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Article: Comparison of the Efficacy and Safety of Left Atrial Appendage Closure and Direct Oral Anticoagulants for Atrial Fibrillation: A Meta-Analysis of Randomized Control Trials and Observational Studies.

Wei, Calvin R / Lim, Roy / Khan, Sara / Ahsan, Syed Ali / Al Omari, Mohammad / Sherpa, Nima D / Rashid, Zarwa / Khan, Areeba

Cureus

2023 Volume 15, Issue 12, Page(s) e49827

Abstract: The aim of this study was to compare the efficacy and safety of left atrial appendage closure (LAAC) and direct oral anticoagulants (DOACs) in patients with atrial fibrillation (AF). This meta-analysis was conducted as per the Preferred Reporting Items ... ...

Abstract	The aim of this study was to compare the efficacy and safety of left atrial appendage closure (LAAC) and direct oral anticoagulants (DOACs) in patients with atrial fibrillation (AF). This meta-analysis was conducted as per the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) 2020 guidelines. Two investigators performed an online database search on PubMed, Web of Science, and Scopus databases from inception to October 31, 2023, without any language or time restrictions. Outcomes assessed in this meta-analysis included all-cause mortality, cardiovascular mortality, stroke, and major bleeding events. Eight studies were included in this meta-analysis, enrolling 7,629 participants with AF (4,287 in the DOAC group and 3,342 in the LAAC group). The pooled analysis showed that the risk of all-cause mortality was significantly higher in patients in the DOAC group compared to LAAC (relative risk (RR): 1.87, 95% confidence interval (CI): 1.50 to 2.34). The risk of cardiovascular mortality was 1.60 times higher in patients receiving DOACs compared to those receiving LAAC (RR: 1.60, 95% CI: 1.12 to 2.28). The risk of stroke was not significantly different between the two groups (RR: 1.15, 95% CI: 0.95 to 1.41). In conclusion, LAAC for AF patients proves to be safe and effective for stroke prevention, exhibiting a superior profile in terms of all-cause mortality, cardiovascular events, and major bleeding compared to oral anticoagulation (OAC). These findings prompt consideration of LAAC as a preferred treatment for cardiovascular event prevention in high-bleeding-risk patients.
Language	English
Publishing date	2023-12-02
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.49827
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Article ; Online: Exploring the potential impact of group identity on post-traumatic growth in the aftermath of Corona outbreak: function of social-emotional competence as a mediator.

Ma, Jinfu / Khan, Ahsan Riaz / Zhang, Hai-Jun / Jun, Zhang / Abonazel, Mohamed R / Ahmad, Muhammad Salman / Tageldin, Elsayed M / Alzahran, Ali Rashash R

Frontiers in public health

2023 Volume 11, Page(s) 1282462

Abstract: Background: This research endeavors to examine the potential effects of human and societal interactions on individuals' post-traumatic growth in the aftermath of the Corona outbreak. To achieve the aforementioned objective, the current research ... ...

Abstract	Background: This research endeavors to examine the potential effects of human and societal interactions on individuals' post-traumatic growth in the aftermath of the Corona outbreak. To achieve the aforementioned objective, the current research investigates the correlations between post-traumatic growth and group identity, while also examining the potential mediating function of social-emotional competence. Methods: A cross-sectional design included a representative sample of 2,637 high school students located in the capital territory of Pakistan using convenience sampling method. To explore the associations, correlation and mediation analyzes utilizing the group identification scale, the social-emotional competence scale, and the post-traumatic growth scale was performed with SPSS PROCESS 4 macro and AMOS. Results: The findings demonstrated that group identification emerged as a substantial predictor substantially associated with post-traumatic growth. Moreover, the relationship linking group identification and post-traumatic growth was found to be partially moderated by social-emotional competence. Conclusion: The phenomenon of group identification can exert influence on post-traumatic growth through both direct and mediating pathways, with the latter being essentially mediated by social-emotional competence. The aforementioned outcomes possess significant academic and practical implications concerning the promotion of post-traumatic growth and the improvement of psychological well-being after the Corona outbreak.
MeSH term(s)	Humans ; Posttraumatic Growth, Psychological ; Cross-Sectional Studies ; Emotions ; Pakistan/epidemiology
Language	English
Publishing date	2023-10-12
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2711781-9
ISSN	2296-2565 ; 2296-2565
ISSN (online)	2296-2565
ISSN	2296-2565
DOI	10.3389/fpubh.2023.1282462
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Article: Lung ultrasound in early SARS-CoV-2 pneumonia and the LUS-CoV criteria

Jalil, Bilal A. / Khan, Ahsan Kugasia Irfanali R. / Ijaz, Mohsin

Baylor University Medical Center Proceedings

Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #900189
Database	COVID19

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Article ; Online: Time Spent by Intensive Care Unit Nurses on the Electronic Health Record.

Khan, Ahsan R / Rosenthal, Courtney D / Ternes, Kelly / Sing, Ronald F / Sachdev, Gaurav

Critical care nurse

2022 Volume 42, Issue 5, Page(s) 44–50

Abstract: Background: The amount of time spent on the electronic health record is often cited as a contributing factor to burnout and work-related stress in nurses. Increased electronic health record use also reduces the time nurses have for direct contact with ... ...

Abstract	Background: The amount of time spent on the electronic health record is often cited as a contributing factor to burnout and work-related stress in nurses. Increased electronic health record use also reduces the time nurses have for direct contact with patients and families. There has been minimal investigation into the amount of time intensive care unit nurses spend on the electronic health record. Objective: To quantify the amount of time spent by intensive care unit nurses on the electronic health record. Methods: In this observational study, active electronic health record use time was analyzed for 317 intensive care unit nurses in a single institution from January 2019 through July 2020. Monthly data on electronic health record use by nurses in the medical, neurosurgical, and surgical-trauma intensive care units were evaluated. Results: Full-time intensive care unit nurses spent 28.9 hours per month on the electronic health record, about 17.5% of their clinical shift, for a total of 346.3 hours per year. Part-time nurses and those working as needed spent 20.5 hours per month (17.6%) and 7.4 hours per month (14.2%) on the electronic health record, respectively. Neurosurgical and medical intensive care unit nurses spent 25.0 hours and 19.9 hours per month, respectively. Nurses averaged 23 clicks per minute during use. Most time was spent on the task of documentation at 12.3 hours per month, which was followed by medical record review at 2.6 hours per month. Conclusion: Intensive care unit nurses spend at least 17% of their shift on the electronic health record, primarily on documentation. Future interventions are necessary to reduce time spent on the electronic health record and to improve nurse and patient satisfaction.
MeSH term(s)	Documentation ; Electronic Health Records ; Humans ; Intensive Care Units ; Time Factors
Language	English
Publishing date	2022-09-27
Publishing country	United States
Document type	Journal Article ; Observational Study
ZDB-ID	632663-8
ISSN	1940-8250 ; 0279-5442
ISSN (online)	1940-8250
ISSN	0279-5442
DOI	10.4037/ccn2022518
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Article ; Online: The Administrative Burden on Palliative Academic Physicians.

Khan, Rida / Tang, Michael / Azhar, Ahsan / Bruera, Eduardo

Journal of pain and symptom management

2024 Volume 67, Issue 5, Page(s) e399–e402

Abstract: Context: Burnout is frequently a workload-related syndrome among palliative care physicians. Mandatory administrative activities contribute to this workload. The purpose of this study was to measure the amount of time involved in multiple required ... ...

Abstract	Context: Burnout is frequently a workload-related syndrome among palliative care physicians. Mandatory administrative activities contribute to this workload. The purpose of this study was to measure the amount of time involved in multiple required administrative activities and the cost of this on academic healthcare facilities. Methods: We measured all mandatory and non-mandatory activities that need to be completed by faculty and reviewed them with all Department of Palliative, Rehabilitation, and Integrative Medicine members for accuracy. Results: Every faculty member spends annually an approximate average of 5300 minutes on administrative activities (approximately the equivalent of 29 consults plus 133 follow-ups). Using the department net average per encounter, the approximate value of these encounters is $36,936 for each faculty member (about 11 clinical days). Conclusion: Academic palliative care physicians are required to complete a number of administrative activities. Institutions do not keep a registry of these activities and do not accommodate for them with a reduction in the annual clinical productivity requirements. We recommend that regulatory agencies and institutions work together to better regulate this list of tasks and their frequency.
MeSH term(s)	Humans ; Physicians ; Workload ; Faculty ; Burnout, Professional/epidemiology
Language	English
Publishing date	2024-02-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	639142-4
ISSN	1873-6513 ; 0885-3924
ISSN (online)	1873-6513
ISSN	0885-3924
DOI	10.1016/j.jpainsymman.2024.01.035
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Article ; Online: A phase II study of ibrutinib in combination with ixazomib in patients with Waldenström macroglobulinaemia.

Parrondo, Ricardo D / Dutta, Navnita / LaPlant, Betsy R / Elliott, Jamie / Fernandez, Andre / Zimmerman, Ashley / Cicco, Gina / Han, Bing / Heslop, Keisha / Chapin, Dustin / Sher, Taimur / Roy, Vivek / Rasheed, Ahsan / Das, Saurav / Chanan-Khan, Asher A / Paulus, Aneel / Ailawadhi, Sikander

British journal of haematology

2024

Abstract: This phase II study evaluated time-limited (24 cycles) treatment with ibrutinib and ixazomib in newly diagnosed (NDWM; n = 9) and relapsed/refractory (RRWM; n = 12) Waldenström macroglobulinaemia (WM). The overall response rate (ORR) was 76.2% (n = 16) ... ...

Abstract	This phase II study evaluated time-limited (24 cycles) treatment with ibrutinib and ixazomib in newly diagnosed (NDWM; n = 9) and relapsed/refractory (RRWM; n = 12) Waldenström macroglobulinaemia (WM). The overall response rate (ORR) was 76.2% (n = 16) in 21 evaluable patients with no patient achieving a complete response (CR). The median duration of treatment was 15.6 months, and after a median follow-up time of 25.7 months, the median progression-free survival (PFS) was 22.9 months. While the primary end-point was not met (CR rate at any time) and 28.5% discontinued treatment due to toxicity, ibrutinib plus ixazomib led to a clinically meaningful ORR and PFS. Combined Bruton's tyrosine kinase (BTK) and proteasome inhibition merits further evaluation in WM.
Language	English
Publishing date	2024-01-29
Publishing country	England
Document type	Journal Article
ZDB-ID	80077-6
ISSN	1365-2141 ; 0007-1048
ISSN (online)	1365-2141
ISSN	0007-1048
DOI	10.1111/bjh.19320
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Article ; Online: Synthesis of novel coumarin-hydrazone hybrids as α-glucosidase inhibitors and their molecular docking studies.

Tariq, Hafiza Zara / Saeed, Aamer / Ullah, Saeed / Fatima, Noor / Halim, Sobia Ahsan / Khan, Ajmal / El-Seedi, Hesham R / Ashraf, Muhammad Zaman / Latif, Muhammad / Al-Harrasi, Ahmed

RSC advances

2023 Volume 13, Issue 37, Page(s) 26229–26238

Abstract: Diabetes mellitus is a metabolic disorder and more than 90% of diabetic patients suffer from type-2 diabetes, which is characterized by hyperglycemia. α-Glucosidase inhibition has become an appropriate approach to tackle high blood glucose levels. The ... ...

Abstract	Diabetes mellitus is a metabolic disorder and more than 90% of diabetic patients suffer from type-2 diabetes, which is characterized by hyperglycemia. α-Glucosidase inhibition has become an appropriate approach to tackle high blood glucose levels. The current study was focused on synthesizing coumarin-hydrazone hybrids (7a-i) by using facile chemical reactions. The synthesized compounds were characterized by using
Language	English
Publishing date	2023-09-04
Publishing country	England
Document type	Journal Article
ISSN	2046-2069
ISSN (online)	2046-2069
DOI	10.1039/d3ra03953f
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Article ; Online: The role of kisspeptin in the pathogenesis of a polycystic ovary syndrome.

Aasif, Adiba / Alam, Roshan / Ahsan, Haseeb / Khan, Mohammad Mustufa / Khan, Arshiya / Khan, Saba

Endocrine regulations

2023 Volume 57, Issue 1, Page(s) 292–303

Abstract: Hypothalamic-pituitary gonadal (HPG) axis is responsible for the development and regulation of the female reproductive system. In polycystic ovary syndrome (PCOS), there is a disturbance in the HPG axis. Kisspeptin, a neuropeptide produced by the KISS1 ... ...

Abstract	Hypothalamic-pituitary gonadal (HPG) axis is responsible for the development and regulation of the female reproductive system. In polycystic ovary syndrome (PCOS), there is a disturbance in the HPG axis. Kisspeptin, a neuropeptide produced by the KISS1 gene, plays a vital role in the regulation of HPG axis by binding with its receptors KISS1R/GPR54, and stimulates gonadotropin secretion from the hypothalamus into pituitary to release luteinizing hormone (LH) and follicle stimulating hormone (FSH). Polymorphisms or mutations in the KISS1 gene can cause disturbance in the kisspeptin signaling pathway and is thought to disrupt HPG axis. Altered signaling of kisspeptin can cause abnormal secretion of GnRH pulse, which leads to increased LH/FSH ratio, thereby affecting androgen levels and ovulation. The increased levels of androgen worsen the symptoms of PCOS. In the present article, we review the molecular physiology and pathology of kisspeptin and how it is responsible for the development of PCOS. The goal of this review article is to provide an overview and metabolic profile of kisspeptin in PCOS patients and the expression of kisspeptin in PCOS animal models. In the present article, we also review the molecular physiology and pathology of kisspeptin and how it is responsible for the development of PCOS.
MeSH term(s)	Animals ; Female ; Humans ; Polycystic Ovary Syndrome/genetics ; Polycystic Ovary Syndrome/metabolism ; Kisspeptins/genetics ; Kisspeptins/metabolism ; Androgens ; Luteinizing Hormone ; Follicle Stimulating Hormone
Chemical Substances	Kisspeptins ; Androgens ; Luteinizing Hormone (9002-67-9) ; Follicle Stimulating Hormone (9002-68-0)
Language	English
Publishing date	2023-12-21
Publishing country	Germany
Document type	Review ; Journal Article
ZDB-ID	1082213-6
ISSN	1336-0329 ; 0013-7200 ; 1210-0668
ISSN (online)	1336-0329
ISSN	0013-7200 ; 1210-0668
DOI	10.2478/enr-2023-0032
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Article ; Online: Synthesis of new phenoxymethylcoumarin clubbed 4-arylthiazolylhydrazines as α-glucosidase inhibitors and their kinetics and molecular docking studies.

Ul Ain, Qurat / Saeed, Aamer / Khan, Ajmal / Ahmed, Atteeque / Ullah, Saeed / Ahsan Halim, Sobia / Irfan, Madiha / Tehzeeb, Arfa / El-Seedi, Hesham R / Bin Muhsinah, Abdullatif / Al-Harrasi, Ahmed

Bioorganic chemistry

2022 Volume 131, Page(s) 106302

Abstract: The current studies mainly demonstrate the coumarin based azomethine-clubbed thiazoles synthesis and their in-vitro evaluation for the first time against α-glucosidase. Due to the catalytic role of α-glucosidase, it has become a precise target for the ... ...

Abstract	The current studies mainly demonstrate the coumarin based azomethine-clubbed thiazoles synthesis and their in-vitro evaluation for the first time against α-glucosidase. Due to the catalytic role of α-glucosidase, it has become a precise target for the treatment of type diabetes mellitus (T2DM). The high rate of prevalence of diabetes and its associated health related problems led us to scrutinize the anti-diabetic capability of the synthesized thiazole derivatives (6a-6k). The anticipated structures of prepared compounds were confirmed through FT-IR and NMR spectroscopic methods. All the compounds showed several times potent activity than the standard drug, acarbose (IC
MeSH term(s)	Humans ; Glycoside Hydrolase Inhibitors/chemistry ; Molecular Docking Simulation ; Molecular Structure ; Diabetes Mellitus, Type 2/drug therapy ; alpha-Glucosidases/metabolism ; Spectroscopy, Fourier Transform Infrared ; Structure-Activity Relationship ; Kinetics ; Thiazoles/chemistry
Chemical Substances	Glycoside Hydrolase Inhibitors ; azomethine ; alpha-Glucosidases (EC 3.2.1.20) ; Thiazoles
Language	English
Publishing date	2022-11-28
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	120080-x
ISSN	1090-2120 ; 0045-2068
ISSN (online)	1090-2120
ISSN	0045-2068
DOI	10.1016/j.bioorg.2022.106302
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Zs.A 4207: Show issues

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Article ; Online: PRKAA2, MTOR, and TFEB in the regulation of lysosomal damage response and autophagy.

Shariq, Mohd / Khan, Mohammad Firoz / Raj, Reshmi / Ahsan, Nuzhat / Kumar, Pramod

Journal of molecular medicine (Berlin, Germany)

2024 Volume 102, Issue 3, Page(s) 287–311

Abstract: Lysosomes function as critical signaling hubs that govern essential enzyme complexes. LGALS proteins (LGALS3, LGALS8, and LGALS9) are integral to the endomembrane damage response. If ESCRT fails to rectify damage, LGALS-mediated ubiquitination occurs, ... ...

Abstract	Lysosomes function as critical signaling hubs that govern essential enzyme complexes. LGALS proteins (LGALS3, LGALS8, and LGALS9) are integral to the endomembrane damage response. If ESCRT fails to rectify damage, LGALS-mediated ubiquitination occurs, recruiting autophagy receptors (CALCOCO2, TRIM16, and SQSTM1) and VCP/p97 complex containing UBXN6, PLAA, and YOD1, initiating selective autophagy. Lysosome replenishment through biogenesis is regulated by TFEB. LGALS3 interacts with TFRC and TRIM16, aiding ESCRT-mediated repair and autophagy-mediated removal of damaged lysosomes. LGALS8 inhibits MTOR and activates TFEB for ATG and lysosomal gene transcription. LGALS9 inhibits USP9X, activates PRKAA2, MAP3K7, ubiquitination, and autophagy. Conjugation of ATG8 to single membranes (CASM) initiates damage repair mediated by ATP6V1A, ATG16L1, ATG12, ATG5, ATG3, and TECPR1. ATG8ylation or CASM activates the MERIT system (ESCRT-mediated repair, autophagy-mediated clearance, MCOLN1 activation, Ca2
MeSH term(s)	Galectin 3/metabolism ; DNA Helicases ; Poly-ADP-Ribose Binding Proteins/metabolism ; RNA Helicases/metabolism ; RNA Recognition Motif Proteins/metabolism ; Autophagy/genetics ; TOR Serine-Threonine Kinases/metabolism ; Lysosomes/metabolism ; GTP Phosphohydrolases/metabolism ; Endosomal Sorting Complexes Required for Transport/metabolism ; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors/metabolism
Chemical Substances	Galectin 3 ; DNA Helicases (EC 3.6.4.-) ; Poly-ADP-Ribose Binding Proteins ; RNA Helicases (EC 3.6.4.13) ; RNA Recognition Motif Proteins ; TOR Serine-Threonine Kinases (EC 2.7.11.1) ; GTP Phosphohydrolases (EC 3.6.1.-) ; Endosomal Sorting Complexes Required for Transport ; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
Language	English
Publishing date	2024-01-06
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	1223802-8
ISSN	1432-1440 ; 0946-2716
ISSN (online)	1432-1440
ISSN	0946-2716
DOI	10.1007/s00109-023-02411-7
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