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  1. Article ; Online: Microglial sex differences in innate high anxiety and modulatory effects of minocycline.

    Ugursu, Bilge / Sah, Anupam / Sartori, Simone / Popp, Oliver / Mertins, Philip / Dunay, Ildiko R / Kettenmann, Helmut / Singewald, Nicolas / Wolf, Susanne A

    Brain, behavior, and immunity

    2024  Volume 119, Page(s) 465–481

    Abstract: Microglia modulate synaptic refinement in the central nervous system (CNS). We have previously shown that a mouse model with innate high anxiety-related behavior (HAB) displays higher ... ...

    Abstract Microglia modulate synaptic refinement in the central nervous system (CNS). We have previously shown that a mouse model with innate high anxiety-related behavior (HAB) displays higher CD68
    Language English
    Publishing date 2024-03-27
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 639219-2
    ISSN 1090-2139 ; 0889-1591
    ISSN (online) 1090-2139
    ISSN 0889-1591
    DOI 10.1016/j.bbi.2024.03.035
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2276: Show issues Location:
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    Zs.MO 327: Show issues

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  2. Article ; Online: Toxoplasma gondii infection and its implications within the central nervous system.

    Matta, Sumit K / Rinkenberger, Nicholas / Dunay, Ildiko R / Sibley, L David

    Nature reviews. Microbiology

    2021  Volume 19, Issue 7, Page(s) 467–480

    Abstract: Toxoplasma gondii is a parasite that infects a wide range of animals and causes zoonotic infections in humans. Although it normally only results in mild illness in healthy individuals, toxoplasmosis is a common opportunistic infection with high mortality ...

    Abstract Toxoplasma gondii is a parasite that infects a wide range of animals and causes zoonotic infections in humans. Although it normally only results in mild illness in healthy individuals, toxoplasmosis is a common opportunistic infection with high mortality in individuals who are immunocompromised, most commonly due to reactivation of infection in the central nervous system. In the acute phase of infection, interferon-dependent immune responses control rapid parasite expansion and mitigate acute disease symptoms. However, after dissemination the parasite differentiates into semi-dormant cysts that form within muscle cells and neurons, where they persist for life in the infected host. Control of infection in the central nervous system, a compartment of immune privilege, relies on modified immune responses that aim to balance infection control while limiting potential damage due to inflammation. In response to the activation of interferon-mediated pathways, the parasite deploys an array of effector proteins to escape immune clearance and ensure latent survival. Although these pathways are best studied in the laboratory mouse, emerging evidence points to unique mechanisms of control in human toxoplasmosis. In this Review, we explore some of these recent findings that extend our understanding for proliferation, establishment and control of toxoplasmosis in humans.
    MeSH term(s) Animals ; Central Nervous System Infections/immunology ; Central Nervous System Infections/parasitology ; Central Nervous System Infections/pathology ; Chronic Disease ; Humans ; Interferons/immunology ; Toxoplasma/growth & development ; Toxoplasma/pathogenicity ; Toxoplasma/physiology ; Toxoplasmosis/drug therapy ; Toxoplasmosis/immunology ; Toxoplasmosis/parasitology ; Virulence
    Chemical Substances Interferons (9008-11-1)
    Language English
    Publishing date 2021-02-24
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 2139054-X
    ISSN 1740-1534 ; 1740-1526
    ISSN (online) 1740-1534
    ISSN 1740-1526
    DOI 10.1038/s41579-021-00518-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5865: Show issues Location:
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    Zs.MG 74: Show issues

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  3. Article ; Online: IFNAR signaling in fibroblastic reticular cells can modulate CD8

    Knop, Laura / Spanier, Julia / Larsen, Pia-Katharina / Witte, Amelie / Bank, Ute / Dunay, Ildiko R / Kalinke, Ulrich / Schüler, Thomas

    European journal of immunology

    2022  Volume 52, Issue 6, Page(s) 895–906

    Abstract: ... ...

    Abstract CD8
    MeSH term(s) Animals ; CD8-Positive T-Lymphocytes ; Cancer Vaccines ; Fibroblasts ; Mice ; Mice, Inbred C57BL ; Vaccines, Subunit ; Vesicular Stomatitis/metabolism ; Vesicular Stomatitis/pathology
    Chemical Substances Cancer Vaccines ; Vaccines, Subunit
    Language English
    Publishing date 2022-04-20
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 120108-6
    ISSN 1521-4141 ; 0014-2980
    ISSN (online) 1521-4141
    ISSN 0014-2980
    DOI 10.1002/eji.202149760
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    Zs.A 489: Show issues Location:
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    Zs.MG 85: Show issues

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  4. Article ; Online: Comprehensive Kinetic Survey of Intestinal, Extra-Intestinal and Systemic Sequelae of Murine Ileitis Following Peroral Low-Dose

    Heimesaat, Markus M / Dunay, Ildiko R / Bereswill, Stefan

    Frontiers in cellular and infection microbiology

    2019  Volume 9, Page(s) 98

    Abstract: We have recently shown that following peroral low- ... ...

    Abstract We have recently shown that following peroral low-dose
    MeSH term(s) Animal Structures/parasitology ; Animal Structures/pathology ; Animals ; Disease Models, Animal ; Dysbiosis ; Gastrointestinal Microbiome ; Histocytochemistry ; Ileitis/complications ; Ileitis/parasitology ; Ileitis/pathology ; Ileum/parasitology ; Ileum/pathology ; Intestinal Mucosa/parasitology ; Intestinal Mucosa/pathology ; Longitudinal Studies ; Mice, Inbred C57BL ; Parasitemia/parasitology ; Parasitemia/pathology ; Toxoplasma/growth & development ; Toxoplasmosis, Animal/parasitology ; Toxoplasmosis, Animal/pathology
    Language English
    Publishing date 2019-04-12
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2619676-1
    ISSN 2235-2988 ; 2235-2988
    ISSN (online) 2235-2988
    ISSN 2235-2988
    DOI 10.3389/fcimb.2019.00098
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Spatio-temporal dynamics of microglia phenotype in human and murine cSVD: impact of acute and chronic hypertensive states.

    Morton, Lorena / Arndt, Philipp / Garza, Alejandra P / Henneicke, Solveig / Mattern, Hendrik / Gonzalez, Marilyn / Dityatev, Alexander / Yilmazer-Hanke, Deniz / Schreiber, Stefanie / Dunay, Ildiko R

    Acta neuropathologica communications

    2023  Volume 11, Issue 1, Page(s) 204

    Abstract: Vascular risk factors such as chronic hypertension are well-established major modifiable factors for the development of cerebral small vessel disease (cSVD). In the present study, our focus was the investigation of cSVD-related phenotypic changes in ... ...

    Abstract Vascular risk factors such as chronic hypertension are well-established major modifiable factors for the development of cerebral small vessel disease (cSVD). In the present study, our focus was the investigation of cSVD-related phenotypic changes in microglia in human disease and in the spontaneously hypertensive stroke-prone rat (SHRSP) model of cSVD. Our examination of cortical microglia in human post-mortem cSVD cortical tissue revealed distinct morphological microglial features specific to cSVD. We identified enlarged somata, an increase in the territory occupied by thickened microglial processes, and an expansion in the number of vascular-associated microglia. In parallel, we characterized microglia in a rodent model of hypertensive cSVD along different durations of arterial hypertension, i.e., early chronic and late chronic hypertension. Microglial somata were already enlarged in early hypertension. In contrast, at late-stage chronic hypertension, they further exhibited elongated branches, thickened processes, and a reduced ramification index, mirroring the findings in human cSVD. An unbiased multidimensional flow cytometric analysis revealed phenotypic heterogeneity among microglia cells within the hippocampus and cortex. At early-stage hypertension, hippocampal microglia exhibited upregulated CD11b/c, P2Y12R, CD200R, and CD86 surface expression. Detailed analysis of cell subpopulations revealed a unique microglial subset expressing CD11b/c, CD163, and CD86 exclusively in early hypertension. Notably, even at early-stage hypertension, microglia displayed a higher association with cerebral blood vessels. We identified several profound clusters of microglia expressing distinct marker profiles at late chronic hypertensive states. In summary, our findings demonstrate a higher vulnerability of the hippocampus, stage-specific microglial signatures based on morphological features, and cell surface protein expression in response to chronic arterial hypertension. These results indicate the diversity within microglia sub-populations and implicate the subtle involvement of microglia in cSVD pathogenesis.
    MeSH term(s) Rats ; Humans ; Mice ; Animals ; Microglia/metabolism ; Hypertension/complications ; Hypertension/pathology ; Rats, Inbred SHR ; Cerebral Small Vessel Diseases/pathology ; Phenotype
    Language English
    Publishing date 2023-12-19
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2715589-4
    ISSN 2051-5960 ; 2051-5960
    ISSN (online) 2051-5960
    ISSN 2051-5960
    DOI 10.1186/s40478-023-01672-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Anti-inflammatory Effects of the Octapeptide NAP in Human Microbiota-Associated Mice Suffering from Subacute Ileitis.

    Escher, Ulrike / Giladi, Eliezer / Dunay, Ildikò R / Bereswill, Stefan / Gozes, Illana / Heimesaat, Markus M

    European journal of microbiology & immunology

    2018  Volume 8, Issue 2, Page(s) 34–40

    Abstract: The octapeptide NAP is well known for its neuroprotective properties. We here investigated whether NAP treatment could alleviate pro-inflammatory immune responses during experimental subacute ileitis. To address this, mice with a human gut microbiota ... ...

    Abstract The octapeptide NAP is well known for its neuroprotective properties. We here investigated whether NAP treatment could alleviate pro-inflammatory immune responses during experimental subacute ileitis. To address this, mice with a human gut microbiota were perorally infected with one cyst of
    Language English
    Publishing date 2018-05-23
    Publishing country Hungary
    Document type Journal Article
    ZDB-ID 2652327-9
    ISSN 2062-8633 ; 2062-509X
    ISSN (online) 2062-8633
    ISSN 2062-509X
    DOI 10.1556/1886.2018.00006
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  7. Article ; Online: Lymphotoxin β Receptor: a Crucial Role in Innate and Adaptive Immune Responses against Toxoplasma gondii.

    Tersteegen, Anne / Sorg, Ursula R / Virgen-Slane, Richard / Helle, Marcel / Petzsch, Patrick / Dunay, Ildiko R / Köhrer, Karl / Degrandi, Daniel / Ware, Carl F / Pfeffer, Klaus

    Infection and immunity

    2021  Volume 89, Issue 6

    Abstract: The lymphotoxin β receptor (LTβR) plays an essential role in the initiation of immune responses to intracellular pathogens. In mice, the LTβR is crucial for surviving acute toxoplasmosis; however, until now, a functional analysis was largely incomplete. ... ...

    Abstract The lymphotoxin β receptor (LTβR) plays an essential role in the initiation of immune responses to intracellular pathogens. In mice, the LTβR is crucial for surviving acute toxoplasmosis; however, until now, a functional analysis was largely incomplete. Here, we demonstrate that the LTβR is a key regulator required for the intricate balance of adaptive immune responses.
    MeSH term(s) Adaptive Immunity ; Animals ; Disease Models, Animal ; Host-Parasite Interactions/immunology ; Immunity, Innate ; Lymphotoxin beta Receptor/genetics ; Lymphotoxin beta Receptor/metabolism ; Mice ; Mice, Knockout ; Toxoplasma/immunology ; Toxoplasmosis/immunology ; Toxoplasmosis/metabolism ; Toxoplasmosis/parasitology
    Chemical Substances LTBR protein, human ; Lymphotoxin beta Receptor
    Language English
    Publishing date 2021-05-17
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 218698-6
    ISSN 1098-5522 ; 0019-9567
    ISSN (online) 1098-5522
    ISSN 0019-9567
    DOI 10.1128/IAI.00026-21
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 684: Show issues Location:
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  8. Article ; Online: Innate Lymphoid Cells in Protection, Pathology, and Adaptive Immunity During Apicomplexan Infection.

    Ivanova, Daria L / Denton, Stephen L / Fettel, Kevin D / Sondgeroth, Kerry S / Munoz Gutierrez, Juan / Bangoura, Berit / Dunay, Ildiko R / Gigley, Jason P

    Frontiers in immunology

    2019  Volume 10, Page(s) 196

    Abstract: Apicomplexans are a diverse and complex group of protozoan pathogens ... ...

    Abstract Apicomplexans are a diverse and complex group of protozoan pathogens including
    MeSH term(s) Adaptive Immunity ; Animals ; Apicomplexa/immunology ; Biomarkers ; Cell Plasticity/immunology ; Cytokines/metabolism ; Host-Parasite Interactions ; Humans ; Immunity, Innate ; Immunophenotyping ; Inflammation Mediators/metabolism ; Lymphocyte Subsets/immunology ; Lymphocyte Subsets/metabolism ; Plasmodium/immunology ; Protozoan Infections/immunology ; Protozoan Infections/parasitology
    Chemical Substances Biomarkers ; Cytokines ; Inflammation Mediators
    Language English
    Publishing date 2019-02-28
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2019.00196
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Microvascular damage, neuroinflammation and extracellular matrix remodeling in Col18a1 knockout mice as a model for early cerebral small vessel disease.

    Khoshneviszadeh, Mahsima / Henneicke, Solveig / Pirici, Daniel / Senthilnathan, Akilashree / Morton, Lorena / Arndt, Philipp / Kaushik, Rahul / Norman, Oula / Jukkola, Jari / Dunay, Ildiko Rita / Seidenbecher, Constanze / Heikkinen, Anne / Schreiber, Stefanie / Dityatev, Alexander

    Matrix biology : journal of the International Society for Matrix Biology

    2024  Volume 128, Page(s) 39–64

    Abstract: Collagen type XVIII (COL18) is an abundant heparan sulfate proteoglycan in vascular basement membranes. Here, we asked (i) if the loss of COL18 would result in blood-brain barrier (BBB) breakdown, pathological alterations of small arteries and ... ...

    Abstract Collagen type XVIII (COL18) is an abundant heparan sulfate proteoglycan in vascular basement membranes. Here, we asked (i) if the loss of COL18 would result in blood-brain barrier (BBB) breakdown, pathological alterations of small arteries and capillaries and neuroinflammation as found in cerebral small vessel disease (CSVD) and (ii) if such changes may be associated with remodeling of synapses and neural extracellular matrix (ECM). We found that 5-month-old Col18a1
    MeSH term(s) Animals ; Humans ; Infant ; Mice ; Cerebral Small Vessel Diseases/genetics ; Cerebral Small Vessel Diseases/metabolism ; Collagen Type XVIII/genetics ; Collagen Type XVIII/metabolism ; Endostatins ; Extracellular Matrix/metabolism ; Heparan Sulfate Proteoglycans/metabolism ; Mice, Knockout ; Neuroinflammatory Diseases
    Chemical Substances Collagen Type XVIII ; Endostatins ; Heparan Sulfate Proteoglycans ; COL18A1 protein, human
    Language English
    Publishing date 2024-02-21
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1183793-7
    ISSN 1569-1802 ; 0945-053X
    ISSN (online) 1569-1802
    ISSN 0945-053X
    DOI 10.1016/j.matbio.2024.02.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1694: Show issues Location:
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  10. Article ; Online: NK Cells Negatively Regulate CD8 T Cells to Promote Immune Exhaustion and Chronic

    Ivanova, Daria L / Krempels, Ryan / Denton, Stephen L / Fettel, Kevin D / Saltz, Giandor M / Rach, David / Fatima, Rida / Mundhenke, Tiffany / Materi, Joshua / Dunay, Ildiko R / Gigley, Jason P

    Frontiers in cellular and infection microbiology

    2020  Volume 10, Page(s) 313

    Abstract: NK cells regulate CD4+ and CD8+ T cells in acute viral infection, vaccination, and the tumor microenvironment. NK cells also become exhausted in chronic activation settings. The mechanisms causing these ILC responses and their impact on adaptive immunity ...

    Abstract NK cells regulate CD4+ and CD8+ T cells in acute viral infection, vaccination, and the tumor microenvironment. NK cells also become exhausted in chronic activation settings. The mechanisms causing these ILC responses and their impact on adaptive immunity are unclear. CD8+ T cell exhaustion develops during chronic
    MeSH term(s) Animals ; CD8-Positive T-Lymphocytes ; Killer Cells, Natural ; Mice ; Spleen ; Toxoplasma ; Toxoplasmosis
    Language English
    Publishing date 2020-07-08
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2619676-1
    ISSN 2235-2988 ; 2235-2988
    ISSN (online) 2235-2988
    ISSN 2235-2988
    DOI 10.3389/fcimb.2020.00313
    Database MEDical Literature Analysis and Retrieval System OnLINE

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