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  1. Book ; Online ; E-Book: Roles of host gene and non-coding RNA expression in virus infection

    Tripp, Ralph A. / Tompkins, S. Mark

    (Current topics in microbiology and immunology ; 419)

    2018  

    Author's details Ralph A. Tripp, S. Mark Tompkins editors
    Series title Current topics in microbiology and immunology ; 419
    Collection
    Language English
    Size 1 Online-Ressource (vii, 280 Seiten), Illustrationen
    Publisher Springer
    Publishing place Cham
    Publishing country Switzerland
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT020013416
    ISBN 978-3-030-05369-7 ; 9783030053680 ; 3-030-05369-5 ; 3030053687
    DOI 10.1007/978-3-030-05369-7
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Understanding immunity to influenza: implications for future vaccine development.

    Tripp, Ralph A

    Expert review of vaccines

    2023  Volume 22, Issue 1, Page(s) 871–875

    Abstract: Introduction: Influenza virus changes its genotype through antigenic drift or shift making it difficult to develop immunity to infection or vaccination. Zoonotic influenza A virus (IAV) strains can become established in humans. Several impediments to ... ...

    Abstract Introduction: Influenza virus changes its genotype through antigenic drift or shift making it difficult to develop immunity to infection or vaccination. Zoonotic influenza A virus (IAV) strains can become established in humans. Several impediments to human infection and transmission include sialic acid expression, host anti-viral factors (including interferons), and other elements that govern viral replication. Controlling influenza infection, replication, and transmission is important because IAVs cause annual epidemics and occasional pandemics. Effective seasonal influenza vaccines exist, but these vaccines do not fully protect against novel or pandemic strains.
    Areas covered: With new vaccine production technology, vaccines can be produced rapidly. Universal IAV vaccines are being developed to protect against seasonal, novel, and zoonotic IAVs. These efforts are being enhanced and accelerated by a better understanding the host immune response to influenza viruses.
    Expert opinion: This review discusses several implications for future influenza vaccine development. Host immune responses to influenza virus infection or vaccination can guide vaccine development as anti-influenza immunity is affected by responses influenced by the previous immune history including first and subsequent exposures to influenza virus infections and vaccinations.
    MeSH term(s) Humans ; Influenza, Human ; Influenza Vaccines ; Orthomyxoviridae Infections/prevention & control ; Orthomyxoviridae ; Influenza A virus/genetics ; Vaccine Development
    Chemical Substances Influenza Vaccines
    Language English
    Publishing date 2023-10-12
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2181284-6
    ISSN 1744-8395 ; 1476-0584
    ISSN (online) 1744-8395
    ISSN 1476-0584
    DOI 10.1080/14760584.2023.2266033
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6077: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  3. Book ; Online: Frontiers in RNAi: Volume 1

    Tripp, Ralph A

    (Frontiers in RNAi)

    2014  

    Series title Frontiers in RNAi
    Keywords Genetics (non-medical) ; RNA interference (RNAi), Small interfering RNA (siRNA), High throughput screen (HTS), microRNA, Host-Pathogen Interactions, Genome-wide screening, Small hairpin RNAs (shRNA), 3D Culture, pathogen, Host genes, bioinformatics, pooled screens, gene silencing, virus, pathway analysis, computational analysis, drug repurposing
    Language English
    Size 1 electronic resource (278 pages)
    Publisher Bentham Science Publishers
    Document type Book ; Online
    Note English
    HBZ-ID HT030612870
    ISBN 9781608059416 ; 1608059413
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  4. Book: Human respiratory syncytial virus

    Tripp, Ralph A. / Jorquera, Patricia A.

    methods and protocols

    (Methods in molecular biology ; 1442 ; Springer protocols)

    2016  

    Author's details edited by Ralph A. Tripp and Patricia A. Jorquera
    Series title Methods in molecular biology ; 1442
    Springer protocols
    Collection
    Language English
    Dates of publication 2016-9999
    Publisher Humana Press
    Publishing place New York
    Publishing country United States
    Document type Book
    HBZ-ID HT019063964
    ISBN 978-1-4939-3685-4 ; 9781493936878 ; 1-4939-3685-9 ; 1493936875
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 7042 -1442- verfügbar in Königswinter Königswinter

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  5. Article ; Online: Understanding immunity to influenza

    Ralph A. Tripp

    Expert Review of Vaccines, Vol 22, Iss 1, Pp 871-

    implications for future vaccine development

    2023  Volume 875

    Abstract: Introduction Influenza virus changes its genotype through antigenic drift or shift making it difficult to develop immunity to infection or vaccination. Zoonotic influenza A virus (IAV) strains can become established in humans. Several impediments to ... ...

    Abstract Introduction Influenza virus changes its genotype through antigenic drift or shift making it difficult to develop immunity to infection or vaccination. Zoonotic influenza A virus (IAV) strains can become established in humans. Several impediments to human infection and transmission include sialic acid expression, host anti-viral factors (including interferons), and other elements that govern viral replication. Controlling influenza infection, replication, and transmission is important because IAVs cause annual epidemics and occasional pandemics. Effective seasonal influenza vaccines exist, but these vaccines do not fully protect against novel or pandemic strains. Areas covered With new vaccine production technology, vaccines can be produced rapidly. Universal IAV vaccines are being developed to protect against seasonal, novel, and zoonotic IAVs. These efforts are being enhanced and accelerated by a better understanding the host immune response to influenza viruses. Expert opinion This review discusses several implications for future influenza vaccine development. Host immune responses to influenza virus infection or vaccination can guide vaccine development as anti-influenza immunity is affected by responses influenced by the previous immune history including first and subsequent exposures to influenza virus infections and vaccinations.
    Keywords influenza ; immunity ; host immunity ; vaccines ; human ; Internal medicine ; RC31-1245
    Subject code 570
    Language English
    Publishing date 2023-12-01T00:00:00Z
    Publisher Taylor & Francis Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  6. Article: Advances in Vaccine Development.

    Tripp, Ralph A

    Vaccines

    2021  Volume 9, Issue 9

    Abstract: The Special Issue titled "Advances in Vaccine Development" contains articles, reviews, and a perspective on advances in vaccine delivery and expression, nanovaccines, epitopes, proteins and adjuvants, and new vaccine platforms [ ... ]. ...

    Abstract The Special Issue titled "Advances in Vaccine Development" contains articles, reviews, and a perspective on advances in vaccine delivery and expression, nanovaccines, epitopes, proteins and adjuvants, and new vaccine platforms [...].
    Language English
    Publishing date 2021-09-18
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2703319-3
    ISSN 2076-393X
    ISSN 2076-393X
    DOI 10.3390/vaccines9091036
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Book: Immunobiology of influenza infection: approaches for an emerging zoonotic disease

    Tripp, Ralph A.

    2008  

    Author's details ed. Ralph A Tripp
    Language English
    Size 163 S. : Ill., graph. Darst.
    Publisher Research Signpost
    Publishing place Trivandrum
    Publishing country India
    Document type Book
    HBZ-ID HT016043431
    ISBN 978-81-308-0244-2 ; 81-308-0244-9
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2009 A 4104 order for loan Magazin

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  8. Article ; Online: Screening Drugs for Broad-Spectrum, Host-Directed Antiviral Activity: Lessons from the Development of Probenecid for COVID-19.

    Tripp, Ralph A / Martin, David E

    Viruses

    2023  Volume 15, Issue 11

    Abstract: In the early stages of drug discovery, researchers develop assays that are compatible with high throughput screening (HTS) and structure activity relationship (SAR) measurements. These assays are designed to evaluate the effectiveness of new and known ... ...

    Abstract In the early stages of drug discovery, researchers develop assays that are compatible with high throughput screening (HTS) and structure activity relationship (SAR) measurements. These assays are designed to evaluate the effectiveness of new and known molecular entities, typically targeting specific features within the virus. Drugs that inhibit virus replication by inhibiting a host gene or pathway are often missed because the goal is to identify active antiviral agents against known viral targets. Screening efforts should be sufficiently robust to identify all potential targets regardless of the antiviral mechanism to avoid misleading conclusions.
    MeSH term(s) Humans ; COVID-19 ; Probenecid/pharmacology ; Antiviral Agents/pharmacology ; Antiviral Agents/therapeutic use ; Drug Discovery ; High-Throughput Screening Assays ; Virus Replication
    Chemical Substances Probenecid (PO572Z7917) ; Antiviral Agents
    Language English
    Publishing date 2023-11-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v15112254
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: RSV Replication, Transmission, and Disease Are Influenced by the RSV G Protein.

    Bergeron, Harrison C / Tripp, Ralph A

    Viruses

    2022  Volume 14, Issue 11

    Abstract: It is important to understand the features affecting virus replication, fitness, and transmissibility as they contribute to the outcome of infection and affect disease intervention approaches. Respiratory syncytial virus (RSV) is a major contributor to ... ...

    Abstract It is important to understand the features affecting virus replication, fitness, and transmissibility as they contribute to the outcome of infection and affect disease intervention approaches. Respiratory syncytial virus (RSV) is a major contributor to respiratory disease, particularly in the infant and elderly populations. Although first described over 60 years ago, there are no approved vaccines and there are limited specific antiviral treatments due in part to our incomplete understanding of the features affecting RSV replication, immunity, and disease. RSV studies have typically focused on using continuous cell lines and conventional RSV strains to establish vaccine development and various antiviral countermeasures. This review outlines how the RSV G protein influences viral features, including replication, transmission, and disease, and how understanding the role of the G protein can improve the understanding of preclinical studies.
    MeSH term(s) Infant ; Humans ; Aged ; Respiratory Syncytial Virus Vaccines ; Respiratory Syncytial Virus Infections ; Respiratory Syncytial Virus, Human ; Antiviral Agents/therapeutic use ; GTP-Binding Proteins ; Antibodies, Viral
    Chemical Substances Respiratory Syncytial Virus Vaccines ; Antiviral Agents ; GTP-Binding Proteins (EC 3.6.1.-) ; Antibodies, Viral
    Language English
    Publishing date 2022-10-29
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v14112396
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Repurposing Probenecid to Inhibit SARS-CoV-2, Influenza Virus, and Respiratory Syncytial Virus (RSV) Replication.

    Tripp, Ralph A / Martin, David E

    Viruses

    2022  Volume 14, Issue 3

    Abstract: Viral replication and transmissibility are the principal causes of endemic and pandemic disease threats. There remains a need for broad-spectrum antiviral agents. The most common respiratory viruses are endemic agents such as coronaviruses, respiratory ... ...

    Abstract Viral replication and transmissibility are the principal causes of endemic and pandemic disease threats. There remains a need for broad-spectrum antiviral agents. The most common respiratory viruses are endemic agents such as coronaviruses, respiratory syncytial viruses, and influenza viruses. Although vaccines are available for SARS-CoV-2 and some influenza viruses, there is a paucity of effective antiviral drugs, while for RSV there is no vaccine available, and therapeutic treatments are very limited. We have previously shown that probenecid is safe and effective in limiting influenza A virus replication and SARS-CoV-2 replication, along with strong evidence showing inhibition of RSV replication in vitro and in vivo. This review article will describe the antiviral activity profile of probenecid against these three viruses.
    MeSH term(s) COVID-19/drug therapy ; Drug Repositioning ; Humans ; Orthomyxoviridae ; Probenecid/pharmacology ; Respiratory Syncytial Virus, Human ; SARS-CoV-2
    Chemical Substances Probenecid (PO572Z7917)
    Language English
    Publishing date 2022-03-15
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v14030612
    Database MEDical Literature Analysis and Retrieval System OnLINE

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