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Artikel ; Online: Antinociceptive Effect of a p-Cymene/β-Cyclodextrin Inclusion Complex in a Murine Cancer Pain Model: Characterization Aided through a Docking Study.

Santos, Wagner B R / Pina, Lícia T S / de Oliveira, Marlange A / Santos, Lucas A B O / Batista, Marcus V A / Trindade, Gabriela G G / Duarte, Marcelo C / Almeida, Jackson R G S / Quintans-Júnior, Lucindo J / Quintans, Jullyana S S / Serafini, Mairim R / Coutinho, Henrique D M / Kowalska, Grażyna / Baj, Tomasz / Kowalski, Radosław / Guimarães, Adriana G

Molecules (Basel, Switzerland)

2023 Band 28, Heft 11

Abstract	Pain is one of the most prevalent and difficult to manage symptoms in cancer patients, and conventional drugs present a range of adverse reactions. The development of β-cyclodextrins (β-CD) complexes has been used to avoid physicochemical and pharmacological limitations due to the lipophilicity of compounds such as p-Cymene (PC), a monoterpene with antinociceptive effects. Our aim was to obtain, characterize, and measure the effect of the complex of p-cymene and β-cyclodextrin (PC/β-CD) in a cancer pain model. Initially, molecular docking was performed to predict the viability of complex formation. Afterward, PC/β-CD was obtained by slurry complexation, characterized by HPLC and NMR. Finally, PC/β-CD was tested in a Sarcoma 180 (S180)-induced pain model. Molecular docking indicated that the occurrence of interaction between PC and β-CD is favorable. PC/β-CD showed complexation efficiency of 82.61%, and NMR demonstrated PC complexation in the β-CD cavity. In the S180 cancer pain model, PC/β-CD significantly reduced the mechanical hyperalgesia, spontaneous nociception, and nociception induced by non-noxious palpation at the doses tested (
Mesh-Begriff(e)	Humans ; Mice ; Animals ; Cancer Pain ; Cyclodextrins ; Molecular Docking Simulation ; beta-Cyclodextrins/chemistry ; Pain/drug therapy ; Pain/etiology ; Analgesics/pharmacology ; Analgesics/therapeutic use ; Analgesics/chemistry ; Solubility ; Neoplasms
Chemische Substanzen	4-cymene (1G1C8T1N7Q) ; betadex (JV039JZZ3A) ; Cyclodextrins ; beta-Cyclodextrins ; Analgesics
Sprache	Englisch
Erscheinungsdatum	2023-05-31
Erscheinungsland	Switzerland
Dokumenttyp	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules28114465
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Cystic Fibrosis: Systems Biology Analysis from Homozygous p.Phe508del Variant Patients' Samples Reveals Perturbations in Tissue-Specific Pathways.

de Faria Poloni, Joice / Rispoli, Thaiane / Rossetti, Maria Lucia / Trindade, Cristiano / Vargas, José Eduardo

BioMed research international

2021 Band 2021, Seite(n) 5262000

Abstract: ... for the CF transmembrane conductance regulator (CFTR) protein. Among these, p.Phe508del is the most prevalent ... at predicting cell signaling pathways present in different tissues of fibrocystic patients, homozygous for p ... and centrality and functional interaction networks were analyzed. The study reported that p.Phe508del ...

Abstract	Cystic fibrosis (CF) is an autosomal recessive disorder, caused by diverse genetic variants for the CF transmembrane conductance regulator (CFTR) protein. Among these, p.Phe508del is the most prevalent variant. The effects of this variant on the physiology of each tissue remains unknown. This study is aimed at predicting cell signaling pathways present in different tissues of fibrocystic patients, homozygous for p.Phe508del. The study involved analysis of two microarray datasets, E-GEOD-15568 and E-MTAB-360 corresponding to the rectal and bronchial epithelium, respectively, obtained from the ArrayExpress repository. Particularly, differentially expressed genes (DEGs) were predicted, protein-protein interaction (PPI) networks were designed, and centrality and functional interaction networks were analyzed. The study reported that p.Phe508del-mutated CFTR-allele in homozygous state influenced the whole gene expression in each tissue differently. Interestingly, gene ontology (GO) term enrichment analysis revealed that only "neutrophil activation" was shared between both tissues; however, nonshared DEGs were grouped into the same GO term. For further verification, functional interaction networks were generated, wherein no shared nodes were reported between these tissues. These results suggested that the p.Phe508del-mutated CFTR-allele in homozygous state promoted tissue-specific pathways in fibrocystic patients. The generated data might further assist in prediction diagnosis to define biomarkers or devising therapeutic strategies.
Mesh-Begriff(e)	Alleles ; Biomarkers/metabolism ; Cystic Fibrosis/genetics ; Epithelium/physiology ; Gene Expression/genetics ; Homozygote ; Humans ; Mutation/genetics ; Protein Interaction Maps/genetics ; Signal Transduction/genetics ; Systems Biology/methods
Chemische Substanzen	Biomarkers
Sprache	Englisch
Erscheinungsdatum	2021-12-02
Erscheinungsland	United States
Dokumenttyp	Journal Article
ZDB-ID	2698540-8
ISSN	2314-6141 ; 2314-6133
ISSN (online)	2314-6141
ISSN	2314-6133
DOI	10.1155/2021/5262000
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Antinociceptive Effect of a p-Cymene/β-Cyclodextrin Inclusion Complex in a Murine Cancer Pain Model

Wagner B. R. Santos / Lícia T. S. Pina / Marlange A. de Oliveira / Lucas A. B. O. Santos / Marcus V. A. Batista / Gabriela G. G. Trindade / Marcelo C. Duarte / Jackson R. G. S. Almeida / Lucindo J. Quintans-Júnior / Jullyana S. S. Quintans / Mairim R. Serafini / Henrique D. M. Coutinho / Grażyna Kowalska / Tomasz Baj / Radosław Kowalski / Adriana G. Guimarães

Molecules, Vol 28, Iss 4465, p

Characterization Aided through a Docking Study

2023 Band 4465

Abstract: ... of compounds such as p-Cymene (PC), a monoterpene with antinociceptive effects. Our aim was to obtain ... characterize, and measure the effect of the complex of p-cymene and β-cyclodextrin (PC/β-CD) in a cancer pain ... the mechanical hyperalgesia, spontaneous nociception, and nociception induced by non-noxious palpation at the doses tested ( p ...

Abstract	Pain is one of the most prevalent and difficult to manage symptoms in cancer patients, and conventional drugs present a range of adverse reactions. The development of β-cyclodextrins (β-CD) complexes has been used to avoid physicochemical and pharmacological limitations due to the lipophilicity of compounds such as p-Cymene (PC), a monoterpene with antinociceptive effects. Our aim was to obtain, characterize, and measure the effect of the complex of p-cymene and β-cyclodextrin (PC/β-CD) in a cancer pain model. Initially, molecular docking was performed to predict the viability of complex formation. Afterward, PC/β-CD was obtained by slurry complexation, characterized by HPLC and NMR. Finally, PC/β-CD was tested in a Sarcoma 180 (S180)-induced pain model. Molecular docking indicated that the occurrence of interaction between PC and β-CD is favorable. PC/β-CD showed complexation efficiency of 82.61%, and NMR demonstrated PC complexation in the β-CD cavity. In the S180 cancer pain model, PC/β-CD significantly reduced the mechanical hyperalgesia, spontaneous nociception, and nociception induced by non-noxious palpation at the doses tested ( p < 0.05) when compared to vehicle differently from free PC ( p > 0.05). Therefore, the complexation of PC in β-CD was shown to improve the pharmacological effect of the drug as well as reducing the required dose.
Schlagwörter	cancer pain ; natural products ; monoterpenes ; inclusion complex ; Organic chemistry ; QD241-441
Thema/Rubrik (Code)	540
Sprache	Englisch
Erscheinungsdatum	2023-05-01T00:00:00Z
Verlag	MDPI AG
Dokumenttyp	Artikel ; Online
Datenquelle	BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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Artikel ; Online: Protective effects of flavonoid composition rich P. subpeltata Ortega. on indomethacin induced experimental ulcerative colitis in rat models of inflammatory bowel diseases.

Shanmugam, Saravanan / Thangaraj, Parimelazhagan / Dos Santos Lima, Bruno / Trindade, Gabriela G G / Narain, Narendra / Mara de Oliveira E Silva, Ana / Santin, José Roberto / Broering, Milena Fronza / Serafini, Mairim Russo / Quintans-Júnior, Lucindo José / Antunes de Souza Araújo, Adriano

Journal of ethnopharmacology

2019 Band 248, Seite(n) 112350

Abstract: ... extract of P. subpeltata against the indomethacin induced ulcerative colitis in rats.: Materials and ... Conclusions: Thus, these results suggest that P. subpeltata extract may have therapeutic potential ...

Abstract	Ethnopharmacological relevance: Polyphenolics (flavonoid and phenolic) rich plants are the effective source for the treatment of acute and chronic degenerative diseases including inflammatory bowel disease. Objective: This study was aimed to examine the effects of polyphenolics rich leaf acetone extract of P. subpeltata against the indomethacin induced ulcerative colitis in rats. Materials and methods: Two consecutive days administration of indomethacin produced chronic inflammation in GIT tissues of rats. Further, the plant extract 200 and 400 mg/kg treatment were continued until 11th day. Then hematological, enzymatic antioxidants, MPO and histological evaluations were analyzed. Moreover, the extracts were treated with RAW267.4 cells for the cytotoxicity, NO and TNF-α analysis. Results: The obtained results revealed, that higher dose of the plant extract dropped neutrophil infiltration followed by inhibiting the MPO enzyme levels and controls the enzymatic antioxidants such as SOD, CAT, GSH and LPO. RAW cells study also proved that the plant extract effectively inhibits NO and TNF-α production. Conclusions: Thus, these results suggest that P. subpeltata extract may have therapeutic potential for the treatment of IBD although further clinical research is still warranted.
Mesh-Begriff(e)	Animals ; Anti-Inflammatory Agents/isolation & purification ; Anti-Inflammatory Agents/pharmacology ; Colitis, Ulcerative/chemically induced ; Colitis, Ulcerative/metabolism ; Colitis, Ulcerative/pathology ; Colitis, Ulcerative/prevention & control ; Colon/drug effects ; Colon/metabolism ; Colon/pathology ; Disease Models, Animal ; Flavonoids/isolation & purification ; Flavonoids/pharmacology ; Gastrointestinal Agents/isolation & purification ; Gastrointestinal Agents/pharmacology ; Indomethacin ; Inflammation Mediators/metabolism ; Macrophages/drug effects ; Macrophages/metabolism ; Male ; Mice ; Neutrophil Infiltration/drug effects ; Nitric Oxide/metabolism ; Passiflora/chemistry ; Plant Extracts/isolation & purification ; Plant Extracts/pharmacology ; RAW 264.7 Cells ; Rats, Wistar ; Tumor Necrosis Factor-alpha/metabolism
Chemische Substanzen	Anti-Inflammatory Agents ; Flavonoids ; Gastrointestinal Agents ; Inflammation Mediators ; Plant Extracts ; Tnf protein, mouse ; Tumor Necrosis Factor-alpha ; Nitric Oxide (31C4KY9ESH) ; Indomethacin (XXE1CET956)
Sprache	Englisch
Erscheinungsdatum	2019-10-24
Erscheinungsland	Ireland
Dokumenttyp	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2019.112350
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Transmission-blocking compound candidates against Plasmodium vivax using P. berghei as an initial screening.

Fabbri, Camila / Trindade, Alexandre Oliveira / Andrade, Francy's Sayara / Souza, Macejane Ferreira de / Ríos-Velásquez, Claudia María / Lacerda, Marcus Vinicius Guimarães de / Monteiro, Wuelton Marcelo / Costa, Fabio Trindade Maranhão / Amino, Rogerio / Lopes, Stefanie Costa Pinto

Memorias do Instituto Oswaldo Cruz

2021 Band 116, Seite(n) e200513

Abstract: ... gametocytes in Plasmodium berghei, mosquito infection in P. vivax and ookinete formation in both species ... of the Malaria Box compounds in P. vivax. For P. berghei we used flow cytometry to evaluate male and female ... which were different from those in P. falciparum. In addition, from the eight Malaria Box compounds tested ...

Abstract	Background: Different strategies for improvement of malaria control and elimination are based on the blockage of malaria parasite transmission to the mosquito vector. These strategies include the drugs that target the plasmodial sexual stages in humans and the early developmental stages inside mosquitoes. Objectives: Here we tested Malaria Box compounds in order to evaluate their activity against male and female gametocytes in Plasmodium berghei, mosquito infection in P. vivax and ookinete formation in both species. Methods/findings: The membrane feeding assay and the development of ookinetes by a 24 h ex vivo culture and the ookinete yield per 1000 erythrocytes were used to test transmission-blocking potential of the Malaria Box compounds in P. vivax. For P. berghei we used flow cytometry to evaluate male and female gametocyte time course and fluorescence microscopy to check the ookinete development. The two species used in this study showed similar results concerning the compounds' activity against gametocytes and ookinetes, which were different from those in P. falciparum. In addition, from the eight Malaria Box compounds tested in both species, compounds MMV665830, MMV665878 and MMV665941 were selected as a hit compounds due the high inhibition observed. Conclusion: Our results showed that P. berghei is suitable as an initial screening system to test compounds against P. vivax.
Mesh-Begriff(e)	Animals ; Malaria, Vivax/drug therapy ; Malaria, Vivax/prevention & control ; Malaria, Vivax/transmission ; Mosquito Vectors/parasitology ; Plasmodium berghei/drug effects ; Plasmodium vivax/drug effects
Sprache	Englisch
Erscheinungsdatum	2021-02-08
Erscheinungsland	Brazil
Dokumenttyp	Journal Article
ZDB-ID	953293-6
ISSN	1678-8060 ; 0074-0276
ISSN (online)	1678-8060
ISSN	0074-0276
DOI	10.1590/0074-02760200513
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Parasitism in Rattus rattus and sympatric Achatina fulica by Angiostrongylus cantonensis in an urban park in southeast Brazil [Correction: Jan. 2023, 122(1), p. 353]

de Almeida, Lara Ribeiro / de Souza Joaquim, Jéssica / Botelho, Lucas Moreira / Vidigal, Teofania Heloisa Dutra Amorim / Ecco, Roselene / de Souza Trindade, Giliane / Paglia, Adriano Pereira / de Jesus Pereira, Cíntia Aparecida / dos Santos Lima, Walter

Parasitol Res. 2023 Jan., v. 122, no. 1, p. 347-352

2023 , Seite(n) 347–352

Abstract: In this study, rodents (Rattus rattus) and mollusks (Achatina fulica) were captured in a small forest located in a large metropolitan city in Brazil, and they were examined to investigate possible parasitism by Angiostrongylus cantonensis. The parasites ... ...

Abstract	In this study, rodents (Rattus rattus) and mollusks (Achatina fulica) were captured in a small forest located in a large metropolitan city in Brazil, and they were examined to investigate possible parasitism by Angiostrongylus cantonensis. The parasites were recovered as helminths from the pulmonary arteries of the synanthropic rodents and as third-stage larvae (with Metastrongylidae family characteristics) from the mollusks. To confirm the species, these larvae were used to experimentally infect Rattus norvegicus for the posterior recovery of adult helminths. To identify the adult helminths, morphological, morphometric, molecular, and phylogenetic techniques were employed. Furthermore, we also characterized the histological lesions associated with parasitism in naturally infected definitive hosts. Our results demonstrated the occurrence of a natural life cycle of A. cantonensis (with the presence of adult helminths) in definitive hosts, Rattus rattus, and third-stage larvae in an intermediate host, A. fulica. In free-living rodents, lesions of granulomatous pneumonia in the lungs and meningitis in the brain were also found. These results warn of the risk of accidental transmission of A. cantonensis to human residents around the park because of the extensive interaction among the fauna of the park, domestic animals, and the surrounding human population.
Schlagwörter	Achatina fulica ; Metastrongylidae ; Parastrongylus cantonensis ; Rattus norvegicus ; Rattus rattus ; adults ; brain ; fauna ; forests ; helminths ; histology ; human population ; humans ; intermediate hosts ; meningitis ; morphometry ; parasitism ; phylogeny ; pneumonia ; risk ; sympatry ; synanthropes ; urban parks ; Brazil
Sprache	Englisch
Erscheinungsverlauf	2023-01
Umfang	p. 347-352
Erscheinungsort	Springer Berlin Heidelberg
Dokumenttyp	Artikel ; Online
ZDB-ID	284966-5
ISSN	1432-1955 ; 0932-0113 ; 0044-3255
ISSN (online)	1432-1955
ISSN	0932-0113 ; 0044-3255
DOI	10.1007/s00436-022-07656-8
Datenquelle	NAL Katalog (AGRICOLA)

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Artikel ; Online: P-22 ANALYSIS OF FEATURES ASSOCIATED WITH DIFFICULTY IN SCREENING AND EARLY DIAGNOSING HEPATOCELLULAR CARCINOMA IN RISK PATIENTS

João Eugênio Loureiro Lopes / Júlia Antunes RizzoBicalho / Livia Zardo Trindade / Mariana Poltronieri Pacheco

Annals of Hepatology, Vol 24, Iss , Pp 100386- (2021)

2021

Abstract: Introduction: Several barriers to access hepatocellular carcinoma (HCC) screening in Brazil and the large number of patients diagnosed at advanced disease stages, without prospect of curative treatment, are indicatives that access to early HCC diagnosis ... ...

Abstract	Introduction: Several barriers to access hepatocellular carcinoma (HCC) screening in Brazil and the large number of patients diagnosed at advanced disease stages, without prospect of curative treatment, are indicatives that access to early HCC diagnosis and treatment is not equitably guaranteed for entire population. Aims: The aim of the current study is to investigate the determining factors hindering the access to HCC screening and early diagnosis, based on abdominal ultrasound (US) application to risk patients. Methods: Descriptive and longitudinal study carried out in reference outpatient clinic, based on questionnaire application to patients at risk for HCC. Results: Fifty patients (mean age of 59 years), whose main disease etiology lied on alcohol, and hepatitis B and C viruses, were evaluated; 76% of them underwent US monitoring on a regular basis and 58% understood the importance of undergoing such an examination. The main barriers to access examination comprised scheduling (25%) and financial issues (12.5%). Eight patients were diagnosed with HCC (16% of sample), 50% of them were diagnosed at the first consultation and 37.50% did not know about the importance of such diagnosis (Table); curative treatment was no longer applicable to 62.50% of these patients. Conclusion: It is worth emphasizing the essential role played by half-yearly screening in the early diagnosis and curative treatment of HCC. It is necessary developing policies focused on identifying and placing HCC patients at risk in health surveillance programs, as well as on providing greater access to, and education about the important role played by these exams.
Schlagwörter	Specialties of internal medicine ; RC581-951
Thema/Rubrik (Code)	610
Sprache	Englisch
Erscheinungsdatum	2021-09-01T00:00:00Z
Verlag	Elsevier
Dokumenttyp	Artikel ; Online
Datenquelle	BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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Artikel ; Online: Transmission-blocking compound candidates against Plasmodium vivax using P. berghei as an initial screening

Camila Fabbri / Alexandre Oliveira Trindade / Francy’s Sayara Andrade / Macejane Ferreira de Souza / Claudia María Ríos-Velásquez / Marcus Vinicius Guimarães de Lacerda / Wuelton Marcelo Monteiro / Fabio Trindade Maranhão Costa / Rogerio Amino / Stefanie Costa Pinto Lopes

Memórias do Instituto Oswaldo Cruz., Vol

2021 Band 116

Abstract: ... gametocytes in Plasmodium berghei, mosquito infection in P. vivax and ookinete formation in both species ... compounds in P. vivax. For P. berghei we used flow cytometry to evaluate male and female gametocyte time ... different from those in P. falciparum. In addition, from the eight Malaria Box compounds tested ...

Abstract	BACKGROUND Different strategies for improvement of malaria control and elimination are based on the blockage of malaria parasite transmission to the mosquito vector. These strategies include the drugs that target the plasmodial sexual stages in humans and the early developmental stages inside mosquitoes. OBJECTIVES Here we tested Malaria Box compounds in order to evaluate their activity against male and female gametocytes in Plasmodium berghei, mosquito infection in P. vivax and ookinete formation in both species. METHODS/FINDINGS The membrane feeding assay and the development of ookinetes by a 24 h ex vivo culture and the ookinete yield per 1000 erythrocytes were used to test transmission-blocking potential of the Malaria Box compounds in P. vivax. For P. berghei we used flow cytometry to evaluate male and female gametocyte time course and fluorescence microscopy to check the ookinete development. The two species used in this study showed similar results concerning the compounds’ activity against gametocytes and ookinetes, which were different from those in P. falciparum. In addition, from the eight Malaria Box compounds tested in both species, compounds MMV665830, MMV665878 and MMV665941 were selected as a hit compounds due the high inhibition observed. CONCLUSION Our results showed that P. berghei is suitable as an initial screening system to test compounds against P. vivax.
Schlagwörter	Malaria Box ; membrane feeding assay and gametocytes ; Arctic medicine. Tropical medicine ; RC955-962 ; Microbiology ; QR1-502
Thema/Rubrik (Code)	500
Sprache	Englisch
Erscheinungsdatum	2021-02-01T00:00:00Z
Verlag	Instituto Oswaldo Cruz, Ministério da Saúde
Dokumenttyp	Artikel ; Online
Datenquelle	BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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Artikel ; Online: Computational Chemogenomics Drug Repositioning Strategy Enables the Discovery of Epirubicin as a New Repurposed Hit for Plasmodium falciparum and P. vivax.

Ferreira, Letícia Tiburcio / Rodrigues, Juliana / Cassiano, Gustavo Capatti / Tavella, Tatyana Almeida / Tomaz, Kaira Cristina Peralis / Baia-da-Silva, Djane Clarys / Souza, Macejane Ferreira / Lima, Marilia Nunes do Nascimento / Mottin, Melina / Almeida, Ludimila Dias / Calit, Juliana / Puça, Maria Carolina Silva de Barros / Melo, Gisely Cardoso / Bargieri, Daniel Youssef / Lopes, Stefanie Costa Pinto / Lacerda, Marcus Vinicius Guimarães / Bilsland, Elizabeth / Sunnerhagen, Per / Neves, Bruno Junior /

Andrade, Carolina Horta / Cravo, Pedro Vitor Lemos / Costa, Fabio Trindade Maranhão

Antimicrobial agents and chemotherapy

2020 Band 64, Heft 9

Abstract: Widespread resistance against antimalarial drugs thwarts current efforts for controlling the disease and urges the discovery of new effective treatments. Drug repositioning is increasingly becoming an attractive strategy since it can reduce costs, risks, ...

Abstract	Widespread resistance against antimalarial drugs thwarts current efforts for controlling the disease and urges the discovery of new effective treatments. Drug repositioning is increasingly becoming an attractive strategy since it can reduce costs, risks, and time-to-market. Herein, we have used this strategy to identify novel antimalarial hits. We used a comparative
Mesh-Begriff(e)	Animals ; Antimalarials/pharmacology ; Antimalarials/therapeutic use ; Drug Repositioning ; Epirubicin/therapeutic use ; Malaria, Vivax/drug therapy ; Mice ; Plasmodium falciparum/genetics ; Plasmodium vivax/genetics
Chemische Substanzen	Antimalarials ; Epirubicin (3Z8479ZZ5X)
Sprache	Englisch
Erscheinungsdatum	2020-08-20
Erscheinungsland	United States
Dokumenttyp	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	217602-6
ISSN	1098-6596 ; 0066-4804
ISSN (online)	1098-6596
ISSN	0066-4804
DOI	10.1128/AAC.02041-19
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Large-scale screening of asymptomatic for SARS-CoV-2 variants of concern and rapid P.1 takeover, Curitiba, Brazil

Adamoski, Douglas / Oliveira, Jaqueline Carvalho de / Bonatto, Ana Claudia / Wassem, Roseli / Nogueira, Meri Bordignon / Raboni, Sonia Mara / Trindade, Edvaldo da Silva / Souza, Emanuel Maltempi de / SCB-UFPR COVID-19 team / Gradia, Daniela Fiori

medRxiv

Abstract: To provide a safer environment for individuals working on-site at the Federal University of Parana, Curitiba, Brazil, we performed a large-scale mass testing SARS-CoV-2 program coupled with variant genotyping using two PCR-based approaches. We observed a ...

Abstract	To provide a safer environment for individuals working on-site at the Federal University of Parana, Curitiba, Brazil, we performed a large-scale mass testing SARS-CoV-2 program coupled with variant genotyping using two PCR-based approaches. We observed a fast dominance of the Gamma variant, displacing other variants in less than three months.
Schlagwörter	covid19
Sprache	Englisch
Erscheinungsdatum	2021-06-21
Verlag	Cold Spring Harbor Laboratory Press
Dokumenttyp	Artikel ; Online
DOI	10.1101/2021.06.18.21258649
Datenquelle	COVID19

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Fernleihe an ZB MED

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Fernleihe an ZB MED

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Verfügbar in ZB MED Köln/Königswinter

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Fernleihe an ZB MED