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  1. Article: Yki stability and activity are regulated by Ca

    Zhai, Chaojun / Wang, Yunfeng / Qi, Shenao / Yang, Muhan / Wu, Shian

    Journal of genetics and genomics = Yi chuan xue bao

    2024  

    Abstract: Yorkie (Yki) is a key effector of the Hippo pathway that activates the expression of targets by associating with the transcription factor Scalloped (Sd). Various upstream signals, such as cell polarity and mechanical cues, control transcriptional ... ...

    Abstract Yorkie (Yki) is a key effector of the Hippo pathway that activates the expression of targets by associating with the transcription factor Scalloped (Sd). Various upstream signals, such as cell polarity and mechanical cues, control transcriptional programs by regulating Yki activity. Searching for Yki regulatory factors has far-reaching significance for studying the Hippo pathway in animal development and human diseases. In this study, we identify Calpain-A (CalpA) and Calpain-B (CalpB), two calcium (Ca
    Language English
    Publishing date 2024-04-23
    Publishing country China
    Document type Journal Article
    ZDB-ID 2374568-X
    ISSN 1873-5533 ; 1673-8527
    ISSN (online) 1873-5533
    ISSN 1673-8527
    DOI 10.1016/j.jgg.2024.04.011
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  2. Article: The Impact of Empowering Leadership on Job Performance of Higher Education Institutions Employees: Mediating Role of Goal Clarity and Self-Efficacy.

    Ahmed, Tanveer / Chaojun, Yang / Hongjuan, Yang / Mahmood, Salman

    Psychology research and behavior management

    2022  Volume 15, Page(s) 677–694

    Abstract: Purpose: The main objective of existing research is to assess empowering leadership effects on employees' job performance at the academic level through mediating variables' goal clarity and self-efficacy.: Methods: Data were congregated from 400 ... ...

    Abstract Purpose: The main objective of existing research is to assess empowering leadership effects on employees' job performance at the academic level through mediating variables' goal clarity and self-efficacy.
    Methods: Data were congregated from 400 employees belonging to higher education institutions of Pakistan through research assistants, hired for data collection. Statistical procedures, such as factor analysis via statistical package for the social sciences (SPSS 23), structural equation modeling with bootstrapping via statistical tool analysis of moment structures (AMOS 24), were used to evaluate data and assess the relationship among the constructs.
    Results: The structural equation modeling analysis uncovered several results. For instance, it shows the positive influence of empowering leadership behaviors on goal clarity, self-efficacy, and employees' job performance. Moreover, the bootstrap investigation showed that goal clarity and self-efficacy mediate empowering leadership behaviors' influence on workers' job performance. Therefore, conferring to existing study results empowering leadership is significantly associated with employees' job performance in the presence of mediators goal clarity and self-efficacy at the academic level of higher education institutions of Sindh, Pakistan.
    Conclusion: The main research question of existing research is to assess empowering leadership effects on employees' job performance through mediating variables' goal clarity and self-efficacy. To investigate this research question, we have conducted this study and empirically established that empowering leadership can affect employees' job performance with and without mediation. We have also shown empowering leadership as collaborative effects produce advanced levels of self-efficacy, goal clarity, and employees' job performance than either leadership behavior could accomplish by itself.
    Language English
    Publishing date 2022-03-17
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2495093-2
    ISSN 1179-1578
    ISSN 1179-1578
    DOI 10.2147/PRBM.S357083
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  3. Article ; Online: VSMCs-derived exosomes: A novel therapeutic target for diabetic atherosclerosis.

    Yang, Chaojun / Fan, Zhixing

    International journal of cardiology

    2021  Volume 343, Page(s) 14

    MeSH term(s) Atherosclerosis/drug therapy ; Diabetes Mellitus ; Exosomes ; Humans ; Muscle, Smooth, Vascular ; Myocytes, Smooth Muscle
    Language English
    Publishing date 2021-09-16
    Publishing country Netherlands
    Document type Letter ; Comment
    ZDB-ID 779519-1
    ISSN 1874-1754 ; 0167-5273
    ISSN (online) 1874-1754
    ISSN 0167-5273
    DOI 10.1016/j.ijcard.2021.09.027
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1673: Show issues Location:
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  4. Article ; Online: Simulation on Harmful Gas Control by Balanced Pressure Ventilation in the Fully Mechanized Caving Face under Sealed Fire Area of Small Coal Mine.

    Fan, Chaojun / Sun, Hao / Yang, Lei / Xiao, Bin / Xu, Lingjin

    ACS omega

    2024  Volume 9, Issue 14, Page(s) 16168–16175

    Abstract: The harmful gas in the sealed fire area of a small coal mine rushes into the mining face of the lower coal seam, which restricts the efficient promotion of the working face. In this paper, based on the evolution law of caving coal rock dilatation ... ...

    Abstract The harmful gas in the sealed fire area of a small coal mine rushes into the mining face of the lower coal seam, which restricts the efficient promotion of the working face. In this paper, based on the evolution law of caving coal rock dilatation coefficient, the characteristics of the heterogeneous distribution of permeability and voidage in goaf were obtained, and the mathematical model of gas migration in goaf is constructed. The numerical solution of gas migration in goaf under the sealed fire area of a small coal mine was realized by using the Free and Porous Media Flow module and the Transport of Dilute Matter in Porous Media module in COMSOL Multiphysics, and the corresponding measure was proposed. The results show that the fresh air flows into the goaf from both the inlet air roadway and the working face and then flows out from the upper corner. Driven by the air flow, the CO in the overlying sealed fire area of a small coal mine flows out from the upper corner of the working face, resulting in the CO overlimit. Due to the influence of air leakage and the CO overlimit in the working face, low oxygen occurs in the working face. According to the characteristics of gas emission, balanced pressure ventilation technology is proposed to control the low oxygen in the working face and the CO overlimit in the upper corner. It is found that the balanced pressure ventilation obviously increases the pressure of the working face, reduces the pressure difference between the two ends of the working face by 45.7-26.7%, and decreases the air leakage to the goaf in the upper corner of the inlet air roadway. The field application shows that the problems of low oxygen in the working face and a CO overlimit in the upper corner are effectively solved.
    Language English
    Publishing date 2024-03-29
    Publishing country United States
    Document type Journal Article
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.3c10149
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: ECs-derived exosomes: A novel therapeutic target for myocardial ischemia-reperfusion injury.

    Yang, Chaojun / Yang, Jian / Fan, Zhixing / Yang, Jun

    International journal of cardiology

    2021  Volume 333, Page(s) 51

    MeSH term(s) Exosomes ; Humans ; Hyperbaric Oxygenation ; MicroRNAs ; Myocardial Reperfusion Injury/drug therapy ; RNA, Long Noncoding
    Chemical Substances MicroRNAs ; RNA, Long Noncoding
    Language English
    Publishing date 2021-03-05
    Publishing country Netherlands
    Document type Letter ; Comment
    ZDB-ID 779519-1
    ISSN 1874-1754 ; 0167-5273
    ISSN (online) 1874-1754
    ISSN 0167-5273
    DOI 10.1016/j.ijcard.2021.03.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1673: Show issues Location:
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  6. Article: Application of low dose aspirin in pre-eclampsia.

    Ren, Yu / Zhao, Yong / Yang, Xiangdong / Shen, Chaojun / Luo, Hua

    Frontiers in medicine

    2023  Volume 10, Page(s) 1111371

    Abstract: Aspirin is widely used in the primary and secondary prevention of cardiovascular and cerebrovascular diseases. Low-dose aspirin is also widely used to prevent pre-eclampsia and fetal growth retardation in utero. However, the use of aspirin during ... ...

    Abstract Aspirin is widely used in the primary and secondary prevention of cardiovascular and cerebrovascular diseases. Low-dose aspirin is also widely used to prevent pre-eclampsia and fetal growth retardation in utero. However, the use of aspirin during pregnancy is controversial. Since 1985, when aspirin was reported to be effective in obstetrics, numerous studies have attempted to determine the effect of low-dose aspirin on the morbidity of pre-eclampsia but have remained inconclusive. Guidelines for aspirin in preventing pre-eclampsia are different in different countries and regions. This article summarizes the research progress, mechanism, and application prospect of aspirin in preventing pre-eclampsia, providing a theoretical basis for the rational use of aspirin in pregnancy.
    Language English
    Publishing date 2023-03-08
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2023.1111371
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  7. Article ; Online: Application of low dose aspirin in pre-eclampsia

    Yu Ren / Yong Zhao / Xiangdong Yang / Chaojun Shen / Hua Luo

    Frontiers in Medicine, Vol

    2023  Volume 10

    Abstract: Aspirin is widely used in the primary and secondary prevention of cardiovascular and cerebrovascular diseases. Low-dose aspirin is also widely used to prevent pre-eclampsia and fetal growth retardation in utero. However, the use of aspirin during ... ...

    Abstract Aspirin is widely used in the primary and secondary prevention of cardiovascular and cerebrovascular diseases. Low-dose aspirin is also widely used to prevent pre-eclampsia and fetal growth retardation in utero. However, the use of aspirin during pregnancy is controversial. Since 1985, when aspirin was reported to be effective in obstetrics, numerous studies have attempted to determine the effect of low-dose aspirin on the morbidity of pre-eclampsia but have remained inconclusive. Guidelines for aspirin in preventing pre-eclampsia are different in different countries and regions. This article summarizes the research progress, mechanism, and application prospect of aspirin in preventing pre-eclampsia, providing a theoretical basis for the rational use of aspirin in pregnancy.
    Keywords aspirin ; pre-eclampsia ; low-dose ; cerebrovascular disease ; guideline ; Medicine (General) ; R5-920
    Language English
    Publishing date 2023-03-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Identifying spatial relations of industrial carbon emissions among provinces of China: evidence from unsupervised clustering algorithms.

    Liu, Shuning / Yang, Chaojun / Liu, Liju

    Environmental science and pollution research international

    2022  Volume 29, Issue 51, Page(s) 77958–77972

    Abstract: Reducing the total carbon emissions of modern industry is of great significance for China to achieve the carbon peak mission. The MD-SNA spatial correlation measure methodology was innovatively proposed in this paper, which was based on the clustering ... ...

    Abstract Reducing the total carbon emissions of modern industry is of great significance for China to achieve the carbon peak mission. The MD-SNA spatial correlation measure methodology was innovatively proposed in this paper, which was based on the clustering algorithm of similarity measure. Furthermore, the social network analysis (SNA) method was incorporated to explore the spatial relationship of provincial industrial carbon emissions. The GINI coefficient, Theil index (GE
    MeSH term(s) Carbon/analysis ; Industry ; Carbon Dioxide/analysis ; China ; Cluster Analysis ; Algorithms ; Economic Development
    Chemical Substances Carbon (7440-44-0) ; Carbon Dioxide (142M471B3J)
    Language English
    Publishing date 2022-06-10
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1178791-0
    ISSN 1614-7499 ; 0944-1344
    ISSN (online) 1614-7499
    ISSN 0944-1344
    DOI 10.1007/s11356-022-20784-z
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    In stock of ZB MED Bonn / Germany

    Z 5915: Show issues

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  9. Article ; Online: Altered glycosylation profiles of serum IgG in Takayasu arteritis

    Lingyu Liu / Jing Li / Yunjiao Yang / Chaojun Hu / Xinping Tian

    European Journal of Medical Research, Vol 28, Iss 1, Pp 1-

    2023  Volume 9

    Abstract: Abstract Background Takayasu arteritis (TAK) is an autoimmune inflammatory disorder with an undefined etiology. This study aimed to characterize the glycosylation profiles of serum immunoglobulin G (IgG) in patients with TAK. Methods Lectin microarrays ... ...

    Abstract Abstract Background Takayasu arteritis (TAK) is an autoimmune inflammatory disorder with an undefined etiology. This study aimed to characterize the glycosylation profiles of serum immunoglobulin G (IgG) in patients with TAK. Methods Lectin microarrays containing 56 types of lectins were used to detect the glycan levels of serum IgG in 164 patients with TAK, 128 patients with atherosclerosis used as disease controls (DCs), and 100 healthy controls (HCs). Differentially altered glycosylation patterns between TAK and control groups as well as between TAK subgroups were identified and further validated by lectin blot. The classification performance of the TAK-specific glycosylation change was measured by receiver-operating characteristic (ROC) curve analysis. Results Lectin microarray analysis revealed significantly increased N-Acetylgalactosamine (GalNAc) levels in the TAK group compared to the DC and HC groups (all p < 0.01). For TAK subgroups, significantly decreased mannosylation was observed in patients with active TAK compared to patients with inactive disease (p < 0.01). These differences were validated by lectin blot. In addition, GalNAc levels exhibited a considerable potential for discriminating patients with TAK from patients with atherosclerosis, with an area under the curve of 0.749 (p < 0.001), a sensitivity of 71.7%, and a specificity of 73.8%. Conclusions Serum IgG in patients with TAK displayed disease-specific glycosylation alterations. Aberrant GalNAc glycosylation showed substantial value as a diagnostic biomarker. The potential proinflammatory properties of the abnormal glycans may provide new insights into the role of humoral immunity in the pathogenesis of TAK.
    Keywords Takayasu arteritis ; Immunoglobulin G ; Glycosylation ; Lectin microarray ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2023-02-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Birth Weight, Cardiometabolic Factors, and Coronary Heart Disease: A Mendelian Randomization Study.

    Su, Shuyao / Fan, Jingwen / Yang, Yongli / Yang, Chaojun / Jia, Xiaocan

    The Journal of clinical endocrinology and metabolism

    2023  Volume 108, Issue 11, Page(s) e1245–e1252

    Abstract: Context: Observational studies have shown associations of birth weight (BW) with coronary heart disease (CHD), but results are inconsistent and do not distinguish the fetal or maternal effect of BW.: Objective: This study aims to explore the causal ... ...

    Abstract Context: Observational studies have shown associations of birth weight (BW) with coronary heart disease (CHD), but results are inconsistent and do not distinguish the fetal or maternal effect of BW.
    Objective: This study aims to explore the causal association between BW and CHD, analyze the fetal and maternal contribution, and quantify mediating effects of cardiometabolic factors.
    Methods: Genetic variants from genome-wide association study summary-level data of own BW (N = 298 142), offspring BW (N = 210 267 mothers), and 16 cardiometabolic (anthropometric, glycemic, lipidemic, and blood pressure) factors were extracted as instrumental variables. We used two-sample Mendelian randomization study (MR) to estimate the causal effect of BW on CHD (60 801 cases and 123 504 controls from mixed ancestry) and explore the fetal and maternal contributions. Mediation analyses were conducted to analyze the potential mediating effects of 16 cardiometabolic factors using two-step MR.
    Results: Inverse variance weighted analysis showed that lower BW raised the CHD risk (β -.30; 95% CI: -0.40, -0.20) and consistent results were observed in fetal-specific/maternal-specific BW. We identified 5 mediators in the causal pathway from BW to CHD, including body mass index-adjusted hip circumference, triglycerides, fasting insulin, diastolic blood pressure, and systolic blood pressure (SBP), with mediated proportion ranging from 7.44% for triglycerides to 27.75% for SBP. Causality between fetal-specific and maternal-specific BW and CHD was mediated by glycemic factors and SBP, respectively.
    Conclusion: Our findings supported that lower BW increased CHD risk and revealed that fetal-specific and maternal-specific BW may both contribute to this effect. The causality between BW and CHD was mediated by several cardiometabolic factors.
    MeSH term(s) Female ; Humans ; Birth Weight/genetics ; Genome-Wide Association Study ; Mendelian Randomization Analysis ; Coronary Disease/epidemiology ; Coronary Disease/genetics ; Triglycerides ; Polymorphism, Single Nucleotide
    Chemical Substances Triglycerides
    Language English
    Publishing date 2023-05-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3029-6
    ISSN 1945-7197 ; 0021-972X
    ISSN (online) 1945-7197
    ISSN 0021-972X
    DOI 10.1210/clinem/dgad308
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    Uh III Zs.134: Show issues Location:
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