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  1. Book ; Thesis: Aufbau und Validierung eines Oligonukleotid-Enzym-Capture-Assays zur quantitativen Bestimmung von Thrombin in humanem Plasma

    Becher, Tobias

    2012  

    Author's details Tobias Becher
    Language German
    Size 128 S. : graph. Darst.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Bonn, Univ., Diss., 2012
    HBZ-ID HT017395628
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2013 D 55 order for loan Magazin

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  2. Article: Methodological considerations in personalized methods for PEEP optimization with electrical impedance tomography.

    Frerichs, Inéz / Becher, Tobias / Zhao, Zhanqi

    Annals of intensive care

    2024  Volume 14, Issue 1, Page(s) 62

    Language English
    Publishing date 2024-04-20
    Publishing country Germany
    Document type Letter
    ZDB-ID 2617094-2
    ISSN 2110-5820
    ISSN 2110-5820
    DOI 10.1186/s13613-024-01288-0
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  3. Article ; Online: The Evolving Role of Dendritic Cells in Atherosclerosis.

    Britsch, Simone / Langer, Harald / Duerschmied, Daniel / Becher, Tobias

    International journal of molecular sciences

    2024  Volume 25, Issue 4

    Abstract: Atherosclerosis, a major contributor to cardiovascular morbidity and mortality, is characterized by chronic inflammation of the arterial wall. This inflammatory process is initiated and maintained by both innate and adaptive immunity. Dendritic cells ( ... ...

    Abstract Atherosclerosis, a major contributor to cardiovascular morbidity and mortality, is characterized by chronic inflammation of the arterial wall. This inflammatory process is initiated and maintained by both innate and adaptive immunity. Dendritic cells (DCs), which are antigen-presenting cells, play a crucial role in the development of atherosclerosis and consist of various subtypes with distinct functional abilities. Following the recognition and binding of antigens, DCs become potent activators of cellular responses, bridging the innate and adaptive immune systems. The modulation of specific DC subpopulations can have either pro-atherogenic or atheroprotective effects, highlighting the dual pro-inflammatory or tolerogenic roles of DCs. In this work, we provide a comprehensive overview of the evolving roles of DCs and their subtypes in the promotion or limitation of atherosclerosis development. Additionally, we explore antigen pulsing and pharmacological approaches to modulate the function of DCs in the context of atherosclerosis.
    MeSH term(s) Humans ; Dendritic Cells ; Atherosclerosis/metabolism ; Adaptive Immunity ; Inflammation/metabolism
    Language English
    Publishing date 2024-02-19
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25042450
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  4. Article ; Online: Setting positive end-expiratory pressure by using electrical impedance tomography.

    Frerichs, Inéz / Schädler, Dirk / Becher, Tobias

    Current opinion in critical care

    2023  Volume 30, Issue 1, Page(s) 43–52

    Abstract: Purpose of review: This review presents the principles and possibilities of setting positive end-expiratory pressure (PEEP) using electrical impedance tomography (EIT). It summarizes the major findings of recent studies where EIT was applied to monitor ... ...

    Abstract Purpose of review: This review presents the principles and possibilities of setting positive end-expiratory pressure (PEEP) using electrical impedance tomography (EIT). It summarizes the major findings of recent studies where EIT was applied to monitor the effects of PEEP on regional lung function and to guide the selection of individualized PEEP setting.
    Recent findings: The most frequent approach of utilizing EIT for the assessment of PEEP effects and the PEEP setting during the time period from January 2022 till June 2023 was based on the analysis of pixel tidal impedance variation, typically acquired during stepwise incremental and/or decremental PEEP variation. The most common EIT parameters were the fraction of ventilation in various regions of interest, global inhomogeneity index, center of ventilation, silent spaces, and regional compliance of the respiratory system. The studies focused mainly on the spatial and less on the temporal distribution of ventilation. Contrast-enhanced EIT was applied in a few studies for the estimation of ventilation/perfusion matching.
    Summary: The availability of commercial EIT devices resulted in an increase in clinical studies using this bedside imaging technology in neonatal, pediatric and adult critically ill patients. The clinical interest in EIT became evident but the potential of this method in clinical decision-making still needs to be fully exploited.
    MeSH term(s) Adult ; Infant, Newborn ; Humans ; Child ; Electric Impedance ; Positive-Pressure Respiration/methods ; Tomography, X-Ray Computed/methods ; Lung ; Perfusion
    Language English
    Publishing date 2023-11-09
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 1235629-3
    ISSN 1531-7072 ; 1070-5295
    ISSN (online) 1531-7072
    ISSN 1070-5295
    DOI 10.1097/MCC.0000000000001117
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4999: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article: Pulmonary function testing in preoperative high-risk patients.

    Eimer, Christine / Urbaniak, Natalia / Dempfle, Astrid / Becher, Tobias / Schädler, Dirk / Weiler, Norbert / Frerichs, Inéz

    Perioperative medicine (London, England)

    2024  Volume 13, Issue 1, Page(s) 14

    Abstract: Background: Postoperative respiratory failure is the most frequent complication in postsurgical patients. The purpose of this study is to assess whether pulmonary function testing in high-risk patients during preoperative assessment detects previously ... ...

    Abstract Background: Postoperative respiratory failure is the most frequent complication in postsurgical patients. The purpose of this study is to assess whether pulmonary function testing in high-risk patients during preoperative assessment detects previously unknown respiratory impairments which may influence patient outcomes.
    Methods: A targeted patient screening by spirometry and the measurement of the diffusing capacity of the lung for carbon monoxide (D
    Results: Among 256 included patients, 230 fulfilled the test quality criteria. Eighty-one (35.2%) patients presented obstructive ventilatory disorders, out of which 65 were previously unknown. 38 of the newly diagnosed obstructive disorders were mild, 18 moderate, and 9 severe. One hundred forty-five D
    Conclusions: Our screening program detected a relevant number of patients with previously unknown obstructive ventilatory disorders and impaired pulmonary gas exchange. This newly discovered sickness is associated with low metabolic equivalents and may influence perioperative outcomes. Whether optimized management of patients with previously unknown impaired lung function leads to a better outcome should be evaluated in multicenter studies.
    Trial registration: German Registry of Clinical Studies (DRKS00029337), registered on: June 22nd, 2022.
    Language English
    Publishing date 2024-03-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 2683800-X
    ISSN 2047-0525
    ISSN 2047-0525
    DOI 10.1186/s13741-024-00368-w
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  6. Article ; Online: Effect of body position on ventilation distribution in healthy newborn infants: an observational study.

    Rahtu, Marika / Frerichs, Inéz / Pokka, Tytti / Becher, Tobias / Peltoniemi, Outi / Kallio, Merja

    Archives of disease in childhood. Fetal and neonatal edition

    2024  Volume 109, Issue 3, Page(s) 322–327

    Abstract: Objectives: Newborn infants have unique respiratory physiology compared with older children and adults due to their lungs' structural and functional immaturity and highly compliant chest wall. To date, ventilation distribution has seldom been studied in ...

    Abstract Objectives: Newborn infants have unique respiratory physiology compared with older children and adults due to their lungs' structural and functional immaturity and highly compliant chest wall. To date, ventilation distribution has seldom been studied in this age group. This study aims to assess the effect of body position on ventilation distribution in spontaneously breathing healthy neonates.
    Design: Prospective observational study.
    Setting: Maternity wards of Oulu University Hospital.
    Patients: 20 healthy, spontaneously breathing, newborn infants.
    Interventions: Electrical impedance tomography data were recorded with a 32-electrode belt (Sentec AG, Landquart, Switzerland) in six different body positions in random order. Ventilation distribution was retrospectively assessed 10 minutes after each position change.
    Main outcome measures: In each position, regional tidal impedance variation (ΔZ) and ventral-to-dorsal and right-to-left centre of ventilation were measured.
    Results: The mean global ΔZ was the largest in supine position and it was smaller in prone and lateral positions. Yet, global ΔZ did not differ in supine positions, ventilation distribution was more directed towards the non-dependent lung region in supine tilted position (p<0.001). In prone, a reduction of global ΔZ was observed (p<0.05) corresponding to an amount of 10% of global tidal variation in supine position. In both lateral positions, tidal ventilation was distributed more to the corresponding non-dependent lung region.
    Conclusions: Prone or lateral body positioning in healthy spontaneously breathing newborns leads to a redistribution of ventilation to the non-dependent lung regions and at the same time global tidal volume is reduced as compared with supine.
    MeSH term(s) Adolescent ; Adult ; Child ; Female ; Humans ; Infant ; Infant, Newborn ; Pregnancy ; Electric Impedance ; Lung ; Prone Position/physiology ; Respiration ; Retrospective Studies ; Supine Position/physiology ; Prospective Studies
    Language English
    Publishing date 2024-04-18
    Publishing country England
    Document type Observational Study ; Journal Article
    ZDB-ID 2007331-8
    ISSN 1468-2052 ; 1359-2998
    ISSN (online) 1468-2052
    ISSN 1359-2998
    DOI 10.1136/archdischild-2023-325967
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    Um IV Zs.106 -F.N.Ed.-: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Mortality in COVID-19 is not merely a question of resource availability.

    Becher, Tobias / Frerichs, Inéz

    The Lancet. Respiratory medicine

    2020  Volume 8, Issue 9, Page(s) 832–833

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections/epidemiology ; Humans ; Pandemics ; Pneumonia, Viral/epidemiology ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-07-28
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 2686754-0
    ISSN 2213-2619 ; 2213-2600
    ISSN (online) 2213-2619
    ISSN 2213-2600
    DOI 10.1016/S2213-2600(20)30312-X
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    Zs.A 7041: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Dynamic imaging for dynamic lung events.

    Becher, Tobias / Schädler, Dirk / Frerichs, Inéz

    Journal of clinical monitoring and computing

    2021  Volume 36, Issue 4, Page(s) 929–931

    MeSH term(s) Diagnostic Imaging ; Humans ; Lung/diagnostic imaging ; Magnetic Resonance Imaging/methods
    Language English
    Publishing date 2021-10-29
    Publishing country Netherlands
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 1418733-4
    ISSN 1573-2614 ; 1387-1307 ; 0748-1977
    ISSN (online) 1573-2614
    ISSN 1387-1307 ; 0748-1977
    DOI 10.1007/s10877-021-00775-0
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    Zs.A 2054: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Mathematical lung model for local gas exchange based on EIT-measurements

    Hennigs Carlotta / Becher Tobias / Rostalski Philipp

    Current Directions in Biomedical Engineering, Vol 8, Iss 2, Pp 376-

    2022  Volume 379

    Abstract: In this work we present a four compartment mathematical lung model to simulate the local gas exchange based on electrical impedance tomography (EIT) input. The model simulates the local and global time course of the volume, the gas fraction in the ... ...

    Abstract In this work we present a four compartment mathematical lung model to simulate the local gas exchange based on electrical impedance tomography (EIT) input. The model simulates the local and global time course of the volume, the gas fraction in the alveoli and the arterial partial pressure. The regional information about the distribution of ventilation and perfusion is extracted from EIT data. In order to illustrate the suitability of this approach, an ARDS patient is simulated. The results show good agreement with measurement data for large portions of the time and seem promising e.g. for the use in medical decision support systems.
    Keywords eit ; local gas exchange ; lung modelling ; mathematical modelling ; Medicine ; R
    Language English
    Publishing date 2022-09-01T00:00:00Z
    Publisher De Gruyter
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Book ; Online ; Thesis: Überprüfung der Effektivität des Gerinnungsalgorithmus bei herzchirurgischen Eingriffen im Rahmen des ,Point of Care‘.

    Wolf, Anna [Verfasser] / Pühler, Thomas [Akademischer Betreuer] / Becher, Tobias [Gutachter]

    2022  

    Author's details Anna Tabea Wolf ; Gutachter: Tobias Becher ; Betreuer: Thomas Pühler
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language English
    Publisher Universitätsbibliothek Kiel
    Publishing place Kiel
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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