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Article ; Online: Delving Deep into the Proteome of Lung Fibrosis Brings Plasma Cells to the Surface.

Gibbons, Michael A / Scotton, Chris J

American journal of respiratory and critical care medicine

2017 Volume 196, Issue 10, Page(s) 1238–1240

Language	English
Publishing date	2017-11-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	1180953-x
ISSN	1535-4970 ; 0003-0805 ; 1073-449X
ISSN (online)	1535-4970
ISSN	0003-0805 ; 1073-449X
DOI	10.1164/rccm.201706-1186ED
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Article: The Role of Herpes Viruses in Pulmonary Fibrosis.

Duckworth, Anna / Longhurst, Hilary J / Paxton, Jane K / Scotton, Chris J

Frontiers in medicine

2021 Volume 8, Page(s) 704222

Abstract: Pulmonary fibrosis (PF) is a serious lung disease which can result from known genetic or environmental exposures but is more commonly idiopathic (IPF). In familial PF (FPF), the majority of identified causal genes play key roles in the maintenance of ... ...

Abstract	Pulmonary fibrosis (PF) is a serious lung disease which can result from known genetic or environmental exposures but is more commonly idiopathic (IPF). In familial PF (FPF), the majority of identified causal genes play key roles in the maintenance of telomeres, the protective end structures of chromosomes. Recent evidence suggests that short telomeres may also be implicated causally in a significant proportion of idiopathic cases. The possible involvement of herpes viruses in PF disease incidence and progression has been examined for many years, with some studies showing strong, statistically significant associations and others reporting no involvement. Evidence is thus polarized and remains inconclusive. Here we review the reported involvement of herpes viruses in PF in both animals and humans and present a summary of the evidence to date. We also present several possible mechanisms of action of the different herpes viruses in PF pathogenesis, including potential contributions to telomere attrition and cellular senescence. Evidence for antiviral treatment in PF is very limited but suggests a potential benefit. Further work is required to definitely answer the question of whether herpes viruses impact PF disease onset and progression and to enable the possible use of targeted antiviral treatments to improve clinical outcomes.
Language	English
Publishing date	2021-07-22
Publishing country	Switzerland
Document type	Systematic Review
ZDB-ID	2775999-4
ISSN	2296-858X
ISSN	2296-858X
DOI	10.3389/fmed.2021.704222
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Article ; Online: Culture-independent multilocus sequence typing of Pseudomonas aeruginosa for cross-infection screening.

Mitchelmore, Philip J / Withers, Nicholas J / Sheldon, Christopher D / Scotton, Chris J / Brown, Alan R

Diagnostic microbiology and infectious disease

2021 Volume 100, Issue 1, Page(s) 115315

Abstract: The genotyping of pathogens within cystic fibrosis cohorts is an important process, enabling the detection of transmissible and clinically-important strains. Traditionally this has been via culture-dependent processes. However, culture-independent ... ...

Abstract	The genotyping of pathogens within cystic fibrosis cohorts is an important process, enabling the detection of transmissible and clinically-important strains. Traditionally this has been via culture-dependent processes. However, culture-independent investigation of respiratory samples is becoming more common, with such approaches highlighting the limitations of culture-based methods. In this study we describe the culture-independent application of multilocus sequence typing (MLST) for Pseudomonas aeruginosa, performed on DNA extracted from the sputa of cystic fibrosis patients. We compare the output to conventional culture-dependent MLST applied to the same samples and demonstrate high concordance. Culture-independent MLST enabled genotyping of culture-negative samples in patients from whom P. aeruginosa was intermittently isolated, and revealed the hidden presence of transmissible strains. Culture-independent MLST is also capable of highlighting samples containing multiple strains, albeit inconsistently. We conclude that culture-independent MLST can be a useful genotyping tool for screening cohorts and identifying patients that warrant further detailed investigation.
MeSH term(s)	Bacterial Typing Techniques/methods ; Cohort Studies ; Cross Infection/diagnosis ; Cross Infection/microbiology ; Cystic Fibrosis/complications ; Humans ; Multilocus Sequence Typing/methods ; Pseudomonas Infections/complications ; Pseudomonas Infections/diagnosis ; Pseudomonas Infections/microbiology ; Pseudomonas aeruginosa/genetics ; Sputum/microbiology
Language	English
Publishing date	2021-01-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	604920-5
ISSN	1879-0070 ; 0732-8893
ISSN (online)	1879-0070
ISSN	0732-8893
DOI	10.1016/j.diagmicrobio.2021.115315
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Article ; Online: Validity and repeatability of cardiopulmonary exercise testing in interstitial lung disease.

Tomlinson, Owen W / Markham, Laura / Wollerton, Rebecca L / Knight, Bridget A / Duckworth, Anna / Gibbons, Michael A / Scotton, Chris J / Williams, Craig A

BMC pulmonary medicine

2022 Volume 22, Issue 1, Page(s) 485

Abstract: Background: Cardiopulmonary exercise testing (CPET), and its primary outcome of peak oxygen uptake (VO: Methods: Twenty-six people with ILD were recruited, and 21 successfully completed three CPETs. Of these, 17 completed two valid CPETs within a 3- ... ...

Abstract	Background: Cardiopulmonary exercise testing (CPET), and its primary outcome of peak oxygen uptake (VO Methods: Twenty-six people with ILD were recruited, and 21 successfully completed three CPETs. Of these, 17 completed two valid CPETs within a 3-month window, and 11 completed two valid CPETs within a 6-month window. Technical standards from the European Respiratory Society established validity, and repeatability was determined using mean change, intraclass correlation coefficient and typical error. Results: Every participant (100%) who successfully exercised to volitional exhaustion produced a maximal, and therefore valid, CPET. Approximately 20% of participants presented with a plateau in VO Conclusion: This work has, for the first time, fully characterised how patients with ILD respond to CPET in terms of primary and secondary verification criteria, and generated novel repeatability data that will prove useful in the assessment of disease progression, and future evaluation of therapeutic regimens where VO
Language	English
Publishing date	2022-12-22
Publishing country	England
Document type	Journal Article
ZDB-ID	2059871-3
ISSN	1471-2466 ; 1471-2466
ISSN (online)	1471-2466
ISSN	1471-2466
DOI	10.1186/s12890-022-02289-0
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Article ; Online: Supporting self-management for patients with Interstitial Lung Diseases: Utility and acceptability of digital devices.

Althobiani, Malik A / Shuttleworth, Rebecca / Conway, John / Dainton, Jonathan / Duckworth, Anna / Da Ponte, Ana Jorge / Mandizha, Jessica / Lanario, Joseph W / Gibbons, Michael A / Lines, Sarah / Scotton, Chris J / Hurst, John R / Porter, Joanna C / Russell, Anne-Marie

PLOS digital health

2024 Volume 3, Issue 1, Page(s) e0000318

Abstract: Introduction: Patients diagnosed with Interstitial Lung Diseases (ILD) use devices to self-monitor their health and well-being. Little is known about the range of devices, selection, frequency and terms of use and overall utility. We sought to quantify ... ...

Abstract	Introduction: Patients diagnosed with Interstitial Lung Diseases (ILD) use devices to self-monitor their health and well-being. Little is known about the range of devices, selection, frequency and terms of use and overall utility. We sought to quantify patients' usage and experiences with home digital devices, and further evaluate their perceived utility and barriers to adaptation. Methods: A team of expert clinicians and patient partners interested in self-management approaches designed a 48-question cross-sectional electronic survey; specifically targeted at individuals diagnosed with ILD. The survey was critically appraised by the interdisciplinary self-management group at Royal Devon University Hospitals NHS Foundation Trust during a 6-month validation process. The survey was open for participation between September 2021 and December 2022, and responses were collected anonymously. Data were analysed descriptively for quantitative aspects and through thematic analysis for qualitative input. Results: 104 patients accessed the survey and 89/104 (86%) reported a diagnosis of lung fibrosis, including 46/89 (52%) idiopathic pulmonary fibrosis (IPF) with 57/89 (64%) of participants diagnosed >3 years and 59/89 (66%) female. 52/65(80%) were in the UK; 33/65 (51%) reported severe breathlessness medical research council MRC grade 3-4 and 32/65 (49%) disclosed co-morbid arthritis or joint problems. Of these, 18/83 (22%) used a hand- held spirometer, with only 6/17 (35%) advised on how to interpret the readings. Pulse oximetry devices were the most frequently used device by 35/71 (49%) and 20/64 (31%) measured their saturations more than once daily. 29/63 (46%) of respondents reported home-monitoring brought reassurance; of these, for 25/63 (40%) a feeling of control. 10/57 (18%) felt it had a negative effect, citing fluctuating readings as causing stress and 'paranoia'. The most likely help-seeking triggers were worsening breathlessness 53/65 (82%) and low oxygen saturation 43/65 (66%). Nurse specialists were the most frequent source of help 24/63 (38%). Conclusion: Patients can learn appropriate technical skills, yet perceptions of home-monitoring are variable; targeted assessment and tailored support is likely to be beneficial.
Language	English
Publishing date	2024-01-08
Publishing country	United States
Document type	Journal Article
ISSN	2767-3170
ISSN (online)	2767-3170
DOI	10.1371/journal.pdig.0000318
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Article ; Online: Improved RE31 Analogues Containing Modified Nucleic Acid Monomers: Thermodynamic, Structural, and Biological Effects.

Kotkowiak, Weronika / Wengel, Jesper / Scotton, Chris J / Pasternak, Anna

Journal of medicinal chemistry

2019 Volume 62, Issue 5, Page(s) 2499–2507

Abstract: RE31 is a 31-nt DNA aptamer, consisting of the G-quadruplex and a duplex domain, which is able to effectively prolong thrombin time. This article reports on the influence of certain modified nucleotide residues on thermodynamic and biological properties ... ...

Abstract	RE31 is a 31-nt DNA aptamer, consisting of the G-quadruplex and a duplex domain, which is able to effectively prolong thrombin time. This article reports on the influence of certain modified nucleotide residues on thermodynamic and biological properties as well as the folding topology of RE31. Particularly, the effect of the presence of nucleosides in unlocked nucleic acid (UNA), locked nucleic acid (LNA), or β-l-RNA series was evaluated. The studies presented herein show that all modified residues can influence thermal and biological stabilities of G-quadruplex in a position-dependent manner. The aptamers modified simultaneously with UNA at the T
MeSH term(s)	Amides/metabolism ; Aptamers, Nucleotide/blood ; Aptamers, Nucleotide/chemistry ; Aptamers, Nucleotide/pharmacology ; Blood Coagulation/drug effects ; Drug Stability ; Humans ; Nucleic Acid Conformation ; Surface Plasmon Resonance ; Thermodynamics ; Thrombin/metabolism
Chemical Substances	Amides ; Aptamers, Nucleotide ; Thrombin (EC 3.4.21.5)
Language	English
Publishing date	2019-02-22
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	218133-2
ISSN	1520-4804 ; 0022-2623
ISSN (online)	1520-4804
ISSN	0022-2623
DOI	10.1021/acs.jmedchem.8b01806
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Article ; Online: The Role of Herpes Viruses in Pulmonary Fibrosis

Anna Duckworth / Hilary J. Longhurst / Jane K. Paxton / Chris J. Scotton

Frontiers in Medicine, Vol

2021 Volume 8

Abstract	Pulmonary fibrosis (PF) is a serious lung disease which can result from known genetic or environmental exposures but is more commonly idiopathic (IPF). In familial PF (FPF), the majority of identified causal genes play key roles in the maintenance of telomeres, the protective end structures of chromosomes. Recent evidence suggests that short telomeres may also be implicated causally in a significant proportion of idiopathic cases. The possible involvement of herpes viruses in PF disease incidence and progression has been examined for many years, with some studies showing strong, statistically significant associations and others reporting no involvement. Evidence is thus polarized and remains inconclusive. Here we review the reported involvement of herpes viruses in PF in both animals and humans and present a summary of the evidence to date. We also present several possible mechanisms of action of the different herpes viruses in PF pathogenesis, including potential contributions to telomere attrition and cellular senescence. Evidence for antiviral treatment in PF is very limited but suggests a potential benefit. Further work is required to definitely answer the question of whether herpes viruses impact PF disease onset and progression and to enable the possible use of targeted antiviral treatments to improve clinical outcomes.
Keywords	pulmonary fibrosis ; herpes virus ; CMV ; EBV ; telomeres ; senescence ; Medicine (General) ; R5-920
Subject code	610
Language	English
Publishing date	2021-07-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Gasping for Sulfide: A Critical Appraisal of Hydrogen Sulfide in Lung Disease and Accelerated Aging.

Pacitti, Dario / Scotton, Chris J / Kumar, Vinod / Khan, Haroon / Wark, Peter A B / Torregrossa, Roberta / Hansbro, Philip M / Whiteman, Matthew

Antioxidants & redox signaling

2021 Volume 35, Issue 7, Page(s) 551–579

Abstract: Hydrogen sulfide ( ... ...

Abstract	Hydrogen sulfide (H
MeSH term(s)	Aging ; Cystathionine beta-Synthase/metabolism ; Cystathionine gamma-Lyase/metabolism ; Humans ; Hydrogen Sulfide/metabolism ; Lung Diseases/drug therapy ; Sulfides/metabolism
Chemical Substances	Sulfides ; Cystathionine beta-Synthase (EC 4.2.1.22) ; Cystathionine gamma-Lyase (EC 4.4.1.1) ; Hydrogen Sulfide (YY9FVM7NSN)
Language	English
Publishing date	2021-06-01
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	1483836-9
ISSN	1557-7716 ; 1523-0864
ISSN (online)	1557-7716
ISSN	1523-0864
DOI	10.1089/ars.2021.0039
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Article ; Online: Supporting self-management for patients with Interstitial Lung Diseases

Malik A Althobiani / Rebecca Shuttleworth / John Conway / Jonathan Dainton / Anna Duckworth / Ana Jorge Da Ponte / Jessica Mandizha / Joseph W Lanario / Michael A Gibbons / Sarah Lines / Chris J Scotton / John R Hurst / Joanna C Porter / Anne-Marie Russell

PLOS Digital Health, Vol 3, Iss 1, p e

Utility and acceptability of digital devices.

2024 Volume 0000318

Abstract: Introduction Patients diagnosed with Interstitial Lung Diseases (ILD) use devices to self-monitor their health and well-being. Little is known about the range of devices, selection, frequency and terms of use and overall utility. We sought to quantify ... ...

Abstract	Introduction Patients diagnosed with Interstitial Lung Diseases (ILD) use devices to self-monitor their health and well-being. Little is known about the range of devices, selection, frequency and terms of use and overall utility. We sought to quantify patients' usage and experiences with home digital devices, and further evaluate their perceived utility and barriers to adaptation. Methods A team of expert clinicians and patient partners interested in self-management approaches designed a 48-question cross-sectional electronic survey; specifically targeted at individuals diagnosed with ILD. The survey was critically appraised by the interdisciplinary self-management group at Royal Devon University Hospitals NHS Foundation Trust during a 6-month validation process. The survey was open for participation between September 2021 and December 2022, and responses were collected anonymously. Data were analysed descriptively for quantitative aspects and through thematic analysis for qualitative input. Results 104 patients accessed the survey and 89/104 (86%) reported a diagnosis of lung fibrosis, including 46/89 (52%) idiopathic pulmonary fibrosis (IPF) with 57/89 (64%) of participants diagnosed >3 years and 59/89 (66%) female. 52/65(80%) were in the UK; 33/65 (51%) reported severe breathlessness medical research council MRC grade 3-4 and 32/65 (49%) disclosed co-morbid arthritis or joint problems. Of these, 18/83 (22%) used a hand- held spirometer, with only 6/17 (35%) advised on how to interpret the readings. Pulse oximetry devices were the most frequently used device by 35/71 (49%) and 20/64 (31%) measured their saturations more than once daily. 29/63 (46%) of respondents reported home-monitoring brought reassurance; of these, for 25/63 (40%) a feeling of control. 10/57 (18%) felt it had a negative effect, citing fluctuating readings as causing stress and 'paranoia'. The most likely help-seeking triggers were worsening breathlessness 53/65 (82%) and low oxygen saturation 43/65 (66%). Nurse specialists were the most ...
Keywords	Computer applications to medicine. Medical informatics ; R858-859.7
Language	English
Publishing date	2024-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: ICAM-1 and ICAM-2 Are Differentially Expressed and Up-Regulated on Inflamed Pulmonary Epithelium, but Neither ICAM-2 nor LFA-1: ICAM-1 Are Required for Neutrophil Migration Into the Airways

Chong, Deborah L W / Rebeyrol, Carine / José, Ricardo J / Williams, Andrew E / Brown, Jeremy S / Scotton, Chris J / Porter, Joanna C

Frontiers in immunology

2021 Volume 12, Page(s) 691957

Abstract: Neutrophil migration into the airways is an important process to fight infection and is mediated by cell adhesion molecules. The intercellular adhesion molecules, ICAM-1 (CD54) and ICAM-2 (CD102) are known ligands for the neutrophil integrins, lymphocyte ...

Abstract	Neutrophil migration into the airways is an important process to fight infection and is mediated by cell adhesion molecules. The intercellular adhesion molecules, ICAM-1 (CD54) and ICAM-2 (CD102) are known ligands for the neutrophil integrins, lymphocyte function associated antigen (LFA)-1 (α
MeSH term(s)	Animals ; Antigens, CD/immunology ; CD18 Antigens/immunology ; Cell Adhesion Molecules/immunology ; Cell Movement ; Cells, Cultured ; Epithelial Cells/immunology ; Humans ; Inflammation/immunology ; Intercellular Adhesion Molecule-1/immunology ; Lung/immunology ; Lymphocyte Function-Associated Antigen-1/immunology ; Macrophages/immunology ; Mice, Inbred C57BL ; Mice, Knockout ; Neutrophils/immunology ; Neutrophils/physiology ; Respiratory Mucosa/immunology ; Up-Regulation ; Mice
Chemical Substances	Antigens, CD ; CD18 Antigens ; Cell Adhesion Molecules ; ICAM-2 protein, mouse ; ICAM2 protein, human ; Lymphocyte Function-Associated Antigen-1 ; Intercellular Adhesion Molecule-1 (126547-89-5)
Language	English
Publishing date	2021-08-16
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2021.691957
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