for the smaller frequencies of these cancers found. More profound investigations of these unusual tumors are warranted to dissect out these mechanistic pathways.
    MeSH term(s) Humans ; Epstein-Barr Virus Infections/complications ; Herpesvirus 4, Human/genetics ; Papillomavirus Infections/complications ; Head and Neck Neoplasms/genetics ; Oncogenic Viruses/genetics ; Carcinogenesis ; Carcinogens ; Nucleic Acids ; Papillomaviridae/genetics
    Chemical Substances Carcinogens ; Nucleic Acids
    Language English
    Publishing date 2022-10-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 752392-0
    ISSN 1096-9071 ; 0146-6615
    ISSN (online) 1096-9071
    ISSN 0146-6615
    DOI 10.1002/jmv.28254
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1320: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Book ; Thesis: Autoantikörper bei Diabetes mellitus und ihre Bedeutung für Klassifikation und Prognose

    Görner, Martin

    1992  

    Author's details vorgelegt von Martin Görner
    Size 74 S. : graph. Darst.
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Tübingen, Univ., Diss., 1992
    HBZ-ID HT004565497
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    93 D 2371 order for loan Magazin

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  6. Book: Rauhfußhühner

    Goerner, Martin

    Ökologie, Vorkommen und Schutz in Thüringen

    (Landschaftspflege und Naturschutz in Thüringen : Sonderheft ; 25)

    1988  

    Author's details Martin Görner
    Series title Landschaftspflege und Naturschutz in Thüringen : Sonderheft ; 25
    Landschaftspflege und Naturschutz in Thüringen
    Landschaftspflege und Naturschutz in Thüringen ; Sonderheft
    Collection Landschaftspflege und Naturschutz in Thüringen
    Landschaftspflege und Naturschutz in Thüringen ; Sonderheft
    Keywords Thüringen ; Auerhuhn ; Ökologie ; Artenschutz ; Birkhuhn
    Subject Umweltbiologie ; Ecology ; Lyrurus tetrix ; Birkhahn ; Tetrao tetrix ; Birkwild ; Auerhahn ; Tetrao ; Tetrao urogallus
    Language German
    Size 16 S. : zahlr. Ill.
    Publisher Räte der Bezirke
    Publishing place Erfurt u.a.
    Publishing country XA-DDDE
    Document type Book
    HBZ-ID HT016617643
    Database Catalogue ZB MED Nutrition, Environment, Agriculture

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    In stock of ZB MED Bonn / Germany

    Shelf markLoan statusLocation
    Z 5229 (25,S) available for loan (reading room) Freihandmagazin (U1)

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  7. Article: The Potential of Tumor Debulking to Support Molecular Targeted Therapies.

    Oppel, Felix / Görner, Martin / Sudhoff, Holger

    Frontiers in oncology

    2020  Volume 10, Page(s) 801

    Abstract: Tumors may consist of billions of cells, which in malignant cases disseminate and form distant metastases. The large number of tumor cells formed by the high number of cell divisions during tumor progression creates a heterogeneous set of genetically ... ...

    Abstract Tumors may consist of billions of cells, which in malignant cases disseminate and form distant metastases. The large number of tumor cells formed by the high number of cell divisions during tumor progression creates a heterogeneous set of genetically diverse tumor cell clones. For cancer therapy this poses unique challenges, as distinct clones have to be targeted in different tissue locations. Recent research has led to the development of specific inhibitors of defined targets in cellular signaling cascades which promise more effective and more tumor-specific therapy approaches. Many of these molecular targeted therapy (MTT) compounds have already been translated into clinics or are currently being tested in clinical studies. However, the outgrowth of tumor cell clones resistant to such inhibitors is a drawback that affects specific inhibitors in a similar way as classical cytotoxic chemotherapeutics, because additionally acquired genetic alterations can enable tumor cells to circumvent the particular regulators of cellular signaling being targeted. Thus, it might be desirable to reduce genetic heterogeneity prior to molecular targeting, which could reduce the statistical chance of tumor relapse initiated by resistant clones. One way to achieve this is employing unspecific methods to remove as much tumor material as possible before MTT, e.g., by tumor debulking (TD). Currently, this is successfully applied in the clinical treatment of ovarian cancer. We believe that TD followed by treatment with a combination of molecular targeted drugs, optimally guided by biomarkers, might advance survival of patients suffering from various cancer types.
    Language English
    Publishing date 2020-06-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2020.00801
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Book ; Thesis: Differential cross sections for top-quark-pair production in the e/my+jets final state at √s

    Görner, Martin

    8 TeV in CMS

    (DESY thesis ; 2014,23)

    2014  

    Author's details by M. Görner
    Series title DESY thesis ; 2014,23
    Language English ; German
    Size VIII, 342 S., graph. Darst.
    Publisher DESY
    Publishing place Hamburg
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Univ., FB Physik, Diss.--Hamburg, 2014
    Note Zsfassungen in dt. und engl. Sprache
    Database Former special subject collection: coastal and deep sea fishing

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  9. Book ; Thesis: Differential cross sections for top-quark-pair production in the e/my+jets final state at √s

    Görner, Martin

    8 TeV in CMS

    (DESY thesis ; 2014,23)

    2014  

    Author's details by M. Görner
    Series title DESY thesis ; 2014,23
    Language English ; German
    Size VIII, 342 S., graph. Darst.
    Publisher DESY
    Publishing place Hamburg
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Univ., FB Physik, Diss.--Hamburg, 2014
    Note Zsfassungen in dt. und engl. Sprache
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  10. Article ; Online: Recurrent Respiratory Papillomatosis (RRP)-Meta-analyses on the use of the HPV vaccine as adjuvant therapy.

    Goon, Peter / Sauzet, Odile / Schuermann, Matthias / Oppel, Felix / Shao, SenYao / Scholtz, Lars-Uwe / Sudhoff, Holger / Goerner, Martin

    NPJ vaccines

    2023  Volume 8, Issue 1, Page(s) 49

    Abstract: Recurrent Respiratory Papillomatosis(RRP) is a rare disease with severe morbidity. Treatment is surgical. Prevailing viewpoint is that prophylactic HPV vaccines do not have therapeutic benefit due to their modus operandi. Studies on HPV vaccination ... ...

    Abstract Recurrent Respiratory Papillomatosis(RRP) is a rare disease with severe morbidity. Treatment is surgical. Prevailing viewpoint is that prophylactic HPV vaccines do not have therapeutic benefit due to their modus operandi. Studies on HPV vaccination alongside surgery were meta-analysed to test effect on burden of disease. Databases were accessed Nov and Dec 2021 [PubMed, Cochrane, Embase and Web of Science]. Main outcome measured was: Mean paired differences in the number of surgeries or recurrences per month. Analyses was performed using: Random effect maximal likelihood estimation model using the Stata module Mataan(StataCorp. 2019. Stata Statistical Software: Release 16. College Station, TX:StataCorp LLC.) Our results found n = 38 patients, suitable for syntheses with one previous meta-analyses (4 published, 2 unpublished studies) n = 63, total of n = 101 patients. Analyses rendered an overall reduction of 0.123 recurrences or surgeries per month (95% confidence interval [0.064, 0.183]). Our meta-analyses concludes that HPV vaccine is a beneficial adjunct therapy alongside surgery.
    Language English
    Publishing date 2023-04-01
    Publishing country England
    Document type Journal Article
    ISSN 2059-0105
    ISSN (online) 2059-0105
    DOI 10.1038/s41541-023-00644-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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