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  1. Article ; Online: Overcoming Barriers to Applying Systems Thinking Mental Models in Policy-Making; Comment on “What Can Policy-Makers Get Out of Systems Thinking? Policy Partners’ Experiences of a Systems-Focused Research Collaboration in Preventive Health”

    Sobia Khan

    International Journal of Health Policy and Management, Vol 10, Iss 5, Pp 281-

    2021  Volume 283

    Abstract: Systems thinking provides the health system with important theories, models and approaches to understanding and assessing complexity. However, the utility and application of systems thinking for solution-generation and decision-making is uncertain at ... ...

    Abstract Systems thinking provides the health system with important theories, models and approaches to understanding and assessing complexity. However, the utility and application of systems thinking for solution-generation and decision-making is uncertain at best, particularly amongst health policy-makers. This commentary aims to elaborate on key themes discussed by Haynes and colleagues in their study exploring policy-makers’ perceptions of an Australian researcher-policy-maker partnership focused on applications of systems thinking. Findings suggest that policy-makers perceive systems thinking as too theoretical and not actionable, and that the value of systems thinking can be gleaned from greater involvement of policy-makers in research (ie, through co-production). This commentary focuses on the idea that systems thinking is a mental model that, contrary to researchers’ beliefs, may be closely aligned with policy-makers’ existing worldviews, which can enhance adoption of this mental model. However, wider application of systems thinking beyond research requires addressing multiple barriers faced by policy-makers related to their capability, opportunity and motivation to action their systems thinking mental models. To make systems thinking applicable to the policy sphere, multiple approaches are required that focus on capacity building, and a shift in shared mental models (or the ideas and institutions that govern policy-making).
    Keywords systems thinking ; complexity ; policy-making ; Public aspects of medicine ; RA1-1270
    Subject code 360
    Language English
    Publishing date 2021-05-01T00:00:00Z
    Publisher Kerman University of Medical Sciences
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Overcoming Barriers to Applying Systems Thinking Mental Models in Policy-Making Comment on "What Can Policy-Makers Get Out of Systems Thinking? Policy Partners' Experiences of a Systems-Focused Research Collaboration in Preventive Health".

    Khan, Sobia

    International journal of health policy and management

    2021  Volume 10, Issue 5, Page(s) 281–283

    Abstract: Systems thinking provides the health system with important theories, models and approaches to understanding and assessing complexity. However, the utility and application of systems thinking for solution-generation and decision-making is uncertain at ... ...

    Abstract Systems thinking provides the health system with important theories, models and approaches to understanding and assessing complexity. However, the utility and application of systems thinking for solution-generation and decision-making is uncertain at best, particularly amongst health policy-makers. This commentary aims to elaborate on key themes discussed by Haynes and colleagues in their study exploring policy-makers' perceptions of an Australian researcher-policy-maker partnership focused on applications of systems thinking. Findings suggest that policy-makers perceive systems thinking as too theoretical and not actionable, and that the value of systems thinking can be gleaned from greater involvement of policy-makers in research (ie, through co-production). This commentary focuses on the idea that systems thinking is a mental model that, contrary to researchers' beliefs, may be closely aligned with policy-makers' existing worldviews, which can enhance adoption of this mental model. However, wider application of systems thinking beyond research requires addressing multiple barriers faced by policy-makers related to their capability, opportunity and motivation to action their systems thinking mental models. To make systems thinking applicable to the policy sphere, multiple approaches are required that focus on capacity building, and a shift in shared mental models (or the ideas and institutions that govern policy-making).
    MeSH term(s) Administrative Personnel ; Australia ; Health Policy ; Humans ; Models, Psychological ; Preventive Health Services ; Systems Analysis
    Language English
    Publishing date 2021-03-15
    Publishing country Iran
    Document type Journal Article ; Comment
    ZDB-ID 2724317-5
    ISSN 2322-5939 ; 2322-5939
    ISSN (online) 2322-5939
    ISSN 2322-5939
    DOI 10.34172/ijhpm.2020.50
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: WITHDRAWN: Original Antigenic Sin in COVID-19: Hoskins Effect and Vaccine

    Khan, Mudassir / Manzoor, Sobia / Ullah, Najeeb / Khan, Dilawar

    Infectious disorders drug targets

    2022  

    Language English
    Publishing date 2022-03-17
    Publishing country United Arab Emirates
    Document type Journal Article
    ZDB-ID 2234298-9
    ISSN 2212-3989 ; 1871-5265
    ISSN (online) 2212-3989
    ISSN 1871-5265
    DOI 10.2174/1871526522666220317154549
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Cross-regulation of cytoskeleton and calcium signaling at plant-pathogen interface.

    Naveed, Zunaira Afzal / Jamil, Mahnoor / Asif, Nouman / Waqas, Muhammad / Ajaz, Sobia / Khan, Sultan Habibullah

    Cellular signalling

    2024  Volume 117, Page(s) 111100

    Abstract: During plant-pathogen interactions, cytoskeleton and calcium signaling work independently as well as in coordination with each other for developing preformed and induced defense responses. A cell wall (CW) - plasma membrane (PM) - cytoskeleton (CS) ... ...

    Abstract During plant-pathogen interactions, cytoskeleton and calcium signaling work independently as well as in coordination with each other for developing preformed and induced defense responses. A cell wall (CW) - plasma membrane (PM) - cytoskeleton (CS) continuum is maintained by coordination of cytoskeleton and calcium signaling. The current review is focused on the current knowledge of cytoskeleton‑calcium cross-regulation during plant-pathogen interactions. Implications of recent technological developments in the existing toolkit that can address the outstanding questions of cytoskeleton‑calcium coordination plant immunity are also discussed.
    MeSH term(s) Calcium Signaling ; Calcium/metabolism ; Cytoskeleton/metabolism ; Plants/metabolism ; Microtubules/metabolism ; Actin Cytoskeleton/metabolism
    Chemical Substances Calcium (SY7Q814VUP)
    Language English
    Publishing date 2024-02-13
    Publishing country England
    Document type Review ; Journal Article
    ZDB-ID 1002702-6
    ISSN 1873-3913 ; 0898-6568
    ISSN (online) 1873-3913
    ISSN 0898-6568
    DOI 10.1016/j.cellsig.2024.111100
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Monitoring Hospitalized Dialysis Patients With COVID-19: Repurposing Baby Monitors for Patient and Staff Safety.

    Khan, Sobia / Mallipattu, Sandeep K

    Kidney medicine

    2020  Volume 3, Issue 1, Page(s) 136–138

    Language English
    Publishing date 2020-12-10
    Publishing country United States
    Document type Journal Article
    ISSN 2590-0595
    ISSN (online) 2590-0595
    DOI 10.1016/j.xkme.2020.10.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Fluorescent DNA-Silver nanoclusters in food safety detection: From synthesis to application.

    Zhou, Bingxuan / Khan, Imran Mahmood / Ding, Xiaowei / Niazi, Sobia / Zhang, Yin / Wang, Zhouping

    Talanta

    2024  Volume 273, Page(s) 125834

    Abstract: In recent years, the conventional preparation of silver nanoclusters (AgNCs) has attracted much attention due to their ultra-small size, tunable fluorescence, easy-to-engineer, as well as biocompatible material. Moreover, its great affinity towards ... ...

    Abstract In recent years, the conventional preparation of silver nanoclusters (AgNCs) has attracted much attention due to their ultra-small size, tunable fluorescence, easy-to-engineer, as well as biocompatible material. Moreover, its great affinity towards cytosine bases on single-stranded DNA has led to the construction of biosensors, especially aptamers, for a broad variety of applications in food safety and environmental protection. In past years, numerous researchers paid attention to the construction of AgNCs aptasensor. Therefore, this review will be an effort to summarize the synthetic strategy along with the influences of factors on synthesis, categorize the sensing mechanism of aptamer-functionalized AgNCs biosensors, as well as their specific applications in food safety detection including heavy metal, toxin, and foodborne pathogenic bacteria. Furthermore, a brief conclusion and outlook regarding the prospects and challenges of their applications in food safety were drawn in line with the developments in DNA-AgNCs.
    MeSH term(s) Silver ; Metal Nanoparticles ; Aptamers, Nucleotide ; DNA ; Spectrometry, Fluorescence ; Fluorescent Dyes ; Biosensing Techniques
    Chemical Substances Silver (3M4G523W1G) ; Aptamers, Nucleotide ; DNA (9007-49-2) ; Fluorescent Dyes
    Language English
    Publishing date 2024-03-08
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 1500969-5
    ISSN 1873-3573 ; 0039-9140
    ISSN (online) 1873-3573
    ISSN 0039-9140
    DOI 10.1016/j.talanta.2024.125834
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Current And Emerging Trends In The Management Of Pyoderma Gangrenosum: A Literature Review.

    Muhammad, Sobia Wali / Hassan, Nadia / Khan, Samra / Gohar, Atia

    Journal of Ayub Medical College, Abbottabad : JAMC

    2024  Volume 35Suppl 1, Issue 4, Page(s) S774–S784

    Abstract: The first description of Pyoderma gangrenosum (PG) was made about a century ago. It is difficult to understand the aetiology, pathophysiology, and therapy of PG. This disease is believed to be caused by a systemic inflammatory response to neutrophil ... ...

    Abstract The first description of Pyoderma gangrenosum (PG) was made about a century ago. It is difficult to understand the aetiology, pathophysiology, and therapy of PG. This disease is believed to be caused by a systemic inflammatory response to neutrophil chemotaxis and faulty innate immune system control. Nearly fifty percent of the cases have underlying systemic symptoms. Significant improvements in PG management have been made over the years. The main goals of treatment are to reduce inflammation and speed up the healing of the PG wound. Even though the most recent medicines show promise, they are found on isolated case reports. The majority of patients are typically managed with topical treatment and local wound care, while resistant cases necessitate immunosuppressive medications. More progress can be made with improvements in technology in deciphering this complex disease and getting a greater understanding of the condition. The present standard therapies for refractory PG are not well supported by studies. In refractory PG, corticosteroids and cyclosporine have historically been administered. Tumour necrosis factor inhibitors are becoming a viable option; nonetheless, this requires careful research and upkeep. This review intended to describe the current trends in managing the PG. Several next-generation treatment options including the conventional therapies introduced to treat PG. We encompass the advantages and disadvantages of new treatments for PG.
    MeSH term(s) Humans ; Pyoderma Gangrenosum/drug therapy ; Pyoderma Gangrenosum/diagnosis ; Inflammation/complications ; Inflammation/drug therapy ; Administration, Topical
    Language English
    Publishing date 2024-02-26
    Publishing country Pakistan
    Document type Review ; Journal Article
    ZDB-ID 2192473-9
    ISSN 1819-2718 ; 1025-9589
    ISSN (online) 1819-2718
    ISSN 1025-9589
    DOI 10.55519/JAMC-S4-12085
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Discovering novel inhibitors of P2Y

    Halim, Sobia Ahsan / Waqas, Muhammad / Asim, Ayesha / Khan, Majid / Khan, Ajmal / Al-Harrasi, Ahmed

    Computers in biology and medicine

    2022  Volume 147, Page(s) 105743

    Abstract: ... ...

    Abstract P2Y
    MeSH term(s) Drug Design ; Ligands ; Molecular Docking Simulation ; Molecular Dynamics Simulation
    Chemical Substances Ligands
    Language English
    Publishing date 2022-06-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 127557-4
    ISSN 1879-0534 ; 0010-4825
    ISSN (online) 1879-0534
    ISSN 0010-4825
    DOI 10.1016/j.compbiomed.2022.105743
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Synthesis of hydrazone-based polyhydroquinoline derivatives - antibacterial activities, α-glucosidase inhibitory capability, and DFT study.

    Ismail, Muhammad / Ahmad, Rashid / Halim, Sobia Ahsan / Khan, Adnan Ali / Ullah, Saeed / Latif, Abdul / Ahmad, Manzoor / Khan, Ajmal / Ozdemir, Fethi Ahmet / Khalid, Asaad / Al-Harrasi, Ahmed / Ali, Mumtaz

    RSC advances

    2024  Volume 14, Issue 16, Page(s) 10978–10994

    Abstract: In recent years, polyhydroquinolines have gained much attention due to their widespread applications in medicine, agriculture, industry, ...

    Abstract In recent years, polyhydroquinolines have gained much attention due to their widespread applications in medicine, agriculture, industry,
    Language English
    Publishing date 2024-04-04
    Publishing country England
    Document type Journal Article
    ISSN 2046-2069
    ISSN (online) 2046-2069
    DOI 10.1039/d4ra00045e
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Biochemical and computational inhibition of α-glucosidase by novel metronidazole-linked 1

    Ullah, Saeed / Halim, Sobia Ahsan / Waqas, Muhammad / Mansoor, Farheen / Avula, Satya Kumar / Khan, Farhan A / Perviaz, Muhammad / Ogaly, Hanan A / Khan, Ajmal / Al-Harrasi, Ahmed

    Journal of biomolecular structure & dynamics

    2024  , Page(s) 1–21

    Abstract: In the current study, metronidazole derivatives containing ... ...

    Abstract In the current study, metronidazole derivatives containing 1
    Language English
    Publishing date 2024-03-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 49157-3
    ISSN 1538-0254 ; 0739-1102
    ISSN (online) 1538-0254
    ISSN 0739-1102
    DOI 10.1080/07391102.2024.2322622
    Database MEDical Literature Analysis and Retrieval System OnLINE

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