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  1. Book ; Thesis: Transport of benzene and trichloroethylene through a landfill soil liner mixed with lignin treated coal fines / by Robert W. Malone

    Malone, Robert W

    1992  

    Keywords Fills (Earthwork)/Design. ; Benzene. ; Trichloroethylene. ; Soil mechanics.
    Language English
    Size xi, 173 leaves :, ill. ;, 29 cm.
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Thesis (M.S.)--University of Kentucky, 1992
    Note Includes vita and abstract.
    Database NAL-Catalogue (AGRICOLA)

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  2. Article ; Online: More Than Just Heartburn: Does Famotidine Effectively Treat Patients with COVID-19?

    Malone, Robert W

    Digestive diseases and sciences

    2021  Volume 66, Issue 11, Page(s) 3672–3673

    MeSH term(s) COVID-19 ; Famotidine/therapeutic use ; Gastroesophageal Reflux/drug therapy ; Heartburn/drug therapy ; Heartburn/etiology ; Humans ; SARS-CoV-2
    Chemical Substances Famotidine (5QZO15J2Z8)
    Language English
    Publishing date 2021-02-24
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 304250-9
    ISSN 1573-2568 ; 0163-2116
    ISSN (online) 1573-2568
    ISSN 0163-2116
    DOI 10.1007/s10620-021-06875-w
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  3. Article ; Online: Simulated nitrous oxide emissions from multiple agroecosystems in the U.S. Corn Belt using the modified SWAT-C model.

    Liang, Kang / Qi, Junyu / Zhang, Xuesong / Emmett, Bryan / Johnson, Jane M F / Malone, Robert W / Moglen, Glenn E / Venterea, Rodney T

    Environmental pollution (Barking, Essex : 1987)

    2023  Volume 337, Page(s) 122537

    Abstract: Agriculture is a major source of nitrous oxide ( ... ...

    Abstract Agriculture is a major source of nitrous oxide (N
    MeSH term(s) Soil ; Zea mays ; Nitrous Oxide/analysis ; Water ; Agriculture/methods ; Fertilizers/analysis
    Chemical Substances Soil ; Nitrous Oxide (K50XQU1029) ; Water (059QF0KO0R) ; Fertilizers
    Language English
    Publishing date 2023-09-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 280652-6
    ISSN 1873-6424 ; 0013-9327 ; 0269-7491
    ISSN (online) 1873-6424
    ISSN 0013-9327 ; 0269-7491
    DOI 10.1016/j.envpol.2023.122537
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    Zs.A 2599: Show issues Location:
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  4. Article ; Online: On the effects of quadrupolar relaxation in Earth's field NMR spectra.

    Altenhof, Adam R / Kaseman, Derrick C / Mason, Harris E / Alvarez, Marc A / Malone, Michael W / Williams, Robert F

    Journal of magnetic resonance (San Diego, Calif. : 1997)

    2023  Volume 355, Page(s) 107540

    Abstract: There is growing interest in using low-field magnetic resonance experiments for routine chemical characterization. Earth's field NMR is one such technique that can garner structural information and enable sample differentiation with low cost and highly ... ...

    Abstract There is growing interest in using low-field magnetic resonance experiments for routine chemical characterization. Earth's field NMR is one such technique that can garner structural information and enable sample differentiation with low cost and highly portable designs. The resulting NMR spectra are primarily influenced by J-couplings, resulting in so-called J-coupled spectra (JCS). Many small molecules include atoms with NMR-active nuclei that are quadrupolar either at natural abundance or are often isotopically enriched (e.g.,
    Language English
    Publishing date 2023-08-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1469665-4
    ISSN 1096-0856 ; 1557-8968 ; 1090-7807 ; 0022-2364
    ISSN (online) 1096-0856 ; 1557-8968
    ISSN 1090-7807 ; 0022-2364
    DOI 10.1016/j.jmr.2023.107540
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  5. Article ; Online: Correction: Plasmids manipulate bacterial behaviour through translational regulatory crosstalk.

    Thompson, Catriona M A / Hall, James P J / Chandra, Govind / Martins, Carlo / Saalbach, Gerhard / Panturat, Supakan / Bird, Susannah M / Ford, Samuel / Little, Richard H / Piazza, Ainelen / Harrison, Ellie / Jackson, Robert W / Brockhurst, Michael A / Malone, Jacob G

    PLoS biology

    2024  Volume 22, Issue 2, Page(s) e3002531

    Abstract: This corrects the article DOI: 10.1371/journal.pbio.3001988.]. ...

    Abstract [This corrects the article DOI: 10.1371/journal.pbio.3001988.].
    Language English
    Publishing date 2024-02-15
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 2126776-5
    ISSN 1545-7885 ; 1544-9173
    ISSN (online) 1545-7885
    ISSN 1544-9173
    DOI 10.1371/journal.pbio.3002531
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    Zs.A 6193: Show issues Location:
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  6. Article ; Online: Stabilizing the Proteomes of Acute Myeloid Leukemia Cells: Implications for Cancer Proteomics.

    Sprung, Robert W / Zhang, Qiang / Kramer, Michael H / Christopher, Matthew C / Erdmann-Gilmore, Petra / Mi, Yiling / Malone, James P / Ley, Timothy J / Townsend, R Reid

    Molecular & cellular proteomics : MCP

    2024  Volume 23, Issue 2, Page(s) 100716

    Abstract: Previous work has shown that inhibition of abundant myeloid azurophil granule-associated serine proteases (ELANE [neutrophil elastase], PRTN3 [protease 3], and CTSG [Cathepsin G]) is required to stabilize some proteins in myeloid cells. We therefore ... ...

    Abstract Previous work has shown that inhibition of abundant myeloid azurophil granule-associated serine proteases (ELANE [neutrophil elastase], PRTN3 [protease 3], and CTSG [Cathepsin G]) is required to stabilize some proteins in myeloid cells. We therefore hypothesized that effective inhibition of these proteases may be necessary for quantitative proteomic analysis of samples containing myeloid cells. To test this hypothesis, we thawed viably preserved acute myeloid leukemia cells from cryovials in the presence or the absence of diisopropyl fluorophosphate (DFP), a cell-permeable and irreversible serine protease inhibitor. Global proteomic analysis was performed, using label-free and isobaric peptide-labeling quantitation. The presence of DFP resulted in an increase of tryptic peptides (14-57%) and proteins (9-31%). In the absence of DFP, 11 to 31% of peptide intensity came from nontryptic peptides; 52 to 75% had cleavage specificity consistent with activities of ELANE-PRTN3. Treatment with DFP reduced the intensity of nontryptic peptides to 4-8% of the total. ELANE inhibition was 95%, based on diisopropyl phosphate modification of active site serine residue. Overall, the relative abundance of 20% of proteins was significantly altered by DFP treatment. These results suggest that active myeloid serine proteases, released during sample processing, can skew quantitative proteomic measurements. Finally, significant ELANE activity was also detected in Clinical Proteomics Tumor Analysis Consortium datasets of solid tumors (many of which have known myeloid infiltration). In the pancreatic cancer dataset, the median percentage of nontryptic intensity detected across patient samples was 34%, with many patient samples having more than half of their detected peptide intensity from nontryptic cleavage events consistent with ELANE-PRTN3 cleavage specificity. Our study suggests that in vitro cleavage of proteins by myeloid serine proteases may be relevant for proteomic studies of any tumor that contains infiltrating myeloid cells.
    MeSH term(s) Humans ; Proteome ; Proteomics ; Endopeptidases/metabolism ; Serine Proteases ; Peptides/chemistry ; Leukemia, Myeloid, Acute
    Chemical Substances Proteome ; Endopeptidases (EC 3.4.-) ; Serine Proteases (EC 3.4.-) ; Peptides
    Language English
    Publishing date 2024-01-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2075924-1
    ISSN 1535-9484 ; 1535-9476
    ISSN (online) 1535-9484
    ISSN 1535-9476
    DOI 10.1016/j.mcpro.2024.100716
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  7. Article ; Online: The

    Malone, Michael W / Espy, Michelle A / He, Sun / Janicke, Michael T / Williams, Robert F

    Solid state nuclear magnetic resonance

    2020  Volume 110, Page(s) 101697

    Abstract: We report ... ...

    Abstract We report the
    Language English
    Publishing date 2020-10-10
    Publishing country Netherlands
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, Non-U.S. Gov't
    ZDB-ID 1122088-0
    ISSN 1527-3326 ; 0926-2040
    ISSN (online) 1527-3326
    ISSN 0926-2040
    DOI 10.1016/j.ssnmr.2020.101697
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  8. Article ; Online: Quantitation of Nuclear Magnetic Resonance Spectra at Earth's Magnetic Field.

    Kaseman, Derrick C / Malone, Michael W / Tondreau, Aaron / Espy, Michelle A / Williams, Robert F

    Analytical chemistry

    2021  Volume 93, Issue 46, Page(s) 15349–15357

    Abstract: The inherently quantitative nature of nuclear magnetic resonance (NMR) spectroscopy is one of the most attractive aspects of this analytical technique. Quantitative NMR analyses have typically been limited to high-field (>1 T) applications. The aspects ... ...

    Abstract The inherently quantitative nature of nuclear magnetic resonance (NMR) spectroscopy is one of the most attractive aspects of this analytical technique. Quantitative NMR analyses have typically been limited to high-field (>1 T) applications. The aspects for quantitation at low magnetic fields (<1 mT) have not been thoroughly investigated and are shown to be impacted by the complex signatures that arise at these fields from strong heteronuclear
    Language English
    Publishing date 2021-11-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1508-8
    ISSN 1520-6882 ; 0003-2700
    ISSN (online) 1520-6882
    ISSN 0003-2700
    DOI 10.1021/acs.analchem.1c02910
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    Zs.A 4033: Show issues Location:
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  9. Article: Highly sensitive

    Mikati, Marwa O / Erdmann-Gilmore, Petra / Connors, Rose / Conway, Sineadh M / Malone, Jim / Woods, Justin / Sprung, Robert W / Reid Townsend, R / Al-Hasani, Ream

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Enkephalins are opioid peptides that modulate analgesia, reward, and stress. ...

    Abstract Enkephalins are opioid peptides that modulate analgesia, reward, and stress.
    Language English
    Publishing date 2023-08-02
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.02.15.528745
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  10. Article ; Online: Beyond Average: α-Particle Distribution and Dose Heterogeneity in Bone Metastatic Prostate Cancer.

    Benabdallah, Nadia / Lu, Peng / Abou, Diane S / Zhang, Hanwen / Ulmert, David / Hobbs, Robert F / Gay, Hiram A / Simons, Brian W / Saeed, Muhammad A / Rogers, Buck E / Jha, Abhinav K / Tai, Yuan-Chuan / Malone, Christopher D / Ippolito, Joseph E / Michalski, Jeff / Jennings, Jack W / Baumann, Brian C / Pachynski, Russell K / Thorek, Daniel L J

    Journal of nuclear medicine : official publication, Society of Nuclear Medicine

    2024  Volume 65, Issue 2, Page(s) 245–251

    Abstract: α-particle emitters are emerging as a potent modality for disseminated cancer therapy because of their high linear energy transfer and localized absorbed dose profile. Despite great interest and pharmaceutical development, there is scant information on ... ...

    Abstract α-particle emitters are emerging as a potent modality for disseminated cancer therapy because of their high linear energy transfer and localized absorbed dose profile. Despite great interest and pharmaceutical development, there is scant information on the distribution of these agents at the scale of the α-particle pathlength. We sought to determine the distribution of clinically approved [
    MeSH term(s) Male ; Humans ; Radiopharmaceuticals ; Prostatic Neoplasms/radiotherapy ; Prostatic Neoplasms/pathology ; Bone and Bones/diagnostic imaging ; Bone and Bones/pathology ; Autoradiography ; Bone Neoplasms/radiotherapy ; Bone Neoplasms/secondary
    Chemical Substances Radiopharmaceuticals
    Language English
    Publishing date 2024-02-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80272-4
    ISSN 1535-5667 ; 0097-9058 ; 0161-5505 ; 0022-3123
    ISSN (online) 1535-5667
    ISSN 0097-9058 ; 0161-5505 ; 0022-3123
    DOI 10.2967/jnumed.123.266571
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