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Article ; Online: Correction to: Temporal analysis of bovine pestivirus diversity in Brazil.

Mosena, Ana Cristina Sbaraini / Wolf, Jonas Michel / Paim, Willian Pinto / Baumbach, Letícia Ferreira / da Silva, Mariana Soares / Silveira, Simone / do Canto Olegário, Juliana / da Fontoura Budaszewski, Renata / Weber, Matheus Nunes / Canal, Cláudio Wageck

Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology

2022 Volume 53, Issue 3, Page(s) 1743

Language	English
Publishing date	2022-04-07
Publishing country	Brazil
Document type	Published Erratum
ZDB-ID	2017175-4
ISSN	1678-4405 ; 1517-8382
ISSN (online)	1678-4405
ISSN	1517-8382
DOI	10.1007/s42770-022-00751-z
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Article ; Online: Morbillivirus Experimental Animal Models: Measles Virus Pathogenesis Insights from Canine Distemper Virus.

da Fontoura Budaszewski, Renata / von Messling, Veronika

Viruses

2016 Volume 8, Issue 10

Abstract: Morbilliviruses share considerable structural and functional similarities. Even though disease severity varies among the respective host species, the underlying pathogenesis and the clinical signs are comparable. Thus, insights gained with one ... ...

Abstract	Morbilliviruses share considerable structural and functional similarities. Even though disease severity varies among the respective host species, the underlying pathogenesis and the clinical signs are comparable. Thus, insights gained with one morbillivirus often apply to the other members of the genus. Since the
MeSH term(s)	Animals ; Disease Models, Animal ; Distemper Virus, Canine/pathogenicity ; Distemper Virus, Canine/physiology ; Dogs ; Ferrets ; Humans ; Immune Evasion ; Immune Tolerance ; Measles virus/pathogenicity ; Measles virus/physiology ; Viral Tropism
Language	English
Publishing date	2016-10-11
Publishing country	Switzerland
Document type	Comparative Study ; Journal Article ; Review
ZDB-ID	2516098-9
ISSN	1999-4915 ; 1999-4915
ISSN (online)	1999-4915
ISSN	1999-4915
DOI	10.3390/v8100274
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Article ; Online: Temporal analysis of bovine pestivirus diversity in Brazil.

Mosena, Ana Cristina Sbaraini / Wolf, Jonas Michel / Paim, Willian Pinto / Baumbach, Letícia Ferreira / da Silva, Mariana Soares / Silveira, Simone / Olegário, Juliana do Canto / Budaszewski, Renata da Fontoura / Weber, Matheus Nunes / Canal, Cláudio Wageck

Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology

2022 Volume 53, Issue 3, Page(s) 1675–1682

Abstract: In this study, phylogenetic and evolutionary analyses of cattle pestiviruses (BVDV-1, 2 and HoBiPeV) originating in Brazil were used to investigate the temporal diversification of subgenotypes in the country. Inferred dated phylogeny and time of the most ...

Abstract	In this study, phylogenetic and evolutionary analyses of cattle pestiviruses (BVDV-1, 2 and HoBiPeV) originating in Brazil were used to investigate the temporal diversification of subgenotypes in the country. Inferred dated phylogeny and time of the most recent common ancestor (tMRCA) demonstrated that some BVDV subgenotypes (1a, 1b, 1d, 1e, and 2b) and HoBi-like sequences clustered according to the region in which they were collected and that the diversification of subgenotypes appears to have occurred around the introduction of first Bos taurus and then Bos indicus, followed by expansion to form the adapted Brazilian breeds. The present results help to elucidate the temporal facts that led to diversification of ruminant pestiviruses in cattle in Brazil.
MeSH term(s)	Animals ; Brazil ; Cattle ; Diarrhea Virus 1, Bovine Viral/genetics ; Diarrhea Viruses, Bovine Viral/genetics ; Pestivirus/genetics ; Phylogeny ; Ruminants
Language	English
Publishing date	2022-03-29
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	2017175-4
ISSN	1678-4405 ; 1517-8382
ISSN (online)	1678-4405
ISSN	1517-8382
DOI	10.1007/s42770-022-00735-z
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Article ; Online: Tropism and molecular pathogenesis of canine distemper virus.

Rendon-Marin, Santiago / da Fontoura Budaszewski, Renata / Canal, Cláudio Wageck / Ruiz-Saenz, Julian

Virology journal

2019 Volume 16, Issue 1, Page(s) 30

Abstract: Background: Canine distemper virus (CDV), currently termed Canine morbillivirus, is an extremely contagious disease that affects dogs. It is identified as a multiple cell tropism pathogen, and its host range includes a vast array of species. As a member ...

Abstract	Background: Canine distemper virus (CDV), currently termed Canine morbillivirus, is an extremely contagious disease that affects dogs. It is identified as a multiple cell tropism pathogen, and its host range includes a vast array of species. As a member of Mononegavirales, CDV has a negative, single-stranded RNA genome, which encodes eight proteins. Main body: Regarding the molecular pathogenesis, the hemagglutinin protein (H) plays a crucial role both in the antigenic recognition and the viral interaction with SLAM and nectin-4, the host cells' receptors. These cellular receptors have been studied widely as CDV receptors in vitro in different cellular models. The SLAM receptor is located in lymphoid cells; therefore, the infection of these cells by CDV leads to immunosuppression, the severity of which can lead to variability in the clinical disease with the potential of secondary bacterial infection, up to and including the development of neurological signs in its later stage. Conclusion: Improving the understanding of the CDV molecules implicated in the determination of infection, especially the H protein, can help to enhance the biochemical comprehension of the difference between a wide range of CDV variants, their tropism, and different steps in viral infection. The regions of interaction between the viral proteins and the identified host cell receptors have been elucidated to facilitate this understanding. Hence, this review describes the significant molecular and cellular characteristics of CDV that contribute to viral pathogenesis.
MeSH term(s)	Animals ; Disease Models, Animal ; Distemper/virology ; Distemper Virus, Canine/genetics ; Distemper Virus, Canine/pathogenicity ; Distemper Virus, Canine/physiology ; Dogs ; Hemagglutinins, Viral/genetics ; Host Microbial Interactions ; Host Specificity ; Humans ; Mice ; Nectins/genetics ; Receptors, Virus/genetics ; Signaling Lymphocytic Activation Molecule Family Member 1/genetics ; Viral Proteins/genetics ; Viral Tropism ; Zoonoses/virology
Chemical Substances	Hemagglutinins, Viral ; Nectins ; Receptors, Virus ; Viral Proteins ; Signaling Lymphocytic Activation Molecule Family Member 1 (169535-43-7)
Language	English
Publishing date	2019-03-07
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ISSN	1743-422X
ISSN (online)	1743-422X
DOI	10.1186/s12985-019-1136-6
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Article ; Online: The virome of the white-winged vampire bat Diaemus youngi is rich in circular DNA viruses.

Witt, André Alberto / Alves, Raquel Silva / do Canto Olegário, Juliana / de Camargo, Laura Junqueira / Weber, Matheus Nunes / da Silva, Mariana Soares / Canova, Raíssa / Mosena, Ana Cristina Sbaraini / Cibulski, Samuel Paulo / Varela, Ana Paula Muterle / Mayer, Fabiana Quoos / Canal, Cláudio Wageck / da Fontoura Budaszewski, Renata

Virus genes

2022 Volume 58, Issue 3, Page(s) 214–226

Abstract: In the Neotropical region, the white-winged vampire bat (Diaemus youngi) is the rarest of the three species of vampire bats. This bat species feeds preferentially on bird blood, and there is limited information on the viruses infecting D. youngi. Hence, ... ...

Abstract	In the Neotropical region, the white-winged vampire bat (Diaemus youngi) is the rarest of the three species of vampire bats. This bat species feeds preferentially on bird blood, and there is limited information on the viruses infecting D. youngi. Hence, this study aimed to expand the knowledge about the viral diversity associated with D. youngi by sampling and pooling the lungs, liver, kidneys, heart, and intestines of all animals using high-throughput sequencing (HTS) on the Illumina MiSeq platform. A total of three complete and 10 nearly complete circular virus genomes were closely related to gemykrogvirus (Genomoviridae family), smacovirus (Smacoviridae family), and torque teno viruses (TTVs) (Anelloviridae family). In addition, three sequences of bat paramyxovirus were detected and found to be closely related to viruses reported in Pomona roundleaf bats and rodents. The present study provides a snapshot of the viral diversity associated with white-winged vampire bats and provides a baseline for comparison to viruses detected in future outbreaks.
MeSH term(s)	Animals ; Chiroptera ; DNA Viruses/genetics ; DNA, Circular/genetics ; Phylogeny ; Virome/genetics ; Viruses/genetics
Chemical Substances	DNA, Circular
Language	English
Publishing date	2022-04-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	639496-6
ISSN	1572-994X ; 0920-8569
ISSN (online)	1572-994X
ISSN	0920-8569
DOI	10.1007/s11262-022-01897-6
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 2397: Show issues

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Article ; Online: Morbillivirus Experimental Animal Models

Renata da Fontoura Budaszewski / Veronika von Messling

Viruses, Vol 8, Iss 10, p

Measles Virus Pathogenesis Insights from Canine Distemper Virus

2016 Volume 274

Abstract	Morbilliviruses share considerable structural and functional similarities. Even though disease severity varies among the respective host species, the underlying pathogenesis and the clinical signs are comparable. Thus, insights gained with one morbillivirus often apply to the other members of the genus. Since the Canine distemper virus (CDV) causes severe and often lethal disease in dogs and ferrets, it is an attractive model to characterize morbillivirus pathogenesis mechanisms and to evaluate the efficacy of new prophylactic and therapeutic approaches. This review compares the cellular tropism, pathogenesis, mechanisms of persistence and immunosuppression of the Measles virus (MeV) and CDV. It then summarizes the contributions made by studies on the CDV in dogs and ferrets to our understanding of MeV pathogenesis and to vaccine and drugs development.
Keywords	morbillivirus genus ; canine distemper virus ; animal models ; pathogenesis ; Microbiology ; QR1-502 ; Science ; Q
Subject code	630
Language	English
Publishing date	2016-10-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Detection of coronavirus in vampire bats (Desmodus rotundus) in southern Brazil.

Alves, Raquel Silva / do Canto Olegário, Juliana / Weber, Matheus Nunes / da Silva, Mariana Soares / Canova, Raissa / Sauthier, Jéssica Tatiane / Baumbach, Letícia Ferreira / Witt, André Alberto / Varela, Ana Paula Muterle / Mayer, Fabiana Quoos / da Fontoura Budaszewski, Renata / Canal, Cláudio Wageck

Transboundary and emerging diseases

2021 Volume 69, Issue 4, Page(s) 2384–2389

Abstract: The vampire bat (Desmodus rotundus) is a haematophagous animal that feeds exclusively on the blood of domestic mammals. Vampire bat feeding habits enable their contact with mammalian hosts and may enhance zoonotic spillover. Moreover, they may carry ... ...

Abstract	The vampire bat (Desmodus rotundus) is a haematophagous animal that feeds exclusively on the blood of domestic mammals. Vampire bat feeding habits enable their contact with mammalian hosts and may enhance zoonotic spillover. Moreover, they may carry several pathogenic organisms, including coronaviruses (CoVs), for which they are important hosts. The human pathogens that cause severe acute respiratory syndrome (SARS-CoV), Middle East respiratory syndrome (MERS-CoV) and possibly coronavirus disease 2019 (SARS-CoV-2) all originated in bats but required bridge hosts to spread into human populations. To monitor the presence of potential zoonotic viruses in bats, the present work evaluated the presence of CoVs in vampire bats from southern Brazil. A total of 101 vampire bats were captured and euthanized between 2017 and 2019 in Rio Grande do Sul state, southern Brazil. The brain, heart, liver, lungs, kidneys and intestines were collected and macerated individually. The samples were pooled and submitted to high-throughput sequencing (HTS) using the Illumina MiSeq platform and subsequently individually screened using a pancoronavirus RT-PCR protocol. We detected CoV-related sequences in HTS, but only two (2/101; 1.98%) animals had CoV detected in the intestines by RT-PCR. Partial sequences of RdRp and spike genes were obtained in the same sample and the RdRp region in the other sample. The sequences were classified as belonging to Alphacoronavirus. The sequences were closely related to alphacoronaviruses detected in vampire bats from Peru. The continuous monitoring of bat CoVs may help to map and predict putative future zoonotic agents with great impacts on human health.
MeSH term(s)	Animals ; Brazil/epidemiology ; Chiroptera/virology ; Coronaviridae/classification ; Coronaviridae/isolation & purification ; Phylogeny ; RNA-Dependent RNA Polymerase
Chemical Substances	RNA-Dependent RNA Polymerase (EC 2.7.7.48)
Language	English
Publishing date	2021-05-28
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2414822-2
ISSN	1865-1682 ; 1865-1674
ISSN (online)	1865-1682
ISSN	1865-1674
DOI	10.1111/tbed.14150
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Article: Tropism and molecular pathogenesis of canine distemper virus

Rendon-Marin, Santiago / da Fontoura Budaszewski, Renata / Canal, Cláudio Wageck / Ruiz-Saenz, Julian

Virology journal. 2019 Dec., v. 16, no. 1

2019

Abstract: BACKGROUND: Canine distemper virus (CDV), currently termed Canine morbillivirus, is an extremely contagious disease that affects dogs. It is identified as a multiple cell tropism pathogen, and its host range includes a vast array of species. As a member ... ...

Abstract	BACKGROUND: Canine distemper virus (CDV), currently termed Canine morbillivirus, is an extremely contagious disease that affects dogs. It is identified as a multiple cell tropism pathogen, and its host range includes a vast array of species. As a member of Mononegavirales, CDV has a negative, single-stranded RNA genome, which encodes eight proteins. MAIN BODY: Regarding the molecular pathogenesis, the hemagglutinin protein (H) plays a crucial role both in the antigenic recognition and the viral interaction with SLAM and nectin-4, the host cells’ receptors. These cellular receptors have been studied widely as CDV receptors in vitro in different cellular models. The SLAM receptor is located in lymphoid cells; therefore, the infection of these cells by CDV leads to immunosuppression, the severity of which can lead to variability in the clinical disease with the potential of secondary bacterial infection, up to and including the development of neurological signs in its later stage. CONCLUSION: Improving the understanding of the CDV molecules implicated in the determination of infection, especially the H protein, can help to enhance the biochemical comprehension of the difference between a wide range of CDV variants, their tropism, and different steps in viral infection. The regions of interaction between the viral proteins and the identified host cell receptors have been elucidated to facilitate this understanding. Hence, this review describes the significant molecular and cellular characteristics of CDV that contribute to viral pathogenesis.
Keywords	host range ; immunosuppression ; genome ; Canine morbillivirus ; dogs ; lymphocytes ; models ; hemagglutinins ; viral proteins ; pathogenesis ; receptors ; RNA ; bacterial infections ; pathogens
Language	English
Dates of publication	2019-12
Size	p. 30.
Publishing place	BioMed Central
Document type	Article
Note	Review
ISSN	1743-422X
DOI	10.1186/s12985-019-1136-6
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Inactivated Recombinant Rabies Viruses Displaying Canine Distemper Virus Glycoproteins Induce Protective Immunity against Both Pathogens.

da Fontoura Budaszewski, Renata / Hudacek, Andrew / Sawatsky, Bevan / Krämer, Beate / Yin, Xiangping / Schnell, Matthias J / von Messling, Veronika

Journal of virology

2017 Volume 91, Issue 8

Abstract: The development of multivalent vaccines is an attractive methodology for the simultaneous prevention of several infectious diseases in vulnerable populations. Both canine distemper virus (CDV) and rabies virus (RABV) cause lethal disease in wild and ... ...

Abstract	The development of multivalent vaccines is an attractive methodology for the simultaneous prevention of several infectious diseases in vulnerable populations. Both canine distemper virus (CDV) and rabies virus (RABV) cause lethal disease in wild and domestic carnivores. While RABV vaccines are inactivated, the live-attenuated CDV vaccines retain residual virulence for highly susceptible wildlife species. In this study, we developed recombinant bivalent vaccine candidates based on recombinant vaccine strain rabies virus particles, which concurrently display the protective CDV and RABV glycoprotein antigens. The recombinant viruses replicated to near-wild-type titers, and the heterologous glycoproteins were efficiently expressed and incorporated in the viral particles. Immunization of ferrets with beta-propiolactone-inactivated recombinant virus particles elicited protective RABV antibody titers, and animals immunized with a combination of CDV attachment protein- and fusion protein-expressing recombinant viruses were protected from lethal CDV challenge. However, animals that were immunized with only a RABV expressing the attachment protein of CDV vaccine strain Onderstepoort succumbed to infection with a more recent wild-type strain, indicating that immune responses to the more conserved fusion protein contribute to protection against heterologous CDV strains.
MeSH term(s)	Animals ; Antibodies, Viral/blood ; Disease Models, Animal ; Distemper/immunology ; Distemper/prevention & control ; Distemper Virus, Canine/genetics ; Distemper Virus, Canine/immunology ; Ferrets ; Rabies virus/genetics ; Rabies virus/immunology ; Survival Analysis ; Vaccines, Inactivated/genetics ; Vaccines, Inactivated/immunology ; Vaccines, Synthetic/genetics ; Vaccines, Synthetic/immunology ; Viral Vaccines/genetics ; Viral Vaccines/immunology
Chemical Substances	Antibodies, Viral ; Vaccines, Inactivated ; Vaccines, Synthetic ; Viral Vaccines
Language	English
Publishing date	2017-03-29
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	80174-4
ISSN	1098-5514 ; 0022-538X
ISSN (online)	1098-5514
ISSN	0022-538X
DOI	10.1128/JVI.02077-16
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Zs.A 609: Show issues

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Article ; Online: Influence of vaccine strains on the evolution of canine distemper virus.

da Fontoura Budaszewski, Renata / Streck, André Felipe / Nunes Weber, Matheus / Maboni Siqueira, Franciele / Muniz Guedes, Rafael Lucas / Wageck Canal, Cláudio

Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases

2016 Volume 41, Page(s) 262–269

Abstract: Canine distemper virus (CDV) is a major dog pathogen belonging to the genus Morbillivirus of the family Paramyxoviridae. CDV causes disease and high mortality in dogs and wild carnivores. Although homologous recombination has been demonstrated in many ... ...

Abstract	Canine distemper virus (CDV) is a major dog pathogen belonging to the genus Morbillivirus of the family Paramyxoviridae. CDV causes disease and high mortality in dogs and wild carnivores. Although homologous recombination has been demonstrated in many members of Paramyxoviridae, these events have rarely been reported for CDV. To detect potential recombination events, the complete CDV genomes available in GenBank up to June 2015 were screened using distinct algorithms to detect genetic conversions and incongruent phylogenies. Eight putative recombinant viruses derived from different CDV genotypes and different hosts were detected. The breakpoints of the recombinant strains were primarily located on fusion and hemagglutinin glycoproteins. These results suggest that homologous recombination is a frequent phenomenon in morbillivirus populations under natural replication, and CDV vaccine strains might play an important role in shaping the evolution of this virus.
Language	English
Publishing date	2016
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2037068-4
ISSN	1567-7257 ; 1567-1348
ISSN (online)	1567-7257
ISSN	1567-1348
DOI	10.1016/j.meegid.2016.04.014
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