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  1. Article ; Online: Monkey viral pathology in the Sukhum colony and modeling human viral infections.

    Lapin, Boris A / Shevtsova, Zinaida V

    Journal of medical primatology

    2018  

    Abstract: The data characterizing spontaneous infections of Old World monkeys: measles, poliomyelitis, hepatitis A (HPA), encephalomyocarditis, coronavirus infection, simian hemorrhagic fever (SHF), are presented. The experimental infections were reproduced with ... ...

    Abstract The data characterizing spontaneous infections of Old World monkeys: measles, poliomyelitis, hepatitis A (HPA), encephalomyocarditis, coronavirus infection, simian hemorrhagic fever (SHF), are presented. The experimental infections were reproduced with the isolated pathogens. On these models, pathogenesis and epidemiology of these diseases were studied. The efficiency of poliomyelitis, measles and HPA vaccines is shown. The priority of data on the discovery of earlier unknown disease-SHF and "Sukhumi" virus-are emphasized. Several important pathogenic mechanisms common for various hemorrhagic fevers were studied on experimental SHF of macaques. This model is uniquely safe and adequate for the assessment of therapy of hemorrhagic fevers dangerous for humans.
    Keywords covid19
    Language English
    Publishing date 2018-05-25
    Publishing country Denmark
    Document type Journal Article ; Review
    ZDB-ID 121206-0
    ISSN 1600-0684 ; 0047-2565
    ISSN (online) 1600-0684
    ISSN 0047-2565
    DOI 10.1111/jmp.12351
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  2. Article ; Online: Enzooty of non-Hodgkin's malignant lymphoma of Papio hamadryas in Sukhumi monkey colony. Clinical and morphological signs of pre-lymphoma.

    Yakovleva, Lelita A / Lapin, Boris A / Agumava, Aslan A

    Journal of medical primatology

    2017  Volume 47, Issue 2, Page(s) 136–138

    Abstract: Inoculation of hamadryas baboons with blood of leukemia ill people-induced malignant non-Hodgkin's lymphoma in experimental animals for a very considerable latency period. At close contact of inoculated baboons with healthy non-inoculated animals, the ... ...

    Abstract Inoculation of hamadryas baboons with blood of leukemia ill people-induced malignant non-Hodgkin's lymphoma in experimental animals for a very considerable latency period. At close contact of inoculated baboons with healthy non-inoculated animals, the lymphoma spread between them. The epidemiological analysis, postmortem examination, histological analysis, tissue culturing, and PCR were used for the diagnostics of lymphoma and pre-lymphoma, purification, identification of STLV-1, and HVP viruses. Characteristic clinical and morphological signs designated by us as pre-lymphoma often precede the lymphoma development. In some cases, pre-lymphoma does not develop in lymphoma because animals die from various diseases and do not reach the point of the lymphoma development. The horizontal transmission of lymphoma arising with the participation of T-lymphotropic retrovirus STLV-1 is shown.
    MeSH term(s) Animals ; Female ; Humans ; Leukemia/blood ; Leukemia/physiopathology ; Lymphoma, Non-Hodgkin/etiology ; Lymphoma, Non-Hodgkin/veterinary ; Monkey Diseases/etiology ; Monkey Diseases/transmission ; Papillomaviridae/physiology ; Papio hamadryas ; Simian T-lymphotropic virus 1/physiology
    Language English
    Publishing date 2017-12-12
    Publishing country Denmark
    Document type Journal Article
    ZDB-ID 121206-0
    ISSN 1600-0684 ; 0047-2565
    ISSN (online) 1600-0684
    ISSN 0047-2565
    DOI 10.1111/jmp.12327
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  3. Article ; Online: Spontaneous and experimental malignancies in non-human primates.

    Lapin, Boris A / Yakovleva, Lelita A

    Journal of medical primatology

    2014  Volume 43, Issue 2, Page(s) 100–110

    Abstract: Contrary to earlier established opinion that tumors in monkeys are found rarely, now the large material confirms that monkey tumors are frequent phenomenon. Tumor incidence clearly increases with age. Frequencies of benign and malignant tumors of various ...

    Abstract Contrary to earlier established opinion that tumors in monkeys are found rarely, now the large material confirms that monkey tumors are frequent phenomenon. Tumor incidence clearly increases with age. Frequencies of benign and malignant tumors of various locations and histogenesis are slightly different. Tumors of hematopoietic system are the most frequent. Sporadic cases and enzootic outbreaks of lymphomas are described for different kinds of monkeys, including apes, and probably are caused by viruses. Two viruses were isolated by us from sick monkeys - the retrovirus C-type STLV-1 and the herpes virus papio HVP. Inoculation of virus cultures into monkeys and rabbits induces neoplasms. Monkey neoplasms can be induced by exposure to various chemical agents, and by oncogenic and non-oncogenic viruses. There is no strict species specificity of tumor viruses. The role of polyoma viruses in neoplasms etiology is discussed.
    MeSH term(s) Age Factors ; Animals ; Haplorhini ; Incidence ; Monkey Diseases/chemically induced ; Monkey Diseases/epidemiology ; Monkey Diseases/virology ; Neoplasms/chemically induced ; Neoplasms/epidemiology ; Neoplasms/veterinary ; Neoplasms/virology ; Neoplasms, Experimental/chemistry ; Neoplasms, Experimental/epidemiology ; Neoplasms, Experimental/virology ; Simian T-lymphotropic virus 1/physiology ; Simplexvirus/physiology
    Language English
    Publishing date 2014-04
    Publishing country Denmark
    Document type Journal Article ; Review
    ZDB-ID 121206-0
    ISSN 1600-0684 ; 0047-2565
    ISSN (online) 1600-0684
    ISSN 0047-2565
    DOI 10.1111/jmp.12098
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  4. Book: Untersuchungen über eine eventuelle Virusätiologie menschlicher Leukämien

    Lapin, Boris A.

    (Versuche an Affen) ; (Vortrag gehalten ... in der Sitzung des Plenums der Deutschen Akademie der Wissenschaften zu Berlin am 28. Januar 1971)

    (Sitzungsberichte des Plenums und der problemgebundenen Klassen der Deutschen Akademie der Wissenschaften zu Berlin ; 1971,2)

    1972  

    Author's details B. A. Lapin
    Series title Sitzungsberichte des Plenums und der problemgebundenen Klassen der Deutschen Akademie der Wissenschaften zu Berlin ; 1971,2
    Collection
    Language German
    Size 13 S. : Ill.
    Publisher Akad.-Verl
    Publishing place Berlin
    Publishing country XA-DDDE
    Document type Book
    HBZ-ID HT004661880
    Database Catalogue ZB MED Medicine, Health

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    1975 B 968 order for loan Magazin

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  5. Article ; Online: Inbreeding, heterozygosity, and lymphoma risk among the baboons (Papio hamadryas) of Sukhumi, USSR.

    Crawford, Michael H / O'Rourke, Dennis H / Dykes, Dale D / Yakovleva, L A / Voevodin, A F / Lapin, Boris / Polesky, H F

    American journal of primatology

    2020  Volume 6, Issue 3, Page(s) 143–153

    Abstract: This paper describes the spread of lymphoma through a baboon (Papio hamadryas) colony in the Institute of Experimental Pathology and Therapy at Sukhumi, USSR. In the late 1960s, Soviet scientists inoculated 12 baboons with cells from hospitalized human ... ...

    Abstract This paper describes the spread of lymphoma through a baboon (Papio hamadryas) colony in the Institute of Experimental Pathology and Therapy at Sukhumi, USSR. In the late 1960s, Soviet scientists inoculated 12 baboons with cells from hospitalized human leukemia patients, causing the death of a total of 135 animals between 1967 and 1978. The death rate from lymphoma averages almost 12 baboons per year in the Sukhumi colony. Genetic investigations of these baboons revealed the following: 1) Six blood protein markers out of 16 systems (38%) tested were polymorphic; 2) the average inbreeding coefficient for the entire colony (N = 1,226) was 0.027 (exclusion of baboons with F values equal to 0.0 raised the mean inbreeding coefficient to 0.096); 3) no relationship between inbreeding and risk of lymphoma was noted; and 4) there was an apparent association between both PGM loci and the incidence of lymphoma at the 0.005 levels of significance. This association was further supported by the significantly lower incidence of PGM2 (2-1) genotype in baboons with high anti-VCA-HVP titers.
    Language English
    Publishing date 2020-01-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1495834-X
    ISSN 1098-2345 ; 0275-2565
    ISSN (online) 1098-2345
    ISSN 0275-2565
    DOI 10.1002/ajp.1350060303
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  6. Article ; Online: Relapsing Evans syndrome and systemic lupus erythematosus with antiphospholipid syndrome treated with Bortezomib in combination with plasma exchange.

    Tkachenko, Olga / Lapin, Sergey / Maslyansky, Alexey / Myachikova, Valentina / Mikhailova, Liya / Gilburd, Boris

    Clinical immunology (Orlando, Fla.)

    2018  Volume 199, Page(s) 44–46

    Abstract: Relapsing Evans syndrome (ES) and systemic lupus erythematosus (SLE) with secondary antiphospholipid syndrome (APS) is very rare association. Coexistence of these syndromes is potentially fatal and require high-dose combined immunosuppressive therapy. We ...

    Abstract Relapsing Evans syndrome (ES) and systemic lupus erythematosus (SLE) with secondary antiphospholipid syndrome (APS) is very rare association. Coexistence of these syndromes is potentially fatal and require high-dose combined immunosuppressive therapy. We describe a case of successful use of Bortezomib and plasma exchange in a patient with ES and APS refractory to standard therapy. Thirty-two-year-old male who presented episodes of relapsing hemolytic anemia, pancytopenia and multiple thrombosis with positive direct and indirect antiglobulin test result, lupus anticoagulant and medium titer of anti-beta-2-glycoprotein 1 and anti-cardiolipin antibodies was diagnosed with ES and SLE with secondary APS. High-dose therapy by steroids and Cyclosporin A were started with temporary improvement. There was also no stable improvement with Rituximab and Cyclophosphamide. Bortezomib in combination with cyclosporine A and plasma exchange was introduced. He had stable improvement in hematological parameters with no evidence of relapse of hemolytic crisis or thrombosis during a follow-up for 1 year.
    MeSH term(s) Adult ; Anemia, Hemolytic, Autoimmune/immunology ; Anemia, Hemolytic, Autoimmune/therapy ; Antiphospholipid Syndrome/immunology ; Antiphospholipid Syndrome/therapy ; Bortezomib/therapeutic use ; Humans ; Lupus Erythematosus, Systemic/immunology ; Lupus Erythematosus, Systemic/therapy ; Male ; Plasma Exchange ; Recurrence ; Thrombocytopenia/immunology ; Thrombocytopenia/therapy ; beta 2-Glycoprotein I/immunology
    Chemical Substances beta 2-Glycoprotein I ; Bortezomib (69G8BD63PP)
    Language English
    Publishing date 2018-12-10
    Publishing country United States
    Document type Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1459903-x
    ISSN 1521-7035 ; 1521-6616
    ISSN (online) 1521-7035
    ISSN 1521-6616
    DOI 10.1016/j.clim.2018.12.010
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  7. Article ; Online: Influence of HLA-DRB1 susceptibility alleles on the autoantibodies spectrum of systemic lupus erythematosus in European part of Russia.

    Tkachenko, Olga / Lapin, Sergey / Maslyansky, Alexey / Myachikova, Valentina / Guseva, Veronika / Belolipetskaia, Elizaveta / Belyaeva, Irina / Mazurov, Vladimir / Ivanova, Nadezhda / Mikhailova, Liya / Gilburd, Boris

    Autoimmunity reviews

    2019  Volume 18, Issue 5, Page(s) 558–560

    Language English
    Publishing date 2019-03-04
    Publishing country Netherlands
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 2144145-5
    ISSN 1873-0183 ; 1568-9972
    ISSN (online) 1873-0183
    ISSN 1568-9972
    DOI 10.1016/j.autrev.2019.03.013
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  8. Book: Biologija i patalogija obez'jan

    Lapin, Boris A.

    izučenie boleznej čeloveka v ėksperimente na obez'janach ; [Meždunarodnyj simpozium v Suchumi, 1966]

    1966  

    Institution Institut Ėksperimental'noj Patologii i Terapii
    Author's details Akademija medicinskich nauk sojuza SSR. Institut ėksperimental'noj patologii i terapii. [Otv. red.: B. A. Lapin]
    Language Russian
    Size 126 S. ; 8-o
    Publishing place Tbilisi
    Publishing country Georgia
    Document type Book
    HBZ-ID HT007988854
    Database Catalogue ZB MED Medicine, Health

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  9. Article ; Online: Concentrations of immunoglobulin free light chains in cerebrospinal fluid predict increased level of brain atrophy in multiple sclerosis.

    Nazarov, Vladimir / Makshakov, Gleb / Kalinin, Ivan / Lapin, Sergey / Surkova, Elena / Mikhailova, Liya / Gilburd, Boris / Skoromets, Alexander / Evdoshenko, Evgeniy

    Immunologic research

    2019  Volume 66, Issue 6, Page(s) 761–767

    Abstract: Recent studies showed that B cells play a major role in the pathogenesis of neurodegeneration in multiple sclerosis (MS). In this study, we aimed to determine the possible link between immunoglobulin free light chains (FLC) and brain atrophy in patients ... ...

    Abstract Recent studies showed that B cells play a major role in the pathogenesis of neurodegeneration in multiple sclerosis (MS). In this study, we aimed to determine the possible link between immunoglobulin free light chains (FLC) and brain atrophy in patients with MS. Ninety-two patients (32 males and 60 females) with MS were included. Kappa and lambda FLC concentrations in serum and cerebrospinal fluid (CSF) samples of MS patients were measured using ELISA assay. FLC quotients (Q-k and Q-λ, respectively) were calculated. In a cross-sectional group (n = 92), the MRI data were acquired within 6 months from the date of the lumbar puncture. Twenty patients from this cohort performed a follow-up MRI after 1 year of observation. Brain volumes were calculated with SIENAX and the brain atrophy (percentage brain volume change (PBVC)) was assessed with SIENA. Spearman's test was performed to assess correlations. We have shown statistically significant correlation of Expanded Disability Status Scale (EDSS) level with normalized brain volume (NBV, r = - 0.2721, p = 0.0062), white matter volume (WMV, r = - 0.2425, p = 0.015), and gray matter volume (GMV, r = - 0.216, p = 0.0309). Multiple Sclerosis Severity Score (MSSS) score correlated with NBV (r = - 0.2521, p = 0.0352) and WMV (r = - 0.315, p = 0.0079). Neither EDSS, nor MSSS scores correlated with the age of patients and relapse rate during the first year and 5 years. In our study, we found statistically significant correlations of k-FLC in the CSF with NBV (r = - 0.311, p = 0.003) and with GMV (r = - 0.213, p = 0.0423). Q-k correlated only with NBV (r = - 0.340, p = 0.006) and Q-λ were negatively correlated with WMV (r = - 0.366, p = 0.003). We did not find correlations of k-FLC in CSF, λ-FLC in CSF, Q-k, and Q-λ with duration of MS course, EDSS, MSSS, number of relapses during the first year, and during the first 5 years of disease. Additionally, we subdivided the study population in accordance with level of k-FLC CSF, Q-k, and Q-λ on the 25th and 75th percentile subgroups (25-k-FLC
    MeSH term(s) Adult ; Atrophy/immunology ; Blood-Brain Barrier/immunology ; Brain/immunology ; Brain Diseases/immunology ; Cerebrospinal Fluid/immunology ; Cross-Sectional Studies ; Female ; Humans ; Immunoglobulin kappa-Chains/immunology ; Immunoglobulin lambda-Chains/immunology ; Male ; Multiple Sclerosis/immunology
    Chemical Substances Immunoglobulin kappa-Chains ; Immunoglobulin lambda-Chains
    Language English
    Publishing date 2019-01-11
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 632857-x
    ISSN 1559-0755 ; 0257-277X
    ISSN (online) 1559-0755
    ISSN 0257-277X
    DOI 10.1007/s12026-018-9058-8
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    Zs.A 1755: Show issues Location:
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  10. Article ; Online: Vimentin as antigenic target in autoimmunity: A comprehensive review.

    Musaelyan, Aram / Lapin, Sergey / Nazarov, Vladimir / Tkachenko, Olga / Gilburd, Boris / Mazing, Alexandra / Mikhailova, Lilia / Shoenfeld, Yehuda

    Autoimmunity reviews

    2018  Volume 17, Issue 9, Page(s) 926–934

    Abstract: Vimentin is a protein of intermediate filament family, which is expressed in all mesenchymal cells. Vimentin plays a key role in the physiology of the cell, cellular interactions and the functioning of the immune system. Post-translationally modified and ...

    Abstract Vimentin is a protein of intermediate filament family, which is expressed in all mesenchymal cells. Vimentin plays a key role in the physiology of the cell, cellular interactions and the functioning of the immune system. Post-translationally modified and native forms of vimentin are involved in the pathogenesis of inflammation and many autoimmune diseases: rheumatoid arthritis, sarcoidosis, systemic lupus erythematosus, antiphospholipid syndrome, Crohn's disease, ankylosing spondyloarthritis and idiopathic pulmonary fibrosis. Modifications of the protein lead to the formation of antigenic epitopes and, as a result, to the synthesis of antibodies. Citrullinated, carbamylated and acetylated forms of vimentin participate in the pathogenesis of RA, and antibodies against them serve as diagnostic and prognostic markers of the disease. Epitopes of native vimentin are antigenic in the group of HLA-DRB1*0301 positive patients with sarcoidosis. In addition, vimentin takes part in pathogenesis of tubulointerstitial inflammation and glomerulonephritis in lupus. In antiphospholipid syndrome interactions of vimentin and cardiolipin on the surface of apoptotic cells lead to the formation of an immunogenic complex. Antibodies against vimentin/cardiolipin complex are involved in the mechanism of thrombogenesis and serve to identify patients seronegative for antibodies to cardiolipin and ß2glycoprotein-I with the clinical features. Post-translationally modified form of the protein is citrullinated and MMP-degraded vimentin, which was found in serum of patients with Crohn's disease and ankylosing spondyloarthritis.
    MeSH term(s) Arthritis, Rheumatoid/immunology ; Autoimmunity/drug effects ; Humans ; Lupus Erythematosus, Systemic/immunology ; Protein Processing, Post-Translational/genetics ; Vimentin/immunology
    Chemical Substances Vimentin
    Language English
    Publishing date 2018-07-17
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2144145-5
    ISSN 1873-0183 ; 1568-9972
    ISSN (online) 1873-0183
    ISSN 1568-9972
    DOI 10.1016/j.autrev.2018.04.004
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