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Article ; Online: A rare case report of nasopharyngeal carcinoma with multi-organ metastasis, clinico- radiologically mimicking lymphoma.

Hajra, Subhajit / Kumar, Alok / Sundriyal, Deepak / Chandra, Harish / Balasubramanian, Priyavadhana

Hematology, transfusion and cell therapy

2023

Language	English
Publishing date	2023-05-10
Publishing country	Brazil
Document type	Case Reports
ISSN	2531-1387
ISSN (online)	2531-1387
DOI	10.1016/j.htct.2023.03.024
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Article ; Online: Necrotising granulomas masking Hodgkin lymphoma: Report of a rare case.

Kunnumbrath, Arathi / Chandra, Harish / Azad, Shweta / Balasubramanian, Priyavadhana

Hematology, transfusion and cell therapy

2021 Volume 45 Suppl 2, Page(s) S157–S160

Language	English
Publishing date	2021-11-29
Publishing country	Brazil
Document type	Case Reports
ISSN	2531-1387
ISSN (online)	2531-1387
DOI	10.1016/j.htct.2021.08.010
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Article: Online Foundation Course Program for First Year Medical Undergraduates Amidst the COVID-19 Pandemic - A New Learning Experience.

Khorwal, Gitanjali / Negi, Gita / Bhute, Ashish / Chandra, Harish / Balasubramanian, Priyavadhana / Pant, Jayanti

Advances in medical education and practice

2021 Volume 12, Page(s) 739–744

Abstract: Foundation programs are conducted in medical schools for undergraduate students, since they are naïve and unaware of the medical profession in depth. The program helps them to become familiar with the undergraduate medical training. The present intake of ...

Abstract	Foundation programs are conducted in medical schools for undergraduate students, since they are naïve and unaware of the medical profession in depth. The program helps them to become familiar with the undergraduate medical training. The present intake of first year medical undergraduates had joined the institute amidst the COVID-19 pandemic and hence the foundation program had to be conducted through an online platform. The present paper is a description of the online program conducted in the institute and is aimed to focus on the pros and cons of using an online platform for conducting the program and the experience gained from it. The online foundation program was conducted over a period of 16 days through the Zoom
Language	English
Publishing date	2021-07-05
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2578539-4
ISSN	1179-7258
ISSN	1179-7258
DOI	10.2147/AMEP.S310625
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Article: Diffuse Large B-Cell Lymphoma Relapsing in Leukaemic Phase Presenting as Acute Leukaemia.

Balasubramanian, Priyavadhana / Ramteke, Prashant / Mallick, Saumyaranjan / Kumar, Lalit / Tanwar, Pranay

Clinical medicine insights. Blood disorders

2019 Volume 12, Page(s) 1179545X18821160

Abstract: Diffuse large B-cell lymphoma (DLBCL) accounts for 30% to 40% of the newly diagnosed adult non-Hodgkin lymphomas, but rarely presents in leukaemic phase. Here in, we report a case of DLBCL presenting in leukaemic phase and masquerading as acute leukaemia. ...

Abstract	Diffuse large B-cell lymphoma (DLBCL) accounts for 30% to 40% of the newly diagnosed adult non-Hodgkin lymphomas, but rarely presents in leukaemic phase. Here in, we report a case of DLBCL presenting in leukaemic phase and masquerading as acute leukaemia. A 28-year-old woman presented to our outpatient department with complaints of fever for 1 week. Her peripheral blood smear showed 5% to 8% blasts. Bone marrow aspirate showed an infiltration by ~30% blasts. Flow cytometry and immunohistochemistry confirmed relapse of DLBCL. Also, patient's poor response to therapeutic regimen for DLBCL prompted to consider second differential diagnosis of acute leukaemia. This case is a learning case, as it emphasizes the combined role of diagnostic ancillary techniques along with clinical judgments for management. The case also makes us more vigilant towards the pathobiology of DLBCL and dynamics of personalized individual treatment response.
Language	English
Publishing date	2019-01-15
Publishing country	United States
Document type	Case Reports
ZDB-ID	2593085-0
ISSN	1179-545X
ISSN	1179-545X
DOI	10.1177/1179545X18821160
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Article ; Online: Prognostic significance of CD45 antigen expression in pediatric acute lymphoblastic leukemia.

Balasubramanian, Priyavadhana / Singh, Jay / Verma, Deepak / Kumar, Rajive / Bakhshi, Sameer / Tanwar, Pranay / Singh, Amar Ranjan / Chopra, Anita

Blood cells, molecules & diseases

2021 Volume 89, Page(s) 102562

Abstract: Objectives: The treatment of pediatric acute lymphoblastic leukemias (ALL) has seen remarkable advances recently. However, relapse occurs in approximately 20% of cases which necessitates identifying additional high risk parameters for treatment ... ...

Abstract	Objectives: The treatment of pediatric acute lymphoblastic leukemias (ALL) has seen remarkable advances recently. However, relapse occurs in approximately 20% of cases which necessitates identifying additional high risk parameters for treatment intensification. The aim of this study is to assess the prognostic significance of CD45 antigen expression in pediatric ALL. Methods: We studied 363 pediatric patients with B cell precursor-ALL (BCP-ALL) (n = 313) and T-ALL (n = 50). The ratio of median fluorescence intensity of CD45 expressed in leukemic blasts and normal lymphocytes was calculated. The 75th percentile was taken as cut-off to categorise patients into CD45 high and CD45 low groups. Results: The 75th percentile was 0.141 in BCP-ALL and 0.548 in T-ALL. In BCP-ALL, there was a statistically significant association of age (≥10 years) (p = 0.027) and National Cancer Institute high risk group (p = 0.001) with high CD45 expression but not in T-ALL. Worse event-free survival (EFS) was seen with high CD45 expression in BCP-ALL (42.17% versus 60.83%, p = 0.0053). In T-ALL, there was no association between CD45 expression and EFS (CD45 high 40.40% versus low 67.35%, p = 0.414). The overall survival (OS) was 70% versus 60% (p = 0.38) in BCP-ALL and the OS was 82% versus 68% (p = 0.16) in T-ALL for CD45 low versus CD45 high groups, respectively. Conclusion: We conclude that high CD45 surface expression is associated with worse EFS in pediatric BCP-ALL.
MeSH term(s)	Bone Marrow/pathology ; Child ; Female ; Humans ; Leukocyte Common Antigens/analysis ; Lymphocytes/pathology ; Male ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/diagnosis ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/pathology ; Prognosis ; Survival Analysis
Chemical Substances	Leukocyte Common Antigens (EC 3.1.3.48) ; PTPRC protein, human (EC 3.1.3.48)
Language	English
Publishing date	2021-03-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	1237083-6
ISSN	1096-0961 ; 1079-9796
ISSN (online)	1096-0961
ISSN	1079-9796
DOI	10.1016/j.bcmd.2021.102562
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Article ; Online: Comparison of Filter Paper and Gelfoam as Templates for Orientation of Endoscopic Duodenal Biopsies

Priyavadhana Balasubramanian / Bhawana Ashok Badhe / Rajesh Nachiappa Ganesh / Lakshmi C Panicker / Pazhanivel Mohan

Journal of Clinical and Diagnostic Research, Vol 13, Iss 2, Pp EM01-EM

2019 Volume 03

Abstract: Introduction: Proper orientation of endoscopic mucosal biopsies is crucial for accurate histomorphologic assessment. Aim: To compare the morphology on two different templates, filter paper and gelfoam for orientation of biopsies. Materials and Methods: ... ...

Abstract	Introduction: Proper orientation of endoscopic mucosal biopsies is crucial for accurate histomorphologic assessment. Aim: To compare the morphology on two different templates, filter paper and gelfoam for orientation of biopsies. Materials and Methods: In this study a total of 21 duodenal biopsies were studied which were taken from the same site, fixed and oriented on wet filter paper and gelfoam in formalin, from patients who presented with malabsorptive symptoms. Histomorphological parameters studied were villous architecture, crypt architecture, intraepithelial lymphocyte (IEL) count per 100 enterocytes, villous tip IEL count per 20 enterocytes, inflammatory cells in lamina propria. Statistical analysis was done using IBM- SPSS software version 21. p-value <0.05 was considered as statistically significant. Results: Twenty-one biopsies were taken in both the templates. Authors had 18 biopsies for analysis as three sections on gelfoam were lost during processing. All the histomorphological parameters were studied and it was similar on both the templates. The level of agreement by kappa statistics was significant with kappa value of 0.727 for villous architecture, 0.852 for lamina propria inflammatory infiltrate, 1 for IEL and eosinophils in lamina propria with p-value of <0.001. Conclusion: Authors concluded, gelfoam or filter paper serves as a good template for proper orientation of tiny mucosal biopsies. However, further studies are needed on larger sample size to validate this finding.
Keywords	endoscopic mucosal biopsies ; gastrointestinal endoscopies ; lamina propria ; Medicine ; R
Subject code	610
Language	English
Publishing date	2019-02-01T00:00:00Z
Publisher	JCDR Research and Publications Private Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Morphologic Spectrum of Duodenal Biopsies in Malabsorption

Priyavadhana Balasubramanian / Bhawana Ashok Badhe / Rajesh Nachiappa Ganesh / Lakshmi C Panicker / Pazhanivel Mohan

Journal of Clinical and Diagnostic Research, Vol 11, Iss 7, Pp EC17-EC

A Study from Southern India

2017 Volume 21

Abstract: Introduction: Duodenal endoscopic biopsy is a common investigation for various non-neoplastic conditions. Malabsorption is a common indication for duodenal biopsy in our setting. Aim: Our study was undertaken to study the morphologic spectrum of non- ... ...

Abstract	Introduction: Duodenal endoscopic biopsy is a common investigation for various non-neoplastic conditions. Malabsorption is a common indication for duodenal biopsy in our setting. Aim: Our study was undertaken to study the morphologic spectrum of non-neoplastic conditions of duodenum emphasizing on Intraepithelial Lymphocytes (IELs) and to have a clinico-pathologic correlation. Materials and Methods: This was a prospective descriptive study. Duodenal biopsies from 101 patients with symptoms of malabsorption were studied according to inclusion and exclusion criteria. Informed written consent was taken. Clinical, laboratory, endoscopic, and serological parameters were collected wherever available. Histomorphological parameters were studied on Haematoxylin and Eosin (H&E) stained sections. Intraepithelial lymphocyte counts were done on CD3, CD4 and CD8 Immunohistochemical (IHC) stained sections and correlated. Results: We studied 101 duodenal biopsies. Our spectrum included 16 patients of celiac disease (CD) (15.8%), 15 autoimmune duodenitis (14%), 13 nutritional deficiency associated duodenitis (12.8%), five infectious duodenitis (5%) and 41 patients of non-specific duodenitis (40.6%) and 10.9% miscellaneous causes of duodenitis. Villous crypt architecture, IEL counts; villous tip IEL counts were statistically significant between CD and other disease groups. Conclusion: A constellation of clinical, serological, endoscopic and histopathologic features is essential in diagnosing CD and autoimmune duodenitis. Biopsy is also a useful tool in diagnosing infectious duodenitis that are missed in other investigations.
Keywords	celiac disease ; duodenum ; intraepithelial lymphocyte ; Medicine ; R
Subject code	610
Language	English
Publishing date	2017-07-01T00:00:00Z
Publisher	JCDR Research and Publications Private Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Morphologic Spectrum of Duodenal Biopsies in Malabsorption: A Study from Southern India.

Balasubramanian, Priyavadhana / Badhe, Bhawana Ashok / Ganesh, Rajesh Nachiappa / Panicker, Lakshmi C / Mohan, Pazhanivel

Journal of clinical and diagnostic research : JCDR

2017 Volume 11, Issue 7, Page(s) EC17–EC21

Abstract: Introduction: Duodenal endoscopic biopsy is a common investigation for various non-neoplastic conditions. Malabsorption is a common indication for duodenal biopsy in our setting.: Aim: Our study was undertaken to study the morphologic spectrum of non- ...

Abstract	Introduction: Duodenal endoscopic biopsy is a common investigation for various non-neoplastic conditions. Malabsorption is a common indication for duodenal biopsy in our setting. Aim: Our study was undertaken to study the morphologic spectrum of non-neoplastic conditions of duodenum emphasizing on Intraepithelial Lymphocytes (IELs) and to have a clinico-pathologic correlation. Materials and methods: This was a prospective descriptive study. Duodenal biopsies from 101 patients with symptoms of malabsorption were studied according to inclusion and exclusion criteria. Informed written consent was taken. Clinical, laboratory, endoscopic, and serological parameters were collected wherever available. Histomorphological parameters were studied on Haematoxylin and Eosin (H&E) stained sections. Intraepithelial lymphocyte counts were done on CD3, CD4 and CD8 Immunohistochemical (IHC) stained sections and correlated. Results: We studied 101 duodenal biopsies. Our spectrum included 16 patients of celiac disease (CD) (15.8%), 15 autoimmune duodenitis (14%), 13 nutritional deficiency associated duodenitis (12.8%), five infectious duodenitis (5%) and 41 patients of non-specific duodenitis (40.6%) and 10.9% miscellaneous causes of duodenitis. Villous crypt architecture, IEL counts; villous tip IEL counts were statistically significant between CD and other disease groups. Conclusion: A constellation of clinical, serological, endoscopic and histopathologic features is essential in diagnosing CD and autoimmune duodenitis. Biopsy is also a useful tool in diagnosing infectious duodenitis that are missed in other investigations.
Language	English
Publishing date	2017-07-01
Publishing country	India
Document type	Journal Article
ZDB-ID	2775283-5
ISSN	0973-709X ; 2249-782X
ISSN (online)	0973-709X
ISSN	2249-782X
DOI	10.7860/JCDR/2017/23871.10231
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Article ; Online: Imatinib resistance in chronic myeloid leukemia due to a rare mutation.

Balasubramanian, Priyavadhana / Chopra, Anita / Verma, Deepak / Singh, Indresh K / Kumar, Akash / Sharma, Atul / Kumar, Rajive

Leukemia & lymphoma

2016 Volume 58, Issue 7, Page(s) 1750–1752

MeSH term(s)	Adult ; Alleles ; Antineoplastic Agents/pharmacology ; Cell Line, Tumor ; DNA Mutational Analysis ; Drug Resistance, Neoplasm/genetics ; Fusion Proteins, bcr-abl/chemistry ; Fusion Proteins, bcr-abl/genetics ; Humans ; Imatinib Mesylate/pharmacology ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/genetics ; Male ; Mutation ; Protein Kinase Inhibitors/pharmacology
Chemical Substances	Antineoplastic Agents ; Protein Kinase Inhibitors ; Imatinib Mesylate (8A1O1M485B) ; Fusion Proteins, bcr-abl (EC 2.7.10.2)
Language	English
Publishing date	2016-11-20
Publishing country	United States
Document type	Case Reports ; Letter
ZDB-ID	1042374-6
ISSN	1029-2403 ; 1042-8194
ISSN (online)	1029-2403
ISSN	1042-8194
DOI	10.1080/10428194.2016.1256479
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Article ; Online: Online Foundation Course Program for First Year Medical Undergraduates Amidst the COVID-19 Pandemic – A New Learning Experience

Khorwal G / Negi G / Bhute A / Chandra H / Balasubramanian P / Pant J

Advances in Medical Education and Practice, Vol Volume 12, Pp 739-

2021 Volume 744

Abstract: Gitanjali Khorwal,1 Gita Negi,2 Ashish Bhute,3 Harish Chandra,4 Priyavadhana Balasubramanian,4 ...

Abstract	Gitanjali Khorwal,1 Gita Negi,2 Ashish Bhute,3 Harish Chandra,4 Priyavadhana Balasubramanian,4 Jayanti Pant5 1Department of Anatomy, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India; 2Department of Transfusion Medicine, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India; 3Department of Forensic Medicine and Toxicology, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India; 4Department of Pathology, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India; 5Department of Physiology, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, IndiaCorrespondence: Jayanti PantDepartment of Physiology, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, 249203, IndiaEmail pant.jayanti@gmail.comAbstract: Foundation programs are conducted in medical schools for undergraduate students, since they are naïve and unaware of the medical profession in depth. The program helps them to become familiar with the undergraduate medical training. The present intake of first year medical undergraduates had joined the institute amidst the COVID-19 pandemic and hence the foundation program had to be conducted through an online platform. The present paper is a description of the online program conducted in the institute and is aimed to focus on the pros and cons of using an online platform for conducting the program and the experience gained from it. The online foundation program was conducted over a period of 16 days through the Zoom© platform. The program was tailored to cater for the orientation of 175 students who were admitted for first year MBBS batch 2020– 2021. Feedback from students was obtained through Google Forms© at the end of the program. The online program was conducted smoothly due to the dedicated efforts of all the team members. Sessions requiring hands-on training and physical field visits had to be omitted in the present program. Network connectivity issues were reported sometimes. The conduction of the online foundation ...
Keywords	orientation ; zoom © platform ; students ; modules ; Special aspects of education ; LC8-6691 ; Medicine (General) ; R5-920
Language	English
Publishing date	2021-07-01T00:00:00Z
Publisher	Dove Medical Press
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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