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  1. Article ; Online: Avaliação dos conhecimentos, atitudes e medidas de prevenção contra a dengue na cidade de Senador Rui Palmeira/AL

    Maria Regina Oliveira da Silva / Pedro Juvino de Souza Júnior / Claudimary Bispo dos Santos

    Diversitas Journal, Vol 2, Iss

    2017  Volume 3

    Abstract: ... se com este estudo avaliar o conhecimento, atitudes e medidas de prevenção da Dengue na cidade de Senador Rui ... prevention measures in the city of Senador Rui Palmeira, the state of Alagoas. The search is called based on ...

    Abstract RESUMO: A Dengue é uma arbovirose que está entre as problemáticas de saúde mais abordadas no Brasil e no mundo, causada pelo Flavivirus transmitido pelo mosquito-fêmea do gênero Aedes. Objetivou-se com este estudo avaliar o conhecimento, atitudes e medidas de prevenção da Dengue na cidade de Senador Rui Palmeira, interior do estado de Alagoas. A pesquisa denomina-se exploratória baseada em trabalho de campo que está em desenvolvimento na zona urbana do município supracitado com uma amostragem de 100 domicílios escolhidos aleatoriamente que serão visitados durante o ano de 2016. Estes dados correspondem a 56 domicílios visitados, onde foram observados 86% do gênero feminino, 30% possuem idades entre 18 e 29 anos e 63% não concluíram o ensino fundamental II. Podendo ser a falta de escolaridade e falta de consciência principal dificuldade para ações de educação em relação a Dengue. Com isso, 96% costumam armazenar água, devido ocorrer intermitência constante no sistema de abastecimento. Havia condições favoráveis para o desenvolvimento das larvas em 66% dos domicílios. Foi possível concluir que o grau de escolaridade e as condições socioeconômicas não afetam as atitudes e medidas de prevenção da Dengue, estando este um fator essencial para a elaboração de outras pesquisas na área. PALAVRAS - CHAVE: Educação, Saúde, Brasil. ABSTRACT: Dengue is an arbovirus which is among the health issues most discussed in Brazil and in the world, caused by flavivirus transmitted by the mosquito-female Aedes genus. This study aims to evaluate the knowledge, attitudes and Dengue prevention measures in the city of Senador Rui Palmeira, the state of Alagoas. The search is called based on exploratory field work that is under development in the urban area of the above municipality with a sample of 100 households randomly selected to be visited during the year 2016. This corresponds to 56 households visited, which were observed 86 % female, 30% are aged between 18 and 29 years and 63% have not completed primary education II. It may be a ...
    Keywords Education ; L ; Science ; Q ; Social Sciences ; H
    Language English
    Publishing date 2017-12-01T00:00:00Z
    Publisher Universidade Estadual de Alagoas
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Book ; Online ; E-Book: Hydrogels for tissue engineering and regenerative medicine

    Oliveira, Joaquim Miguel / Silva-Correia, Joana / Reis, Rui L.

    from fundamentals to applications

    2024  

    Abstract: Hydrogels for Tissue Engineering and Regenerative Medicine: From Fundaments to Applications provides the reader with a comprehensive, concise and thoroughly up-to-date resource on the different types of hydrogels in tissue engineering and regenerative ... ...

    Author's details edited by J. Miguel Oliveira, Joana Silva-Correia, and Rui L. Reis
    Abstract Hydrogels for Tissue Engineering and Regenerative Medicine: From Fundaments to Applications provides the reader with a comprehensive, concise and thoroughly up-to-date resource on the different types of hydrogels in tissue engineering and regenerative medicine. The book is divided into three main sections that describe biological activities and the structural and physicochemical properties of hydrogels, along with a wide range of applications, including their combination with emerging technologies. Written by a diverse range of international academics for professionals, researchers, undergraduate and graduate students, this groundbreaking publication fills a gap in literature needed in the tissue engineering and regenerative medicine field.
    MeSH term(s) Hydrogels/therapeutic use. ; Tissue Engineering. ; Regenerative Medicine.
    Keywords Tissue engineering ; Colloids/Therapeutic use.
    Subject code 621
    Language English
    Size 1 online resource (851 pages)
    Edition First edition.
    Publisher Academic Press
    Publishing place London
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 0-12-824225-6 ; 9780128239483 ; 978-0-12-824225-4 ; 0128239484
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article ; Online: Single-Particle Plasmon Sensor to Monitor Proteolytic Activity in Real Time.

    Oliveira-Silva, Rui / Wang, Yuyang / Nooteboom, Sjoerd W / Prazeres, Duarte M F / Paulo, Pedro M R / Zijlstra, Peter

    ACS applied optical materials

    2023  Volume 1, Issue 10, Page(s) 1661–1669

    Abstract: We have established a label-free plasmonic platform that monitors proteolytic activity in real time. The sensor consists of a random array of gold nanorods that are functionalized with a design peptide that is specifically cleaved by thrombin, resulting ... ...

    Abstract We have established a label-free plasmonic platform that monitors proteolytic activity in real time. The sensor consists of a random array of gold nanorods that are functionalized with a design peptide that is specifically cleaved by thrombin, resulting in a blueshift of the longitudinal plasmon. By monitoring the plasmon of many individual nanorods, we determined thrombin's proteolytic activity in real time and inferred relevant kinetic parameters. Furthermore, a comparison to a kinetic model revealed that the plasmon shift is dictated by a competition between peptide cleavage and thrombin binding, which have opposing effects on the measured plasmon shift. The dynamic range of the sensor is greater than two orders of magnitude, and it is capable of detecting physiologically relevant levels of active thrombin down to 3 nM in buffered conditions. We expect these plasmon-mediated label-free sensors to open the window to a range of applications stretching from the diagnostic and characterization of bleeding disorders to fundamental proteolytic and pharmacological studies.
    Language English
    Publishing date 2023-10-04
    Publishing country United States
    Document type Journal Article
    ISSN 2771-9855
    ISSN (online) 2771-9855
    DOI 10.1021/acsaom.3c00226
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Bioenergetic modelling of a marine top predator's responses to changes in prey structure.

    Silva, Mariana P / Oliveira, Cláudia / Prieto, Rui / Silva, Mónica A / New, Leslie / Pérez-Jorge, Sergi

    Ecology and evolution

    2024  Volume 14, Issue 3, Page(s) e11135

    Abstract: Determining how animals allocate energy, and how external factors influence this allocation, is crucial to understand species' life history requirements and response to disturbance. This response is driven in part by individuals' energy balance, prey ... ...

    Abstract Determining how animals allocate energy, and how external factors influence this allocation, is crucial to understand species' life history requirements and response to disturbance. This response is driven in part by individuals' energy balance, prey characteristics, foraging behaviour and energy required for essential functions. We developed a bioenergetic model to estimate minimum foraging success rate (FSR), that is, the lowest possible prey capture rate for individuals to obtain the minimum energy intake needed to meet daily metabolic requirements, for female sperm whale (
    Language English
    Publishing date 2024-03-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 2635675-2
    ISSN 2045-7758
    ISSN 2045-7758
    DOI 10.1002/ece3.11135
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Lessons from Four Decades of Systemic Amyloidosis with Renal Involvement.

    Oliveira-Silva, Catarina / Marques, Nídia / Pinho, Ana / Poínhos, Rui / Bergantim, Rui / Nunes, Ana Teresa / Sampaio, Susana / Rodrigues-Pereira, Pedro / Silva, Roberto / Praça, Augusta / Frazão, João / Pestana, Manuel / Tavares, Isabel

    Nephron

    2022  Volume 147, Issue 3-4, Page(s) 158–169

    Abstract: Background: Apart from ATTR amyloidosis, the epidemiology and outcomes of the most common subtypes of systemic amyloidosis in Portugal remain primarily unknown.: Methods: This retrospective cohort study evaluated patients with renal biopsy-proven ... ...

    Abstract Background: Apart from ATTR amyloidosis, the epidemiology and outcomes of the most common subtypes of systemic amyloidosis in Portugal remain primarily unknown.
    Methods: This retrospective cohort study evaluated patients with renal biopsy-proven amyloidosis, diagnosed from January 1978 to December 2019. Follow-up started at kidney disease presentation and ended at death or August 2020. Clinical presentation, survival, and prognostic factors were analysed.
    Results: Of 123 patients with amyloid nephropathy, 111 had definite amyloid typing and were analysed. AA amyloidosis was the most frequent type (56.1%) and was related mainly to chronic infection (47.8%) and chronic inflammatory arthritis (29.0%). AL amyloidosis was present in 25.2% of patients and hereditary forms in 6.5% (4.1% AFibE526V, 2.4% ATTRV30M). During follow-up, 73.9% of AA and 54.8% of AL patients progressed to end-stage renal disease, and 79.7% of AA and 77.4% of AL died; median overall survival was 66.0 (95% CI, 33.0-99.0) and 18.0 (95% CI, 9.3-26.7) months (p = 0.025), respectively. There were no significant differences in renal outcome and survival on dialysis between these two types. In multivariate analysis, cardiac involvement at presentation (HR 6.26 [95% CI, 2.89-13.56]) and estimated glomerular filtration rate <30 mL/min/1.73 m2 (HR 2.05 [95% CI, 1.06-3.99]) independently influenced AA and AL amyloidosis survival. Cardiac involvement at presentation was an independent predictor of death (HR 9.65 [95% CI, 2.91-31.95]) and early mortality in AL amyloidosis.
    Conclusions: In Portugal, AA amyloidosis and related chronic infections are still relevant. Regarding AL amyloidosis, the low incidence and advanced disease at presentation result from missed and erroneous diagnoses, leading to delayed referrals and poor outcomes in these patients.
    MeSH term(s) Humans ; Immunoglobulin Light-chain Amyloidosis ; Retrospective Studies ; Renal Dialysis ; Amyloidosis/epidemiology
    Language English
    Publishing date 2022-09-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 207121-6
    ISSN 2235-3186 ; 1423-0186 ; 1660-8151 ; 0028-2766
    ISSN (online) 2235-3186 ; 1423-0186
    ISSN 1660-8151 ; 0028-2766
    DOI 10.1159/000525675
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 169: Show issues Location:
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  6. Article: Exploring the Bioactive Potential of

    Oliveira, Rui S / Preto, Marco / Santos, Germana / Silva, Ana Margarida / Vasconcelos, Vitor / Martins, Rosário

    Microorganisms

    2024  Volume 12, Issue 3

    Abstract: Addressing pressing health concerns, modern medical research seeks to identify new antimicrobials to combat drug resistance, novel molecules for cancer treatment, and antioxidants for inflammation-related diseases. ...

    Abstract Addressing pressing health concerns, modern medical research seeks to identify new antimicrobials to combat drug resistance, novel molecules for cancer treatment, and antioxidants for inflammation-related diseases.
    Language English
    Publishing date 2024-02-23
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms12030450
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  7. Article ; Online: Organisational culture and balanced scorecard

    Cidália Oliveira / Margarida Rodrigues / Rui Silva / Mário Franco

    Management : Journal of Contemporary Management Issues, Vol 28, Iss 2, Pp 133-

    An empirical study in Portugal

    2023  Volume 149

    Abstract: This study aims to identify and characterize the culture of the largest exporters without the Balanced Scorecard (BSC) and with the BSC implemented. In addition, it confirms whether there are different characteristics in the type of organizational ... ...

    Abstract This study aims to identify and characterize the culture of the largest exporters without the Balanced Scorecard (BSC) and with the BSC implemented. In addition, it confirms whether there are different characteristics in the type of organizational culture of the largest exporters without the BSC and with the BSC. To achieve this objective, data were collected through questionnaires sent to the 250 largest exporters in Portugal. Multivariate statistical techniques were used to validate the research hypotheses. This research shows that the Adhocracy (turbulent management) culture type prevails in organizations without BSC, while the Market (productivity) culture type prevails in organizations with BSC. The study is based on the characterization of the culture type of the organizations. This characterization is significant because organizational culture shapes and differentiates organizations’ actions, goal definitions, and strategic objectives, which can affect organizational performance. Although recent literature has addressed organizational culture and performance monitoring in isolation, not many studies have been found that link the topics of organizational culture, BSC, and performance.
    Keywords Balanced Scorecard ; organizational culture ; performance ; major Portuguese exporters ; Economic growth ; development ; planning ; HD72-88 ; Economics as a science ; HB71-74
    Subject code 650
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher University of Split, Faculty of Economics
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article: Neurological Spectrum of Epstein-Barr Virus Infection: A Rare Clinical Case.

    Gomes, Dora / André, Rui / Oliveira, Catarina / Camões, Sofia / Silva, Catarina R / Mendes, Miguel L

    Cureus

    2024  Volume 16, Issue 1, Page(s) e53302

    Abstract: The Epstein-Barr virus (EBV) is a DNA virus that has been infecting humans since ancient times, capable of causing a wide range of pathologies and affecting approximately 90% of the population. A 61-year-old male with no significant medical history ... ...

    Abstract The Epstein-Barr virus (EBV) is a DNA virus that has been infecting humans since ancient times, capable of causing a wide range of pathologies and affecting approximately 90% of the population. A 61-year-old male with no significant medical history presented with a 5-day history of imbalance and difficulty walking. Neurological examination revealed specific findings, including absent reflexes, bilateral asynergy, and gait abnormalities. Contrasting with Guillain-Barré Syndrome, lumbar puncture suggested a central nervous system infection. Serological testing confirmed Epstein-Barr virus (EBV) positivity, and intravenous immunoglobulin led to significant improvement. Electromyogram results suggested inflammatory/ipnfectious polyradiculopathy. Repeat EBV serology, showing strongly positive IgG and negative IgM, confirmed the diagnosis of Polyradiculoneuropathy secondary to EBV. This case underscores the rare neurological complications of EBV and the importance of considering viral infections in such presentations.
    Language English
    Publishing date 2024-01-31
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.53302
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  9. Article: Monitoring Proteolytic Activity in Real Time: A New World of Opportunities for Biosensors.

    Oliveira-Silva, Rui / Sousa-Jerónimo, Mariana / Botequim, David / Silva, Nuno J O / Paulo, Pedro M R / Prazeres, Duarte M F

    Trends in biochemical sciences

    2020  Volume 45, Issue 7, Page(s) 604–618

    Abstract: Proteases play a pivotal role in several biological processes, from digestion, cell proliferation, and differentiation to fertility. Deregulation of protease metabolism can result in several pathological conditions (i.e., cancer, neurodegenerative ... ...

    Abstract Proteases play a pivotal role in several biological processes, from digestion, cell proliferation, and differentiation to fertility. Deregulation of protease metabolism can result in several pathological conditions (i.e., cancer, neurodegenerative disorders, and others). Therefore, monitoring proteolytic activity in real time could have a fundamental role in the early diagnosis of these diseases. Herein, the main approaches used to develop biosensors for monitoring proteolytic activity are reviewed. A comparison of the advantages and disadvantages of each approach is provided along with a discussion of their importance and promising opportunities for the early diagnosis of severe diseases. This new era of biosensors can be characterized by the ability to control and monitor biological processes, ultimately improving the potential of personalized medicine.
    MeSH term(s) Biosensing Techniques ; Humans ; Peptide Hydrolases/metabolism ; Precision Medicine ; Proteolysis
    Chemical Substances Peptide Hydrolases (EC 3.4.-)
    Keywords covid19
    Language English
    Publishing date 2020-05-05
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 194216-5
    ISSN 1362-4326 ; 0968-0004 ; 0376-5067
    ISSN (online) 1362-4326
    ISSN 0968-0004 ; 0376-5067
    DOI 10.1016/j.tibs.2020.03.011
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1207: Show issues Location:
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  10. Article ; Online: Mucinous tubular and spindle cell carcinoma of the kidney

    Oliveira, Rui Caetano / Tavares Silva, Edgar / Abrantes, Carlos / Rodrigues, Pedro / Marinho, Carol / Sousa, Vítor / Simões, Pedro / Prado e Castro1, Ligia

    Diagnostic pathology 1 , 7, S. 1 - 9 : Ill.

    case report with literature review

    2015  

    Author's details Rui Caetano Oliveira ; Edgar Tavares Silva ; Carlos Abrantes ; Pedro Rodrigues ; Carol Marinho ; Vítor Sousa ; Pedro Simões ; Lígia Prado e Castro1
    Subject code 610
    Language English
    Publishing place Waltrop
    Publishing country Germany
    Document type Article ; Online
    HBZ-ID HT018616630
    DOI 10.17629/www.diagnosticpathology.eu-2015-1:7
    Database Repository for Life Sciences

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