LIVIVO - Search results -

Search results

Result 1 - 10 of total 103

Search options

Article ; Online: Confocal Endomicroscopy Monitoring of Tumor Formation.

Preaudet, Adele / Fung, Ka Yee / Putoczki, Tracy L

Methods in molecular biology (Clifton, N.J.)

2023 Volume 2691, Page(s) 257–262

Abstract: The utilization of preclinical murine models of colorectal cancer (CRC) has been essential to our understanding of the onset and progression of disease. As the genetic complexity of these models evolves to better recapitulate emerging CRC subtypes, our ... ...

Abstract	The utilization of preclinical murine models of colorectal cancer (CRC) has been essential to our understanding of the onset and progression of disease. As the genetic complexity of these models evolves to better recapitulate emerging CRC subtypes, our ability to utilize these models to discover and validate novel therapeutic targets will also improve. This will be aided, in part, by the development of live animal imaging techniques, including confocal endomicroscopy for mice. Here in this chapter, we describe the combined use of standard white light endoscopy and confocal endomicroscopy thereby providing a method to rapidly image and assess changes in the colon of an individual live mouse in real time. These methods permit the generation of high-resolution cross-sectional images of the tumor microenvironment for immediate visualization of cells of interest, avoiding the need for euthanasia and tissue collection across multiple cohorts of mice.
MeSH term(s)	Animals ; Mice ; Colon/pathology ; Endoscopy/methods ; Neoplasms/pathology ; Microscopy, Confocal/methods ; Tumor Microenvironment
Language	English
Publishing date	2023-06-24
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1940-6029
ISSN (online)	1940-6029
DOI	10.1007/978-1-0716-3331-1_20
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾
- Full text online
- Order with fees

Article: JAK-STAT Signalling Pathway in Cancer.

Brooks, Andrew J / Putoczki, Tracy

Cancers

2020 Volume 12, Issue 7

Language	English
Publishing date	2020-07-20
Publishing country	Switzerland
Document type	Editorial
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers12071971
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Identification of Serum Biomarkers to Monitor Therapeutic Response in Intestinal-Type Gastric Cancer.

Dagley, Laura F / Yousef, Jumana / Preaudet, Adele / Loving, Andrea / Webb, Andrew I / Ernst, Matthias / Putoczki, Tracy L

International journal of molecular sciences

2024 Volume 25, Issue 6

Abstract: There are a limited number of clinically useful serum biomarkers to predict tumor onset or treatment response in gastric cancer (GC). For this reason, we explored the serum proteome of ... ...

Abstract	There are a limited number of clinically useful serum biomarkers to predict tumor onset or treatment response in gastric cancer (GC). For this reason, we explored the serum proteome of the
MeSH term(s)	Mice ; Animals ; Signal Transduction/physiology ; Stomach Neoplasms/pathology ; Cytokine Receptor gp130/metabolism ; Biomarkers ; Biomarkers, Tumor
Chemical Substances	Cytokine Receptor gp130 (133483-10-0) ; Biomarkers ; Biomarkers, Tumor
Language	English
Publishing date	2024-03-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms25063129
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Could the inhibition of IL-17 or IL-18 be a potential therapeutic opportunity for gastric cancer?

Nguyen, Paul M / Putoczki, Tracy L

Cytokine

2018 Volume 118, Page(s) 8–18

Abstract: Chronic inflammation is recognized as a key tumor-promoting factor in a number of epithelial cancers, including gastric cancer (GC). The production of pro-inflammatory cytokines in the tumor microenvironment by both the innate and the adaptive immune ... ...

Abstract	Chronic inflammation is recognized as a key tumor-promoting factor in a number of epithelial cancers, including gastric cancer (GC). The production of pro-inflammatory cytokines in the tumor microenvironment by both the innate and the adaptive immune response can activate signaling pathways that are associated with increased cell survival and proliferation of cancer cells. Among the cytokines that have most commonly been linked to inflammation-associated cancers, are the Th17 cell-associated cytokines IL-17A, IL-23, IL-22, and the IL-1 family members IL-1β and IL-18. However, whether their contribution to inflammation-associated cancers is universal, or specific to individual types of cancers, remains to be elucidated. This review will explore our current understanding of the known roles of these cytokines in gastritis and discuss how their therapeutic inhibition may be useful for GC.
MeSH term(s)	Animals ; Antineoplastic Agents/immunology ; Humans ; Inflammation/immunology ; Interleukin-17/antagonists & inhibitors ; Interleukin-17/immunology ; Interleukin-18/antagonists & inhibitors ; Interleukin-18/immunology ; Stomach Neoplasms/immunology ; Stomach Neoplasms/therapy ; Tumor Microenvironment/drug effects ; Tumor Microenvironment/immunology
Chemical Substances	Antineoplastic Agents ; Interleukin-17 ; Interleukin-18
Language	English
Publishing date	2018-02-01
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	1018055-2
ISSN	1096-0023 ; 1043-4666
ISSN (online)	1096-0023
ISSN	1043-4666
DOI	10.1016/j.cyto.2018.01.008
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 2840: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Emerging Roles for Interleukin-18 in the Gastrointestinal Tumor Microenvironment.

Fung, Ka Yee / Nguyen, Paul M / Putoczki, Tracy L

Advances in experimental medicine and biology

2020 Volume 1240, Page(s) 59–72

Abstract: Interleukin (IL)-18, a member of the IL-1 family of cytokines, has emerged as a key regulator of mucosal homeostasis within the gastrointestinal tract. Like other members of this family, IL-18 is secreted as an inactive protein and is processed into its ... ...

Abstract	Interleukin (IL)-18, a member of the IL-1 family of cytokines, has emerged as a key regulator of mucosal homeostasis within the gastrointestinal tract. Like other members of this family, IL-18 is secreted as an inactive protein and is processed into its active form by caspase-1, although other contributors to precursor processing are emerging.Numerous studies have evaluated the role of IL-18 within the gastrointestinal tract using genetic or complementary pharmacological tools and have revealed multiple roles in tumorigenesis. Most striking among these are the divergent roles for IL-18 in colon and gastric cancers. Here, we review our current understanding of IL-18 biology and how this applies to colorectal and gastric cancers.
MeSH term(s)	Animals ; Caspase 1/metabolism ; Colorectal Neoplasms/pathology ; Humans ; Interleukin-18/metabolism ; Stomach Neoplasms/pathology ; Tumor Microenvironment
Chemical Substances	Interleukin-18 ; Caspase 1 (EC 3.4.22.36)
Language	English
Publishing date	2020-02-14
Publishing country	United States
Document type	Journal Article ; Review
ISSN	2214-8019 ; 0065-2598
ISSN (online)	2214-8019
ISSN	0065-2598
DOI	10.1007/978-3-030-38315-2_5
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Structural Understanding of Interleukin 6 Family Cytokine Signaling and Targeted Therapies: Focus on Interleukin 11.

Metcalfe, Riley D / Putoczki, Tracy L / Griffin, Michael D W

Frontiers in immunology

2020 Volume 11, Page(s) 1424

Abstract: Cytokines are small signaling proteins that have central roles in inflammation and cell survival. In the half-century since the discovery of the first cytokines, the interferons, over fifty cytokines have been identified. Amongst these is interleukin (IL) ...

Abstract	Cytokines are small signaling proteins that have central roles in inflammation and cell survival. In the half-century since the discovery of the first cytokines, the interferons, over fifty cytokines have been identified. Amongst these is interleukin (IL)-6, the first and prototypical member of the IL-6 family of cytokines, nearly all of which utilize the common signaling receptor, gp130. In the last decade, there have been numerous advances in our understanding of the structural mechanisms of IL-6 family signaling, particularly for IL-6 itself. However, our understanding of the detailed structural mechanisms underlying signaling by most IL-6 family members remains limited. With the emergence of new roles for IL-6 family cytokines in disease and, in particular, roles of IL-11 in cardiovascular disease, lung disease, and cancer, there is an emerging need to develop therapeutics that can progress to clinical use. Here we outline our current knowledge of the structural mechanism of signaling by the IL-6 family of cytokines. We discuss how this knowledge allows us to understand the mechanism of action of currently available inhibitors targeting IL-6 family cytokine signaling, and most importantly how it allows for improved opportunities to pharmacologically disrupt cytokine signaling. We focus specifically on the need to develop and understand inhibitors that disrupt IL-11 signaling.
MeSH term(s)	Animals ; Humans ; Interleukin-11/chemistry ; Interleukin-11/immunology ; Interleukin-11/metabolism ; Interleukin-6/chemistry ; Interleukin-6/immunology ; Interleukin-6/metabolism ; Signal Transduction/immunology ; Structure-Activity Relationship
Chemical Substances	Interleukin-11 ; Interleukin-6
Keywords	covid19
Language	English
Publishing date	2020-07-16
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2020.01424
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: In Vivo Models of Inflammatory Bowel Disease and Colitis-Associated Cancer.

Fung, Ka Yee / Putoczki, Tracy

Methods in molecular biology (Clifton, N.J.)

2017 Volume 1725, Page(s) 3–13

Abstract: A single layer of epithelial cells separates luminal antigens from the host immune system throughout the gastrointestinal tract. A breakdown in the integrity of the epithelial barrier can lead to chronic inflammation, which is associated with numerous ... ...

Abstract	A single layer of epithelial cells separates luminal antigens from the host immune system throughout the gastrointestinal tract. A breakdown in the integrity of the epithelial barrier can lead to chronic inflammation, which is associated with numerous complications including cancer. Here we describe three experimental protocols to chemically induce acute and chronic inflammatory bowel disease (IBD) symptoms and colitis-associated colorectal cancer (CRC) progression. These in vivo mouse models are based on the induction of damage to the colonic epithelium, resulting in an inflammatory and wound healing response. In addition, we outline colonoscopy procedures to monitor the onset of disease in individual live mice.
MeSH term(s)	Animals ; Colitis/complications ; Colonic Neoplasms/etiology ; Colonic Neoplasms/pathology ; Disease Models, Animal ; Female ; Humans ; Inflammatory Bowel Diseases/complications ; Mice
Language	English
Publishing date	2017-12-28
Publishing country	United States
Document type	Journal Article
ISSN	1940-6029
ISSN (online)	1940-6029
DOI	10.1007/978-1-4939-7568-6_1
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾
- Full text online
- Order with fees

Article ; Online: Emerging roles for Interleukin-11 in disease.

Nguyen, Paul M / Abdirahman, Suad M / Putoczki, Tracy L

Growth factors (Chur, Switzerland)

2019 Volume 37, Issue 1-2, Page(s) 1–11

Abstract: Interleukin (IL)-11 belongs to the IL-6 family of cytokines, discovered over 30 years ago. While early studies focused on the ability of IL-11 to stimulate megakaryocytopoiesis, the importance of this cytokine to inflammatory disease and cancers is only ... ...

Abstract	Interleukin (IL)-11 belongs to the IL-6 family of cytokines, discovered over 30 years ago. While early studies focused on the ability of IL-11 to stimulate megakaryocytopoiesis, the importance of this cytokine to inflammatory disease and cancers is only just beginning to be uncovered. This review outlines recent advances in our understanding of IL-11 biology, and highlights the development of novel therapeutics with the potential for clinical targeting of signaling by this cytokine in multiple diseases.
MeSH term(s)	Animals ; Cardiovascular Diseases/genetics ; Craniofacial Dysostosis/genetics ; Humans ; Immune System Diseases/genetics ; Interleukin-11/genetics ; Interleukin-11/metabolism ; Mutation ; Neoplasms/genetics
Chemical Substances	Interleukin-11
Language	English
Publishing date	2019-06-04
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	1035755-5
ISSN	1029-2292 ; 0897-7194
ISSN (online)	1029-2292
ISSN	0897-7194
DOI	10.1080/08977194.2019.1620227
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 2612: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Emerging roles for the IL-6 family of cytokines in pancreatic cancer.

van Duijneveldt, Gemma / Griffin, Michael D W / Putoczki, Tracy L

Clinical science (London, England : 1979)

2020 Volume 134, Issue 16, Page(s) 2091–2115

Abstract: Pancreatic cancer has one of the poorest prognoses of all malignancies, with little improvement in clinical outcome over the past 40 years. Pancreatic ductal adenocarcinoma is responsible for the vast majority of pancreatic cancer cases, and is ... ...

Abstract	Pancreatic cancer has one of the poorest prognoses of all malignancies, with little improvement in clinical outcome over the past 40 years. Pancreatic ductal adenocarcinoma is responsible for the vast majority of pancreatic cancer cases, and is characterised by the presence of a dense stroma that impacts therapeutic efficacy and drives pro-tumorigenic programs. More specifically, the inflammatory nature of the tumour microenvironment is thought to underlie the loss of anti-tumour immunity and development of resistance to current treatments. Inflammatory pathways are largely mediated by the expression of, and signalling through, cytokines, chemokines, and other cellular messengers. In recent years, there has been much attention focused on dual targeting of cancer cells and the tumour microenvironment. Here we review our current understanding of the role of IL-6, and the broader IL-6 cytokine family, in pancreatic cancer, including their contribution to pancreatic inflammation and various roles in pancreatic cancer pathogenesis. We also summarise potential opportunities for therapeutic targeting of these pathways as an avenue towards combating poor patient outcomes.
MeSH term(s)	Carcinoma, Pancreatic Ductal/metabolism ; Carcinoma, Pancreatic Ductal/pathology ; Carcinoma, Pancreatic Ductal/therapy ; Cytokines/metabolism ; Humans ; Interleukin-6/metabolism ; Janus Kinase 2/metabolism ; Pancreatic Neoplasms/metabolism ; Pancreatic Neoplasms/pathology ; Pancreatic Neoplasms/therapy ; STAT3 Transcription Factor/metabolism ; Signal Transduction ; Suppressor of Cytokine Signaling 3 Protein/metabolism ; Tumor Microenvironment
Chemical Substances	Cytokines ; Interleukin-6 ; SOCS3 protein, human ; STAT3 Transcription Factor ; STAT3 protein, human ; Suppressor of Cytokine Signaling 3 Protein ; JAK2 protein, human (EC 2.7.10.2) ; Janus Kinase 2 (EC 2.7.10.2)
Keywords	covid19
Language	English
Publishing date	2020-08-18
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	206835-7
ISSN	1470-8736 ; 0301-0538 ; 0009-0360 ; 0143-5221
ISSN (online)	1470-8736
ISSN	0301-0538 ; 0009-0360 ; 0143-5221
DOI	10.1042/CS20191211
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Ua VI Zs.220: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: IL-11 signaling as a therapeutic target for cancer.

Putoczki, Tracy L / Ernst, Matthias

Immunotherapy

2015 Volume 7, Issue 4, Page(s) 441–453

Abstract: IL-11 is a member of the IL-6 family of cytokines. While it was discovered over 20 years ago, we have very little understanding of the role of IL-11 during normal homeostasis and disease. Recently, IL-11 has gained interest for its newly recognized role ... ...

Abstract	IL-11 is a member of the IL-6 family of cytokines. While it was discovered over 20 years ago, we have very little understanding of the role of IL-11 during normal homeostasis and disease. Recently, IL-11 has gained interest for its newly recognized role in the pathogenesis of diseases that are attributed to deregulated mucosal homeostasis, including gastrointestinal cancers. IL-11 can increase the tumorigenic capacity of cells, including survival of the cell or origin, proliferation of cancerous cells and survival of metastatic cells at distant organs. Here we outline our current understanding of IL-11 biology and recent advances in our understanding of its role in cancer. We advocate that inhibition of IL-11 signaling may represent an emerging therapeutic opportunity for numerous cancers.
MeSH term(s)	Animals ; Carcinogenesis ; Cell Survival ; Gastrointestinal Neoplasms/immunology ; Gastrointestinal Neoplasms/therapy ; Homeostasis ; Humans ; Immunity, Mucosal ; Immunotherapy/methods ; Interleukin-11/immunology ; Interleukin-11/metabolism ; Interleukin-6/metabolism ; Molecular Targeted Therapy ; Neoplasm Metastasis ; Signal Transduction/drug effects
Chemical Substances	Interleukin-11 ; Interleukin-6
Language	English
Publishing date	2015-04-27
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2495964-9
ISSN	1750-7448 ; 1750-743X
ISSN (online)	1750-7448
ISSN	1750-743X
DOI	10.2217/imt.15.17
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

Order via subito

Details ▾
- Full text online
- Order with fees

To top

Full text online

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

Order via subito