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Article ; Online: A Consideration of the Relationship in COVID-19 Infection Status and Previously Reported Anti-SARS-CoV-2 Nucleocapsid (N).

Onishi, Hidenori / Yamamura, Osamu / Sakamaki, Ippei / Miyashita, Hirofumi / Iwasaki, Hiromichi

2023 Volume 35, Issue 8, Page(s) 580–582

MeSH term(s)	Humans ; SARS-CoV-2 ; COVID-19 ; Nucleocapsid
Language	English
Publishing date	2023-09-07
Publishing country	China
Document type	Journal Article
ZDB-ID	1025444-4
ISSN	1941-2479 ; 1010-5395
ISSN (online)	1941-2479
ISSN	1010-5395
DOI	10.1177/10105395231198602
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Article ; Online: Ensitrelvir eradicates persistent SARS-CoV-2 infection in a follicular lymphoma patient treated with anti-CD20 antibodies.

Sakamaki, Ippei / Negoro, Eiju / Iwasaki, Hiromichi / Yamauchi, Takahiro

Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy

2023 Volume 30, Issue 2, Page(s) 147–149

Abstract: Patients with hematological malignancies, especially B-cell malignancies, who received anti-CD20 antibodies exhibit a poor immune response to the mRNA coronavirus disease 2019 (COVID-19) vaccine within 6-12 months after the last administration. These ... ...

Abstract	Patients with hematological malignancies, especially B-cell malignancies, who received anti-CD20 antibodies exhibit a poor immune response to the mRNA coronavirus disease 2019 (COVID-19) vaccine within 6-12 months after the last administration. These patients occasionally present with severe COVID-19 symptoms. Additionally, patients with hematologic diseases who have persistent COVID-19 after receiving anti-CD20 antibodies, postpone chemotherapy for the primary disease. Despite the efficacy of ensitrelvir in shortening the duration of symptoms, evidence of improved prognosis is lacking. However, prognosis might be improved if ensitrelvir treatment could reduce the viral load and shorten the time to postpone chemotherapy. It is unclear whether viral reduction directly improves prognosis. However, faster viral reduction may lead to faster resumption of chemotherapy for the underlying disease, resulting in better prognosis. Here, we present a case wherein we administered ensitrelvir fumaric acid to a 75-year-old woman with persistent COVID-19 after anti-CD20 antibody treatment. Her symptoms resolved quickly, with a reduction of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral load, and she could continue receiving chemotherapy for lymphoma. Our findings suggest that ensitrelvir administration should be considered in patients with SARS-CoV-2 infection after anti-CD20 antibody treatment.
MeSH term(s)	Humans ; Female ; Aged ; COVID-19 ; Lymphoma, Follicular ; SARS-CoV-2 ; COVID-19 Vaccines ; Antibodies, Viral ; Indazoles ; Triazines ; Triazoles
Chemical Substances	ensitrelvir (PX665RAA3H) ; COVID-19 Vaccines ; Antibodies, Viral ; Indazoles ; Triazines ; Triazoles
Language	English
Publishing date	2023-09-09
Publishing country	Netherlands
Document type	Case Reports
ZDB-ID	1355399-9
ISSN	1437-7780 ; 1341-321X
ISSN (online)	1437-7780
ISSN	1341-321X
DOI	10.1016/j.jiac.2023.09.008
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Zs.A 5236: Show issues

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Article ; Online: Can the Brinkman Index Predict the Need for Treatment in Patients With COVID-19?

Onishi, Hidenori / Yamamura, Osamu / Sakamaki, Ippei / Miyashita, Hirofumi / Iwasaki, Hiromichi

Asia-Pacific journal of public health

2022 Volume 34, Issue 6-7, Page(s) 692–694

MeSH term(s)	COVID-19 ; Humans
Language	English
Publishing date	2022-07-20
Publishing country	China
Document type	Journal Article
ZDB-ID	1025444-4
ISSN	1941-2479 ; 1010-5395
ISSN (online)	1941-2479
ISSN	1010-5395
DOI	10.1177/10105395221113773
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Article ; Online: An elderly man with a locked jaw.

Ueno, Akitoshi / Sakamaki, Ippei / Yamamoto, Yoshihiro

European journal of internal medicine

2021 Volume 89, Page(s) 108–109

MeSH term(s)	Aged, 80 and over ; Humans ; Male ; Tetanus/diagnosis ; Tetanus/therapy ; Tetanus Antitoxin/therapeutic use
Chemical Substances	Tetanus Antitoxin
Language	English
Publishing date	2021-06-10
Publishing country	Netherlands
Document type	Case Reports ; Journal Article
ZDB-ID	1038679-8
ISSN	1879-0828 ; 0953-6205
ISSN (online)	1879-0828
ISSN	0953-6205
DOI	10.1016/j.ejim.2021.05.015
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Zs.A 2608: Show issues

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Article ; Online: Frequency and Risk Factors for Persistent and Concomitant Symptoms after Hospital Discharge for Coronavirus Disease 2019 in the Pre-omicron Period: An Exploratory Longitudinal Study.

Kobuchi, Taketsune / Onishi, Hidenori / Yamamura, Osamu / Sakamaki, Ippei / Iwasaki, Hiromichi / Hayashi, Hiroyuki

JMA journal

2023 Volume 6, Issue 4, Page(s) 437–447

Abstract: Introduction: Many countries have reported persistent and concomitant symptoms of coronavirus disease 2019 (COVID-19). This study aimed to identify persistent COVID-19 and concomitant symptoms in discharged patients and identify the risk factors for ... ...

Abstract	Introduction: Many countries have reported persistent and concomitant symptoms of coronavirus disease 2019 (COVID-19). This study aimed to identify persistent COVID-19 and concomitant symptoms in discharged patients and identify the risk factors for such symptoms. Methods: This study enrolled patients with COVID-19 who were admitted to the University of Fukui Hospital, Japan, and discharged between April 3, 2020, and August 19, 2021. Persistent and concomitant symptoms were confirmed based on medical examinations approximately 2 weeks after discharge. Patient characteristics and symptoms were collected from the patients' medical records by a technical assistant. Results: This study included 120 patients (60 men and 60 women; mean age, 53.5 ± 17.0 years). Persistent COVID-19 symptoms were observed in 62 patients (51.7%). The most common persistent symptom was weakened physical function, manifesting as physical weakness (48.4%) and muscle weakness (29.0%). Binary logistic regression analysis revealed that cough with expectoration within the acute phase of COVID-19 was a risk factor predisposing patients to COVID-19 sequelae (odds ratio: 2.94, 95% confidence interval: 1.300 - 6.630, Conclusions: The study findings suggest that productive cough in the acute phase is associated with subsequent physical and muscle weaknesses in the subacute phase.
Language	English
Publishing date	2023-09-27
Publishing country	Japan
Document type	Journal Article
ZDB-ID	3053329-6
ISSN	2433-3298 ; 2433-328X
ISSN (online)	2433-3298
ISSN	2433-328X
DOI	10.31662/jmaj.2023-0054
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Article ; Online: Infection rate among close contacts of patients with coronavirus disease in Japan: a descriptive study and literature review.

Yamamura, Osamu / Onishi, Hidenori / Sakamaki, Ippei / Fujita, Ryousuke / Miyashita, Hirofumi / Iwasaki, Hiromichi

Asian biomedicine : research, reviews and news

2023 Volume 17, Issue 3, Page(s) 115–123

Abstract: Background: In Japan, on April 20, 2020, the definition of a close contact regarding coronavirus disease (COVID-19) was changed from a long-term contact time to a specified contact time of 15 min and from a contact distance of 2 m to 1 m.: Objectives!# ...

Abstract	Background: In Japan, on April 20, 2020, the definition of a close contact regarding coronavirus disease (COVID-19) was changed from a long-term contact time to a specified contact time of 15 min and from a contact distance of 2 m to 1 m. Objectives: We aimed to determine the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection rate among close contacts of patients with COVID-19 and determine the impact of the infection on transmission among close contacts. Methods: The numbers of SARS-CoV-2 tests, SARS-CoV-2-positive cases, and close contacts of patients with COVID-19 were assessed between March 2020 and February 2021 in Fukui Prefecture, Japan. The study period was subdivided into 3 periods. The second and third period contained data with the changed definition of close contact. Results: Overall, 32,238 SARS-CoV-2 tests were performed. There were 545 patients with COVID-19 and 1487 close contacts, of whom 267 tested positive. The highest infection rate occurred in period 3. Distance, protective measures, and contact time with COVID-19 patients influenced the increased infection rate. The infection rate showed a rising trend from 11.1% in period 1 to 19.2% and 20.0% in periods 2 and 3, respectively (Cochran-Armitage test; Conclusions: Female sex is a risk factor for transmission by close contacts. The rate of infection among close contacts may be associated with contact time, contact distance, and protective measures.
Language	English
Publishing date	2023-10-09
Publishing country	Thailand
Document type	Journal Article
ZDB-ID	2583850-7
ISSN	1875-855X ; 1875-855X
ISSN (online)	1875-855X
ISSN	1875-855X
DOI	10.2478/abm-2023-0051
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Article ; Online: Evaluation of minocycline combined with favipiravir therapy in coronavirus disease 2019 patients: A case-series study.

Itoh, Kazuhiro / Sakamaki, Ippei / Hirota, Tomoya / Iwasaki, Hiromichi

Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy

2021 Volume 28, Issue 1, Page(s) 124–127

Abstract: The aim of this study was to investigate the efficacy and safety of minocycline (MIN) and favipiravir combination therapy in patients with coronavirus disease 2019 (COVID-19) admitted to our hospital in Fukui Prefecture, Japan, in March and April of 2020. ...

Abstract	The aim of this study was to investigate the efficacy and safety of minocycline (MIN) and favipiravir combination therapy in patients with coronavirus disease 2019 (COVID-19) admitted to our hospital in Fukui Prefecture, Japan, in March and April of 2020. In this retrospective study, a favipiravir monotherapy group (Control group, n = 9) was compared with a combined favipiravir plus MIN therapy group (MIN group, n = 12). No severe cases were present. The primary comparative endpoints evaluated were duration of fever, duration of hospitalization, duration from treatment initiation to severe acute respiratory syndrome coronavirus 2 polymerase chain reaction (PCR)-negative results, and changes in cytokine and chemokine production. Median duration from start of treatment to negative PCR test was significantly shorter in the MIN group than in the Control group. Mean rates of cytokine and chemokine reduction were significantly greater for interleukin-6 and interleukin-8 in the MIN group. No difference in adverse event rates were seen between groups, and only minor adverse events were encountered. MIN has been reported to have not only broad antibacterial activity, but also antiviral and anti-inflammatory activity. The present results support the efficacy and safety of MIN plus favipiravir therapy for the treatment of COVID-19.
MeSH term(s)	Amides ; Antiviral Agents/adverse effects ; COVID-19 ; Humans ; Minocycline/adverse effects ; Pyrazines ; Retrospective Studies ; SARS-CoV-2 ; Treatment Outcome
Chemical Substances	Amides ; Antiviral Agents ; Pyrazines ; favipiravir (EW5GL2X7E0) ; Minocycline (FYY3R43WGO)
Language	English
Publishing date	2021-10-02
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1355399-9
ISSN	1437-7780 ; 1341-321X
ISSN (online)	1437-7780
ISSN	1341-321X
DOI	10.1016/j.jiac.2021.09.016
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Zs.A 5236: Show issues

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Article ; Online: Droplets Adhesion to Surgical Masks during Standard Oral Surgery.

Yoshida, Hisato / Makino, Akira / Yamaguchi, Ayaka / Matsuda, Shinpei / Sakamaki, Ippei / Yoshimura, Hitoshi / Iwasaki, Hiromichi

Japanese journal of infectious diseases

2022 Volume 76, Issue 1, Page(s) 84–86

Abstract: The most common routes of transmission of coronavirus disease 2019 are droplet and contact infections. During dental treatment, several instruments and procedures used generate droplets of saliva and blood, such as during the extraction of an impacted ... ...

Abstract	The most common routes of transmission of coronavirus disease 2019 are droplet and contact infections. During dental treatment, several instruments and procedures used generate droplets of saliva and blood, such as during the extraction of an impacted third molar (M3). Surgical masks are often used during tooth extraction. However, the surface structures of surgical masks against droplets are not fully understood. Therefore, we analyzed the droplets that adhered to the surgical masks during impacted M3 extraction using electron microscopy. The surgical mask was divided into three layers and observed using electron microscopy. The outer and inner layers had a similar mesh-like structure, whereas the middle layer had a denser three-dimensional structure. Droplets ranging from 20-100 µm in size, generated during the extraction, adhered to the fibers of the outer layer of the mask. Fewer droplets adhered to the middle layer than to the outer layer. Droplets did not reach the inner layer. In conclusion, we suggest that a surgical mask can prevent droplet infection when performing impacted M3 extraction. This study is expected to contribute to the study of infection control strategies during dental treatments in the future.
MeSH term(s)	Humans ; COVID-19/prevention & control ; Masks ; SARS-CoV-2 ; Infection Control ; Tooth Extraction
Language	English
Publishing date	2022-09-30
Publishing country	Japan
Document type	Journal Article
ZDB-ID	1478383-6
ISSN	1884-2836 ; 1344-6304
ISSN (online)	1884-2836
ISSN	1344-6304
DOI	10.7883/yoken.JJID.2022.184
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Article ; Online: Evaluation of tetracycline and fluoroquinolone therapy against Japanese spotted fever: Analysis based on individual data from case reports and case series.

Itoh, Kazuhiro / Kabata, Daijiro / Shigemi, Hiroko / Hirota, Tomoya / Sakamaki, Ippei / Tsutani, Hiroshi / Mitsuke, Yasuhiko / Iwasaki, Hiromichi

International journal of antimicrobial agents

2023 Volume 62, Issue 2, Page(s) 106895

Abstract: Objectives: Although approximately 40 years have passed since Japanese spotted fever (JSF) was first reported in Japan, its treatment has not yet been standardised. As in other rickettsial infections, tetracycline (TC) is the first-line treatment, but ... ...

Abstract	Objectives: Although approximately 40 years have passed since Japanese spotted fever (JSF) was first reported in Japan, its treatment has not yet been standardised. As in other rickettsial infections, tetracycline (TC) is the first-line treatment, but successful instances of fluoroquinolone (FQ) combination therapy in severe cases have been reported. However, the effectiveness of TC plus FQ combined treatment (TC+FQ) remains controversial. Therefore, the antipyretic effect of TC+FQ was evaluated in this study. Methods: A comprehensive search of published JSF case reports was conducted to extract individual patient data. In cases where it was possible to extract temperature data, after homogenising patient characteristics, time-dependent changes in fever type from the date of the first visit was evaluated for the TC and TC+FQ groups. Results: The primary search yielded 182 cases, with individual data evaluations resulting in a final analysis of 102 cases (84 in the TC group and 18 in the TC+FQ group) that included temperature data. The TC+FQ group had significantly lower body temperature compared with the TC group from Days 3 to 4. Conclusions: Although TC monotherapy for JSF can eventually result in defervescence, the duration of fever is longer compared with other rickettsial infections such as scrub typhus. The results suggest that the antipyretic effect of TC+FQ was more effective, with a potential shortening of the duration that patients suffer from febrile symptoms.
MeSH term(s)	Humans ; Anti-Bacterial Agents/therapeutic use ; Antipyretics ; East Asian People ; Fever/drug therapy ; Fluoroquinolones/therapeutic use ; Spotted Fever Group Rickettsiosis/diagnosis ; Spotted Fever Group Rickettsiosis/drug therapy ; Tetracycline/therapeutic use
Chemical Substances	Anti-Bacterial Agents ; Antipyretics ; Fluoroquinolones ; Tetracycline (F8VB5M810T)
Language	English
Publishing date	2023-06-18
Publishing country	Netherlands
Document type	Journal Article ; Systematic Review
ZDB-ID	1093977-5
ISSN	1872-7913 ; 0924-8579
ISSN (online)	1872-7913
ISSN	0924-8579
DOI	10.1016/j.ijantimicag.2023.106895
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Zs.A 3368: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 500: Show issues

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Article: Antibody level dynamics until after the third dose of COVID-19 vaccination.

Asahi, Nanae / Sakamaki, Ippei / Hida, Yukio / Torii, Kunio / Hashimoto, Norikazu / Iwasaki, Hiromichi / Iwano, Masayuki / Kimura, Hideki

Heliyon

2023 , Page(s) e17477

Abstract: The antibody titers of volunteers, including elderly people, were investigated after the second dose of the BNT162b2 vaccine (Pfizer-BioNTech) as an mRNA vaccine against the coronavirus disease 2019 (COVID-19). Serum samples were collected from 105 ... ...

Abstract	The antibody titers of volunteers, including elderly people, were investigated after the second dose of the BNT162b2 vaccine (Pfizer-BioNTech) as an mRNA vaccine against the coronavirus disease 2019 (COVID-19). Serum samples were collected from 105 volunteers (44 healthcare workers and 61 elderly people) 7-14 days after the second vaccine dose, and antibody titers were measured. The antibody titers of study participants in their 20s were significantly higher than those of other age groups. Furthermore, the antibody titers of participants aged <60 years were significantly higher than those of participants aged ≥60 years. Serum samples were repeatedly collected from 44 healthcare workers until after the third vaccine dose. Eight months after the second round of vaccination, the antibody titer levels decreased to the same level as that before the second vaccine dose. After the third booster vaccination, the antibody titer recovered to the same level as that after the second dose. Neutralizing activities were also investigated at four time points before and after the second vaccine dose. The antibody titers and neutralizing activity were positively correlated. Therefore, neutralizing activity can be predicted by measuring the antibody titer. In conclusion, the antibody titers in the elderly population were significantly lower than those in the younger population. Although the antibody titers increased following vaccination, their levels showed a decline after several months, returning to the same level as that after a single dose of mRNA vaccination. The antibody titer levels recovered after the third dose of vaccination, which had already been administered in Japan. Routine administration of vaccine should be considered in the future.
Language	English
Publishing date	2023-06-22
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2023.e17477
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