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Article ; Online: Geographic Variation in the Quality of Heart Failure Care Among U.S. Veterans.

Kosaraju, Revanth S / Fonarow, Gregg C / Ong, Michael K / Heidenreich, Paul A / Washington, Donna L / Wang, Xiaoyan / Ziaeian, Boback

JACC. Heart failure

2023 Volume 11, Issue 11, Page(s) 1534–1545

Abstract: Background: The burden of heart failure is growing. Guideline-directed medical therapies (GDMT) reduce adverse outcomes in heart failure with reduced ejection fraction (HFrEF). Whether there is geographic variation in HFrEF quality of care is not well ... ...

Abstract	Background: The burden of heart failure is growing. Guideline-directed medical therapies (GDMT) reduce adverse outcomes in heart failure with reduced ejection fraction (HFrEF). Whether there is geographic variation in HFrEF quality of care is not well described. Objectives: This study evaluated variation nationally for prescription of GDMT within the Veterans Health Administration. Methods: A cohort of Veterans with HFrEF had their address linked to hospital referral regions (HRRs). GDMT prescription was defined using pharmacy data between July 1, 2020, and July 1, 2021. Within HRRs, we calculated the percentage of Veterans prescribed GDMT and a composite GDMT z-score. National choropleth maps were created to evaluate prescription variation. Associations between GDMT performance and demographic characteristics were evaluated using linear regression. Results: Maps demonstrated significant variation in the HRR composite score and GDMT prescriptions. Within HRRs, the prescription of beta-blockers to Veterans was highest with a median of 80% (IQR: 77.3%-82.2%) followed by angiotensin-converting enzyme inhibitor/angiotensin receptor blocker/angiotensin receptor-neprilysin inhibitors (69.3%; IQR: 66.4%-72.1%), sodium-glucose cotransporter-2 inhibitors (10.3%; IQR: 7.7%-12.8%), mineralocorticoid receptor antagonists (29.2%; IQR: 25.8%-33.9%), and angiotensin receptor-neprilysin inhibitors (12.2%; IQR: 8.6%-15.3%). HRR composite GDMT z-scores were inversely associated with the HRR median Gini coefficient (R = -0.13; P = 0.0218) and the percentage of low-income residents (R = -0.117; P = 0.0413). Conclusions: Wide geographic differences exist for HFrEF care. Targeted strategies may be required to increase GDMT prescription for Veterans in lower-performing regions, including those affected by income inequality and poverty.
MeSH term(s)	Humans ; Heart Failure/drug therapy ; Heart Failure/epidemiology ; Veterans ; Neprilysin ; Sodium-Glucose Transporter 2 Inhibitors ; Stroke Volume ; Adrenergic beta-Antagonists/therapeutic use ; Receptors, Angiotensin ; Angiotensin Receptor Antagonists/therapeutic use
Chemical Substances	Neprilysin (EC 3.4.24.11) ; Sodium-Glucose Transporter 2 Inhibitors ; Adrenergic beta-Antagonists ; Receptors, Angiotensin ; Angiotensin Receptor Antagonists
Language	English
Publishing date	2023-08-02
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2705621-1
ISSN	2213-1787 ; 2213-1779
ISSN (online)	2213-1787
ISSN	2213-1779
DOI	10.1016/j.jchf.2023.06.010
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The reception of Kant’s doctrine of postulates in Neo-Kantianism

Heidenreich Hauke

SHS Web of Conferences, Vol 161, p

2023 Volume 05001

Abstract: The Doctrine of Postulates is one of the most disputed segments in Kant’s philosophy. How ...

Abstract	The Doctrine of Postulates is one of the most disputed segments in Kant’s philosophy. How could the objective reality of the immortality of the soul and the existence of God fit in an understanding of modernity that is brought up as “secular” and “rational”? Leading scholars see the Highest Good as a “theological” denial of modernity itself. The question is how this central critique emerged in the discourse. Traces in modern Kant research lead to the period around 1900, when Neo-Kantianism was claimed to be the most important philosophy dealing with Kant. Today, most philosophers regard Neo-Kantianism as a consistent set of philosophical practices that refer to one specific meaning. In fact, “Neo-Kantianism” was thrown into the discourse within the debate between Neo-Kantian authors – Friedrich Paulsen, Hans Vaihinger, Hermann Cohen – and the famous Darwinist Ernst Haeckel, who published his wide-ranging best-seller The Riddles of the Universe in 1899. Haeckel undertook a sharp critique against the Highest Good, arguing it contained occultism, and “Neo-Kantianism” promoted this owing to its Kant “obsession”. He refers to the 1888 Kant interpretation by German occultist Carl du Prel. The reaction of Neo-Kantian authors was a broad rejection of the doctrine of the postulates, which subsequently constituted the new “essence” of Neo-Kantianism. Every differing position was excluded as non-Neo-Kantian und occult. The claimed unity of Neo-Kantianism was produced in a specific historical context to reject the postulates. The “essence” of Neo-Kantianism was then defined to provide the “right” non-occult interpretation of the postulates.
Keywords	neo-kantianism ; doctrine of postulates ; highest good ; spiritism ; materialism ; kant ; swedenborg ; Social Sciences ; H
Subject code	100
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	EDP Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Clinical predictors of improvement in left ventricular ejection fraction in U.S. veterans with heart failure.

Nallamshetty, Shriram / Castillo, Adrian / Nguyen, Andrew / Haddad, Francois / Heidenreich, Paul

American heart journal plus : cardiology research and practice

2022 Volume 19, Page(s) 100183

Abstract: Background: Our understanding of the factors associated with improvement of LVEF and a heart failure with improved EF (HFimpEF) phenotype remains incomplete.: Methods: We conducted a retrospective study using a national database of patients followed ... ...

Abstract	Background: Our understanding of the factors associated with improvement of LVEF and a heart failure with improved EF (HFimpEF) phenotype remains incomplete. Methods: We conducted a retrospective study using a national database of patients followed in the Veterans Affairs (VA) health system with serial assessment of left ventricular ejection fraction (LVEF) by echocardiography. We identified US veterans with a new diagnosis of heart failure with: (i) LVEF of <40 % in the 12 months prior to diagnosis, and (ii) follow-up LVEF assessment at least 6 months after their diagnosis. We defined HFimpEF as a final LVEF of ≥40 %. Results: Among the 106,414 US veterans with an initial LVEF of <40 % in this analysis, 39,994 (37.6 %) had a final EF of >40 % after a median follow up of 5 years. Multivariate regression analysis identified several factors that were independently associated with LVEF improvement including female sex, younger age, higher BMI, and a history of specific comorbid conditions such as hypertension, valve disease, atrial fibrillation, connective tissue disease, liver disease, and malignancy (p < 0.001). Conversely, a history of ischemic heart disease and peripheral arterial disease, as well as specific racial backgrounds (Black and Hispanic) were associated with lower rates of LVEF improvement. The model c-statistic for predicting LVEF improvement was 0.70. Conclusions: This large, detailed dataset facilitated an analysis of a large number of variables that significantly associated with HFimpEF; however, their combined discriminatory value for LVEF improvement remained modest, underscoring the complexity of the gene-environment-treatment interactions that govern LV function.
Language	English
Publishing date	2022-07-22
Publishing country	United States
Document type	Journal Article
ISSN	2666-6022
ISSN (online)	2666-6022
DOI	10.1016/j.ahjo.2022.100183
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Conference proceedings: The first doctor’ advice as a remarkable factor in the mortality of Fournier’s gangrene

Rieger, Constantin / Hübers, Max / Kastner, Lucas / Pfister, David / Heidenreich, Axel

2023 , Page(s) V 4.5

Event/congress	68. Kongress der Nordrhein-Westfälischen Gesellschaft für Urologie; Essen; Nordrhein-Westfälische Gesellschaft für Urologie; 2023
Keywords	Medizin, Gesundheit
Publishing date	2023-03-28
Publisher	German Medical Science GMS Publishing House; Düsseldorf
Document type	Conference proceedings
DOI	10.3205/23nrwgu32
Database	German Medical Science

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Article: Die Dritte Welle und Aaron T. Beck: Standing on the shoulder(s) of (a) giant(s)

Michalak, Johannes / Heidenreich, Thomas

Verhaltenstherapie & psychosoziale Praxis

2021 Volume 53, Issue 3, Page(s) 531

Language	German
Document type	Article
ZDB-ID	627290-3
ISSN	0721-7234
Database	Current Contents Medicine

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Book ; Audio / Video ; Thesis: Einfluss der Genpolymorphismen von Glutathion S-Transferase M1 und T1 auf die Entstehung einer koronaren Herzkrankheit

Heidenreich, Yvonne

2006

Author's details	vorgelegt von Yvonne Heidenreich
Language	German
Size	1 CD-ROM, 12 cm
Publishing country	Germany
Document type	Book ; Audio / Video ; Thesis
Thesis / German Habilitation thesis	Witten, Herdecke, Univ., Diss., 2006
HBZ-ID	HT015517176
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Article ; Online: Department of Veterans Affairs (VA) and U.S. Department of Defense (DoD) guidelines for management of dyslipidemia and cardiovascular disease risk reduction: Putting evidence in context.

Al Rifai, Mahmoud / Blumenthal, Roger S / Stone, Neil J / Schofield, Richard S / Orringer, Carl Edward / Michos, Erin D / Heidenreich, Paul A / Braun, Lynne / Birtcher, Kim K / Smith, Sidney C / Nambi, Vijay / Grundy, Scott / Virani, Salim S

Progress in cardiovascular diseases

2021 Volume 68, Page(s) 2–6

Abstract: ... in the United States (U.S.) and incurs significant cost to the healthcare system. Management of cholesterol remains ... we compare the American Heart Association (AHA)/American College of Cardiology (ACC) and the U.S. Department ... of Veterans Affairs (VA) and U.S. Department of Defense (DoD) Cholesterol guidelines. We review the evidence ...

Abstract	Atherosclerotic cardiovascular disease (ASCVD) remains the leading cause of morbidity and mortality in the United States (U.S.) and incurs significant cost to the healthcare system. Management of cholesterol remains central for ASCVD prevention and has been the focus of multiple national guidelines. In this review, we compare the American Heart Association (AHA)/American College of Cardiology (ACC) and the U.S. Department of Veterans Affairs (VA) and U.S. Department of Defense (DoD) Cholesterol guidelines. We review the evidence base that was used to generate recommendations focusing on 4 distinct themes: 1) the threshold of absolute 10-year ASCVD risk to start a clinician-patient discussion for the initiation of statin therapy in primary prevention patients; 2) the utility of coronary artery calcium score to guide clinician-patient risk discussion pertaining to the initiation of statin therapy for primary ASCVD prevention; 3) the use of moderate versus high-intensity statin therapy in patients with established ASCVD; and 4) the utility of ordering lipid panels after initiation or intensification of lipid lowering therapy to document efficacy and monitor adherence to lipid lowering therapy. We discuss why the VA/DoD and AHA/ACC may have reached different conclusions on these key issues.
MeSH term(s)	Biomarkers/blood ; Cardiovascular Diseases/diagnosis ; Cardiovascular Diseases/mortality ; Cardiovascular Diseases/prevention & control ; Cholesterol/blood ; Clinical Decision-Making ; Consensus ; Drug Monitoring/standards ; Dyslipidemias/blood ; Dyslipidemias/diagnosis ; Dyslipidemias/drug therapy ; Dyslipidemias/mortality ; Heart Disease Risk Factors ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/adverse effects ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use ; Military Medicine/standards ; Primary Prevention/standards ; Protective Factors ; Risk Assessment ; Secondary Prevention/standards ; Time Factors ; Treatment Outcome ; United States/epidemiology ; United States Department of Defense ; United States Department of Veterans Affairs
Chemical Substances	Biomarkers ; Hydroxymethylglutaryl-CoA Reductase Inhibitors ; Cholesterol (97C5T2UQ7J)
Language	English
Publishing date	2021-08-08
Publishing country	United States
Document type	Journal Article ; Practice Guideline ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
ZDB-ID	209312-1
ISSN	1873-1740 ; 1532-8643 ; 0033-0620
ISSN (online)	1873-1740 ; 1532-8643
ISSN	0033-0620
DOI	10.1016/j.pcad.2021.08.001
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Article ; Online: Functional reconstitution of mitochondrial Fe/S cluster synthesis on Isu1 reveals the involvement of ferredoxin.

Webert, Holger / Freibert, Sven-Andreas / Gallo, Angelo / Heidenreich, Torsten / Linne, Uwe / Amlacher, Stefan / Hurt, Ed / Mühlenhoff, Ulrich / Banci, Lucia / Lill, Roland

Nature communications

2014 Volume 5, Page(s) 5013

Abstract: Maturation of iron-sulphur (Fe/S) proteins involves complex biosynthetic machinery. In vivo ... enigmatic, because they are not required for in vitro Fe/S cluster assembly. Here, we reconstitute [2Fe-2S ... in the bacterial system, frataxin is an essential part of Fe/S cluster biosynthesis and is required simultaneously ...

Abstract	Maturation of iron-sulphur (Fe/S) proteins involves complex biosynthetic machinery. In vivo synthesis of [2Fe-2S] clusters on the mitochondrial scaffold protein Isu1 requires the cysteine desulphurase complex Nfs1-Isd11, frataxin, ferredoxin Yah1 and its reductase Arh1. The roles of Yah1-Arh1 have remained enigmatic, because they are not required for in vitro Fe/S cluster assembly. Here, we reconstitute [2Fe-2S] cluster synthesis on Isu1 in a reaction depending on Nfs1-Isd11, frataxin, Yah1, Arh1 and NADPH. Unlike in the bacterial system, frataxin is an essential part of Fe/S cluster biosynthesis and is required simultaneously and stoichiometrically to Yah1. Reduced but not oxidized Yah1 tightly interacts with apo-Isu1 indicating a dynamic interaction between Yah1-apo-Isu1. Nuclear magnetic resonance structural studies identify the Yah1-apo-Isu1 interaction surface and suggest a pathway for electron flow from reduced ferredoxin to Isu1. Together, our study defines the molecular function of the ferredoxin Yah1 and its human orthologue FDX2 in mitochondrial Fe/S cluster synthesis.
MeSH term(s)	Adrenodoxin/chemistry ; Adrenodoxin/metabolism ; Biocatalysis ; Chaetomium ; Escherichia coli ; Ferredoxin-NADP Reductase/metabolism ; Ferredoxins/metabolism ; Humans ; Iron-Sulfur Proteins/biosynthesis ; Membrane Proteins/metabolism ; Mitochondria/metabolism ; Mitochondrial Proteins/chemistry ; Mitochondrial Proteins/metabolism ; Saccharomyces cerevisiae ; Saccharomyces cerevisiae Proteins/chemistry ; Saccharomyces cerevisiae Proteins/metabolism ; Sulfurtransferases/metabolism
Chemical Substances	Ferredoxins ; ISU1 protein, S cerevisiae ; Iron-Sulfur Proteins ; Isd11 protein, S cerevisiae ; Membrane Proteins ; Mitochondrial Proteins ; Saccharomyces cerevisiae Proteins ; YAH1 protein, S cerevisiae ; Adrenodoxin (12687-22-8) ; Arh1 protein, S cerevisiae (EC 1.18.1.2) ; Ferredoxin-NADP Reductase (EC 1.18.1.2) ; Sulfurtransferases (EC 2.8.1.-) ; NFS1 protein, S cerevisiae (EC 2.8.1.7)
Language	English
Publishing date	2014-10-31
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2041-1723
ISSN (online)	2041-1723
DOI	10.1038/ncomms6013
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Article ; Online: Men’s preferences for the treatment of lower urinary tract symptoms associated with benign prostatic hyperplasia

Mankowski C / Ikenwilo D / Heidenreich S / Ryan M / Nazir J / Newman C / Watson V

Patient Preference and Adherence, Vol Volume 10, Pp 2407-

a discrete choice experiment

2016 Volume 2417

Abstract: ... 27, 2015 Objective: To explore and quantify men’s preferences and willingness to pay (WTP ... Colette Mankowski,1 Divine Ikenwilo,2,† Sebastian Heidenreich,2 Mandy Ryan,2 Jameel Nazir,1 Cathy ...

Abstract	Colette Mankowski,1 Divine Ikenwilo,2,† Sebastian Heidenreich,2 Mandy Ryan,2 Jameel Nazir,1 Cathy Newman,1 Verity Watson2 1Health Economics and Outcomes Research, Astellas Pharma Europe Ltd., Chertsey, 2Health Economics Research Unit, University of Aberdeen, Aberdeen, UK †Dr Ikenwilo passed away on November 27, 2015 Objective: To explore and quantify men’s preferences and willingness to pay (WTP) for attributes of medications for lower urinary tract symptoms associated with benign prostatic hyperplasia using a discrete choice experiment. Subjects and methods: Men in the UK aged ≥45 years with moderate-to-severe lower urinary tract symptoms/benign prostatic hyperplasia (based on self-reported International Prostate Symptom Score ≥8) were recruited. An online discrete choice experiment survey was administered. Eligible men were asked to consider different medication scenarios and select their preferred medication according to seven attributes: daytime and nighttime (nocturia) urinary frequency, urinary urgency, sexual and nonsexual side effects, number of tablets/day, and cost/month. A mixed-logit model was used to estimate preferences and WTP for medication attributes. Results: In all, 247 men completed the survey. Men were willing to trade-off symptom improvements and treatment side effects. Men preferred medications that reduced urinary urgency and reduced day- and nighttime urinary frequency. Men preferred medications without side effects (base-case level), but did not care about the number of tablets per day. WTP for symptomatic improvement was £25.33/month for reduced urgency (urge incontinence to mild urgency), and £6.65/month and £1.39/month for each unit reduction in night- and daytime urination frequency, respectively. The sexual and nonsexual side effects reduced WTP by up to £30.07/month. There was significant heterogeneity in preferences for most attributes, except for reduced urinary urgency from urge incontinence to mild urgency and no fluid during ejaculation (dry orgasm). Conclusion: To ...
Keywords	benign prostatic hyperplasia ; discrete choice experiment ; erectile dysfunction ; lower urinary tract symptoms ; storage symptoms ; urge incontinence ; Medicine (General) ; R5-920
Subject code	150
Language	English
Publishing date	2016-11-01T00:00:00Z
Publisher	Dove Medical Press
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Difúzní obrovskobuněčný tumor šlachových pochev krční páteře s destrukcí obratle C6 - kazuistika.

Kinkor, Zdeněk / Svoboda, Tomáš / Grossman, Petr / Bludovský, David / Heidenreich, Filip / Švec, Andrej / Mečiarová, Iveta

Ceskoslovenska patologie

2016 Volume 52, Issue 4, Page(s) 218–221

Abstract: Presented is a case of 59-year-old woman with longstanding neck pain who has been promptly operated for spinal cord compression. Imaging studies disclosed ill-defined cervical paravertebral soft tissue mass at the level of vertebra C5/6 abutting left- ... ...

Title translation	Diffuse tenosynovial giant cell tumor of the cervical spine destroying vertebra C6 - a case report.
Abstract	Presented is a case of 59-year-old woman with longstanding neck pain who has been promptly operated for spinal cord compression. Imaging studies disclosed ill-defined cervical paravertebral soft tissue mass at the level of vertebra C5/6 abutting left-sided intervertebral joint and destroying neighboring both vertebral arch and processus spinosus. Submitted specimen was interpreted as a possible metastatic skeletal process by clinicians and referring pathologist favored diagnosis of giant cell tumor/osteoclastoma of the bone. Microscopic features were consistent with giant cell lesion where uniform mononuclear mosaic stromal component dominated the unevenly distributed loose clusters of osteoclast-like giant cells frequently imparting appearance of peculiar pseudoalveolar spaces. Additionally, alternating geographic xanthomatous and densely hyalinized/ osteoid-like zones with speckled, coarsely granular haemosiderin pigment completed the variegated structural composition. The tumor infiltrated adjacent striated muscles; either original bone structures and/or extracellular matrix deposits were not identified. Immunohistochemical stains with p63, SATB2, desmin, EMA, clusterin and S100protein turned out to be completely negative. FISH analysis revealed no rearrangement of CSF1 gene. The diagnosis of the diffuse tenosynovial giant cell tumor was rendered.
Language	Czech
Publishing date	2016
Publishing country	Czech Republic
Document type	Journal Article ; English Abstract
ZDB-ID	138273-1
ISSN	1210-7875 ; 0009-0611 ; 0371-1854
ISSN	1210-7875 ; 0009-0611 ; 0371-1854
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