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Article ; Online: Temperature-Dependent n-p-n Switching and Highly Selective Room-Temperature n-SnSe

Rani, Sanju / Kumar, Manoj / Garg, Parveen / Parmar, Rahul / Kumar, Ashish / Singh, Yogesh / Baloria, Vishal / Deshpande, Uday / Singh, Vidya Nand

ACS applied materials & interfaces

2022 Volume 14, Issue 13, Page(s) 15381–15390

Abstract: ... the thermal evaporation method to deposit an n-SnSe ...

Abstract	Many toxic gases are mixed into the atmosphere because of increased air pollution. An efficient gas sensor is required to detect these poisonous gases with its ultrasensitive ability. We employed the thermal evaporation method to deposit an n-SnSe
Language	English
Publishing date	2022-03-28
Publishing country	United States
Document type	Journal Article
ISSN	1944-8252
ISSN (online)	1944-8252
DOI	10.1021/acsami.1c24679
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: N-Acetyltransferase 9 ameliorates Aβ42-mediated neurodegeneration in the Drosophila eye.

Deshpande, Prajakta / Chimata, Anuradha Venkatakrishnan / Snider, Emily / Singh, Aditi / Kango-Singh, Madhuri / Singh, Amit

Cell death & disease

2023 Volume 14, Issue 7, Page(s) 478

Abstract: ... neurodegeneration. To address this gap in information, we conducted a forward genetic screen, and identified N ... to stabilize microtubules by inhibiting c-Jun-N- terminal kinase (JNK) signaling. We found that gain ...

Abstract	Alzheimer's disease (AD), a progressive neurodegenerative disorder, manifests as accumulation of amyloid-beta-42 (Aβ42) plaques and intracellular accumulation of neurofibrillary tangles (NFTs) that results in microtubule destabilization. Targeted expression of human Aβ42 (GMR > Aβ42) in developing Drosophila eye retinal neurons results in Aβ42 plaque(s) and mimics AD-like extensive neurodegeneration. However, there remains a gap in our understanding of the underlying mechanism(s) for Aβ42-mediated neurodegeneration. To address this gap in information, we conducted a forward genetic screen, and identified N-acetyltransferase 9 (Mnat9) as a genetic modifier of GMR > Aβ42 neurodegenerative phenotype. Mnat9 is known to stabilize microtubules by inhibiting c-Jun-N- terminal kinase (JNK) signaling. We found that gain-of-function of Mnat9 rescues GMR > Aβ42 mediated neurodegenerative phenotype whereas loss-of-function of Mnat9 exhibits the converse phenotype of enhanced neurodegeneration. Here, we propose a new neuroprotective function of Mnat9 in downregulating the JNK signaling pathway to ameliorate Aβ42-mediated neurodegeneration, which is independent of its acetylation activity. Transgenic flies expressing human NAT9 (hNAT9), also suppresses Aβ42-mediated neurodegeneration thereby suggesting functional conservation in the interaction of fly Mnat9 or hNAT9 with JNK-mediated neurodegeneration. These studies add to the repertoire of molecular mechanisms that mediate cell death response following accumulation of Aβ42 and may provide new avenues for targeting neurodegeneration.
MeSH term(s)	Animals ; Humans ; Alzheimer Disease/genetics ; Alzheimer Disease/metabolism ; Amyloid beta-Peptides/genetics ; Amyloid beta-Peptides/metabolism ; Disease Models, Animal ; Drosophila/genetics ; Drosophila/metabolism ; Drosophila melanogaster/genetics ; Drosophila melanogaster/metabolism ; Peptide Fragments/metabolism ; JNK Mitogen-Activated Protein Kinases ; Acetyltransferases
Chemical Substances	Amyloid beta-Peptides ; amyloid beta-protein (1-42) ; Peptide Fragments ; JNK Mitogen-Activated Protein Kinases (EC 2.7.11.24) ; Acetyltransferases (EC 2.3.1.-)
Language	English
Publishing date	2023-07-28
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2541626-1
ISSN	2041-4889 ; 2041-4889
ISSN (online)	2041-4889
ISSN	2041-4889
DOI	10.1038/s41419-023-05973-z
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Article: A high ratio of linoleic acid (n-6 PUFA) to alpha-linolenic acid (n-3 PUFA) adversely affects early stage of human neuronal differentiation and electrophysiological activity of glutamatergic neurons

Dec, Karolina / Alsaqati, Mouhamed / Morgan, Joanne / Deshpande, Sumukh / Wood, Jamie / Hall, Jeremy / Harwood, Adrian J

Frontiers in cell and developmental biology

2023 Volume 11, Page(s) 1166808

Abstract: Introduction: ...

Abstract	Introduction:
Language	English
Publishing date	2023-05-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2737824-X
ISSN	2296-634X
ISSN	2296-634X
DOI	10.3389/fcell.2023.1166808
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Article ; Online: A first principles analysis of potential-dependent structural evolution of active sites in Fe-N-C catalysts.

Morankar, Ankita / Deshpande, Siddharth / Zeng, Zhenhua / Atanassov, Plamen / Greeley, Jeffrey

Proceedings of the National Academy of Sciences of the United States of America

2023 Volume 120, Issue 49, Page(s) e2308458120

Abstract: Fe-N-C (iron-nitrogen-carbon) electrocatalysts have emerged as potential alternatives ...

Abstract	Fe-N-C (iron-nitrogen-carbon) electrocatalysts have emerged as potential alternatives to precious metal-based materials for the oxygen reduction reaction (ORR). However, the structure of these materials under electrochemical conditions is not well understood, and their poor stability in acidic environments poses a formidable challenge for successful adoption in commercial fuel cells. To provide molecular-level insights into these complex phenomena, we combine periodic density functional theory (DFT) calculations, exhaustive treatment of coadsorption effects for ORR reaction intermediates, including O and OH, and comprehensive analysis of solvation stabilization effects to construct voltage-dependent ab initio thermodynamic phase diagrams that describe the in situ structure of the active sites. These structures are further linked to activity and stability descriptors that can be compared with experimental parameters such as the half-wave potential for ORR and the onset potential for carbon corrosion and CO
Language	English
Publishing date	2023-11-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	209104-5
ISSN	1091-6490 ; 0027-8424
ISSN (online)	1091-6490
ISSN	0027-8424
DOI	10.1073/pnas.2308458120
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Zs.A 1148: Show issues

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Article: Temperature-Dependent n–p–n Switching and Highly Selective Room-Temperature n-SnSe₂/p-SnO/n-SnSe Heterojunction-Based NO₂ Gas Sensor

Rani, Sanju / Kumar, Manoj / Garg, Parveen / Parmar, Rahul / Kumar, Ashish / Singh, Yogesh / Baloria, Vishal / Deshpande, Uday / Singh, Vidya Nand

ACS applied materials & interfaces. 2022 Mar. 28, v. 14, no. 13

2022

Abstract: ... the thermal evaporation method to deposit an n-SnSe₂/p-SnO/n-SnSe heterojunction and observed a temperature ... dependent n–p–n switching NO₂ gas sensor with high selectivity working at room temperature (RT ... H₂S, CO, H₂, and NH₃. The mechanism of temperature-dependent n–p–n switching, fast response, recovery ...

Abstract	Many toxic gases are mixed into the atmosphere because of increased air pollution. An efficient gas sensor is required to detect these poisonous gases with its ultrasensitive ability. We employed the thermal evaporation method to deposit an n-SnSe₂/p-SnO/n-SnSe heterojunction and observed a temperature-dependent n–p–n switching NO₂ gas sensor with high selectivity working at room temperature (RT). The structural and morphological properties of the material were studied using the characterization techniques such as XRD, SEM, Raman spectroscopy, XPS, and HRTEM, respectively. At RT, the device response was 256% for 5 ppm NO₂. The response/recovery times were 34 s/272 s, respectively. The calculated limit of detection (LOD) was ∼115 ppb with a 38% response. The device response was better with NO₂ gas than with SO₂, NO, H₂S, CO, H₂, and NH₃. The mechanism of temperature-dependent n–p–n switching, fast response, recovery, and selective detection of NO₂ at RT has been discussed on the basis of physisorption and charge transfer. Thus, this work will add a new dimension to 2D materials as selective gas detectors at room temperature.
Keywords	Raman spectroscopy ; air pollution ; ambient temperature ; detection limit ; evaporation ; toxicity
Language	English
Dates of publication	2022-0328
Size	p. 15381-15390.
Publishing place	American Chemical Society
Document type	Article
ISSN	1944-8252
DOI	10.1021/acsami.1c24679
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Inactivation of Hippo and cJun-N-terminal Kinase (JNK) signaling mitigate FUS mediated neurodegeneration in vivo.

Gogia, Neha / Sarkar, Ankita / Mehta, Abijeet Singh / Ramesh, Nandini / Deshpande, Prajakta / Kango-Singh, Madhuri / Pandey, Udai Bhan / Singh, Amit

Neurobiology of disease

2020 Volume 140, Page(s) 104837

Abstract: Amyotrophic Lateral Sclerosis (ALS), a late-onset neurodegenerative disorder characterized by the loss of motor neurons in the central nervous system, has no known cure to-date. Disease causing mutations in human Fused in Sarcoma (FUS) leads to ... ...

Abstract	Amyotrophic Lateral Sclerosis (ALS), a late-onset neurodegenerative disorder characterized by the loss of motor neurons in the central nervous system, has no known cure to-date. Disease causing mutations in human Fused in Sarcoma (FUS) leads to aggressive and juvenile onset of ALS. FUS is a well-conserved protein across different species, which plays a crucial role in regulating different aspects of RNA metabolism. Targeted misexpression of FUS in Drosophila model recapitulates several interesting phenotypes relevant to ALS including cytoplasmic mislocalization, defects at the neuromuscular junction and motor dysfunction. We screened for the genetic modifiers of human FUS-mediated neurodegenerative phenotype using molecularly defined deficiencies. We identified hippo (hpo), a component of the evolutionarily conserved Hippo growth regulatory pathway, as a genetic modifier of FUS mediated neurodegeneration. Gain-of-function of hpo triggers cell death whereas its loss-of-function promotes cell proliferation. Downregulation of the Hippo signaling pathway, using mutants of Hippo signaling, exhibit rescue of FUS-mediated neurodegeneration in the Drosophila eye, as evident from reduction in the number of TUNEL positive nuclei as well as rescue of axonal targeting from the retina to the brain. The Hippo pathway activates c-Jun amino-terminal (NH
MeSH term(s)	Amyotrophic Lateral Sclerosis/metabolism ; Animals ; Axons/metabolism ; Cytoplasm/metabolism ; Disease Models, Animal ; Drosophila/metabolism ; Drosophila Proteins/metabolism ; Intracellular Signaling Peptides and Proteins/metabolism ; MAP Kinase Kinase 4/metabolism ; Motor Neurons/metabolism ; Mutation ; Nerve Degeneration/metabolism ; Neuromuscular Junction/metabolism ; Phenotype ; Protein Serine-Threonine Kinases/metabolism ; Protein Transport ; RNA-Binding Protein FUS/metabolism ; Signal Transduction
Chemical Substances	Drosophila Proteins ; Intracellular Signaling Peptides and Proteins ; RNA-Binding Protein FUS ; Protein Serine-Threonine Kinases (EC 2.7.11.1) ; hpo protein, Drosophila (EC 2.7.11.1) ; MAP Kinase Kinase 4 (EC 2.7.12.2)
Language	English
Publishing date	2020-03-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	1211786-9
ISSN	1095-953X ; 0969-9961
ISSN (online)	1095-953X
ISSN	0969-9961
DOI	10.1016/j.nbd.2020.104837
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Zs.A 4444: Show issues

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Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: A high ratio of linoleic acid (n-6 PUFA) to alpha-linolenic acid (n-3 PUFA) adversely affects early stage of human neuronal differentiation and electrophysiological activity of glutamatergic neurons in vitro

Karolina Dec / Mouhamed Alsaqati / Joanne Morgan / Sumukh Deshpande / Jamie Wood / Jeremy Hall / Adrian J. Harwood

Frontiers in Cell and Developmental Biology, Vol

2023 Volume 11

Abstract: ... have suggested that of the two important classes of polyunsaturated fatty acids, omega-6 (n-6) and ... omega-3 (n-3), n-3 polyunsaturated fatty acids support brain development and function, and when used ... dosage and use of specific n-3 polyunsaturated fatty acids. The aim of this study is to generate ...

Abstract	Introduction: There is a growing interest in the possibility of dietary supplementation with polyunsaturated fatty acids (PUFAs) for treatment and prevention of neurodevelopmental and neuropsychiatric disorders. Studies have suggested that of the two important classes of polyunsaturated fatty acids, omega-6 (n-6) and omega-3 (n-3), n-3 polyunsaturated fatty acids support brain development and function, and when used as a dietary supplement may have beneficial effects for maintenance of a healthy brain. However, to date epidemiological studies and clinical trials on children and adults have been inconclusive regarding treatment length, dosage and use of specific n-3 polyunsaturated fatty acids. The aim of this study is to generate a simplified in vitro cell-based model system to test how different n-6 to n-3 polyunsaturated fatty acids ratios affect human-derived neurons activity as a cellular correlate for brain function and to probe the mechanism of their action.Methods: All experiments were performed by use of human induced pluripotent stem cells (iPSCs). In this study, we examined the effect of different ratios of linoleic acid (n-6) to alpha-linolenic acid in cell growth medium on induced pluripotent stem cell proliferation, generation of neuronal precursors and electrophysiology of cortical glutamatergic neurons by multielectrode array (MEA) analysis.Results: This study shows that at a n-6:n-3 ratio of 5:1 polyunsaturated fatty acids induce stem cell proliferation, generating a large increase in number of cells after 72 h treatment; suppress generation of neuronal progenitor cells, as measured by decreased expression of FOXG1 and Nestin in neuronal precursor cells (NPC) after 20 days of development; and disrupt neuronal activity in vitro, increasing spontaneous neuronal firing, reducing synchronized bursting receptor subunits. We observed no significant differences for neuronal precursor cells treated with ratios 1:3 and 3:1, in comparison to 1:1 control ratio, but higher ratios of n-6 to n-3 ...
Keywords	polyunsaturated fatty acids ; neurodevelopment ; human induced pluripotent stem cells ; linoleic acid ; alpha-linolenic acid ; GABA signaling ; Biology (General) ; QH301-705.5
Subject code	571
Language	English
Publishing date	2023-05-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: First report on bio-catalytic N-formylation of amines using ethyl formate.

Patre, Rupesh E / Mal, Sanjib / Nilkanth, Pankaj R / Ghorai, Sujit K / Deshpande, Sudhindra H / El Qacemi, Myriem / Smejkal, Tomas / Pal, Sitaram / Manjunath, Bhanu N

Chemical communications (Cambridge, England)

2017 Volume 53, Issue 15, Page(s) 2382–2385

Abstract: A bio-catalyzed N-formylation reaction of different amines has been developed using ethyl formate ...

Abstract	A bio-catalyzed N-formylation reaction of different amines has been developed using ethyl formate as a formylating agent. This protocol provides a facile and convenient strategy featuring mild reaction conditions, high efficacy, a broad substrate scope and recyclability of lipase. This method also works on a large scale in high yield.
Language	English
Publishing date	2017-02-16
Publishing country	England
Document type	Journal Article
ZDB-ID	1472881-3
ISSN	1364-548X ; 1359-7345 ; 0009-241X
ISSN (online)	1364-548X
ISSN	1359-7345 ; 0009-241X
DOI	10.1039/c6cc07679c
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Article ; Online: Hyperkalemia due to fertilizer (N:P:K) poisoning.

Korade, M B / Sangle, S A / Deshpande, N S / Dhadke, S V

Journal of postgraduate medicine

2013 Volume 59, Issue 4, Page(s) 333–334

MeSH term(s)	Adult ; Electrocardiography ; Fertilizers/poisoning ; Humans ; Hyperkalemia/chemically induced ; Hyperkalemia/therapy ; Male ; Nitrogen/poisoning ; Phosphorus/poisoning ; Potassium/blood ; Potassium/poisoning
Chemical Substances	Fertilizers ; Phosphorus (27YLU75U4W) ; Nitrogen (N762921K75) ; Potassium (RWP5GA015D)
Language	English
Publishing date	2013-10
Publishing country	India
Document type	Case Reports ; Letter
ZDB-ID	410691-x
ISSN	0972-2823 ; 0022-3859
ISSN (online)	0972-2823
ISSN	0022-3859
DOI	10.4103/0022-3859.123179
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Article: Optimal n-Type Al-Doped ZnO Overlayers for Charge Transport Enhancement in p-Type Cu

Lee, Hak Hyeon / Kim, Dong Su / Choi, Ji Hoon / Kim, Young Been / Jung, Sung Hyeon / Sarker, Swagotom / Deshpande, Nishad G / Suh, Hee Won / Cho, Hyung Koun

Micromachines

2021 Volume 12, Issue 3

Abstract: An effective strategy for improving the charge transport efficiency of p-type ... ...

Abstract	An effective strategy for improving the charge transport efficiency of p-type Cu
Language	English
Publishing date	2021-03-22
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2620864-7
ISSN	2072-666X
ISSN	2072-666X
DOI	10.3390/mi12030338
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