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Article ; Online: Potential mechanism of transient receptor potential cation channel subfamily V member 1 combined with an ATP‑sensitive potassium channel in severe preeclampsia.

Zhou, Xianyi / Lin, Hairui / Wei, Li / Tan, Yingyun / Fu, Xiaodong

2023 Volume 26, Issue 1, Page(s) 318

Abstract: Severe preeclampsia is one of the most serious obstetric diseases. However, the pathogenesis of the disease is not fully understood. In the present study, placental artery and blood serum was collected from patients with severe preeclampsia, as well as ... ...

Abstract	Severe preeclampsia is one of the most serious obstetric diseases. However, the pathogenesis of the disease is not fully understood. In the present study, placental artery and blood serum was collected from patients with severe preeclampsia, as well as from normal pregnant women. The results of reverse transcription-quantitative (q)PCR, western blotting, and immunohistochemical staining revealed markedly decreased transient receptor potential cation channel subfamily V member 1 (TRPV1), ATP-sensitive potassium channel (KATP) subtype Kir6.1/SUR2B and endothelial nitric oxide synthase (eNOS) expression in severe preeclampsia tissue specimens compared with those in samples from normal pregnant women. The nitrate reduction method indicated lower NO levels in the tissue specimens and serum of patients with severe preeclampsia. Moreover, hematoxylin-eosin staining showed that the endothelial cell layer in the placental artery of patients with severe preeclampsia was notably damaged. To investigate the potential role of TRPV1-KATP channels in severe preeclampsia, HUVECs were used for
Language	English
Publishing date	2023-05-15
Publishing country	Greece
Document type	Journal Article
ZDB-ID	2683844-8
ISSN	1792-1015 ; 1792-0981
ISSN (online)	1792-1015
ISSN	1792-0981
DOI	10.3892/etm.2023.12017
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: A Tandem Adsorption-Catalysis Strategy for the Removal of Copper Ions and Catalytic Reduction of 4-Nitrophenol.

Chen, Muhua / Gao, Yingyun / Fu, Bo / Yang, Fan

ACS omega

2020 Volume 5, Issue 36, Page(s) 23372–23377

Abstract: In this work, a consecutive adsorption-catalysis approach to remove ... ...

Abstract	In this work, a consecutive adsorption-catalysis approach to remove Cu
Language	English
Publishing date	2020-09-02
Publishing country	United States
Document type	Journal Article
ISSN	2470-1343
ISSN (online)	2470-1343
DOI	10.1021/acsomega.0c03329
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: A Tandem Adsorption-Catalysis Strategy for the Removal of Copper Ions and Catalytic Reduction of 4‑Nitrophenol

Muhua Chen / Yingyun Gao / Bo Fu / Fan Yang

ACS Omega, Vol 5, Iss 36, Pp 23372-

2020 Volume 23377

Keywords	Chemistry ; QD1-999
Language	English
Publishing date	2020-09-01T00:00:00Z
Publisher	American Chemical Society
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Genetic analysis and functional study of a novel ABCG5 mutation in sitosterolemia with hematologic disease.

Jiang, Wanzi / Xu, Yiwen / Fu, Zhenzhen / Hu, Moran / Wu, Qinyi / Ji, Yong / Li, John Zhong / Gong, Yingyun / Zhou, Hongwen

Gene

2023 Volume 879, Page(s) 147596

Abstract: Sitosterolemia is a rare autosomal recessive hereditary disease caused by loss-of-function genetic mutations in either ATP-binding cassette subfamily G member 5 or member 8 (ABCG5 or ABCG8). Here, we investigate novel variants in ABCG5 and ABCG8 that are ...

Abstract	Sitosterolemia is a rare autosomal recessive hereditary disease caused by loss-of-function genetic mutations in either ATP-binding cassette subfamily G member 5 or member 8 (ABCG5 or ABCG8). Here, we investigate novel variants in ABCG5 and ABCG8 that are associated with the sitosterolemia phenotype. We describe a 32-year-old woman with hypercholesterolemia, tendon and hip xanthomas, autoimmune hemolytic anemia and macrothrombocytopenia from early life, which make us highly suspicious of the possibility of sitosterolemia. A novel homozygous variant in ABCG5 (c.1769C>A, p.S590X) was identified by genomic sequencing. We also examined the lipid profile, especially plant sterols levels, using gas chromatography-mass spectrometry. Functional studies, including western blotting and immunofluorescence staining, showed that the nonsense mutation ABCG5 1769C>A hinders the formation of ABCG5 and ABCG8 heterodimers and the function of transporting sterols. Our study expands the knowledge of variants in sitosterolemia and provides diagnosis and treatment recommendations.
MeSH term(s)	Female ; Humans ; Adult ; Hypercholesterolemia/genetics ; Hypercholesterolemia/complications ; Lipoproteins/genetics ; ATP Binding Cassette Transporter, Subfamily G, Member 5/genetics ; Phytosterols/adverse effects ; Phytosterols/genetics ; Lipid Metabolism, Inborn Errors/genetics ; Lipid Metabolism, Inborn Errors/complications ; Lipid Metabolism, Inborn Errors/diagnosis ; Mutation ; Thrombocytopenia/genetics
Chemical Substances	Lipoproteins ; ATP Binding Cassette Transporter, Subfamily G, Member 5 ; Phytosterols ; ABCG5 protein, human
Language	English
Publishing date	2023-06-28
Publishing country	Netherlands
Document type	Case Reports ; Journal Article
ZDB-ID	391792-7
ISSN	1879-0038 ; 0378-1119
ISSN (online)	1879-0038
ISSN	0378-1119
DOI	10.1016/j.gene.2023.147596
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Article: Noninvasive Ventilation in Patients With COVID-19-Related Acute Hypoxemic Respiratory Failure: A Retrospective Cohort Study.

Fu, Yingyun / Guan, Lili / Wu, Weibo / Yuan, Jing / Zha, Shanshan / Wen, Junmin / Lin, Zhenghao / Qiu, Chen / Chen, Rongchang / Liu, Lei

Frontiers in medicine

2021 Volume 8, Page(s) 638201

Abstract: Introduction: ...

Abstract	Introduction:
Language	English
Publishing date	2021-05-24
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2775999-4
ISSN	2296-858X
ISSN	2296-858X
DOI	10.3389/fmed.2021.638201
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Article ; Online: The diagnostic potential of plasma SCUBE-1 concentration for pulmonary embolism: A pilot study.

Xiao, Lu / Wang, Minlian / Yang, Sicong / Li, Shulin / Huang, Qijun / Xu, Lan / Li, Yazhen / Fu, Yingyun

The clinical respiratory journal

2023 Volume 17, Issue 4, Page(s) 263–269

Abstract: Introduction: This study aimed to investigate the potential application of plasma signal peptide-complement C1r/C1s, Uegf and Bmp1-epidermal growth factor domain-containing protein 1 (SCUBE-1) as a biomarker in the diagnosis of pulmonary embolism (PE).!# ...

Abstract	Introduction: This study aimed to investigate the potential application of plasma signal peptide-complement C1r/C1s, Uegf and Bmp1-epidermal growth factor domain-containing protein 1 (SCUBE-1) as a biomarker in the diagnosis of pulmonary embolism (PE). Methods: This cross-sectional study enrolled 177 patients who underwent PE diagnostic test and 87 healthy controls. The results of CT pulmonary angiogram (CTPA) were used as reference standards for PE diagnosis. The levels of SCUBE-1 and D-dimer in participants' plasma were detected with enzyme-linked immunosorbent assay and compared among patients with confirmed PE, suspicious PE and healthy controls. The diagnostic values were analysed using receiver operating characteristic (ROC) curve analysis. In addition, differences in plasma SCUBE-1 levels were compared among patients with different risk stratifications. Results: The plasma SCUBE-1 concentration levels in patients with CTPA confirmed PE (14.28 ± 7.74 ng/ml) was significantly higher than those in the suspicious patients (11.11 ± 4.48 ng/ml) and in healthy control (4.40 ± 3.23 ng/ml) (P < 0.01). ROC curve analysis showed that at the cut-off of 7.789 ng/ml, SCUBE-1 has significant diagnostic value in differentiating PE patients from healthy control (AUC = 0.919, sensitivity = 81.25%, specificity = 92.13%), and the performance is more accurate than D-dimer (cut-off 273.4 ng/ml, AUC = 0.648, sensitivity = 65.75%, specificity = 67.42%). The combination of D-dimer with SCUBE-1 did not further improve the diagnostic value. However, SCUBE-1 did not show significant diagnostic value in identifying PE among suspicious patients There was no significant difference in SCUBE-1 level among different risk groups (P > 0.05). Conclusion: We believe that SCUBE-1 could be a potential coagulation-related marker for the diagnosis of PE.
MeSH term(s)	Humans ; Biomarkers ; Cross-Sectional Studies ; Fibrin Fibrinogen Degradation Products/analysis ; Pilot Projects ; Pulmonary Embolism/diagnostic imaging ; ROC Curve
Chemical Substances	Biomarkers ; Fibrin Fibrinogen Degradation Products ; SCUBE1 protein, human
Language	English
Publishing date	2023-02-07
Publishing country	England
Document type	Journal Article
ZDB-ID	2442214-9
ISSN	1752-699X ; 1752-6981
ISSN (online)	1752-699X
ISSN	1752-6981
DOI	10.1111/crj.13588
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Functional Characterization of MC4R Variants in Chinese Morbid Obese Patients and Weight Loss after Bariatric Surgery.

Gong, Yingyun / Wu, Qinyi / Huang, Shushu / Fu, Zhenzhen / Ye, Jingya / Liu, Ruiping / Lin, Shibo / Guan, Wei / Yang, Ningli / Li, John Zhong / Liang, Hui / Zhou, Hongwen

Advanced biology

2023 Volume 7, Issue 9, Page(s) e2300007

Abstract: Mutations in MC4R are the most common genetic cause of obesity. In the reported Chinese morbid obesity cohort, 10 out of 59 harbor six MC4R variants, including Y35C, T53I, V103I, R165W, G233S, and C277X, among which V103I has a relatively high frequency, ...

Abstract	Mutations in MC4R are the most common genetic cause of obesity. In the reported Chinese morbid obesity cohort, 10 out of 59 harbor six MC4R variants, including Y35C, T53I, V103I, R165W, G233S, and C277X, among which V103I has a relatively high frequency, while other five variants are rare in the population. The prevalence of MC4R carriers in Chinese morbid obese patients (body mass index ≥ 45 kg m
MeSH term(s)	Humans ; Obesity, Morbid/genetics ; Obesity, Morbid/surgery ; East Asian People ; Receptor, Melanocortin, Type 4/genetics ; Receptor, Melanocortin, Type 4/metabolism ; Weight Loss/genetics ; Bariatric Surgery/adverse effects
Chemical Substances	Receptor, Melanocortin, Type 4 ; MC4R protein, human
Language	English
Publishing date	2023-05-04
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2701-0198
ISSN (online)	2701-0198
DOI	10.1002/adbi.202300007
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Genetic analysis and functional study of a novel ABCG5 mutation in sitosterolemia with hematologic disease

Jiang, Wanzi / Xu, Yiwen / Fu, Zhenzhen / Hu, Moran / Wu, Qinyi / Ji, Yong / Li, John Zhong / Gong, Yingyun / Zhou, Hongwen

Gene. 2023 Aug., v. 879 p.147596-

2023

Abstract	Sitosterolemia is a rare autosomal recessive hereditary disease caused by loss-of-function genetic mutations in either ATP-binding cassette subfamily G member 5 or member 8 (ABCG5 or ABCG8). Here, we investigate novel variants in ABCG5 and ABCG8 that are associated with the sitosterolemia phenotype. We describe a 32-year-old woman with hypercholesterolemia, tendon and hip xanthomas, autoimmune hemolytic anemia and macrothrombocytopenia from early life, which make us highly suspicious of the possibility of sitosterolemia. A novel homozygous variant in ABCG5 (c.1769C>A, p.S590X) was identified by genomic sequencing. We also examined the lipid profile, especially plant sterols levels, using gas chromatography-mass spectrometry. Functional studies, including western blotting and immunofluorescence staining, showed that the nonsense mutation ABCG5 1769C>A hinders the formation of ABCG5 and ABCG8 heterodimers and the function of transporting sterols. Our study expands the knowledge of variants in sitosterolemia and provides diagnosis and treatment recommendations.
Keywords	ABC transporters ; fluorescent antibody technique ; gas chromatography-mass spectrometry ; genes ; genetic analysis ; genetic disorders ; genomics ; hemolytic anemia ; homozygosity ; hypercholesterolemia ; lipid composition ; loss-of-function mutation ; nonsense mutation ; phenotype ; phytosterols ; women ; Sitosterolemia ; ABCG5 ; Gene mutation ; Lipid profile ; Hematological disorders ; ABCG8 ; AIHA ; IF ; TC ; TG ; HDL-C ; LDL-C ; Lp(a) ; GC-MS ; ExAC ; WT ; HA ; HEK293T ; PCR ; BCA ; PVDF ; PFA ; PBS ; ECD ; TMD ; NBD ; ER ; NPC1L1
Language	English
Dates of publication	2023-08
Publishing place	Elsevier B.V.
Document type	Article ; Online
ZDB-ID	391792-7
ISSN	1879-0038 ; 0378-1119
ISSN (online)	1879-0038
ISSN	0378-1119
DOI	10.1016/j.gene.2023.147596
Database	NAL-Catalogue (AGRICOLA)

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Article: Chinese expert consensus on the diagnosis, treatment, and management of asthma in women across life.

Hu, Qiurong / Chen, Xiaoyan / Fu, Wanyi / Fu, Yingyun / He, Ke / Huang, Huaqiong / Jia, Nan / Jin, Meiling / Liu, Enmei / Shi, Xu / Song, Cui / Su, Nan / Tan, Weiping / Tang, Wei / Wu, Yanxin / Xie, Hua / Zhang, Min / Zou, Mengchen / Shen, Kunling /

Cai, Shaoxi / Li, Jing

Journal of thoracic disease

2024 Volume 16, Issue 1, Page(s) 773–797

Abstract: Background: The epidemiology and severity of asthma vary by sex and age. The diagnosis, treatment, and management of asthma in female patients are quite challenging. However, there is hitherto no comprehensive and standardized guidance for female ... ...

Abstract	Background: The epidemiology and severity of asthma vary by sex and age. The diagnosis, treatment, and management of asthma in female patients are quite challenging. However, there is hitherto no comprehensive and standardized guidance for female patients with asthma. Methods: Corresponding search strategies were determined based on clinical concerns regarding female asthma. Search terms included "sex hormones and lung development", "sex hormone changes and asthma", "hormones and asthma immune response", "women, asthma", "children, asthma", "puberty, asthma", "menstruation, asthma", "pregnancy, asthma", "lactation, asthma", "menopause, asthma", "obesity, asthma", and "women, refractory, severe asthma". Literature was retrieved from PubMed/Medline, Embase, Cochrane Library, China Biology Medicine disc, China National Knowledge Infrastructure, Wanfang Data with the search date of July 30, 2022 as the last day. This consensus used the Grading of Recommendations Assessment, Development, and Evaluation to evaluate the strength of recommendation and quality of evidence. Results: We collected basic research results and clinical evidence-based medical data and reviewed the effects of sex hormones, classical genetics, and epigenetics on the clinical presentation and treatment response of female patients with asthma under different environmental effects. Based on that, we formulated this expert consensus on the management of female asthma throughout the life cycle. Conclusions: This expert consensus on the management of asthma in women throughout the life cycle provides diagnosis, treatment, and research reference for clinical and basic medical practitioners.
Language	English
Publishing date	2024-01-24
Publishing country	China
Document type	Journal Article ; Review
ZDB-ID	2573571-8
ISSN	2077-6624 ; 2072-1439
ISSN (online)	2077-6624
ISSN	2072-1439
DOI	10.21037/jtd-23-1069
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Flexible Dual-Channel Digital Auscultation Patch With Active Noise Reduction for Bowel Sound Monitoring and Application.

Wang, Gang / Yang, Yingyun / Chen, Siyu / Fu, Ji / Wu, Dong / Yang, Aiming / Ma, Yinji / Feng, Xue

IEEE journal of biomedical and health informatics

2022 Volume 26, Issue 7, Page(s) 2951–2962

Abstract: Bowel sounds (BSs) have important clinical value in the auxiliary diagnosis of digestive diseases, but due to the inconvenience of long-term monitoring and too much interference from environmental noise, they have not been well studied. Most of the ... ...

Abstract	Bowel sounds (BSs) have important clinical value in the auxiliary diagnosis of digestive diseases, but due to the inconvenience of long-term monitoring and too much interference from environmental noise, they have not been well studied. Most of the current electronic stethoscopes are hard and bulky without the function of noise reduction, and their application for long-term wearable monitoring of BS in noisy clinical environments is very limited. In this paper, a flexible dual-channel digital auscultation patch with active noise reduction is designed and developed, which is wireless, wearable, and conformably attached to abdominal skin to record BS more accurately. The ambient noise can be greatly reduced through active noise reduction based on the adaptive filter. At the same time, some nonstationary noises appearing intermittently (e.g., frictional noise) can also be removed from BS by the cross validation of multichannel simultaneous acquisition. Then, two kinds of typical BS signals are taken as examples, and the feature parameters of the BS in the time domain and frequency domain are extracted through the time-frequency analysis algorithm. Furthermore, based on the short-term energy ratio between the four channels of dual patches, the two-dimensional localization of BS on the abdomen mapping plane is realized. Finally, the continuous wearable monitoring of BS for patients with postoperative ileus (POI) in the noisy ward from pre-operation (POD0) to postoperative Day 7 (POD7) was carried out. The obtained change curve of the occurrence frequency of BS provides guidance for doctors to choose a reasonable feeding time for patients after surgery and accelerate their recovery. Therefore, flexible dual-channel digital auscultation patches with active noise reduction will have promising applications in the clinical auxiliary diagnosis of digestive diseases.
MeSH term(s)	Algorithms ; Auscultation ; Humans ; Noise
Language	English
Publishing date	2022-07-01
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2695320-1
ISSN	2168-2208 ; 2168-2194
ISSN (online)	2168-2208
ISSN	2168-2194
DOI	10.1109/JBHI.2022.3151927
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 5483: Show issues

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