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  1. Article ; Online: Monocyte HLA-DR Measurement by Flow Cytometry in COVID-19 Patients: An Interim Review.

    Benlyamani, Ihsane / Venet, Fabienne / Coudereau, Rémy / Gossez, Morgane / Monneret, Guillaume

    Cytometry. Part A : the journal of the International Society for Analytical Cytology

    2020  Volume 97, Issue 12, Page(s) 1217–1221

    Abstract: Several months after the sudden emergence of SARS-CoV-2 and COVID-19, the understanding of the appropriate host immune response to a virus totally unknown of human immune surveillance is still of major importance. By international definition, COVID-19 ... ...

    Abstract Several months after the sudden emergence of SARS-CoV-2 and COVID-19, the understanding of the appropriate host immune response to a virus totally unknown of human immune surveillance is still of major importance. By international definition, COVID-19 falls in the scope of septic syndromes (organ dysfunction due to dysregulated host response to an infection) in which immunosuppression is a significant driver of mortality. Sepsis-induced immunosuppression is mostly defined and monitored by the measurement of decreased expression of HLA-DR molecules on circulating monocytes (mHLA-DR). In this interim review, we summarize the first mHLA-DR results in COVID-19 patients. In critically ill patients, results homogenously indicate a decreased mHLA-DR expression, which, along with profound lymphopenia and other functional alterations, is indicative of a status of immunosuppression. © 2020 International Society for Advancement of Cytometry.
    MeSH term(s) COVID-19/immunology ; COVID-19/pathology ; COVID-19/virology ; Female ; Flow Cytometry ; HLA-DR Antigens/genetics ; HLA-DR Antigens/immunology ; Humans ; Immune Tolerance/genetics ; Male ; Monocytes/immunology ; SARS-CoV-2/pathogenicity
    Chemical Substances HLA-DR Antigens
    Keywords covid19
    Language English
    Publishing date 2020-11-04
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2099868-5
    ISSN 1552-4930 ; 0196-4763 ; 1552-4922
    ISSN (online) 1552-4930
    ISSN 0196-4763 ; 1552-4922
    DOI 10.1002/cyto.a.24249
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1688: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 68: Show issues

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  2. Article ; Online: COVID-19: What type of cytokine storm are we dealing with?

    Monneret, Guillaume / Benlyamani, Ihsane / Gossez, Morgane / Bermejo-Martin, Jesus F / Martín-Fernandez, Marta / Sesques, Pierre / Wallet, Florent / Venet, Fabienne

    Journal of medical virology

    2020  Volume 93, Issue 1, Page(s) 197–198

    MeSH term(s) Antibodies, Monoclonal, Humanized ; COVID-19/drug therapy ; Cytokine Release Syndrome ; Humans ; SARS-CoV-2
    Chemical Substances Antibodies, Monoclonal, Humanized ; tocilizumab (I031V2H011)
    Keywords covid19
    Language English
    Publishing date 2020-07-27
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 752392-0
    ISSN 1096-9071 ; 0146-6615
    ISSN (online) 1096-9071
    ISSN 0146-6615
    DOI 10.1002/jmv.26317
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    Zs.A 1320: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article: Monocyte HLA-DR Measurement by Flow Cytometry in COVID-19 Patients: An Interim Review

    Benlyamani, Ihsane / Venet, Fabienne / Coudereau, Rémy / Gossez, Morgane / Monneret, Guillaume

    Cytometry, Part A

    Abstract: Several months after the sudden emergence of SARS-CoV-2 and COVID-19, the understanding of the appropriate host immune response to a virus totally unknown of human immune surveillance is still of major importance. By international definition, COVID-19 ... ...

    Abstract Several months after the sudden emergence of SARS-CoV-2 and COVID-19, the understanding of the appropriate host immune response to a virus totally unknown of human immune surveillance is still of major importance. By international definition, COVID-19 falls in the scope of septic syndromes (organ dysfunction due to dysregulated host response to an infection) in which immunosuppression is a significant driver of mortality. Sepsis-induced immunosuppression is mostly defined and monitored by the measurement of decreased expression of HLA-DR molecules on circulating monocytes (mHLA-DR). In this interim review, we summarize the first mHLA-DR results in COVID-19 patients. In critically ill patients, results homogenously indicate a decreased mHLA-DR expression, which, along with profound lymphopenia and other functional alterations, is indicative of a status of immunosuppression. © 2020 International Society for Advancement of Cytometry.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #893217
    Database COVID19

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  4. Article ; Online: Human serum albumin nanoparticles as nanovector carriers for proteins: Application to the antibacterial proteins "neutrophil elastase" and "secretory leukocyte protease inhibitor".

    Tarhini, Mohamad / Pizzoccaro, Anne / Benlyamani, Ihsane / Rebaud, Chloé / Greige-Gerges, Hélène / Fessi, Hatem / Elaissari, Abdelhamid / Bentaher, Abderrazzak

    International journal of pharmaceutics

    2020  Volume 579, Page(s) 119150

    Abstract: The use of proteins and defined amino acid sequences as therapeutic drugs have gained a certain interest in the past decade. However, protein encapsulation within protein nanoparticles was never endeavored. For this reason, human serum albumin (HSA) ... ...

    Abstract The use of proteins and defined amino acid sequences as therapeutic drugs have gained a certain interest in the past decade. However, protein encapsulation within protein nanoparticles was never endeavored. For this reason, human serum albumin (HSA) nanoparticles were prepared by nanoprecipitation method. The process was optimized, and particles were obtained with a size of 120 nm and zeta potential of -25 mV. Neutrophil elastase (NE) and secretory leukocyte protease inhibitor (SLPI) were encapsulated separately within HSA nanoparticles. Gel electrophoresis and western blot studies demonstrate the successful encapsulation and the stability of the particles. On the other hand, enzymatic assays show that encapsulated NE lost its proteolytic activity, whereas encapsulated SLPI maintained its inhibitory property. In addition, the antibacterial studies showed that both formulations were able to drastically reduce bacterial growth of Pseudomonas aeruginosa. This work showed the possibility of using both NE and SLPI as anti-bacterial agents through encapsulation within HSA nanoparticles.
    MeSH term(s) Anti-Bacterial Agents/administration & dosage ; Anti-Bacterial Agents/chemistry ; Drug Carriers/chemistry ; Drug Compounding/methods ; Drug Stability ; Enzyme Assays ; Humans ; Leukocyte Elastase/administration & dosage ; Leukocyte Elastase/chemistry ; Microbial Sensitivity Tests ; Nanoparticles/chemistry ; Protein Stability ; Pseudomonas Infections/drug therapy ; Pseudomonas Infections/microbiology ; Pseudomonas aeruginosa/drug effects ; Pseudomonas aeruginosa/growth & development ; Recombinant Proteins/administration & dosage ; Recombinant Proteins/chemistry ; Secretory Leukocyte Peptidase Inhibitor/administration & dosage ; Secretory Leukocyte Peptidase Inhibitor/chemistry ; Serum Albumin, Human/chemistry
    Chemical Substances Anti-Bacterial Agents ; Drug Carriers ; Recombinant Proteins ; SLPI protein, human ; Secretory Leukocyte Peptidase Inhibitor ; ELANE protein, human (EC 3.4.21.37) ; Leukocyte Elastase (EC 3.4.21.37) ; Serum Albumin, Human (ZIF514RVZR)
    Language English
    Publishing date 2020-02-15
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 428962-6
    ISSN 1873-3476 ; 0378-5173
    ISSN (online) 1873-3476
    ISSN 0378-5173
    DOI 10.1016/j.ijpharm.2020.119150
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1409: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article: COVID-19: What type of cytokine storm are we dealing with?

    Monneret, Guillaume / Benlyamani, Ihsane / Gossez, Morgane / Bermejo-Martin, Jesus F / Martín-Fernandez, Marta / Sesques, Pierre / Wallet, Florent / Venet, Fabienne

    J. med. virol

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #651592
    Database COVID19

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  6. Article ; Online: COVID‐19

    Monneret, Guillaume / Benlyamani, Ihsane / Gossez, Morgane / Bermejo‐Martin, Jesus F / Martín‐Fernandez, Marta / Sesques, Pierre / Wallet, Florent / Venet, Fabienne

    Journal of Medical Virology ; ISSN 0146-6615 1096-9071

    What type of cytokine storm are we dealing with?

    2020  

    Keywords Virology ; Infectious Diseases ; covid19
    Language English
    Publisher Wiley
    Publishing country us
    Document type Article ; Online
    DOI 10.1002/jmv.26317
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  7. Article: Protein-Based Nanoparticle Preparation via Nanoprecipitation Method.

    Tarhini, Mohamad / Benlyamani, Ihsane / Hamdani, Selim / Agusti, Géraldine / Fessi, Hatem / Greige-Gerges, Hélène / Bentaher, Abderrazzak / Elaissari, Abdelhamid

    Materials (Basel, Switzerland)

    2018  Volume 11, Issue 3

    Abstract: Nanoparticles are nowadays largely investigated in the field of drug delivery. Among nanoparticles, protein-based particles are of paramount importance since they are natural, biodegradable, biocompatible, and nontoxic. There are several methods to ... ...

    Abstract Nanoparticles are nowadays largely investigated in the field of drug delivery. Among nanoparticles, protein-based particles are of paramount importance since they are natural, biodegradable, biocompatible, and nontoxic. There are several methods to prepare proteins containing nanoparticles, but only a few studies have been dedicated to the preparation of protein- based nanoparticles. Then, the aim of this work was to report on the preparation of bovine serum albumin (BSA)-based nanoparticles using a well-defined nanoprecipitation process. Special attention has been dedicated to a systematic study in order to understand separately the effect of each operating parameter of the method (such as protein concentration, solvent/non-solvent volume ratio, non-solvent injection rate, ionic strength of the buffer solution, pH, and cross-linking) on the colloidal properties of the obtained nanoparticles. In addition, the mixing processes (batch or drop-wise) were also investigated. Using a well-defined formulation, submicron protein-based nanoparticles have been obtained. All prepared particles have been characterized in terms of size, size distribution, morphology, and electrokinetic properties. In addition, the stability of nanoparticles was investigated using Ultraviolet (UV) scan and electrophoresis, and the optimal conditions for preparing BSA nanoparticles by the nanoprecipitation method were concluded.
    Language English
    Publishing date 2018-03-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2487261-1
    ISSN 1996-1944
    ISSN 1996-1944
    DOI 10.3390/ma11030394
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