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  1. Article ; Online: Neurotrophic effects of G

    Schwarz, S / Lehmbecker, A / Tongtako, W / Hahn, K / Wang, Y / Felmy, F / Zdora, I / Brogden, G / Branitzki-Heinemann, K / von Köckritz-Blickwede, M / Baumgärtner, W / Gerhauser, I

    Scientific reports

    2020  Volume 10, Issue 1, Page(s) 5380

    Abstract: ... functional changes induced by G ...

    Abstract Dogs share many chronic morbidities with humans and thus represent a powerful model for translational research. In comparison to rodents, the canine ganglioside metabolism more closely resembles the human one. Gangliosides are components of the cell plasma membrane playing a role in neuronal development, intercellular communication and cellular differentiation. The present in vitro study aimed to characterize structural and functional changes induced by G
    MeSH term(s) Animals ; Cell Death/drug effects ; Cell Survival/drug effects ; Cells, Cultured ; Dogs ; Fibroblast Growth Factor 2/metabolism ; G(M1) Ganglioside/metabolism ; Ganglia, Spinal/cytology ; Ganglia, Spinal/metabolism ; Ganglia, Spinal/physiology ; Gangliosides/metabolism ; Nerve Growth Factor/metabolism ; Nerve Growth Factors/metabolism ; Neurons/metabolism ; Neuroprotective Agents/pharmacology
    Chemical Substances Gangliosides ; Nerve Growth Factors ; Neuroprotective Agents ; Fibroblast Growth Factor 2 (103107-01-3) ; G(M1) Ganglioside (37758-47-7) ; Nerve Growth Factor (9061-61-4)
    Language English
    Publishing date 2020-03-25
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-020-61852-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: β-arrestin-dependent and -independent endosomal G protein activation by the vasopressin type 2 receptor.

    Daly, Carole / Guseinov, Akim Abdul / Hahn, Hyunggu / Wright, Adam / Tikhonova, Irina G / Thomsen, Alex Rojas Bie / Plouffe, Bianca

    bioRxiv : the preprint server for biology

    2023  

    Abstract: The vasopressin type 2 receptor ( ... ...

    Abstract The vasopressin type 2 receptor (V
    Language English
    Publishing date 2023-08-21
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.04.01.535208
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: β-Arrestin-dependent and -independent endosomal G protein activation by the vasopressin type 2 receptor.

    Daly, Carole / Guseinov, Akim Abdul / Hahn, Hyunggu / Wright, Adam / Tikhonova, Irina G / Thomsen, Alex Rojas Bie / Plouffe, Bianca

    eLife

    2023  Volume 12

    Abstract: The vasopressin type 2 receptor ( ... ...

    Abstract The vasopressin type 2 receptor (V
    MeSH term(s) beta-Arrestins/metabolism ; Receptors, Vasopressin ; Arrestins/metabolism ; beta-Arrestin 1/metabolism ; Endosomes/metabolism ; GTP-Binding Proteins/metabolism ; Vasopressins/metabolism
    Chemical Substances beta-Arrestins ; Receptors, Vasopressin ; Arrestins ; beta-Arrestin 1 ; GTP-Binding Proteins (EC 3.6.1.-) ; Vasopressins (11000-17-2)
    Language English
    Publishing date 2023-10-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.87754
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Global phylogeography of ridley sea turtles (

    Vilaça, Sibelle Torres / Hahn, Anelise Torres / Naro-Maciel, Eugenia / Abreu-Grobois, F Alberto / Bowen, Brian W / Castilhos, Jaqueline C / Ciofi, Claudio / FitzSimmons, Nancy N / Jensen, Michael P / Formia, Angela / Limpus, Colin J / Natali, Chiara / Soares, Luciano S / de Thoisy, Benoit / Whiting, Scott D / Bonatto, Sandro L

    Conservation genetics (Print)

    2022  Volume 23, Issue 6, Page(s) 995–1010

    Abstract: Globally distributed marine taxa are well suited for investigations of biogeographic impacts on genetic diversity, connectivity, and population demography. The sea turtle genus : Supplementary information: The online version contains supplementary ... ...

    Abstract Globally distributed marine taxa are well suited for investigations of biogeographic impacts on genetic diversity, connectivity, and population demography. The sea turtle genus
    Supplementary information: The online version contains supplementary material available at 10.1007/s10592-022-01465-3.
    Language English
    Publishing date 2022-08-29
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2059560-8
    ISSN 1572-9737 ; 1566-0621
    ISSN (online) 1572-9737
    ISSN 1566-0621
    DOI 10.1007/s10592-022-01465-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 7626: Show issues

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  5. Article ; Online: β-Arrestin-dependent and -independent endosomal G protein activation by the vasopressin type 2 receptor

    Carole Daly / Akim Abdul Guseinov / Hyunggu Hahn / Adam Wright / Irina G Tikhonova / Alex Rojas Bie Thomsen / Bianca Plouffe

    eLife, Vol

    2023  Volume 12

    Abstract: The vasopressin type 2 receptor (V2R) is an essential G protein-coupled receptor (GPCR) in renal ... interact with G protein/β-arrestin and promote endosomal G protein signaling is not restricted to Gαs ... promote endosomal G protein activation independent of β-arrestins to a minor degree. These new ...

    Abstract The vasopressin type 2 receptor (V2R) is an essential G protein-coupled receptor (GPCR) in renal regulation of water homeostasis. Upon stimulation, the V2R activates Gαs and Gαq/11, which is followed by robust recruitment of β-arrestins and receptor internalization into endosomes. Unlike canonical GPCR signaling, the β-arrestin association with the V2R does not terminate Gαs activation, and thus, Gαs-mediated signaling is sustained while the receptor is internalized. Here, we demonstrate that this V2R ability to co-interact with G protein/β-arrestin and promote endosomal G protein signaling is not restricted to Gαs, but also involves Gαq/11. Furthermore, our data imply that β-arrestins potentiate Gαs/Gαq/11 activation at endosomes rather than terminating their signaling. Surprisingly, we found that the V2R internalizes and promote endosomal G protein activation independent of β-arrestins to a minor degree. These new observations challenge the current model of endosomal GPCR signaling and suggest that this event can occur in both β-arrestin-dependent and -independent manners.
    Keywords vasopressin type 2 receptor ; G proteins ; endosomal signaling ; megaplex ; arrestin ; Medicine ; R ; Science ; Q ; Biology (General) ; QH301-705.5
    Subject code 612
    Language English
    Publishing date 2023-10-01T00:00:00Z
    Publisher eLife Sciences Publications Ltd
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Book ; Online ; Thesis: Postnataler Bilirubinanstieg bei Frühgeborenen < 1500 g Geburtsgewicht

    Hahn, Sigrid [Verfasser]

    2021  

    Author's details Sigrid Hahn
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Medizinische Fakultät Charité - Universitätsmedizin Berlin
    Publishing place Berlin
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  7. Article: Axonopathy and Reduction of Membrane Resistance: Key Features in a New Murine Model of Human G

    Eikelberg, Deborah / Lehmbecker, Annika / Brogden, Graham / Tongtako, Witchaya / Hahn, Kerstin / Habierski, Andre / Hennermann, Julia B / Naim, Hassan Y / Felmy, Felix / Baumgärtner, Wolfgang / Gerhauser, Ingo

    Journal of clinical medicine

    2020  Volume 9, Issue 4

    Abstract: G ...

    Abstract G
    Language English
    Publishing date 2020-04-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm9041004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: G-CSF Infusion for Stem Cell Mobilization Transiently Increases Serum Cell-Free DNA and Protease Concentrations.

    Stoikou, Maria / van Breda, Shane V / Schäfer, Günther / Vokalova, Lenka / Giaglis, Stavros / Plattner, Alexandra / Infanti, Laura / Holbro, Andreas / Hahn, Sinuhe / Rossi, Simona W / Buser, Andreas

    Frontiers in medicine

    2020  Volume 7, Page(s) 155

    Abstract: G-CSF for stem cell mobilization increases circulating levels of myeloid cells at different stages ... that G-CSF primes PMNs toward the release of neutrophils extracellular traps (NETs). Since NETs are often ... involved in thrombotic events, we hypothesized that high G-CSF blood concentrations could enhance PMN ...

    Abstract G-CSF for stem cell mobilization increases circulating levels of myeloid cells at different stages of maturation. Polymorphonuclear cells (PMNs) are also mobilized in high numbers. It was previously reported that G-CSF primes PMNs toward the release of neutrophils extracellular traps (NETs). Since NETs are often involved in thrombotic events, we hypothesized that high G-CSF blood concentrations could enhance PMN priming toward NET formation in healthy hematopoietic stem cell donors, predisposing them to thrombotic events. However, we found that G-CSF does not prime PMNs toward NETs formation, but increases the serum concentration of cell-free DNA, proteases like neutrophils elastase and myeloperoxidase, and reactive oxygen species. This could possibly create an environment disposed to induce thrombotic events in the presence of additional predisposing factors.
    Language English
    Publishing date 2020-04-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2020.00155
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  9. Book ; Thesis: Wertigkeit der 8-11-G-Vakuumbiopsieunit, dem ST-Treiber, bei der Abklärung von BI-RADS IV-Herdbefunden

    Küster, Tanja

    2011  

    Author's details vorgelegt von Tanja Küster
    Language German
    Size 119 S. : Ill., graph. Darst.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Frankfurt (Main), Univ., Diss., 2013
    HBZ-ID HT017766348
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2013 D 791 order for loan Magazin

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  10. Article: Der German-Nutrition Care Prozess (G-NCP) mit besonderem Fokus auf Ernährungsberatung: Update 2022

    Ohlrich-Hahn, Sabine / Buchholz, Daniel

    Ernährungs-Umschau

    2022  Volume 69, Issue 12, Page(s) M668

    Language German
    Document type Article
    ZDB-ID 216425-5
    ISSN 0174-0008 ; 0340-2371
    Database Current Contents Nutrition, Environment, Agriculture

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    In stock of ZB MED Bonn / Germany

    Z 2230: Show issues

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