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Article ; Online: Remembering Fred S. Wright, M.D. (1937-2023).

Aronson, Peter S / Ellison, David H / Okusa, Mark D / Perazella, Mark A

Kidney360

2024

Language	English
Publishing date	2024-04-03
Publishing country	United States
Document type	Journal Article
ISSN	2641-7650
ISSN (online)	2641-7650
DOI	10.34067/KID.0000000000000438
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Article ; Online: Commentary on "Inherited DNA-repair gene mutations in men with metastatic prostate cancer". Pritchard CC, Mateo J, Walsh MF, De Sarkar N, Abida W, Beltran H, Garofalo A, Gulati R, Carreira S, Eeles R, Elemento O, Rubin MA, Robinson D, Lonigro R, Hussain M, Chinnaiyan A, Vinson J, Filipenko J, Garraway L, Taplin ME, AlDubayan S, Han GC, Beightol M, Morrissey C, Nghiem B, Cheng HH, Montgomery B, Walsh T, Casadei S, Berger M, Zhang L, Zehir A, Vijai J, Scher HI, Sawyers C, Schultz N, Kantoff PW, Solit D, Robson M, Van Allen EM, Offit K, de Bono J, Nelson PS. N Engl J Med. 2016;375(5):443-53.

Freedland, Stephen J / Aronson, William J

Urologic oncology

2017 Volume 35, Issue 8, Page(s) 536–537

Abstract: Background: Inherited mutations in DNA-repair genes such as BRCA2 are associated with increased risks of lethal prostate cancer. Although the prevalence of germline mutations in DNA-repair genes among men with localized prostate cancer who are ... ...

Abstract	Background: Inherited mutations in DNA-repair genes such as BRCA2 are associated with increased risks of lethal prostate cancer. Although the prevalence of germline mutations in DNA-repair genes among men with localized prostate cancer who are unselected for family predisposition is insufficient to warrant routine testing, the frequency of such mutations in patients with metastatic prostate cancer has not been established. Methods: We recruited 692 men with documented metastatic prostate cancer who were unselected for family history of cancer or age at diagnosis. We isolated germline DNA and used multiplex sequencing assays to assess mutations in 20 DNA-repair genes associated with autosomal dominant cancer-predisposition syndromes. Results: A total of 84 germline DNA-repair gene mutations that were presumed to be deleterious were identified in 82 men (11.8%); mutations were found in 16 genes, including BRCA2 (37 men [5.3%]), ATM (11 [1.6%]), CHEK2 (10 [1.9% of 534 men with data]), BRCA1 (6 [0.9%]), RAD51D (3 [0.4%]), and PALB2 (3 [0.4%]). Mutation frequencies did not differ according to whether a family history of prostate cancer was present or according to age at diagnosis. Overall, the frequency of germline mutations in DNA-repair genes among men with metastatic prostate cancer significantly exceeded the prevalence of 4.6% among 499 men with localized prostate cancer (P<0.001), including men with high-risk disease, and the prevalence of 2.7% in the Exome Aggregation Consortium, which includes 53,105 persons without a known cancer diagnosis (P<0.001). Conclusions: In our multicenter study, the incidence of germline mutations in genes mediating DNA-repair processes among men with metastatic prostate cancer was 11.8%, which was significantly higher than the incidence among men with localized prostate cancer. The frequencies of germline mutations in DNA-repair genes among men with metastatic disease did not differ significantly according to age at diagnosis or family history of prostate cancer.
Language	English
Publishing date	2017-06-13
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	1336505-8
ISSN	1873-2496 ; 1078-1439
ISSN (online)	1873-2496
ISSN	1078-1439
DOI	10.1016/j.urolonc.2017.05.012
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Zs.A 4817: Show issues

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Article ; Online: Commentary on "Integrative clinical genomics of advanced prostate cancer". Robinson D, Van Allen EM, Wu YM, Schultz N, Lonigro RJ, Mosquera JM, Montgomery B, Taplin ME, Pritchard CC, Attard G, Beltran H, Abida W, Bradley RK, Vinson J, Cao X, Vats P, Kunju LP, Hussain M, Feng FY, Tomlins SA, Cooney KA, Smith DC, Brennan C, Siddiqui J, Mehra R, Chen Y, Rathkopf DE, Morris MJ, Solomon SB, Durack JC, Reuter VE, Gopalan A, Gao J, Loda M, Lis RT, Bowden M, Balk SP, Gaviola G, Sougnez C, Gupta M, Yu EY, Mostaghel EA, Cheng HH, Mulcahy H, True LD, Plymate SR, Dvinge H, Ferraldeschi R, Flohr P, Miranda S, Zafeiriou Z, Tunariu N, Mateo J, Perez-Lopez R, Demichelis F, Robinson BD, Schiffman M, Nanus DM, Tagawa ST, Sigaras A, Eng KW, Elemento O, Sboner A, Heath EI, Scher HI, Pienta KJ, Kantoff P, de Bono JS, Rubin MA, Nelson PS, Garraway LA, Sawyers CL, Chinnaiyan AM.Cell. 21 May 2015;161(5):1215-1228.

Freedland, Stephen J / Aronson, William J

Urologic oncology

2017 Volume 35, Issue 8, Page(s) 535

Abstract: Toward development of a precision medicine framework for metastatic, castration-resistant prostate cancer (mCRPC), we established a multi-institutional clinical sequencing infrastructure to conduct prospective whole-exome and transcriptome sequencing of ... ...

Abstract	Toward development of a precision medicine framework for metastatic, castration-resistant prostate cancer (mCRPC), we established a multi-institutional clinical sequencing infrastructure to conduct prospective whole-exome and transcriptome sequencing of bone or soft tissue tumor biopsies from a cohort of 150 mCRPC affected individuals. Aberrations of AR, ETS genes, TP53, and PTEN were frequent (40%-60% of cases), with TP53 and AR alterations enriched in mCRPC compared to primary prostate cancer. We identified new genomic alterations in PIK3CA/B, R-spondin, BRAF/RAF1, APC, β-catenin, and ZBTB16/PLZF. Moreover, aberrations of BRCA2, BRCA1, and ATM were observed at substantially higher frequencies (19.3% overall) compared to those in primary prostate cancers. A total of 89% of affected individuals harbored a clinically actionable aberration, including 62.7% with aberrations in AR, 65% in other cancer-related genes, and 8% with actionable pathogenic germline alterations. This cohort study provides clinically actionable information that could affect treatment decisions for these affected individuals.
Language	English
Publishing date	2017-06-13
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	1336505-8
ISSN	1873-2496 ; 1078-1439
ISSN (online)	1873-2496
ISSN	1078-1439
DOI	10.1016/j.urolonc.2017.05.010
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Article ; Online: Words of wisdom. Re: Weight loss with a low-carbohydrate, Mediterranean, or low-fat diet. Shai I, Schwarzfuchs D, Henkin Y, Shahar DR, Witkow S, Greenberg I, Golan R, Fraser D, Bolotin A, Vardi H, Tangi-Rozental O, Zuk-Ramot R, Sarusi B, Brickner D, Schwartz Z, Sheiner E, Marko R, Katorza E, Thiery J, Fiedler GM, Blüher M, Stumvoll M, Stampfer MJ. Dietary Intervention Randomized Controlled Trial (DIRECT) Group. N Engl J Med 2008;359:229-41.

Freedland, Stephen J / Aronson, William J

European urology

2009 Volume 55, Issue 1, Page(s) 249–250

Language	English
Publishing date	2009-12-24
Publishing country	Switzerland
Document type	Comment ; Journal Article
ZDB-ID	193790-x
ISSN	1873-7560 ; 1421-993X ; 0302-2838
ISSN (online)	1873-7560 ; 1421-993X
ISSN	0302-2838
DOI	10.1016/j.eururo.2008.09.036
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Zs.A 1247: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 294: Show issues

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Article ; Online: Evidence-Based Practices in Cleft Palate Surgery.

Applebaum, Sarah A / Aronson, Sofia / Termanini, Kareem M / Gosain, Arun K

Plastic and reconstructive surgery

2024 Volume 153, Issue 2, Page(s) 448e–461e

Abstract: Learning objectives: After studying this article, the participant should be able to: (1) Understand the embryologic origins, cause, and incidence of cleft palate. (2) Review the anatomy and common classifications of cleft palate and associated defects. ( ...

Abstract	Learning objectives: After studying this article, the participant should be able to: (1) Understand the embryologic origins, cause, and incidence of cleft palate. (2) Review the anatomy and common classifications of cleft palate and associated defects. (3) Describe surgical techniques for palatoplasty and understand their respective indications. (4) Gain an awareness of general perioperative care considerations, timing of repair, and risk factors for and operative mitigation of complications. Summary: Cleft palate affects 0.1 to 1.1 per 1000 births, with a higher incidence in certain ethnic groups but affecting both sexes equally. Cleft palate may occur in isolation or in combination with cleft lip or in association with other congenital anomalies including various syndromes. The goals of cleft palate repair are to anatomically separate the oral and nasal cavities for normal feeding and improved speech and minimize the risk of oronasal fistulas, velopharyngeal dysfunction, and disruption of facial growth. This review discusses the incidence, causes, and classification of cleft palate; surgical techniques for palatoplasty and perioperative patient management; and complications of palatoplasty.
MeSH term(s)	Female ; Male ; Humans ; Cleft Palate/surgery ; Oral Surgical Procedures ; Surgery, Oral ; Cleft Lip ; Evidence-Based Practice
Language	English
Publishing date	2024-01-24
Publishing country	United States
Document type	Review ; Journal Article
ZDB-ID	208012-6
ISSN	1529-4242 ; 0032-1052 ; 0096-8501
ISSN (online)	1529-4242
ISSN	0032-1052 ; 0096-8501
DOI	10.1097/PRS.0000000000011035
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Uk I Zs.142: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 293: Show issues

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Article ; Online: Palliative lower leg reconstruction.

Bai, Jennifer / Aronson, Sofia / Kearney, Aaron / Teven, Chad M

Annals of palliative medicine

2023 Volume 12, Issue 6, Page(s) 1396–1404

Abstract: Palliative care is a multidisciplinary field that aims to relieve physical pain and psychological suffering with the goal of improving quality of life rather than focusing on curing or prolonging life. Plastic surgeons may have a role in this near end-of- ...

Abstract	Palliative care is a multidisciplinary field that aims to relieve physical pain and psychological suffering with the goal of improving quality of life rather than focusing on curing or prolonging life. Plastic surgeons may have a role in this near end-of-life care through palliative reconstruction. The use of palliative reconstruction has been frequently described in the setting of head and neck and thoracic malignancies However, there is a paucity in the literature about the role of palliative reconstruction in the lower extremity. In this review, we provide a summary of the current literature in support of the benefits of palliative reconstruction in the lower extremity as well as three case examples to demonstrate scenarios in which palliative lower extremity reconstruction may be used for select patients. In order to determine whether a patient may benefit from palliative reconstruction to merit its risks, the treatment goals and limitations must be assessed on a case-by-case basis in collaboration with the patient. Careful patient selection, focus on patient's ambulatory and personal goals, and minimizing donor site morbidity are important considerations in palliative reconstruction of the lower extremity. Together with a multidisciplinary approach, plastic surgeons can provide valuable contributions to improve the quality of life for certain palliative oncological patients by providing palliative reconstruction of the lower extremity.
MeSH term(s)	Humans ; Leg ; Quality of Life ; Palliative Care ; Terminal Care ; Hospice Care
Language	English
Publishing date	2023-10-27
Publishing country	China
Document type	Review ; Journal Article
ZDB-ID	2828544-X
ISSN	2224-5839 ; 2224-5839
ISSN (online)	2224-5839
ISSN	2224-5839
DOI	10.21037/apm-23-358
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Article: Technology Use and Technological Self-Efficacy Among Undergraduate Nursing Faculty.

Roney, Linda N / Westrick, Susan J / Acri, Mary C / Aronson, Barbara S / Rebeschi, Lisa M

Nursing education perspectives

2023 Volume 38, Issue 3, Page(s) 113–118

Abstract: Aim: This study explored faculty responses to a survey about using technology to teach undergraduate nursing students.: Background: Little is known regarding faculty confidence, technology use, or supports for integrating technology into nursing ... ...

Abstract	Aim: This study explored faculty responses to a survey about using technology to teach undergraduate nursing students. Background: Little is known regarding faculty confidence, technology use, or supports for integrating technology into nursing education. Method: A descriptive correlational design was utilized to explore the relationship between technology use and technological self-efficacy in faculty (N = 272) who teach at Commission on Collegiate Nursing Education-accredited nursing programs. Instruments used were a sociodemographic questionnaire, the Roney Technology Use Scale, and the Technology Self-Efficacy Scale. Results: Participants who taught didactic content had moderate technology use as compared to those teaching didactic and clinical/laboratory who reported high levels of technology use. A weak relationship between age and technological self-efficacy (ρ = .127, p < .05) was also found. Conlusion: This research was an initial step in understanding levels of technology use and responses to this challenge by undergraduate nursing faculty.
Language	English
Publishing date	2023-03-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	2075410-3
ISSN	1943-4685 ; 1536-5026
ISSN (online)	1943-4685
ISSN	1536-5026
DOI	10.1097/01.NEP.0000000000000141
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Zs.A 3023: Show issues

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Article ; Online: Future of HIPEC for ovarian cancer.

Aronson, S Lot / van Stein, Ruby M / Sonke, Gabe S / van Driel, Willemien J

BJOG : an international journal of obstetrics and gynaecology

2022 Volume 130, Issue 2, Page(s) 135–140

Language	English
Publishing date	2022-09-25
Publishing country	England
Document type	Journal Article
ZDB-ID	2000931-8
ISSN	1471-0528 ; 0306-5456 ; 1470-0328
ISSN (online)	1471-0528
ISSN	0306-5456 ; 1470-0328
DOI	10.1111/1471-0528.17289
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Article ; Online: Turning up the heat does not affect quality of life.

van Driel, Willemien J / Aronson, S Lot / van Stein, Ruby M / Sonke, Gabe S

Journal of gynecologic oncology

2022 Volume 33, Issue 4, Page(s) e68

MeSH term(s)	Humans ; Quality of Life
Language	English
Publishing date	2022-07-01
Publishing country	Korea (South)
Document type	Editorial ; Research Support, Non-U.S. Gov't ; Comment
ZDB-ID	2478405-9
ISSN	2005-0399 ; 2005-0380
ISSN (online)	2005-0399
ISSN	2005-0380
DOI	10.3802/jgo.2022.33.e68
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Article ; Online: Reduction of Raman scattering and fluorescence from anvils in high pressure Raman scattering.

Dierker, S B / Aronson, M C

The Review of scientific instruments

2018 Volume 89, Issue 5, Page(s) 53902

Abstract: We describe a new design and use of a high pressure anvil cell that significantly reduces the Raman scattering and fluorescence from the anvils in high pressure Raman scattering experiments. The approach is particularly useful in Raman scattering studies ...

Abstract	We describe a new design and use of a high pressure anvil cell that significantly reduces the Raman scattering and fluorescence from the anvils in high pressure Raman scattering experiments. The approach is particularly useful in Raman scattering studies of opaque, weakly scattering samples. The effectiveness of the technique is illustrated with measurements of two-magnon Raman scattering in La
Language	English
Publishing date	2018-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	209865-9
ISSN	1089-7623 ; 0034-6748
ISSN (online)	1089-7623
ISSN	0034-6748
DOI	10.1063/1.5027722
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