Article: Montelukast is a dual-purpose inhibitor of SARS-CoV-2 infection and virus-induced IL-6 expression identified by structure-based drug repurposing.
Computational and structural biotechnology journal
2022 Volume 20, Page(s) 799–811
Abstract: Drug-repurposing has been instrumental to identify drugs preventing SARS-CoV-2 replication or attenuating the disease course of COVID-19. Here, we identify through structure-based drug-repurposing a dual-purpose inhibitor of SARS-CoV-2 infection and of ... ...
Abstract | Drug-repurposing has been instrumental to identify drugs preventing SARS-CoV-2 replication or attenuating the disease course of COVID-19. Here, we identify through structure-based drug-repurposing a dual-purpose inhibitor of SARS-CoV-2 infection and of IL-6 production by immune cells. We created a computational structure model of the receptor binding domain (RBD) of the SARS-CoV-2 spike 1 protein, and used this model for |
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Language | English |
Publishing date | 2022-01-29 |
Publishing country | Netherlands |
Document type | Journal Article |
ZDB-ID | 2694435-2 |
ISSN | 2001-0370 |
ISSN | 2001-0370 |
DOI | 10.1016/j.csbj.2022.01.024 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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