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Article ; Online: Full-thickness skin grafts in nasal reconstruction: A retrospective study.

Chen, Joyce / Costello, Collin M / Mead-Harvey, Carolyn / Kunze, Katie L / Martinez, Juan-Carlos / Ochoa, Shari A

JAAD international

2023 Volume 13, Page(s) 91–94

Language	English
Publishing date	2023-08-12
Publishing country	United States
Document type	Journal Article
ISSN	2666-3287
ISSN (online)	2666-3287
DOI	10.1016/j.jdin.2023.08.004
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Postoperative infections in Mohs micrographic surgery: Practicing antibiotic stewardship.

Costello, Collin M / Yonan, Yousif / Kunze, Katie L / Ochoa, Shari A

Journal of the American Academy of Dermatology

2021 Volume 85, Issue 4, Page(s) 1020–1021

MeSH term(s)	Antimicrobial Stewardship ; Carcinoma, Basal Cell/surgery ; Humans ; Mohs Surgery ; Skin Neoplasms/drug therapy ; Skin Neoplasms/surgery
Language	English
Publishing date	2021-01-15
Publishing country	United States
Document type	Letter
ZDB-ID	603641-7
ISSN	1097-6787 ; 0190-9622
ISSN (online)	1097-6787
ISSN	0190-9622
DOI	10.1016/j.jaad.2021.01.019
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Zs.A 1540: Show issues

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Article ; Online: Adoption of High-sensitivity Troponin Testing and Emergency Physician Ordering Behavior.

Hodgson, Nicole R / Kunze, Katie L / Lim, Elisabeth S / Maher, Steven A / Traub, Stephen J

The western journal of emergency medicine

2022 Volume 23, Issue 3, Page(s) 439–442

Abstract: Introduction: Emergency departments (ED) are rapidly replacing conventional troponin assays with high-sensitivity troponin tests. We sought to evaluate emergency physician utilization of troponin tests before and after high-sensitivity troponin ... ...

Abstract	Introduction: Emergency departments (ED) are rapidly replacing conventional troponin assays with high-sensitivity troponin tests. We sought to evaluate emergency physician utilization of troponin tests before and after high-sensitivity troponin introduction in our ED. Methods: We retrospectively examined 9,477 ED encounters, identifying the percentage in which physicians ordered a serum troponin both before and after our institution adopted a high-sensitivity troponin test. Results: After introduction of high-sensitivity troponin testing, the percentage of ED encounters in which physicians ordered troponin studies decreased (28.3% before vs 22% after; P <.001), with the drop most pronounced in admitted patients (decrease of 10.9% [95% confidence interval [CI]: 7.3%-14.5%] in admitted patients vs decrease of 3.6% [95% CI: 1.7%-5.4%] in discharged patients; P<.001) CONCLUSION: Introduction of high-sensitivity troponin testing was associated with a decrease in troponin ordering. While the reasons for this are unclear, it is possible that physicians became more selective in their ordering behavior because of the lower specificity of high-sensitivity troponin.
MeSH term(s)	Biomarkers ; Emergency Service, Hospital ; Humans ; Physicians ; Retrospective Studies ; Troponin
Chemical Substances	Biomarkers ; Troponin
Language	English
Publishing date	2022-04-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	2375700-0
ISSN	1936-9018 ; 1936-9018
ISSN (online)	1936-9018
ISSN	1936-9018
DOI	10.5811/westjem.2022.2.54242
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Article ; Online: Response by Tseng et al to Letter Regarding Article, "Efficacy of Pharmacologic and Cardiac Implantable Electronic Device Therapies in Patients With Heart Failure and Reduced Ejection Fraction: A Systematic Review and Network Meta-Analysis".

Tseng, Andrew S / Kunze, Katie L / Mulpuru, Siva K

Circulation. Arrhythmia and electrophysiology

2019 Volume 12, Issue 8, Page(s) e007710

MeSH term(s)	Cardiac Resynchronization Therapy ; Heart Failure ; Humans ; Network Meta-Analysis
Language	English
Publishing date	2019-08-19
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	2426129-4
ISSN	1941-3084 ; 1941-3149
ISSN (online)	1941-3084
ISSN	1941-3149
DOI	10.1161/CIRCEP.119.007710
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Zs.A 6667: Show issues

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Article ; Online: Rehabilitation in the intensive care unit: How amount of physical and occupational therapy affects patients' function and hospital length of stay.

Jenkins, Anna S / Isha, Shahin / Hanson, Abby J / Kunze, Katie L / Johnson, Patrick W / Sura, Lydia / Cornelius, Patrick J / Hightower, Jenna / Heise, Katherine J / Davis, Olivia / Satashia, Parthkumar H / Hasan, Mohammed Mustafa / Esterov, Dmitry / Worsowicz, Gregory M / Sanghavi, Devang K

PM & R : the journal of injury, function, and rehabilitation

2024 Volume 16, Issue 3, Page(s) 219–225

Abstract: Background: Patients in the intensive care unit (ICU) often experience extended periods of immobility. Following hospital discharge, many face impaired mobility and never return to their baseline function. Although the benefits of physical and ... ...

Abstract	Background: Patients in the intensive care unit (ICU) often experience extended periods of immobility. Following hospital discharge, many face impaired mobility and never return to their baseline function. Although the benefits of physical and occupational rehabilitation are well established in non-ICU patients, a paucity of work describes effective practices to alleviate ICU-related declines in mobility. Objective: To assess how rehabilitation with physical and occupational therapy (PT-OT) during ICU stays affects patients' mobility, self-care, and length of hospital stay. Design: Retrospective cohort study. Setting: Inpatient ICU. Participants: A total of 6628 adult patients who received physical rehabilitation across multiple sites (Arizona, Florida, Minnesota, and Wisconsin) of a single institution between January 2018 and December 2021. Interventions: Not applicable. Main outcome measures: Descriptive statistics, linear regression models, and gradient boosting machine methods were used to determine the relationship between the amount of PT-OT received and outcomes of hospital length of stay (LOS), Activity Measure for Post-Acute Care Daily Activity and Basic Mobility scores. Results: The 6628 patients who met inclusion criteria received an average (median) of 23 (range: 1-89) minutes of PT-OT per day. Regression analyses showed each additional 10 minutes of PT-OT per day was associated with a 1.0% (95% confidence interval [CI]: 0.41-1.66, p < .001) higher final Basic Mobility score, a 1.8% (95% CI: 1.30%-2.34%, p < .001) higher final Daily Activity score, and a 1.2-day (95% CI: -1.28 to -1.09, p < .001) lower hospital LOS. One-dimensional partial dependence plots revealed an exponential decrease in predicted LOS as minutes of PT-OT received increased. Conclusion: Higher rehabilitation minutes provided to patients in the ICU may reduce the LOS and improve patients' functional outcomes at discharge. The benefits of rehabilitation increased with increasing amounts of time of therapy received.
MeSH term(s)	Adult ; Humans ; Length of Stay ; Occupational Therapy ; Retrospective Studies ; Intensive Care Units ; Hospitals
Language	English
Publishing date	2024-02-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	2608988-9
ISSN	1934-1563 ; 1934-1482
ISSN (online)	1934-1563
ISSN	1934-1482
DOI	10.1002/pmrj.13116
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Zs.A 6951: Show issues

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Article ; Online: Shoulder-Specific Patient-Reported Outcome Measures for Use in Patients With Head and Neck Cancer: An Assessment of Reliability, Construct Validity, and Overall Appropriateness of Test Score Interpretation Using Rasch Analysis.

Eden, Melissa M / Kunze, Katie L / Galantino, Mary Lou / Kolber, Morey J / Cheng, M Samuel

Physical therapy

2021 Volume 101, Issue 11

Abstract: Objectives: The purpose of this study was to investigate the construct validity and overall appropriateness of test score interpretation of 4 shoulder-related patient-reported outcome (PRO) measures for use in a population of patients with head and neck ...

Abstract	Objectives: The purpose of this study was to investigate the construct validity and overall appropriateness of test score interpretation of 4 shoulder-related patient-reported outcome (PRO) measures for use in a population of patients with head and neck cancer using Rasch analysis. Methods: One hundred eighty-two individuals who had received a neck dissection procedure within the past 2 weeks to 18 months were recruited for this cross-sectional psychometric study. Rasch methodologies were used to investigate scale dimensionality, scale hierarchy, response scale structure, and reliability of Disabilities of the Arm, Shoulder and Hand (DASH), QuickDASH, Shoulder Pain and Disability Index (SPADI), and Neck Dissection Impairment Index (NDII). Results: DASH did not meet criteria for unidimensionality and was deemed inappropriate for use in this sample. The QuickDASH, SPADI, and NDII were all determined to be unidimensional. All scales had varying issues with person and item misfit, differential item functioning, coverage of ability levels, and optimal rating scale requirements. The NDII met most requirements. All measures were found to meet thresholds for person and item separation as well as reliability statistics. Conclusions: Rasch analysis indicates the NDII is the most appropriate measure studied for this population. The QuickDASH and SPADI are recommended with reservation, whereas the DASH is not recommended. Impact: This study demonstrates the use of objective methodologies, using Rasch analysis, to validate PRO recommendations provided by clinical experts in forums such as the Evaluation Database to Guide Effectiveness (EDGE) TaskForce, which are based upon a comprehensive literature review, consideration of published psychometric properties, and expert consensus. Use of Rasch methodologies demonstrates weaknesses in this model and provides opportunities to strengthen recommendations for clinicians.
MeSH term(s)	Head and Neck Neoplasms/therapy ; Humans ; Patient Reported Outcome Measures ; Reproducibility of Results ; Shoulder Pain/therapy ; Surveys and Questionnaires/standards
Language	English
Publishing date	2021-06-26
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Validation Study
ZDB-ID	415886-6
ISSN	1538-6724 ; 0031-9023
ISSN (online)	1538-6724
ISSN	0031-9023
DOI	10.1093/ptj/pzab160
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Article ; Online: Germline Genetic Testing in Unselected Squamous and Non-Squamous Head and Neck Cancers.

Brake, Daniela A / Idler, Beau M / Kunze, Katie L / Golafshar, Michael A / Heald, Brandie / Young, Sarah / Klint, Margaret / Barrus, Kathleen / Esplin, Edward D / Nussbaum, Robert L / Samadder, N Jewel / Hinni, Michael L / Chang, Brent A

The Laryngoscope

2023 Volume 133, Issue 12, Page(s) 3378–3388

Abstract: Objective: This study describes the prevalence of pathogenic germline variants (PGVs) in head and neck cancer patients, the incremental yield compared to a guideline-based approach to genetic evaluation, and the uptake of family variant testing.: ... ...

Abstract	Objective: This study describes the prevalence of pathogenic germline variants (PGVs) in head and neck cancer patients, the incremental yield compared to a guideline-based approach to genetic evaluation, and the uptake of family variant testing. Study design: Prospective cohort study. Setting: Three tertiary academic medical centers. Methods: Germline sequencing using an 84-gene screening platform among unselected head and neck cancer patients who received care at Mayo Clinic Cancer Centers between April 2018 and March 2020. Results: Amongst 200 patients, the median age was 62.0 years (Q1, Q3: 55, 71), 23.0% were female, 89.0% white/non-Hispanic, 5.0% Hispanic/Latinx, 6% of another race, and 42.0% had prognostic stage IV disease. The most common subsites were the oropharyngeal (45.0%) and salivary glands (12.0%). The most common histology was squamous cell carcinoma (74.5%). Twenty-one patients (10.5%) had a total of 22 PGVs; 20 of the 21 patients (95.2%) did not meet criteria for testing by current guidelines. Regarding penetrance of the 22 PGVs, 11 were high or moderate (most common PMS2 or HOXB13), and 11 were low or recessive (most common MUTYH, WNR, or RECQL4). One patient had a change in care based on an identified PGV. Family variant testing was completed at a rate of 4.8%. Conclusions: Universal gene panel testing identified a PGV in 10.5% of head and neck cancer patients; almost all would have been missed by current guideline-based testing. One of 21 patients had a treatment change due to their PGV, indicating that head and neck cancer treatment decisions are not yet widely informed by germline alterations. Level of evidence: 3 Laryngoscope, 133:3378-3388, 2023.
MeSH term(s)	Humans ; Female ; Middle Aged ; Male ; Prospective Studies ; Head and Neck Neoplasms/genetics ; Genetic Testing ; Carcinoma, Squamous Cell/genetics ; Carcinoma, Squamous Cell/pathology ; Germ Cells/pathology ; Genetic Predisposition to Disease
Language	English
Publishing date	2023-05-03
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80180-x
ISSN	1531-4995 ; 0023-852X
ISSN (online)	1531-4995
ISSN	0023-852X
DOI	10.1002/lary.30720
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Article ; Online: Adoption of High-sensitivity Troponin Testing and Emergency Physician Ordering Behavior

Nicole R. Hodgson / Katie L. Kunze / Elisabeth S. Lim / Steven A. Maher / Stephen J. Traub

Western Journal of Emergency Medicine, Vol 23, Iss

2022 Volume 3

Abstract	Introduction: Emergency departments (ED) are rapidly replacing conventional troponin assays with high-sensitivity troponin tests. We sought to evaluate emergency physician utilization of troponin tests before and after high-sensitivity troponin introduction in our ED. Methods: We retrospectively examined 9,477 ED encounters, identifying the percentage in which physicians ordered a serum troponin both before and after our institution adopted a high-sensitivity troponin test. Results: After introduction of high-sensitivity troponin testing, the percentage of ED encounters in which physicians ordered troponin studies decreased (28.3% before vs 22% after; P <.001), with the drop most pronounced in admitted patients (decrease of 10.9% [95% confidence interval [CI]: 7.3%–14.5%] in admitted patients vs decrease of 3.6% [95% CI: 1.7%–5.4%] in discharged patients; P<.001) Conclusion: Introduction of high-sensitivity troponin testing was associated with a decrease in troponin ordering. While the reasons for this are unclear, it is possible that physicians became more selective in their ordering behavior because of the lower specificity of high-sensitivity troponin.
Keywords	Medicine ; R ; Medical emergencies. Critical care. Intensive care. First aid ; RC86-88.9
Language	English
Publishing date	2022-03-01T00:00:00Z
Publisher	eScholarship Publishing, University of California
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Does early chimerism testing predict outcomes after allogeneic hematopoietic stem cell transplantation?

Mountjoy, Luke / Palmer, Jeanne / Kunze, Katie L / Khera, Nandita / Sproat, Lisa Z / Leis, Jose F / Noel, Pierre / Slack, James L / Jain, Tania

Leukemia & lymphoma

2020 Volume 62, Issue 1, Page(s) 252–254

MeSH term(s)	Chimerism ; Hematopoietic Stem Cell Transplantation/adverse effects ; Transplantation Chimera ; Transplantation Conditioning ; Transplantation, Homologous
Language	English
Publishing date	2020-10-04
Publishing country	United States
Document type	Letter
ZDB-ID	1042374-6
ISSN	1029-2403 ; 1042-8194
ISSN (online)	1029-2403
ISSN	1042-8194
DOI	10.1080/10428194.2020.1827249
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Zs.A 2997: Show issues

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Article ; Online: The Pitfalls of Mining for QuantiFERON Gold in Severely Ill Patients With COVID-19.

Cortes, Melissa P / Schultz, Carrie S / Isha, Shahin / Sinclair, Jorge E / Bhakta, Shivang / Kunze, Katie L / Johnson, Patrick W / Cowart, Jennifer B / Carter, Rickey E / Franco, Pablo Moreno / Sanghavi, Devang K / Roy, Archana

Mayo Clinic proceedings. Innovations, quality & outcomes

2022 Volume 6, Issue 5, Page(s) 409–419

Abstract: Objective: To assess the proportion of indeterminate QuantiFERON-TB Gold Plus (QFT-Plus) results in patients admitted for severe coronavirus disease 2019 (COVID-19) pneumonia and evaluate the factors associated with indeterminate QFT-Plus results.: ... ...

Abstract	Objective: To assess the proportion of indeterminate QuantiFERON-TB Gold Plus (QFT-Plus) results in patients admitted for severe coronavirus disease 2019 (COVID-19) pneumonia and evaluate the factors associated with indeterminate QFT-Plus results. Patients and methods: Data on COVID-19 admissions at Mayo Clinic in Florida were extracted between October 13, 2020, and September 20, 2021, and data from a prepandemic cohort were extracted between October 13, 2018, and September 20, 2019. A secondary analysis of the COVID-19 cohort was performed using gradient boosting modeling to generate variable importance and SHapley Additive exPlanations plots. Results: Our findings demonstrated more indeterminate QFT-Plus test results in patients hospitalized for severe COVID-19 infection than in patients without COVID-19 (139 of 495, 28.1%). The factors associated with indeterminate QFT-Plus test results included elevated levels of C-reactive protein, ferritin, lactate dehydrogenase and interleukin-6 and included lower levels of leukocyte, lymphocyte, and platelet counts. Conclusion: The patients with severe COVID-19 had a higher likelihood of indeterminate QFT-Plus results, which were associated with elevated levels of inflammatory markers consistent with severe infection. Interferon-gamma release assay screening tests are likely confounded by COVID-19 infection itself, limiting the screening ability for latent tuberculosis infection reactivation. Indeterminate QFT-Plus results may also require follow-up QFT-Plus testing after patient recovery from COVID-19, increasing the cost and complexity of medical decision making and management. Additional risk assessments may be needed in this patient population for screening for latent tuberculosis infection in patients with severe COVID-19.
Language	English
Publishing date	2022-07-07
Publishing country	Netherlands
Document type	Journal Article
ISSN	2542-4548
ISSN (online)	2542-4548
DOI	10.1016/j.mayocpiqo.2022.06.004
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