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  1. Article ; Online: Reply to Reiffel-Numbers Don't Lie-But They Tell Only Part of the Story.

    Brophy, James M

    CJC open

    2023  Volume 5, Issue 5, Page(s) 401

    Language English
    Publishing date 2023-03-13
    Publishing country United States
    Document type Journal Article
    ISSN 2589-790X
    ISSN (online) 2589-790X
    DOI 10.1016/j.cjco.2023.03.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Understanding Associations, Social Inequities, and Cardiovascular Risks.

    Brophy, James M

    The Canadian journal of cardiology

    2022  Volume 38, Issue 12, Page(s) 1918–1920

    Language English
    Publishing date 2022-09-29
    Publishing country England
    Document type Editorial
    ZDB-ID 632813-1
    ISSN 1916-7075 ; 0828-282X
    ISSN (online) 1916-7075
    ISSN 0828-282X
    DOI 10.1016/j.cjca.2022.09.024
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  3. Article ; Online: Big Data, Big Expectations, and Big Judgements.

    Brophy, James M

    The Canadian journal of cardiology

    2022  Volume 38, Issue 10, Page(s) 1567–1569

    MeSH term(s) Big Data ; Humans ; Motivation
    Language English
    Publishing date 2022-07-08
    Publishing country England
    Document type Editorial
    ZDB-ID 632813-1
    ISSN 1916-7075 ; 0828-282X
    ISSN (online) 1916-7075
    ISSN 0828-282X
    DOI 10.1016/j.cjca.2022.07.001
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  4. Article ; Online: In HF, SGLT2 inhibitors reduce HF hospitalizations at up to 2 y.

    Brophy, James M

    Annals of internal medicine

    2022  Volume 175, Issue 8, Page(s) JC87

    Abstract: Source citation: Zou X, Shi Q, Vandvik PO, et al. ...

    Abstract Source citation: Zou X, Shi Q, Vandvik PO, et al.
    Language English
    Publishing date 2022-08-02
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 336-0
    ISSN 1539-3704 ; 0003-4819
    ISSN (online) 1539-3704
    ISSN 0003-4819
    DOI 10.7326/J22-0055
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  5. Article ; Online: After DES implantation, DAPT for 1 y vs. ≤6 mo increased major bleeding in patients with high baseline bleeding risk.

    Brophy, James M

    Annals of internal medicine

    2022  Volume 175, Issue 4, Page(s) JC45

    Abstract: Source citation: Palmerini T, Bruno AG, Redfors B, et al. ...

    Abstract Source citation: Palmerini T, Bruno AG, Redfors B, et al.
    MeSH term(s) Drug Therapy, Combination ; Drug-Eluting Stents/adverse effects ; Hemorrhage/chemically induced ; Humans ; Percutaneous Coronary Intervention/adverse effects ; Platelet Aggregation Inhibitors/adverse effects ; Treatment Outcome
    Chemical Substances Platelet Aggregation Inhibitors
    Language English
    Publishing date 2022-04-05
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 336-0
    ISSN 1539-3704 ; 0003-4819
    ISSN (online) 1539-3704
    ISSN 0003-4819
    DOI 10.7326/J22-0012
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  6. Article ; Online: Molnupiravir's authorisation was premature.

    Brophy, James M

    BMJ (Clinical research ed.)

    2022  Volume 376, Page(s) o443

    MeSH term(s) Antiviral Agents/standards ; COVID-19/drug therapy ; COVID-19/virology ; Cytidine/analogs & derivatives ; Cytidine/standards ; Drug Approval ; Humans ; Hydroxylamines/standards ; SARS-CoV-2
    Chemical Substances Antiviral Agents ; Hydroxylamines ; Cytidine (5CSZ8459RP) ; molnupiravir (YA84KI1VEW)
    Language English
    Publishing date 2022-03-03
    Publishing country England
    Document type Editorial
    ZDB-ID 1362901-3
    ISSN 1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    ISSN (online) 1756-1833
    ISSN 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    DOI 10.1136/bmj.o443
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  7. Article ; Online: mRNA COVID-19 vaccines were linked to myocarditis at 28 d (0.15 to 10 excess events/100 000 vaccinated persons).

    Brophy, James M

    Annals of internal medicine

    2022  Volume 175, Issue 8, Page(s) JC94

    Abstract: Source citation: Karlstad Ø, Hovi P, Husby A, et al. ...

    Abstract Source citation: Karlstad Ø, Hovi P, Husby A, et al.
    MeSH term(s) COVID-19/prevention & control ; COVID-19 Vaccines/adverse effects ; Cohort Studies ; Humans ; Myocarditis ; RNA, Messenger ; SARS-CoV-2/genetics ; Vaccination/adverse effects ; Viral Vaccines
    Chemical Substances COVID-19 Vaccines ; RNA, Messenger ; Viral Vaccines
    Language English
    Publishing date 2022-08-02
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 336-0
    ISSN 1539-3704 ; 0003-4819
    ISSN (online) 1539-3704
    ISSN 0003-4819
    DOI 10.7326/J22-0057
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  8. Article ; Online: Effect of bempedoic acid on mortality and cardiovascular events in primary and secondary prevention: A post-hoc analysis of the CLEAR-outcomes trial.

    Sayed, Ahmed / Brophy, James M

    International journal of cardiology

    2024  Volume 406, Page(s) 132074

    Abstract: Background: The effects of bempedoic acid on mortality in the secondary prevention setting have not been examined.: Methods: We used data from the overall and primary prevention reports of CLEAR - Outcomes to reconstruct data for the secondary ... ...

    Abstract Background: The effects of bempedoic acid on mortality in the secondary prevention setting have not been examined.
    Methods: We used data from the overall and primary prevention reports of CLEAR - Outcomes to reconstruct data for the secondary prevention population. A Bayesian analyses was employed to calculate the posterior probability of benefit or harm for the outcomes of all-cause mortality, cardiovascular mortality, and major adverse cardiovascular events (MACE). Relative effect sizes are presented as risk ratios (RR) with 95% credible intervals (CrI), which represent the intervals that true effect sizes are expected to fall in with 95% probability, given the priors and model.
    Results: In primary prevention, the posterior probability of bempedoic acid decreasing all-cause and cardiovascular mortality was 99.4% (RR: 0.70; 95% CrI: 0.51 to 0.92) and 99.7% (RR: 0.58; 95% CrI: 0.38 to 0.86) respectively. In secondary prevention, the posterior probability of bempedoic acid increasing all-cause and cardiovascular mortality was 96.6% (RR: 1.15; 95% CrI: 0.99 to 1.33) and 97.2% (RR: 1.21; 95% CrI: 1.00 to 1.45) respectively. The probability of bemepdoic acid reducing MACE in the primary and secondary prevention settings was 99.9% (RR: 0.70; 95% CrI: 0.54 to 0.88) and 95.8% (RR: 0.92; 95% CrI: 0.84 to 1.01) respectively.
    Conclusion: In contrast to its effect in the primary prevention subgroup of CLEAR - Outcomes, bempedoic acid resulted in a more modest MACE reduction and a potential increase in mortality in the secondary prevention subgroup. Whether these findings represent true treatment effect heterogeneity or the play of chance requires further evidence.
    Language English
    Publishing date 2024-04-21
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 779519-1
    ISSN 1874-1754 ; 0167-5273
    ISSN (online) 1874-1754
    ISSN 0167-5273
    DOI 10.1016/j.ijcard.2024.132074
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  9. Article ; Online: SARS-CoV-2 testing in travellers: Can we be smarter?

    Brophy, James M

    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne

    2021  Volume 194, Issue 1, Page(s) E20

    MeSH term(s) COVID-19/diagnosis ; COVID-19 Testing/economics ; COVID-19 Testing/methods ; Canada ; Costs and Cost Analysis ; Health Policy ; Humans ; Public Health ; Travel
    Language English
    Publishing date 2021-12-16
    Publishing country Canada
    Document type Letter
    ZDB-ID 215506-0
    ISSN 1488-2329 ; 0008-4409 ; 0820-3946
    ISSN (online) 1488-2329
    ISSN 0008-4409 ; 0820-3946
    DOI 10.1503/cmaj.80779
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  10. Article ; Online: Key Issues in the Statistical Interpretation of Randomized Clinical Trials.

    Brophy, James M

    The Canadian journal of cardiology

    2021  Volume 37, Issue 9, Page(s) 1312–1321

    Abstract: Traditional statistical analyses of randomized clinical trials typically use P values within a null hypothesis significance testing paradigm. Clinical adoption of randomized trials results, by guideline writers and individual clinicians, are often ... ...

    Abstract Traditional statistical analyses of randomized clinical trials typically use P values within a null hypothesis significance testing paradigm. Clinical adoption of randomized trials results, by guideline writers and individual clinicians, are often unequivocally determined by a deification of P < 0.05. Although the many limitations and large potential for misinterpretations with this approach have long been appreciated in the statistical literature, these issues are less frequently considered in the clinical literature. Discussions of these limitations might be viewed as esoteric, so that many cardiovascular specialists believe they are of little clinical importance. Using contemporary examples from the cardiovascular literature the potential, interpretative pitfalls in assessing "negative," "positive," and "noninferiority" trials are discussed accompanied by caveats on the statistical issues of the strength of the evidence and researcher degrees of freedom. Considerations such as effect size overestimation, robustness of results, statistical power issues, pitfalls in noninferiority trial interpretation, researcher degrees of freedom, and strength of evidence are discussed, using examples from well known trials in the areas of surgical and interventional management of coronary artery disease, heart failure management, and pharmacotherapy. The examples provided illustrate how even landmark trials in prestigious journals can present statistical problems that substantially undermine their conclusions or even make them unreliable. The goal of this article is to help clinicians more accurately reflect on and interpret research findings, by emphasizing the importance of the choice and interpretation of some of the current statistical techniques used in the analyses of randomized clinical trials.
    MeSH term(s) Data Interpretation, Statistical ; Humans ; Randomized Controlled Trials as Topic ; Research Design
    Language English
    Publishing date 2021-01-05
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 632813-1
    ISSN 1916-7075 ; 0828-282X
    ISSN (online) 1916-7075
    ISSN 0828-282X
    DOI 10.1016/j.cjca.2020.12.014
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