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  1. Article ; Online: Chemogenetic activation of G

    Ono, Yuki / Ito, Ryo / Arai, Kaito / Singh, Gurdeep / Saitoh, Tsuyoshi / Russell, Robert B / Raimondi, Francesco / Aoki, Junken / Sakai, Juro / Inoue, Asuka

    Signal transduction and targeted therapy

    2023  Volume 8, Issue 1, Page(s) 307

    MeSH term(s) Signal Transduction/genetics ; Adipose Tissue, Brown/physiology ; GTP-Binding Proteins/genetics
    Chemical Substances GTP-Binding Proteins (EC 3.6.1.-)
    Language English
    Publishing date 2023-08-21
    Publishing country England
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 2886872-9
    ISSN 2059-3635 ; 2095-9907
    ISSN (online) 2059-3635
    ISSN 2095-9907
    DOI 10.1038/s41392-023-01524-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Role of G-Proteins and GPCRs in Cardiovascular Pathologies.

    Kaur, Geetika / Verma, Shailendra Kumar / Singh, Deepak / Singh, Nikhlesh K

    Bioengineering (Basel, Switzerland)

    2023  Volume 10, Issue 1

    Abstract: ... might be a hormone, light, an antigen, an odorant, a neurotransmitter, etc. Similarly, heterotrimeric G ... proteins principally provide communication from the plasma membrane G-protein-coupled receptors (GPCRs ... to the inner compartments of the cells to control various biochemical activities. G-protein-coupled signaling ...

    Abstract Cell signaling is a fundamental process that enables cells to survive under various ecological and environmental contexts and imparts tolerance towards stressful conditions. The basic machinery for cell signaling includes a receptor molecule that senses and receives the signal. The primary form of the signal might be a hormone, light, an antigen, an odorant, a neurotransmitter, etc. Similarly, heterotrimeric G-proteins principally provide communication from the plasma membrane G-protein-coupled receptors (GPCRs) to the inner compartments of the cells to control various biochemical activities. G-protein-coupled signaling regulates different physiological functions in the targeted cell types. This review article discusses G-proteins' signaling and regulation functions and their physiological relevance. In addition, we also elaborate on the role of G-proteins in several cardiovascular diseases, such as myocardial ischemia, hypertension, atherosclerosis, restenosis, stroke, and peripheral artery disease.
    Language English
    Publishing date 2023-01-06
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2746191-9
    ISSN 2306-5354
    ISSN 2306-5354
    DOI 10.3390/bioengineering10010076
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  3. Article ; Online: G-quadruplex formation at human

    Nain, Nishu / Singh, Anju / Khan, Shoaib / Kukreti, Shrikant

    Biochemistry and biophysics reports

    2023  Volume 34, Page(s) 101464

    Abstract: The dopamine transporter gene ( ...

    Abstract The dopamine transporter gene (
    Language English
    Publishing date 2023-04-06
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2831046-9
    ISSN 2405-5808 ; 2405-5808
    ISSN (online) 2405-5808
    ISSN 2405-5808
    DOI 10.1016/j.bbrep.2023.101464
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  4. Article ; Online: Complete genome sequences of G

    Meng, Bowen / Bleau, Alexander / Bombaywala, Riddhi R / DeGraw, Audrey S / Deol, Manjot S / Dollard, Kendall E / Gentile, Nicolas / Jebaraj, Julianna / Kayayan, Gregory N / Miranda, Briana C / Momoh, Ayobamidele E / Morales, Elias / Nunes, Amalia C / Oropallo, Antonia M / Otterstedt, Sophia C / Pridell, Anna T / Roberts, Jenna I / Ruiz, Gabriel A / Sangasani, Dhatri /
    Smith, Renee D / Tarar, Mahad / Singh, Vir / Jayachandran, Pradeepa

    Microbiology resource announcements

    2023  Volume 12, Issue 10, Page(s) e0071823

    Abstract: We report the genomes of two viruses with siphovirus morphology, OtterstedtS21 and Patos, from Albany, New York, ... ...

    Abstract We report the genomes of two viruses with siphovirus morphology, OtterstedtS21 and Patos, from Albany, New York, using
    Language English
    Publishing date 2023-09-29
    Publishing country United States
    Document type Journal Article
    ISSN 2576-098X
    ISSN (online) 2576-098X
    DOI 10.1128/MRA.00718-23
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  5. Book ; Online: CARL-G

    Shiao, William / Saini, Uday Singh / Liu, Yozen / Zhao, Tong / Shah, Neil / Papalexakis, Evangelos E.

    Clustering-Accelerated Representation Learning on Graphs

    2023  

    Abstract: ... dissimilar items apart. As a result, we propose CARL-G - a novel clustering-based framework for graph ... of cluster quality (no ground truth required). CARL-G is adaptable to different clustering methods and CVIs ... and we show that with the right choice of clustering method and CVI, CARL-G outperforms node ...

    Abstract Self-supervised learning on graphs has made large strides in achieving great performance in various downstream tasks. However, many state-of-the-art methods suffer from a number of impediments, which prevent them from realizing their full potential. For instance, contrastive methods typically require negative sampling, which is often computationally costly. While non-contrastive methods avoid this expensive step, most existing methods either rely on overly complex architectures or dataset-specific augmentations. In this paper, we ask: Can we borrow from classical unsupervised machine learning literature in order to overcome those obstacles? Guided by our key insight that the goal of distance-based clustering closely resembles that of contrastive learning: both attempt to pull representations of similar items together and dissimilar items apart. As a result, we propose CARL-G - a novel clustering-based framework for graph representation learning that uses a loss inspired by Cluster Validation Indices (CVIs), i.e., internal measures of cluster quality (no ground truth required). CARL-G is adaptable to different clustering methods and CVIs, and we show that with the right choice of clustering method and CVI, CARL-G outperforms node classification baselines on 4/5 datasets with up to a 79x training speedup compared to the best-performing baseline. CARL-G also performs at par or better than baselines in node clustering and similarity search tasks, training up to 1,500x faster than the best-performing baseline. Finally, we also provide theoretical foundations for the use of CVI-inspired losses in graph representation learning.

    Comment: 14 pages. Accepted at KDD 2023
    Keywords Computer Science - Machine Learning
    Subject code 006 ; 004
    Publishing date 2023-06-12
    Publishing country us
    Document type Book ; Online
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  6. Article ; Online: g-C

    Vavilapalli, Durga Sankar / Peri, Raja Gopal / Sharma, R K / Goutam, U K / Muthuraaman, B / Ramachandra Rao, M S / Singh, Shubra

    Scientific reports

    2021  Volume 11, Issue 1, Page(s) 19639

    Abstract: g-C ...

    Abstract g-C
    Language English
    Publishing date 2021-10-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-021-99020-6
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  7. Article ; Online: Sunlight active cellulose/g-C

    Garg, Anushka / Chauhan, Anjali / Agnihotri, Charu / Singh, Bhim Pratap / Mondem, Vasundhara / Basu, Soumen / Agnihotri, Shekhar

    Nanotechnology

    2023  Volume 34, Issue 50

    Abstract: ... to fabricate a cellulose/g-C ...

    Abstract The paper critically addresses two contemporary environmental challenges, the water crisis and the unrestricted discharge of organic pollutants in waterways together. An eco-friendly method was used to fabricate a cellulose/g-C
    Language English
    Publishing date 2023-10-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 1362365-5
    ISSN 1361-6528 ; 0957-4484
    ISSN (online) 1361-6528
    ISSN 0957-4484
    DOI 10.1088/1361-6528/acf9ad
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  8. Article ; Online: Graphitic carbon nitride (g-C

    Kumar, Naveen / Kumari, Monika / Ismael, Mohammed / Tahir, Muhammad / Sharma, Raj Kishore / Kumari, Kavitha / Koduru, Janardhan Reddy / Singh, Pardeep

    Environmental research

    2023  Volume 231, Issue Pt 2, Page(s) 116149

    Abstract: Graphitic carbon nitride (g-C ...

    Abstract Graphitic carbon nitride (g-C
    MeSH term(s) Graphite/chemistry ; Volatile Organic Compounds ; Gases ; Oxides
    Chemical Substances graphitic carbon nitride ; Graphite (7782-42-5) ; Volatile Organic Compounds ; Gases ; Oxides
    Language English
    Publishing date 2023-05-18
    Publishing country Netherlands
    Document type Review ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 205699-9
    ISSN 1096-0953 ; 0013-9351
    ISSN (online) 1096-0953
    ISSN 0013-9351
    DOI 10.1016/j.envres.2023.116149
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 726: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Role of APOC3 3238C/G polymorphism in HIV-associated neurocognitive disorder.

    Singh, HariOm / Dhotre, Kishore / Shyamveer / Namdev, Goldi / Mahajan, Supriya D / Parvez, Mohammad Khalid / Al-Dosari, Mohammed S

    Microbial pathogenesis

    2023  Volume 179, Page(s) 106107

    Abstract: ... Therefore, we assed ApoC33238 C/G polymorphism in a total of 248 patient infected with HIV (45 with HAND, 89 ... an inclination of risk for the severity of HAND and HIV disease progression. The polymorphism of APOC3 3238C/G ...

    Abstract Apolipoprotein not only have a role in cholesterol metabolism but also play a role in normal brain function. Apolipoprotein gene polymorphisms are known risk factors for a number of mental and neurological disorders. The expression of brain apolipoproteins is significantly altered in several brain disorders. Therefore, we assed ApoC33238 C/G polymorphism in a total of 248 patient infected with HIV (45 with HAND, 89 without HAND, 114 without ART) and 134 healthy controls using PCR-RFLP. ApoC3 3238CG, 3238 GG genotypes and 3238G allele showed a non-significant increased risk for severity of HAND (P = 0.16, OR = 1.83; P = 0.32, OR = 2.78; P = 0.10, OR = 1.65) while comparing individuals with and without HAND. ApoC3 3238 GG genotype and 3238G allele revealed an increased risk for disease progression when compared between HIV patients with and without ART (P = 0.55, OR = 1.76; P = 0.65, OR = 1.12) though risk could not reach statistical significance. ApoC3 3238 GG genotype and 3238G allele were associated with the reduced risk of acquiring HIV infection when comparing HIV patients who are not on ART with healthy controls (P = 0.05, OR = 0.29; P = 0.04, OR = 0.66). In HIV patients on ART,ApoC3 3238 GG genotype showed an increased susceptibility to development of HAND (P = 0.48, OR = 2.24) when comparing alcohol drinkers and non-drinkers however risk could not reach statistical significance. In conclusion, the genotype ApoC33238GG displayed an inclination of risk for the severity of HAND and HIV disease progression. The polymorphism of APOC3 3238C/G may have a role to reduce the risk for acquisition of HIV infection. ApoC33238GG genotype in presence of alcohol may increase susceptibility to development of HAND.
    MeSH term(s) Humans ; Alcohols ; Apolipoprotein C-III/genetics ; Apolipoproteins/genetics ; Disease Progression ; Genotype ; HIV Infections/complications ; HIV Infections/genetics ; Neurocognitive Disorders/genetics ; Neurocognitive Disorders/complications ; Polymorphism, Genetic ; Polymorphism, Single Nucleotide
    Chemical Substances Alcohols ; Apolipoprotein C-III ; Apolipoproteins ; APOC3 protein, human
    Language English
    Publishing date 2023-04-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 632772-2
    ISSN 1096-1208 ; 0882-4010
    ISSN (online) 1096-1208
    ISSN 0882-4010
    DOI 10.1016/j.micpath.2023.106107
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2136: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: G-DIRT

    Sahu, T K / Singh, A K / Mittal, S / Jha, S K / Kumar, S / Jacob, S R / Singh, K

    a web server for identification and removal of duplicate germplasms based on identity-by-state analysis using single nucleotide polymorphism genotyping data

    2022  

    Abstract: ... Tool (G-DIRT), which allows germplasm duplicate identification based on identity-by-state analysis ... the constraint of high-dimensional genotypic data, an offline version of G-DIRT in the interface of R has also ... been developed. The G-DIRT is expected to help genebank curators, breeders and other researchers across ...

    Abstract Maintaining duplicate germplasms in genebanks hampers effective conservation and utilization of genebank resources. The redundant germplasm adds to the cost of germplasm conservation by requiring a large proportion of the genebank financial resources towards conservation rather than enriching the diversity. Besides, genome-wide-association analysis using an association panel with over-represented germplasms can be biased resulting in spurious marker-trait associations. The conventional methods of germplasm duplicate removal using passport information suffer from incomplete or missing passport information and data handling errors at various stages of germplasm enrichment. This limitation is less likely in the case of genotypic data. Therefore, we developed a web-based tool, Germplasm Duplicate Identification and Removal Tool (G-DIRT), which allows germplasm duplicate identification based on identity-by-state analysis using single-nucleotide polymorphism genotyping information along with pre-processing of genotypic data. A homozygous genotypic difference threshold of 0.1% for germplasm duplicates has been determined using tetraploid wheat genotypic data with 94.97% of accuracy. Based on the genotypic difference, the tool also builds a dendrogram that can visually depict the relationship between genotypes. To overcome the constraint of high-dimensional genotypic data, an offline version of G-DIRT in the interface of R has also been developed. The G-DIRT is expected to help genebank curators, breeders and other researchers across the world in identifying germplasm duplicates from the global genebank collections by only using the easily sharable genotypic data instead of physically exchanging the seeds or propagating materials. The web server will complement the existing methods of germplasm duplicate identification based on passport or phenotypic information being freely accessible at
    Keywords Germplasm ; Gene Bank
    Subject code 005
    Publishing date 2022-08-30
    Publisher Oxford University Press
    Publishing country in
    Document type Article ; Online
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