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  1. Article ; Online: Unfavourable treatment outcomes in tuberculosis patients with different vitamin D status and blood glucose levels in a programme setting in China.

    Lin, Yan / Bai, Yunlong / Zhang, Tiejuan / Kang, Wanli / Kang, Demei / Miao, Qiang / Wang, Yunlong / Shao, Hongshan / Li, Xiangwen / Brigden, Grania / Dlodlo, Riitta A / Harries, Anthony D

    Tropical medicine & international health : TM & IH

    2020  Volume 25, Issue 3, Page(s) 373–379

    Abstract: ... vitamin D status were associated with UTO.: Method: Prospective cohort study conducted between November ... patients had vitamin D deficiency/severe deficiency. There were 125 (40.8%) patients with UTO ...

    Abstract Objective: Tuberculosis (TB) treatment success rates are high in China, but there are still a considerable number of cases who have unfavourable treatment outcomes (UTO). We aimed to determine the proportion of TB patients with UTO and to assess whether baseline characteristics that included glycaemic status [normal fasting blood glucose (FBG), transient hyperglycaemia and diabetes mellitus (DM)] and vitamin D status were associated with UTO.
    Method: Prospective cohort study conducted between November 2015 and July 2016 at six clinics within routine TB services in Jilin province, where persons with TB were consecutively recruited. Data analysis was performed using the chi-squared test and multivariate logistic regression.
    Results: Of the 306 recruited TB patients, 96 (31.4%) had smear-positive pulmonary TB, 187 (61.1%) had smear-negative pulmonary TB and 23 (7.5%) had extrapulmonary TB (EPTB). Of these, 95 (31.1%) had normal blood glucose, 83 (27.1%) had transient hyperglycaemia and 128 (41.8%) had DM. 227 (74.2%) patients had vitamin D deficiency/severe deficiency. There were 125 (40.8%) patients with UTO of whom the majority were lost to follow-up (57.6%) or not evaluated (28.8%). UTO was significantly associated with smear-negative pulmonary TB (P = 0.009), EPTB (P < 0.001) and DM (P = 0.007).
    Conclusion: The proportion of TB patients with UTO increased with smear-negative pulmonary TB, EPTB and DM. TB programmes need to pay more attention to these issues and ensure intensive patient support to those at risk and early detection of DM.
    MeSH term(s) Aged ; Blood Glucose/metabolism ; China/epidemiology ; Cohort Studies ; Diabetes Mellitus, Type 2/complications ; Female ; Humans ; Male ; Middle Aged ; Prospective Studies ; Treatment Outcome ; Tuberculosis, Pulmonary/blood ; Tuberculosis, Pulmonary/complications ; Tuberculosis, Pulmonary/drug therapy ; Tuberculosis, Pulmonary/epidemiology ; Vitamin D/blood ; Vitamin D Deficiency/complications
    Chemical Substances Blood Glucose ; Vitamin D (1406-16-2)
    Language English
    Publishing date 2020-01-05
    Publishing country England
    Document type Journal Article ; Multicenter Study
    ZDB-ID 1314080-2
    ISSN 1365-3156 ; 1360-2276
    ISSN (online) 1365-3156
    ISSN 1360-2276
    DOI 10.1111/tmi.13355
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  2. Article ; Online: Vitamin D status of tuberculosis patients with diabetes mellitus in different economic areas and associated factors in China.

    Zhao, Xin / Yuan, Yanli / Lin, Yan / Zhang, Tiejuan / Bai, Yunlong / Kang, Demei / Li, Xianhui / Kang, Wanli / Dlodlo, Riitta A / Harries, Anthony D

    PloS one

    2018  Volume 13, Issue 11, Page(s) e0206372

    Abstract: Background: Vitamin D could be a mediator in the association between tuberculosis (TB) and ... serum vitamin D level compared with those without DM and reported that DM was a strong independent ... risk factor for vitamin D deficiency.: Objectives: This study was undertaken to determine amongst patients ...

    Abstract Background: Vitamin D could be a mediator in the association between tuberculosis (TB) and diabetes mellitus (DM). A large scale multi-center study confirmed that TB patients with DM had significantly lower serum vitamin D level compared with those without DM and reported that DM was a strong independent risk factor for vitamin D deficiency.
    Objectives: This study was undertaken to determine amongst patients with both TB and DM living in different economically defined areas in China: i) their baseline characteristics, ii) their vitamin D status and iii) whether certain baseline characteristics were associated with vitamin D deficiency.
    Methods: In DM-TB patients consecutively attending seven clinics or hospitals, we measured 25 hydroxycholecalciferol at the time of registration using electrochemiluminescence in a COBASE 601 Roche analyser by chemiluminescence immunoassay. Data analysis was performed using chi square test and multivariate logistic regression.
    Results: There were 178 DM-TB patients that included 50 from economically well-developed areas, 103 from better-off areas and 25 from a poverty area. Median vitamin D levels in well-developed, better-off and poverty areas were 11.5ng/ml, 12.2ng/ml and 11.5ng/ml respectively. Amongst all patients, 149 (84%) had vitamin D deficiency-91 (51%) with vitamin D deficiency (10-19.9 ng/ml) and 58 (33%) with severe deficiency (< 10 ng/ml). There was a significantly higher proportion with vitamin D deficiency in the poverty area. The adjusted odds of vitamin D deficiency (25-(OH)D3 <20 ng/ml) were significantly higher in those with longer history of DM (P = 0.038) and with HbA1c≥10% (P = 0.003).
    Conclusion: Over 80% of TB patients with DM in China were vitamin D deficient, with risk factors being residence in a poverty area, a long duration of DM and uncontrolled DM. TB programme managers and clinicians need to pay more attention to the vitamin D status of their patients.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; China/epidemiology ; Cross-Sectional Studies ; Diabetes Complications/blood ; Diabetes Complications/epidemiology ; Diabetes Mellitus/blood ; Diabetes Mellitus/economics ; Diabetes Mellitus/epidemiology ; Economic Status/statistics & numerical data ; Female ; Humans ; Male ; Middle Aged ; Poverty Areas ; Risk Factors ; Social Class ; Tuberculosis/blood ; Tuberculosis/complications ; Tuberculosis/economics ; Tuberculosis/epidemiology ; Vitamin D/blood ; Vitamin D Deficiency/blood ; Vitamin D Deficiency/complications ; Vitamin D Deficiency/economics ; Vitamin D Deficiency/epidemiology
    Chemical Substances Vitamin D (1406-16-2)
    Language English
    Publishing date 2018-11-01
    Publishing country United States
    Document type Journal Article ; Multicenter Study
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0206372
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  3. Article ; Online: Vitamin D status in tuberculosis patients with diabetes, prediabetes and normal blood glucose in China: a cross-sectional study.

    Zhao, Xin / Yuan, Yanli / Lin, Yan / Zhang, Tiejuan / Ma, Jianjun / Kang, Wanli / Bai, Yunlong / Wang, Yunlong / Shao, Hongshan / Dlodlo, Riitta A / Harries, Anthony D

    BMJ open

    2017  Volume 7, Issue 9, Page(s) e017557

    Abstract: Objective: The association between tuberculosis (TB), diabetes mellitus (DM) and vitamin D status ... is poorly characterised. We therefore: (1) determined vitamin D status in patients with TB ... whether baseline characteristics in patients with TB, including their DM status, were associated with vitamin D ...

    Abstract Objective: The association between tuberculosis (TB), diabetes mellitus (DM) and vitamin D status is poorly characterised. We therefore: (1) determined vitamin D status in patients with TB in relation to whether they had normal fasting blood glucose (FBG), pre-DM or DM and (2) assessed whether baseline characteristics in patients with TB, including their DM status, were associated with vitamin D deficiency.
    Methods: In patients with TB consecutively attending six clinics or hospitals in China, we measured 25-hydroxycholecalciferol (25-(OH)D
    Results: There were 306 eligible patients with TB, including 96 with smear positive pulmonary TB, 187 with smear negative pulmonary TB and 23 with extrapulmonary TB. Of these, 95 (31%) had normal blood glucose, 83 (27%) had pre-DM and 128 (42%) had DM. Median serum vitamin D levels were 16.1 ng/mL in patients with TB with normal FBG, 12.6 ng/mL in patients with TB with pre-DM and 12.1 ng/mL in patients with TB with DM (p<0.001). The study highlighted certain baseline characteristics associated with vitamin D deficiency (25-(OH)D
    Conclusion: Vitamin D levels are lower in patients with TB with pre-DM and DM and are also affected by certain baseline characteristics that include being registered in the cold season and having DM. TB programmes need to pay more attention to vitamin D status in their patients, especially if there is coexisting pre-DM or DM.
    MeSH term(s) Adolescent ; Adult ; Aged ; Aged, 80 and over ; Blood Glucose/metabolism ; Calcifediol/blood ; China/epidemiology ; Cross-Sectional Studies ; Diabetes Mellitus/blood ; Female ; Humans ; Male ; Middle Aged ; Poverty Areas ; Prediabetic State/blood ; Prediabetic State/complications ; Risk Factors ; Rural Population/statistics & numerical data ; Tuberculosis, Pulmonary/blood ; Tuberculosis, Pulmonary/complications ; Urban Population/statistics & numerical data ; Vitamin D Deficiency/blood ; Vitamin D Deficiency/epidemiology ; Young Adult
    Chemical Substances Blood Glucose ; Calcifediol (P6YZ13C99Q)
    Language English
    Publishing date 2017-09-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 2747269-3
    ISSN 2044-6055 ; 2044-6055 ; 2053-3624
    ISSN (online) 2044-6055
    ISSN 2044-6055 ; 2053-3624
    DOI 10.1136/bmjopen-2017-017557
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  4. Article ; Online: Vitamin D status of tuberculosis patients with diabetes mellitus in different economic areas and associated factors in China.

    Xin Zhao / Yanli Yuan / Yan Lin / Tiejuan Zhang / Yunlong Bai / Demei Kang / Xianhui Li / Wanli Kang / Riitta A Dlodlo / Anthony D Harries

    PLoS ONE, Vol 13, Iss 11, p e

    2018  Volume 0206372

    Abstract: BACKGROUND:Vitamin D could be a mediator in the association between tuberculosis (TB) and ... serum vitamin D level compared with those without DM and reported that DM was a strong independent ... risk factor for vitamin D deficiency. OBJECTIVES:This study was undertaken to determine amongst patients ...

    Abstract BACKGROUND:Vitamin D could be a mediator in the association between tuberculosis (TB) and diabetes mellitus (DM). A large scale multi-center study confirmed that TB patients with DM had significantly lower serum vitamin D level compared with those without DM and reported that DM was a strong independent risk factor for vitamin D deficiency. OBJECTIVES:This study was undertaken to determine amongst patients with both TB and DM living in different economically defined areas in China: i) their baseline characteristics, ii) their vitamin D status and iii) whether certain baseline characteristics were associated with vitamin D deficiency. METHODS:In DM-TB patients consecutively attending seven clinics or hospitals, we measured 25 hydroxycholecalciferol at the time of registration using electrochemiluminescence in a COBASE 601 Roche analyser by chemiluminescence immunoassay. Data analysis was performed using chi square test and multivariate logistic regression. RESULTS:There were 178 DM-TB patients that included 50 from economically well-developed areas, 103 from better-off areas and 25 from a poverty area. Median vitamin D levels in well-developed, better-off and poverty areas were 11.5ng/ml, 12.2ng/ml and 11.5ng/ml respectively. Amongst all patients, 149 (84%) had vitamin D deficiency-91 (51%) with vitamin D deficiency (10-19.9 ng/ml) and 58 (33%) with severe deficiency (< 10 ng/ml). There was a significantly higher proportion with vitamin D deficiency in the poverty area. The adjusted odds of vitamin D deficiency (25-(OH)D3 <20 ng/ml) were significantly higher in those with longer history of DM (P = 0.038) and with HbA1c≥10% (P = 0.003). CONCLUSION:Over 80% of TB patients with DM in China were vitamin D deficient, with risk factors being residence in a poverty area, a long duration of DM and uncontrolled DM. TB programme managers and clinicians need to pay more attention to the vitamin D status of their patients.
    Keywords Medicine ; R ; Science ; Q
    Subject code 610
    Language English
    Publishing date 2018-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article: Preferential inspection of views of 3-D model heads.

    Harries, Mark H / Perrett, David I / Lavender, Alan

    Perception

    2013  Volume 42, Issue 11, Page(s) 1215–1226

    Abstract: The importance of different perspective views for the recognition of model heads was studied. In experiment 1 subjects were instructed to learn the appearance of six heads placed individually on a turntable free to rotate through 360 degrees. Subjects ... ...

    Abstract The importance of different perspective views for the recognition of model heads was studied. In experiment 1 subjects were instructed to learn the appearance of six heads placed individually on a turntable free to rotate through 360 degrees. Subjects did not distribute their time evenly but focussed their inspection on particular views (the full face view and a view close to the profile). Despite differential inspection of these two views during the learning phase, the face, half profile, and profile views were recognized with equal efficiency in a subsequent recognition task with static views. Experiment 2 used the inspection paradigm to investigate view preference during the recognition of heads from memory. In this experiment subjects were asked to learn the appearance of three heads each seen rotating at an even speed. In a subsequent retrieval task the subjects actively inspected six model heads on the turntable and were asked to differentiate the three heads previously seen rotating from three novel heads. The pattern of inspection in this retrieval task was equivalent to that in experiment 1. Results suggest that during the encoding into memory subjects construct descriptions of specific prototypical views of the head and that descriptions of these same views are preferentially utilised during recognition.
    MeSH term(s) Adult ; Head ; Humans ; Pattern Recognition, Visual/physiology ; Recognition (Psychology)/physiology ; Young Adult
    Language English
    Publishing date 2013
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 185533-5
    ISSN 1468-4233 ; 0301-0066
    ISSN (online) 1468-4233
    ISSN 0301-0066
    DOI 10.1068/p200669n
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  6. Article ; Online: Chronic kidney disease, tuberculosis and climate change.

    Harries, A D

    The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease

    2020  Volume 24, Issue 1, Page(s) 132–133

    MeSH term(s) Climate Change ; Cohort Studies ; Humans ; Renal Insufficiency, Chronic ; Tuberculosis ; Tuberculosis, Pulmonary
    Language English
    Publishing date 2020-01-28
    Publishing country France
    Document type Letter ; Comment
    ZDB-ID 1385624-8
    ISSN 1815-7920 ; 1027-3719
    ISSN (online) 1815-7920
    ISSN 1027-3719
    DOI 10.5588/ijtld.19.0556
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  7. Article ; Online: In Response to Reinout van Crevel et al.

    Harries, A D

    The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease

    2020  Volume 24, Issue 6, Page(s) 634

    MeSH term(s) Asia ; Diabetes Mellitus ; Humans ; Risk Factors ; Thinness ; Tuberculosis
    Language English
    Publishing date 2020-07-03
    Publishing country France
    Document type Letter ; Comment
    ZDB-ID 1385624-8
    ISSN 1815-7920 ; 1027-3719
    ISSN (online) 1815-7920
    ISSN 1027-3719
    DOI 10.5588/ijtld.20.0040
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  8. Article ; Online: Having diabetes and being underweight in Asia: a potent risk factor for tuberculosis.

    Harries, A D

    The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease

    2020  Volume 23, Issue 12, Page(s) 1237–1238

    MeSH term(s) Asia ; Body Mass Index ; Diabetes Mellitus ; Humans ; Prospective Studies ; Risk Factors ; Thinness ; Tuberculosis
    Language English
    Publishing date 2020-01-11
    Publishing country France
    Document type Editorial ; Comment
    ZDB-ID 1385624-8
    ISSN 1815-7920 ; 1027-3719
    ISSN (online) 1815-7920
    ISSN 1027-3719
    DOI 10.5588/ijtld.19.0599
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  9. Article ; Online: Protecting healthcare workers from TB.

    Harries, A D / Zellweger, J-P

    The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease

    2022  Volume 26, Issue 2, Page(s) 89–90

    MeSH term(s) Health Personnel ; Humans ; Tuberculosis, Pulmonary
    Language English
    Publishing date 2022-01-27
    Publishing country France
    Document type Editorial ; Comment
    ZDB-ID 1385624-8
    ISSN 1815-7920 ; 1027-3719
    ISSN (online) 1815-7920
    ISSN 1027-3719
    DOI 10.5588/ijtld.21.0641
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  10. Article ; Online: Visuospatial memory in apraxia: Exploring quantitative drawing metrics to assess the representation of local and global information.

    Salo, Sarah K / Harries, Cathryn A / Riddoch, M Jane / Smith, Alastair D

    Memory & cognition

    2024  

    Abstract: Neuropsychological evidence suggests that visuospatial memory is subserved by two separable processing systems, with dorsal underpinnings for global form and ventral underpinnings for the integration of part elements. Previous drawing studies have ... ...

    Abstract Neuropsychological evidence suggests that visuospatial memory is subserved by two separable processing systems, with dorsal underpinnings for global form and ventral underpinnings for the integration of part elements. Previous drawing studies have explored the effects of Gestalt organisation upon memory for hierarchical stimuli, and we here present an exploratory study of an apraxic dorsal stream patient's (MH) performance. We presented MH with a stimulus set (previously reported by Riddoch et al., Cognitive Neuropsychology, 20(7), 641-671, 2003) and devised a novel quantitative scoring system to obtain a finer grain of insight into performance. Stimuli possessed either good or poor Gestalt qualities and were reproduced in a copy condition and two visual memory conditions (with unlimited viewing before the model was removed, or with 3 s viewing). MH's copying performance was impaired in comparison to younger adult and age-matched older adult controls, with a variety of errors at the local level but relatively few at the global level. However, his performance in the visual memory conditions revealed impairments at the global level. For all participants, drawing errors were modulated by the Gestalt qualities of the stimuli, with accuracy at the global and local levels being lesser for poor global stimuli in all conditions. These data extend previous observations of this patient, and support theories that posit interaction between dorsal and ventral streams in the representation of hierarchical stimuli. We discuss the implications of these findings for our understanding of visuospatial memory in neurological patients, and also evaluate the application of quantitative metrics to the interpretation of drawings.
    Language English
    Publishing date 2024-02-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 185691-1
    ISSN 1532-5946 ; 0090-502X
    ISSN (online) 1532-5946
    ISSN 0090-502X
    DOI 10.3758/s13421-024-01531-w
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