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Article ; Online: Both "Vitamin L for Life" and "One Milligram of Satan": A Multi-Perspective Qualitative Exploration of Adjuvant Endocrine Therapy Use after Breast Cancer.

Toivonen, Kirsti I / Oberoi, Devesh / King-Shier, Kathryn / Piedalue, Katherine-Ann L / Rash, Joshua A / Carlson, Linda E / Campbell, Tavis S

Current oncology (Toronto, Ont.)

2021 Volume 28, Issue 4, Page(s) 2496–2515

Abstract: Adjuvant endocrine therapy (AET) is recommended after hormone receptor-positive breast cancer to reduce risk of recurrence, but adherence is sub-optimal in many women. Behavioral interventions have been ineffective in improving adherence rates to AET. ... ...

Abstract	Adjuvant endocrine therapy (AET) is recommended after hormone receptor-positive breast cancer to reduce risk of recurrence, but adherence is sub-optimal in many women. Behavioral interventions have been ineffective in improving adherence rates to AET. This qualitative descriptive study investigates factors that support women in AET use and suggestions for interventions to improve AET use and management. Interviews with women who persisted with AET (
MeSH term(s)	Breast Neoplasms/drug therapy ; Chemotherapy, Adjuvant ; Combined Modality Therapy ; Female ; Humans ; Neoplasm Recurrence, Local ; Vitamins/therapeutic use
Chemical Substances	Vitamins
Language	English
Publishing date	2021-07-05
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1236972-x
ISSN	1718-7729 ; 1198-0052
ISSN (online)	1718-7729
ISSN	1198-0052
DOI	10.3390/curroncol28040227
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Article ; Online: Climatic effects on water quality in areas with acid sulfate soils with commensurable consequences on the reproduction of burbot (Lota lota L.).

Toivonen, Janne / Hudd, Richard / Nystrand, Miriam / Österholm, Peter

Environmental geochemistry and health

2020 Volume 42, Issue 10, Page(s) 3141–3156

Abstract: ... of the burbot (Lota lota L.) was shown to be sensitive to acidity during the wintertime spawning migration and ...

Abstract	Due to discharge from acid sulfate (a.s.) soils, watercourses and coastal areas in the Gulf of Bothnia are periodically heavily acidified with high concentrations of potentially toxic metals. Data on water quality from 2005 to 2014 in an embanked lake, an estuary of four rivers in western Finland, showed repeated events with acidic water (pH < 5.5) with high concentrations of Al. Size fractionation and species modeling of Al showed that a significant part of the Al occurred as highly toxic small-size fractions (dissolved < 1 kDa and colloidal 1 kDa-0.45 µm) as free ions and complexed to sulfate. The larval abundance of the burbot (Lota lota L.) was shown to be sensitive to acidity during the wintertime spawning migration and spawning. Bearing in mind the importance of estuaries of the northern Baltic Sea as spawning and nursery areas of fish, the reoccurring failure in the reproduction of fish may cause a more serious threat for the lake and adjacent coastal fish stocks than the spectacular, but less frequent, mass kills of adult fish. This demonstrates the close relationship between climate, hydrology, water geochemistry and the aquatic coastal ecosystem in areas affected by a.s. soils. As the current forecast of climate chance indicates warmer winters with more continuous runoff, the effects can become even more prominent. This study also shows that the annual larvae abundance of burbot may be used as a bioindicator and an instrument for the fisheries for obtaining more comprehensive knowledge of the ecological effects of acidic metal discharge from a.s. soils.
MeSH term(s)	Animals ; Climate ; Environmental Exposure ; Finland ; Gadiformes/physiology ; Hydrogen-Ion Concentration ; Lakes/chemistry ; Reproduction/drug effects ; Rivers/chemistry ; Soil/chemistry ; Sulfates/chemistry ; Water Quality
Chemical Substances	Soil ; Sulfates
Language	English
Publishing date	2020-03-17
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	52039-1
ISSN	1573-2983 ; 0142-7245 ; 0269-4042
ISSN (online)	1573-2983
ISSN	0142-7245 ; 0269-4042
DOI	10.1007/s10653-020-00550-1
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Article: Climatic effects on water quality in areas with acid sulfate soils with commensurable consequences on the reproduction of burbot (Lota lota L.)

Toivonen, Janne / Hudd, Richard / Nystrand, Miriam / Österholm, Peter

Environmental geochemistry and health. 2020 Oct., v. 42, no. 10

2020

Abstract: ... of the burbot (Lota lota L.) was shown to be sensitive to acidity during the wintertime spawning migration and ...

Abstract	Due to discharge from acid sulfate (a.s.) soils, watercourses and coastal areas in the Gulf of Bothnia are periodically heavily acidified with high concentrations of potentially toxic metals. Data on water quality from 2005 to 2014 in an embanked lake, an estuary of four rivers in western Finland, showed repeated events with acidic water (pH < 5.5) with high concentrations of Al. Size fractionation and species modeling of Al showed that a significant part of the Al occurred as highly toxic small-size fractions (dissolved < 1 kDa and colloidal 1 kDa—0.45 µm) as free ions and complexed to sulfate. The larval abundance of the burbot (Lota lota L.) was shown to be sensitive to acidity during the wintertime spawning migration and spawning. Bearing in mind the importance of estuaries of the northern Baltic Sea as spawning and nursery areas of fish, the reoccurring failure in the reproduction of fish may cause a more serious threat for the lake and adjacent coastal fish stocks than the spectacular, but less frequent, mass kills of adult fish. This demonstrates the close relationship between climate, hydrology, water geochemistry and the aquatic coastal ecosystem in areas affected by a.s. soils. As the current forecast of climate chance indicates warmer winters with more continuous runoff, the effects can become even more prominent. This study also shows that the annual larvae abundance of burbot may be used as a bioindicator and an instrument for the fisheries for obtaining more comprehensive knowledge of the ecological effects of acidic metal discharge from a.s. soils.
Keywords	Lota lota ; acidity ; adults ; climate ; coastal ecosystems ; estuaries ; fish ; fractionation ; geochemistry ; lakes ; larvae ; pH ; runoff ; sulfates ; toxicity ; water quality ; winter ; Finland ; Gulf of Bothnia
Language	English
Dates of publication	2020-10
Size	p. 3141-3156.
Publishing place	Springer Netherlands
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	52039-1
ISSN	1573-2983 ; 0142-7245 ; 0269-4042
ISSN (online)	1573-2983
ISSN	0142-7245 ; 0269-4042
DOI	10.1007/s10653-020-00550-1
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Article: L-Arginine in lung graft preservation and reperfusion.

Vainikka, T / Heikkilä, L / Kukkonen, S / Toivonen, H J

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation

2001 Volume 20, Issue 5, Page(s) 559–567

Abstract: ... to evaluate whether the benefits of exogenously administered gas could be achieved easier by adding L-arginine ... containing L-arginine (2 g/liter). After cold (4 degrees C) storage, the left lung was transplanted. Ischemic ... time was 260 minutes. The recipients received intravenous boluses of L-arginine (30 mg/kg), followed ...

Abstract	Background: Inhaled nitric oxide has been shown to ameliorate early lung graft dysfunction. It improves oxygenation by inducing pulmonary vasodilatation in well-ventilated lung areas, and it also modulates leukocyte-endothelium interactions. We used a porcine, single lung transplantation model to evaluate whether the benefits of exogenously administered gas could be achieved easier by adding L-arginine, the substrate of endogenous nitric oxide synthesis, as an additive to the flush solution and intravenously during reperfusion. Methods: Six pig lungs were flushed with modified Euro-Collins solutions containing L-arginine (2 g/liter). After cold (4 degrees C) storage, the left lung was transplanted. Ischemic time was 260 minutes. The recipients received intravenous boluses of L-arginine (30 mg/kg), followed by infusion (20 mg/kg/min) during the first 30 minutes of reperfusion. Six control animals received saline as placebo. We measured the blood flow and pulmonary vascular resistance (PVR) in the transplanted and in the native lung using a right heart bypass model. We measured blood gases, leukocyte counts, plasma free-radical trapping capacity, and diene conjugates in pulmonary venous blood and myeloperoxidase activity of the lung tissue. Results: Pulmonary vascular resistance was 4 to 5-fold higher in the transplanted lung than in the native lung, which received 80% of the total blood flow. L-arginine reduced PVR by 30% in the native lung (p < 0.001), but not in the transplanted lung. L-arginine had no effect on oxygenation or carbon dioxide exchange of the transplanted lung. Nor did L-arginine treatment have any effect on leukocyte sequestration or myeloperoxidase activity in the transplanted lung. The plasma antioxidant capacity in venous blood of the transplanted lung almost doubled shortly during early reperfusion without influence of L-arginine. Conclusions: L-arginine reduced PVR in the native lung but did not improve pulmonary hemodynamics, gas exchange, or reduce leukocyte sequestration of the transplanted lung.
MeSH term(s)	Animals ; Arginine/pharmacology ; Free Radicals/blood ; Leukocyte Count ; Lung/blood supply ; Lung/drug effects ; Lung Transplantation ; Models, Animal ; Organ Preservation ; Peroxidase/metabolism ; Pulmonary Gas Exchange/drug effects ; Regional Blood Flow/drug effects ; Reperfusion ; Swine ; Vascular Resistance/drug effects
Chemical Substances	Free Radicals ; Arginine (94ZLA3W45F) ; Peroxidase (EC 1.11.1.7)
Language	English
Publishing date	2001-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	1062522-7
ISSN	1557-3117 ; 1053-2498
ISSN (online)	1557-3117
ISSN	1053-2498
DOI	10.1016/s1053-2498(00)00332-6
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Article ; Online: Optimized extraction and characterization of antimicrobial phenolic compounds from mangosteen (Garcinia mangostana L.) cultivation and processing waste.

Palakawong, Choothaweep / Sophanodora, Pairat / Toivonen, Peter / Delaquis, Pascal

Journal of the science of food and agriculture

2013 Volume 93, Issue 15, Page(s) 3792–3800

Abstract: Background: Applications for antimicrobials derived from the mangosteen (Garcinia mangostana L ...

Abstract	Background: Applications for antimicrobials derived from the mangosteen (Garcinia mangostana L.) plant are presently restricted by high production costs. Extraction from cultivation or processing waste streams using a solvent-free approach could lessen to permit commercial applications in food processing and preservation. Results: Phenolics were extracted from mangosteen bark, leaf and fruit pericarp in methanol and in water using response surface methodology to optimize recovery. Initial examination of antimicrobial effects revealed a lack of antimicrobial activity against fungi and weak activity against the Gram-negative bacteria Escherichia coli and Salmonella typhimurium. In contrast, extracts prepared from bark or fruit pericarp exhibited strong pH-dependent bacteriostatic and bactericidal effects against Listeria monocytogenes and Staphylococcus aureus. Activity was slightly weaker in aqueous extracts due to lower concentrations of tartaric acid esters and flavonols than in methanolic extracts. Measurement of propidium iodide uptake and ATP leakage indicated that the extracts induced damage to the membrane of Gram-positive bacteria. Conclusion: Extracts of mangosteen bark and fruit pericarp contain mixtures of phenolic compounds with activity against Gram-positive bacteria, notably Listeria monocytogenes. Extraction of phenolics from mangosteen waste could yield fractions for potential applications in the formulation of low-cost processing aids or sanitizers for the food industry.
MeSH term(s)	Agriculture ; Anti-Bacterial Agents/pharmacology ; Cell Membrane/drug effects ; Flavonols/pharmacology ; Food Handling ; Fruit ; Garcinia mangostana/chemistry ; Gram-Negative Bacteria/drug effects ; Listeria monocytogenes/drug effects ; Microbial Sensitivity Tests ; Phenols/pharmacology ; Plant Bark ; Plant Extracts/pharmacology ; Staphylococcus aureus/drug effects ; Tartrates/pharmacology
Chemical Substances	Anti-Bacterial Agents ; Flavonols ; Phenols ; Plant Extracts ; Tartrates ; tartaric acid (W4888I119H)
Language	English
Publishing date	2013-12
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	184116-6
ISSN	1097-0010 ; 0022-5142
ISSN (online)	1097-0010
ISSN	0022-5142
DOI	10.1002/jsfa.6277
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Article: Optimized extraction and characterization of antimicrobial phenolic compounds from mangosteen (Garcinia mangostana L.) cultivation and processing waste

Palakawong, Choothaweep / Sophanodora, Pairat / Toivonen, Peter / Delaquis, Pascal

Journal of the science of food and agriculture. 2013 Dec., v. 93, no. 15

2013

Abstract: BACKGROUND: Applications for antimicrobials derived from the mangosteen (Garcinia mangostana L ...

Abstract	BACKGROUND: Applications for antimicrobials derived from the mangosteen (Garcinia mangostana L.) plant are presently restricted by high production costs. Extraction from cultivation or processing waste streams using a solvent‐free approach could lessen to permit commercial applications in food processing and preservation. RESULTS: Phenolics were extracted from mangosteen bark, leaf and fruit pericarp in methanol and in water using response surface methodology to optimize recovery. Initial examination of antimicrobial effects revealed a lack of antimicrobial activity against fungi and weak activity against the Gram‐negative bacteria Escherichia coli and Salmonella typhimurium. In contrast, extracts prepared from bark or fruit pericarp exhibited strong pH‐dependent bacteriostatic and bactericidal effects against Listeria monocytogenes and Staphylococcus aureus. Activity was slightly weaker in aqueous extracts due to lower concentrations of tartaric acid esters and flavonols than in methanolic extracts. Measurement of propidium iodide uptake and ATP leakage indicated that the extracts induced damage to the membrane of Gram‐positive bacteria. CONCLUSION: Extracts of mangosteen bark and fruit pericarp contain mixtures of phenolic compounds with activity against Gram‐positive bacteria, notably Listeria monocytogenes. Extraction of phenolics from mangosteen waste could yield fractions for potential applications in the formulation of low‐cost processing aids or sanitizers for the food industry. © 2013 Her Majesty the Queen in Right of Canada, as represented by the Minister of Agriculture and Agri‐Food Canada, Journal of the Science of Food and Agriculture © 2013 Society of Chemical Industry
Keywords	Escherichia coli ; Garcinia mangostana ; Listeria monocytogenes ; Salmonella typhimurium ; Staphylococcus aureus ; adenosine triphosphate ; antibacterial properties ; antimicrobial agents ; bacteria ; bark ; esters ; food industry ; food processing ; fungi ; leaves ; methanol ; pericarp ; phenolic compounds ; processing waste ; production costs ; response surface methodology ; sanitizers ; tartaric acid ; Canada
Language	English
Dates of publication	2013-12
Size	p. 3792-3800.
Publishing place	John Wiley & Sons, Ltd
Document type	Article
ZDB-ID	184116-6
ISSN	1097-0010 ; 0022-5142
ISSN (online)	1097-0010
ISSN	0022-5142
DOI	10.1002/jsfa.6277
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Article: Adaptatsionnye izmeneniia v spektrakh zhirnykh kislot tkanevykh lipidov siga Coregonus lavaretus L. pri vliianii antropogennykh nagruzok.

Toĭvonen, L V / Nefedova, Z A / Sidorov, V S / Sharova, Iu N

Prikladnaia biokhimiia i mikrobiologiia

2001 Volume 37, Issue 3, Page(s) 364–368

Abstract: Adaptive processes in the body of whitefish (Coregonus lavaretus L.) caused by anthropogenic ...

Title translation	Adaptive changes in fatty acid compositions of whitefish Coregonus lavaretus L. tissue lipids induced by anthropogenic factors.
Abstract	Adaptive processes in the body of whitefish (Coregonus lavaretus L.) caused by anthropogenic effects on aquatic systems were studied. It was demonstrated that the content of fatty acid acyls correlated with the water pollution level. The role of a decrease in the content of arachidonic acid in fish reproduction under adverse conditions is discussed. It is underlined that the quantitative alterations in the gonad and liver fatty acid patterns are unidirectional. A compensatory character of the changes discovered is hypothesized.
MeSH term(s)	Adaptation, Biological ; Animals ; Arachidonic Acid/metabolism ; Fatty Acids/metabolism ; Salmonidae/metabolism ; Water Pollution
Chemical Substances	Fatty Acids ; Arachidonic Acid (27YG812J1I)
Language	Russian
Publishing date	2001-05
Publishing country	Russia (Federation)
Document type	English Abstract ; Journal Article
ZDB-ID	412549-6
ISSN	0555-1099
ISSN	0555-1099
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Article ; Online: ST2 and IL-33 polymorphisms and the development of childhood asthma: a prospective birth cohort study in Finnish children.

Teräsjärvi, Johanna T / Toivonen, Laura / Mertsola, Jussi / Peltola, Ville / He, Qiushui

APMIS : acta pathologica, microbiologica, et immunologica Scandinavica

2024

Abstract: The ST2/IL-33 signaling pathway has an important role in the host inflammatory response. Here we aimed to study the association of ST2 and IL-33 polymorphisms with serum soluble (s) ST2 and IL-33 concentrations in healthy Finnish children and, in ... ...

Abstract	The ST2/IL-33 signaling pathway has an important role in the host inflammatory response. Here we aimed to study the association of ST2 and IL-33 polymorphisms with serum soluble (s) ST2 and IL-33 concentrations in healthy Finnish children and, in addition, their association with childhood asthma. In total, 146 children were followed from birth to the age 7 years for the development of asthma. Single-nucleotide polymorphisms (SNPs) in ST2 and IL-33 were determined, and associations of the SNP variants with serum levels of sST2 and IL-33 at age of 13 months and with recurrent wheezing and childhood asthma at 7 years of age were analyzed. Children with ST2 rs1041973 AC/AA genotypes had significantly lower level of serum sST2 (2453 pg/mL; IQR 2265) than those with CC genotype (5437 pg/mL; IQR 2575; p = < 0.0001). Similar difference was also observed with ST2 rs13408661. No differences were observed between subjects with studied IL-33 SNPs. Children who carried genetic variants of ST2 rs1041973 or rs13408661 seemed to have a higher risk of asthma. In contrast, children who carried genetic variants of IL-33 rs12551268 were less often diagnosed with asthma. Even though these SNPs seemed to associate with asthma, the differences were not statistically significant.
Language	English
Publishing date	2024-04-02
Publishing country	Denmark
Document type	Journal Article
ZDB-ID	93340-5
ISSN	1600-0463 ; 0903-4641
ISSN (online)	1600-0463
ISSN	0903-4641
DOI	10.1111/apm.13411
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Article ; Online: Asymmetric Roughness of Elastic Interfaces at the Depinning Threshold.

Toivonen, Esko / Molkkari, Matti / Räsänen, Esa / Laurson, Lasse

Physical review letters

2022 Volume 129, Issue 17, Page(s) 175701

Abstract: Roughness of driven elastic interfaces in random media is typically understood to be characterized by a single roughness exponent ζ. We show that at the depinning threshold, due to symmetry breaking caused by the direction of the driving force, elastic ... ...

Abstract	Roughness of driven elastic interfaces in random media is typically understood to be characterized by a single roughness exponent ζ. We show that at the depinning threshold, due to symmetry breaking caused by the direction of the driving force, elastic interfaces with local, long-range, and mean-field elasticity exhibit asymmetric roughness. It is manifested as a skewed distribution of the local interface heights, and can be quantified by using detrended fluctuation analysis to compute a spectrum of local, segment-level scaling exponents. The asymmetry is observed as approximately linear dependence of the local scaling exponents on the difference of the segment height from the mean interface height.
Language	English
Publishing date	2022-10-31
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.129.175701
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Article: Hybridization selects for prime-numbered life cycles in

Toivonen, Jaakko / Fromhage, Lutz

Ecology and evolution

2020 Volume 10, Issue 12, Page(s) 5259–5269

Abstract: We investigate competition between separate periodical cicada populations each possessing different life-cycle lengths. We build an individual-based model to simulate the cicada life cycle and allow random migrations to occur between patches inhabited by ...

Abstract	We investigate competition between separate periodical cicada populations each possessing different life-cycle lengths. We build an individual-based model to simulate the cicada life cycle and allow random migrations to occur between patches inhabited by the different populations. We show that if hybridization between different cycle lengths produces offspring that have an intermediate life-cycle length, then predation acts disproportionately to select against the hybrid offspring. This happens because they emerge in low densities without the safety-in-numbers provided by either parent population. Thus, prime-numbered life cycles that can better avoid hybridization are favored. However, we find that this advantage of prime-numbered cycles occurs only if there is some mechanism that can occasionally synchronize emergence between local populations in sufficiently many patches.
Language	English
Publishing date	2020-04-29
Publishing country	England
Document type	Journal Article
ZDB-ID	2635675-2
ISSN	2045-7758
ISSN	2045-7758
DOI	10.1002/ece3.6270
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