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  1. Article ; Online: Morbidity and Mortality From COVID-19 Are Not Increased Among Children or Patients With Autoimmune Rheumatic Disease-Possible Immunologic Rationale: Comment on the Article by Henderson et al.

    Ferraccioli, Edoardo Sean / Gremese, Elisa / Ferraccioli, Gianfranco

    Arthritis & rheumatology (Hoboken, N.J.)

    2020  Volume 72, Issue 10, Page(s) 1772–1774

    MeSH term(s) COVID-19 ; Child ; Cytokine Release Syndrome ; Humans ; Morbidity ; Pandemics ; Rheumatic Diseases/epidemiology ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-09-06
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2756371-6
    ISSN 2326-5205 ; 2326-5191
    ISSN (online) 2326-5205
    ISSN 2326-5191
    DOI 10.1002/art.41399
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    Zs.A 24: Show issues Location:
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  2. Article ; Online: Comprehensive review on intravertebral intraspinal, intrajoint, and intradiscal vacuum phenomenon: From anatomy and physiology to pathology.

    Cianci, Francesco / Ferraccioli, Gianfranco / Ferraccioli, Edoardo Sean / Gremese, Elisa

    Modern rheumatology

    2020  Volume 31, Issue 2, Page(s) 303–311

    Abstract: The term 'vacuum phenomenon' (VP), is characterized by gas-like density areas due to a rapid increase in the joint space volume ('acute VP') or represent a chronic gas collection. It can occur within a collapsed vertebral body, the spinal canal, joints ... ...

    Abstract The term 'vacuum phenomenon' (VP), is characterized by gas-like density areas due to a rapid increase in the joint space volume ('acute VP') or represent a chronic gas collection. It can occur within a collapsed vertebral body, the spinal canal, joints but mainly the intervertebral disc. Studies support that VP is originated by a dynamic process involving the balance between tissues' liquid and gaseous components, influenced by the duration and the depth of mechanical and metabolic alterations, by the nature of neighboring tissues and the variability in both pressure and permeability of disc or vertebral or joint structures. Prevalence of VP in the general population is about 2%, reaching 20% in the elderly with disc degeneration. Although it's often a random finding in asymptomatic patients, VP is an eventually painful expression of disc degeneration, or disc or vertebral fracture, or bone lesions. In sporadic cases, intradiscal gas can be expelled (all-in-one or gradually), resulting in a gaseous cyst, causing pain and neurological symptoms. Considering that spontaneous resolution and recurrence after surgery are both possible, most of the authors recommend conservative treatment in patients with intradiscal and intravertebral VP; occasionally percutaneous CT(computed tomography) -guided aspiration or vertebral stabilization.
    MeSH term(s) Cysts/diagnostic imaging ; Cysts/epidemiology ; Cysts/pathology ; Gases ; Humans ; Intervertebral Disc/anatomy & histology ; Intervertebral Disc/pathology ; Intervertebral Disc/physiology ; Intervertebral Disc Degeneration/diagnostic imaging ; Intervertebral Disc Degeneration/epidemiology ; Intervertebral Disc Degeneration/pathology ; Vacuum
    Chemical Substances Gases
    Language English
    Publishing date 2020-05-22
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2078157-X
    ISSN 1439-7609 ; 1439-7595
    ISSN (online) 1439-7609
    ISSN 1439-7595
    DOI 10.1080/14397595.2020.1764744
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 2982: Show issues Location:
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  3. Article ; Online: Checkpoint inhibitors (CPI) and autoimmune chronic inflammatory diseases (ACIDs): tolerance and loss of tolerance in the occurrence of immuno-rheumatologic manifestations.

    Gremese, Elisa / Alivernini, Stefano / Ferraccioli, Edoardo Sean / Ferraccioli, Gianfranco

    Clinical immunology (Orlando, Fla.)

    2020  Volume 214, Page(s) 108395

    Abstract: Immune related adverse events (irAEs) have been observed with all checkpoint inhibitors and are very frequent. The evidences coming from experimental models of congenital or acquired deficiency of CTLA-4 or from PD-1 knock-out mice, provided all the ... ...

    Abstract Immune related adverse events (irAEs) have been observed with all checkpoint inhibitors and are very frequent. The evidences coming from experimental models of congenital or acquired deficiency of CTLA-4 or from PD-1 knock-out mice, provided all the informations to interpret the organ or systemic manifestations (endocrine, or systemic autoimmune chronic inflammatory diseases-ACIDs) observed in trials as well as in registries of cohorts treated with anti-CTLA-4 or anti-PD-1/PD-L1 inhibitors, or combination therapies. Finally the concern raised by cancers occurring in patients with autoimmune diseases (Systemic Lupus Erythematosus, Myositis, Rheumatoid Arthritis, Psoriatic Arthritis, Vasculitis, Scleroderma, Polymyalgia Rheumatica and others) and how to deal with immunotherapy was discussed. The biological knowledges acquired with the immunotherapy trials, have paved to way to better treat autoimmune diseases in patients developing cancer during the autoimmune illness. Immunotherapy without Autoimmunity is the unmet need within our reach in the future.
    MeSH term(s) Abatacept/adverse effects ; Abatacept/pharmacology ; Abatacept/therapeutic use ; Animals ; Antineoplastic Agents, Immunological/adverse effects ; Antineoplastic Agents, Immunological/pharmacology ; Antineoplastic Agents, Immunological/therapeutic use ; Arthritis, Experimental/immunology ; Arthritis, Psoriatic/immunology ; Arthritis, Psoriatic/therapy ; Autoimmune Diseases/chemically induced ; Autoimmune Diseases/complications ; Autoimmune Diseases/immunology ; B-Lymphocyte Subsets/drug effects ; B-Lymphocyte Subsets/immunology ; B7-H1 Antigen/antagonists & inhibitors ; CTLA-4 Antigen/antagonists & inhibitors ; Clone Cells/immunology ; Disease Models, Animal ; Humans ; Inflammation ; Lupus Erythematosus, Systemic/immunology ; Mice ; Neoplasms/complications ; Neoplasms/immunology ; Neoplasms/therapy ; Programmed Cell Death 1 Receptor/antagonists & inhibitors ; Rheumatic Diseases/chemically induced ; Rheumatic Diseases/complications ; Self Tolerance/drug effects ; T-Lymphocyte Subsets/drug effects ; T-Lymphocyte Subsets/immunology ; Tumor Suppressor Proteins/physiology
    Chemical Substances Antineoplastic Agents, Immunological ; B7-H1 Antigen ; CD274 protein, human ; CTLA-4 Antigen ; CTLA4 protein, human ; PDCD1 protein, human ; Programmed Cell Death 1 Receptor ; Tumor Suppressor Proteins ; Abatacept (7D0YB67S97)
    Language English
    Publishing date 2020-03-30
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1459903-x
    ISSN 1521-7035 ; 1521-6616
    ISSN (online) 1521-7035
    ISSN 1521-6616
    DOI 10.1016/j.clim.2020.108395
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 880: Show issues Location:
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  4. Article: Morbidity and mortality from COVID-19 are not increased among children or patients with autoimmune rheumatic disease-possible immunologic rationale: comment on the article by Henderson et al

    Ferraccioli, Edoardo Sean / Gremese, Elisa / Ferraccioli, Gianfranco

    Arthritis rheumatol. (Malden. Online)

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #601978
    Database COVID19

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  5. Article ; Online: Morbidity and Mortality From COVID‐19 Are Not Increased Among Children or Patients With Autoimmune Rheumatic Disease—Possible Immunologic Rationale

    Ferraccioli, Edoardo Sean / Gremese, Elisa / Ferraccioli, Gianfranco

    Arthritis & Rheumatology

    Comment on the Article by Henderson et al

    2020  Volume 72, Issue 10, Page(s) 1772–1774

    Keywords covid19
    Language English
    Publisher Wiley
    Publishing country us
    Document type Article ; Online
    ZDB-ID 127294-9
    ISSN 1529-0131 ; 0004-3591 ; 2326-5191
    ISSN (online) 1529-0131
    ISSN 0004-3591 ; 2326-5191
    DOI 10.1002/art.41399
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    Zs.A 24: Show issues Location:
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    Zs.MO 523: Show issues

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  6. Article ; Online: Basic immunology may lead to translational therapeutic rationale: SARS-CoV-2 and rheumatic diseases.

    Gremese, Elisa / Ferraccioli, Edoardo Sean / Alivernini, Stefano / Tolusso, Barbara / Ferraccioli, Gianfranco

    European journal of clinical investigation

    2020  Volume 50, Issue 9, Page(s) e13342

    Abstract: COVID-19 pandemia is a major concern for patients and healthcare systems. The fear of infection by patients with concomitant rheumatic diseases (either adult or children) and connective tissue diseases is arising worldwide, because of their immunological ...

    Abstract COVID-19 pandemia is a major concern for patients and healthcare systems. The fear of infection by patients with concomitant rheumatic diseases (either adult or children) and connective tissue diseases is arising worldwide, because of their immunological background and immunological therapies. Analysing the basic biology of single diseases, the data suggest that there is an "immunological umbrella" that seems to protect against the infection, through IFN type 1 and NK cell function. To date, reports from China, United States and Europe did not reveal an higher risk of infection, either for rheumatoid arthritis, juvenile idiopathic arthritis nor for lupus erythematosus. Antimalarials, anti-IL6-Anti-IL6 receptor, anti-IL1, anti-GM-CSF receptor and JAK1/2/3 inhibitors, are under investigation in COVID-dedicated clinical trials to control the inflammation raised by SARS-CoV-2 infection. Initial reports on the occurrence of autoimmune phenomena in the convalescence phase of SARS-CoV-2 infection suggests that the immunological consequences of the infection need to be strictly understood. Reporting of the study conforms to broad EQUATOR guidelines (Simera et al January 2010 issue of EJCI).
    MeSH term(s) Adaptive Immunity/drug effects ; Adaptive Immunity/immunology ; Aged ; Antirheumatic Agents/administration & dosage ; Comorbidity ; Coronavirus Infections/drug therapy ; Coronavirus Infections/epidemiology ; Coronavirus Infections/immunology ; Disease Outbreaks/statistics & numerical data ; Female ; Humans ; Hydroxychloroquine/administration & dosage ; Immunity, Innate/drug effects ; Immunity, Innate/immunology ; Immunologic Factors/administration & dosage ; Immunosuppressive Agents/administration & dosage ; Italy/epidemiology ; Male ; Middle Aged ; Pandemics ; Pneumonia, Viral/drug therapy ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/immunology ; Rheumatic Diseases/drug therapy ; Rheumatic Diseases/epidemiology ; Rheumatic Diseases/immunology ; Risk Assessment ; Severe Acute Respiratory Syndrome/drug therapy ; Severe Acute Respiratory Syndrome/epidemiology ; Severe Acute Respiratory Syndrome/immunology
    Chemical Substances Antirheumatic Agents ; Immunologic Factors ; Immunosuppressive Agents ; Hydroxychloroquine (4QWG6N8QKH)
    Keywords covid19
    Language English
    Publishing date 2020-07-29
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 186196-7
    ISSN 1365-2362 ; 0014-2972 ; 0960-135X
    ISSN (online) 1365-2362
    ISSN 0014-2972 ; 0960-135X
    DOI 10.1111/eci.13342
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    Zs.A 677: Show issues Location:
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  7. Article ; Online: Antimalarial use and arrhythmias in COVID-19 and rheumatic patients: a matter of dose and inflammation?

    Erre, Gian Luca / Ferraccioli, Edoardo Sean / Piga, Matteo / Mangoni, Arduino / Passiu, Giuseppe / Gremese, Elisa / Ferraccioli, Gianfranco

    Annals of the rheumatic diseases

    2020  Volume 80, Issue 3, Page(s) e29

    MeSH term(s) Antimalarials/therapeutic use ; Antirheumatic Agents/therapeutic use ; Arrhythmias, Cardiac/chemically induced ; COVID-19 ; Humans ; Hydroxychloroquine/therapeutic use ; Inflammation/drug therapy ; Rheumatic Diseases/complications ; Rheumatic Diseases/drug therapy
    Chemical Substances Antimalarials ; Antirheumatic Agents ; Hydroxychloroquine (4QWG6N8QKH)
    Keywords covid19
    Language English
    Publishing date 2020-05-18
    Publishing country England
    Document type Letter ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 7090-7
    ISSN 1468-2060 ; 0003-4967
    ISSN (online) 1468-2060
    ISSN 0003-4967
    DOI 10.1136/annrheumdis-2020-217828
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Basic immunology may lead to translational therapeutic rationale

    Gremese, Elisa / Ferraccioli, Edoardo Sean / Alivernini, Stefano / Tolusso, Barbara / Ferraccioli, Gianfranco

    European Journal of Clinical Investigation

    SARS‐CoV‐2 and rheumatic diseases

    2020  Volume 50, Issue 9

    Keywords Clinical Biochemistry ; Biochemistry ; General Medicine ; covid19
    Language English
    Publisher Wiley
    Publishing country us
    Document type Article ; Online
    ZDB-ID 186196-7
    ISSN 1365-2362 ; 0014-2972 ; 0960-135X
    ISSN (online) 1365-2362
    ISSN 0014-2972 ; 0960-135X
    DOI 10.1111/eci.13342
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    In stock of ZB MED Cologne/Königswinter

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  9. Article: Basic immunology may lead to translational therapeutic rationale: SARS-CoV-2 and rheumatic diseases

    Gremese, Elisa / Ferraccioli, Edoardo Sean / Alivernini, Stefano / Tolusso, Barbara / Ferraccioli, Gianfranco

    Eur J Clin Invest

    Abstract: COVID-19 pandemia is a major concern for patients and healthcare systems. The fear of infection by patients with concomitant rheumatic diseases (either adult or children) and connective tissue diseases is arising worldwide, because of their immunological ...

    Abstract COVID-19 pandemia is a major concern for patients and healthcare systems. The fear of infection by patients with concomitant rheumatic diseases (either adult or children) and connective tissue diseases is arising worldwide, because of their immunological background and immunological therapies. Analysing the basic biology of single diseases, the data suggest that there is an "immunological umbrella" that seems to protect against the infection, through IFN type 1 and NK cell function. To date, reports from China, United States and Europe did not reveal an higher risk of infection, either for rheumatoid arthritis, juvenile idiopathic arthritis nor for lupus erythematosus. Antimalarials, anti-IL6-Anti-IL6 receptor, anti-IL1, anti-GM-CSF receptor and JAK1/2/3 inhibitors, are under investigation in COVID-dedicated clinical trials to control the inflammation raised by SARS-CoV-2 infection. Initial reports on the occurrence of autoimmune phenomena in the convalescence phase of SARS-CoV-2 infection suggests that the immunological consequences of the infection need to be strictly understood. Reporting of the study conforms to broad EQUATOR guidelines (Simera et al January 2010 issue of EJCI).
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #636108
    Database COVID19

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  10. Article: Antimalarial use and arrhythmias in COVID-19 and rheumatic patients: a matter of dose and inflammation?

    Erre, Gian Luca / Ferraccioli, Edoardo Sean / Piga, Matteo / Mangoni, Arduino / Passiu, Giuseppe / Gremese, Elisa / Ferraccioli, Gianfranco

    Ann. rheum. dis

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #306205
    Database COVID19

    Kategorien

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