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  1. Article ; Online: Sexual Health and Relationship Abuse Interventions in Pediatric Primary Care: A Systematic Review.

    Khetarpal, Susheel Kant / Tiffany-Appleton, Sarah / Mickievicz, Erin E / Barral, Romina L / Randell, Kimberly A / Temple, Jeff R / Miller, Elizabeth / Ragavan, Maya I

    The Journal of adolescent health : official publication of the Society for Adolescent Medicine

    2023  Volume 72, Issue 4, Page(s) 487–501

    Abstract: ... topics (e.g., sexually transmitted infections, contraception, ARA). Interventions largely focused ...

    Abstract Purpose: Supporting adolescents in developing healthy relationships and promoting sexual and reproductive health (SRH) is an important responsibility of pediatric primary care providers. Less is known about evidence-based interventions in pediatric settings focused on healthy relationships and SRH.
    Methods: We conducted a systematic review to describe SRH and healthy relationship/adolescent relationship abuse (ARA) interventions for pediatric primary care over the past 20 years. Eligible articles were original research on an SRH-focused or ARA-focused intervention, conducted in-person within pediatric primary care or school-based health centers specifically for middle or high school-aged adolescents. Data abstracted from included articles included intervention description, content, delivery, evaluation design, and effectiveness of primary outcomes. Heterogeneous outcomes and evidence levels made conducting a meta-analysis infeasible.
    Results: Nineteen studies described 17 interventions targeting a variety of SRH and ARA topics (e.g., sexually transmitted infections, contraception, ARA). Interventions largely focused on screening/counseling adolescents (89%). Interventions generally were reported as being effective in changing adolescent health or practice-level outcomes.
    Discussion: This review provides preliminary evidence that SRH and ARA interventions in pediatric primary care settings can be effective in promoting adolescent health. Future work should consider ARA-specific prevention interventions, including parents in interventions, and strategies for implementation, dissemination, and scaling.
    MeSH term(s) Adolescent ; Child ; Humans ; Contraception ; Primary Health Care ; Reproductive Health ; Sexual Behavior ; Sexual Health ; Sexually Transmitted Diseases/prevention & control
    Language English
    Publishing date 2023-01-07
    Publishing country United States
    Document type Journal Article ; Review ; Systematic Review ; Research Support, N.I.H., Extramural
    ZDB-ID 1063374-1
    ISSN 1879-1972 ; 1054-139X
    ISSN (online) 1879-1972
    ISSN 1054-139X
    DOI 10.1016/j.jadohealth.2022.11.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Protocol: The effects of nutrient- vs food- vs food-substitution-based dietary recommendations for reducing free sugar intakes, on free sugar intakes, dietary profiles and sweet taste outcomes: A randomised controlled trial.

    Boxall, Lucy R / Arden-Close, Emily / James, Janet / Appleton, Katherine M

    Nutrition and health

    2022  , Page(s) 2601060221111234

    Abstract: Background: Dietary guidelines are intended to inform and aid the general public, with the aim of improving healthy diets and reducing health risk. The effectiveness of these guidelines, however, is rarely investigated.: Aim: This work investigates ... ...

    Abstract Background: Dietary guidelines are intended to inform and aid the general public, with the aim of improving healthy diets and reducing health risk. The effectiveness of these guidelines, however, is rarely investigated.
    Aim: This work investigates the effects of three different types of dietary recommendations for reducing free sugars, on free sugar intakes over 12 weeks. Secondary aims will also investigate how these different recommendations affect secondary outcomes, outcomes in subsets of the trial population, and identify barriers and facilitators to dietary change.
    Methods: Using a randomised controlled parallel-group trial with three intervention and one control arms, 240 individuals consuming >5% total energy intake from free sugars will be randomized to receive: nutrient-based, nutrient- and food-based, nutrient-, food- and food-substitution-based recommendations or no recommendations, with outcomes assessed for the following 12 weeks. Our primary outcomes are free sugar intakes and adherence to the recommendations. Secondary outcomes are daily energy intake, dietary composition, anthropometry, sweet food perceptions and preferences, sweet food choice, attitudes towards sweet foods, eating behaviour and food choice, knowledge and lifestyle variables, quality of life, adverse events, and barriers and facilitators towards intervention adherence.
    Results: Data will contribute to three distinct analyses: 1) Analyses to investigate the effects of the three different dietary recommendations versus control; 2) Analyses of the effects of the dietary recommendations in different population subgroups, and 3) Investigation of the barriers and facilitators to success.
    Conclusion: This work offers new perspectives on the effects of different dietary recommendations to enact behaviour change.
    Language English
    Publishing date 2022-07-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 603215-1
    ISSN 2047-945X ; 0260-1060
    ISSN (online) 2047-945X
    ISSN 0260-1060
    DOI 10.1177/02601060221111234
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The Birth and Beyond (BABY) study: protocol for a birth cohort study investigating the social and environmental determinants of pregnancy-related outcomes in Black American families.

    Lin, Betty / Middleton, Rachel R / Terefe, Bethlehem / Appleton, Allison A / Feingold, Beth J / Lynch, Tara / Pieterse, Alex L / Rogers, Rebecca / Armah, Annabelle E / Bierce, Lydia F / Flagg, Amanda M / McCarthy, Sarah

    BMJ open

    2024  Volume 14, Issue 4, Page(s) e087141

    Abstract: Introduction: In the USA, Black birthing people and infants experience disproportionately worse pregnancy-related health outcomes. The causes for these disparities are unknown, but evidence suggests that they are likely socially and environmentally ... ...

    Abstract Introduction: In the USA, Black birthing people and infants experience disproportionately worse pregnancy-related health outcomes. The causes for these disparities are unknown, but evidence suggests that they are likely socially and environmentally based. Efforts to identify the determinants of these racial disparities are urgently needed to elucidate the highest priority targets for intervention. The Birth and Beyond (BABY) study evaluates how micro-level (eg, interpersonal and family) and macro-level (eg, neighbourhood and environmental) risk and resiliency factors transact to shape birth person-infant health, and underlying psychobiological mechanisms.
    Methods and analysis: The BABY study will follow 350 Black families (birthing parents, non-birthing parents and infants) from pregnancy through the first postpartum year, with research visits during pregnancy and at infant ages 6 and 12 months. Research visits comprise a combination of interview about a range of recent and life course stress and resiliency exposures and supports, psychophysiological (sympathetic, parasympathetic and adrenocortical) assessment and behavioural observations of parent-infant coregulatory behaviours. Spatial analyses are completed by mapping parent current and past residential addresses onto archival public data (eg, about neighbourhood quality and racial segregation). Finally, EMRs are abstracted for information about birthing parent relevant medical history, pregnancy conditions and infant birth outcomes. Analyses will evaluate the risk and resiliency mechanisms that contribute to pregnancy and birth-related outcomes for Black birthing people and their infants, and the protective role of individual, familial, cultural, and community supports.
    Ethics and dissemination: The BABY study has been approved by the Institutional Review Board at Albany Medical Centre. The study team consulted with local organisations and groups comprised of stakeholders and community leaders and continues to do so throughout the study. Research results will be disseminated with the scientific and local community as appropriate.
    MeSH term(s) Humans ; Pregnancy ; Female ; Black or African American/psychology ; Infant ; Research Design ; Pregnancy Outcome/ethnology ; Infant, Newborn ; United States ; Birth Cohort ; Adult ; Resilience, Psychological ; Residence Characteristics ; Social Determinants of Health ; Male ; Health Status Disparities ; Stress, Psychological ; Social Environment
    Language English
    Publishing date 2024-04-23
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2599832-8
    ISSN 2044-6055 ; 2044-6055
    ISSN (online) 2044-6055
    ISSN 2044-6055
    DOI 10.1136/bmjopen-2024-087141
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Cerebral palsy: not always what it seems.

    Appleton, Richard E / Gupta, Rajat

    Archives of disease in childhood

    2018  Volume 104, Issue 8, Page(s) 809–814

    Abstract: Cerebral palsy (CP) is not a disease, but a neurological syndrome, a combination of signs and symptoms, some of which may occur in neurodegenerative or metabolic disorders, particularly those with an onset in the first 2 years of life. There are many ... ...

    Abstract Cerebral palsy (CP) is not a disease, but a neurological syndrome, a combination of signs and symptoms, some of which may occur in neurodegenerative or metabolic disorders, particularly those with an onset in the first 2 years of life. There are many different causes of the syndrome. All children with CP should undergo brain MRI, even with an identified antenatal or perinatal insult. Children with CP should be referred to a paediatric neurologist or a clinical geneticist, or both, if appropriate and particularly in the absence of a known perinatal cerebral insult, with brain MRI that is reported to be normal, a progression in, or new, signs or where there is a reported 'family history of CP'. Finally, a few of the CP syndromes may be readily treatable and potentially prevent irreversible neurological and cognitive impairment.
    MeSH term(s) Ataxia/etiology ; Cerebral Palsy/diagnosis ; Cerebral Palsy/genetics ; Child ; Child, Preschool ; Diagnosis, Differential ; Dystonia/etiology ; Humans ; Muscle Weakness/etiology ; Mutation/genetics ; Psychomotor Disorders/etiology ; Quadriplegia/etiology
    Language English
    Publishing date 2018-11-09
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 524-1
    ISSN 1468-2044 ; 0003-9888 ; 1359-2998
    ISSN (online) 1468-2044
    ISSN 0003-9888 ; 1359-2998
    DOI 10.1136/archdischild-2018-315633
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Handbook of pediatric epilepsy.

    Appleton, R E

    Archives of disease in childhood

    2010  Volume 69, Issue 4, Page(s) 475

    Language English
    Publishing date 2010-10-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 524-1
    ISSN 1468-2044 ; 0003-9888 ; 1359-2998
    ISSN (online) 1468-2044
    ISSN 0003-9888 ; 1359-2998
    DOI 10.1136/adc.69.4.475-a
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: The effectiveness, implementation, and experiences of peer support approaches for mental health: a systematic umbrella review.

    Cooper, Ruth E / Saunders, Katherine R K / Greenburgh, Anna / Shah, Prisha / Appleton, Rebecca / Machin, Karen / Jeynes, Tamar / Barnett, Phoebe / Allan, Sophie M / Griffiths, Jessica / Stuart, Ruth / Mitchell, Lizzie / Chipp, Beverley / Jeffreys, Stephen / Lloyd-Evans, Brynmor / Simpson, Alan / Johnson, Sonia

    BMC medicine

    2024  Volume 22, Issue 1, Page(s) 72

    Abstract: ... outcomes, self-efficacy, and recovery. Certain populations, e.g. perinatal populations, may especially ...

    Abstract Background: Peer support for mental health is recommended across international policy guidance and provision. Our systematic umbrella review summarises evidence on the effectiveness, implementation, and experiences of paid peer support approaches for mental health.
    Methods: We searched MEDLINE, EMBASE, PsycINFO, The Campbell Collaboration, and The Cochrane Database of Systematic Reviews (2012-2022) for reviews of paid peer support interventions for mental health. The AMSTAR2 assessed quality. Results were synthesised narratively, with implementation reported using the CFIR (Consolidated Framework for Implementation Research). The protocol was registered with PROSPERO (registration number: CRD42022362099).
    Results: We included 35 reviews (426 primary studies, n = 95-40,927 participants): systematic reviews with (n = 13) or without (n = 13) meta-analysis, or with qualitative synthesis (n = 3), scoping reviews (n = 6). Most reviews were low or critically low (97%) quality, one review was high quality. Effectiveness was investigated in 23 reviews. Results were mixed; there was some evidence from meta-analyses that peer support may improve depression symptoms (particularly perinatal depression), self-efficacy, and recovery. Factors promoting successful implementation, investigated in 9 reviews, included adequate training and supervision, a recovery-oriented workplace, strong leadership, and a supportive and trusting workplace culture with effective collaboration. Barriers included lack of time, resources and funding, and lack of recognised peer support worker (PSW) certification. Experiences of peer support were explored in 11 reviews, with 3 overarching themes: (i) what the PSW role can bring, including recovery and improved wellbeing for service users and PSWs; (ii) confusion over the PSW role, including role ambiguity and unclear boundaries; and (iii) organisational challenges and impact, including low pay, negative non-peer staff attitudes, and lack of support and training.
    Conclusions: Peer support may be effective at improving some clinical outcomes, self-efficacy, and recovery. Certain populations, e.g. perinatal populations, may especially benefit from peer support. Potential strategies to successfully implement PSWs include co-production, clearly defined PSW roles, a receptive hierarchical structure and staff, appropriate PSW and staff training with clinical and/or peer supervision alongside safeguarding. Services could benefit from clear, coproduced, setting specific implementation guidelines for PSW. PSW roles tend to be poorly defined and associations between PSW intervention content and impacts need further investigation. Future research should reflect the priorities of providers/service users involved in peer support.
    MeSH term(s) Female ; Humans ; Pregnancy ; Mental Health ; Systematic Reviews as Topic ; Workplace
    Language English
    Publishing date 2024-02-29
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2131669-7
    ISSN 1741-7015 ; 1741-7015
    ISSN (online) 1741-7015
    ISSN 1741-7015
    DOI 10.1186/s12916-024-03260-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Scoping Review and Evidence Map of the Relation between Exposure to Dietary Sweetness and Body Weight-Related Outcomes in Adults.

    Higgins, Kelly A / Rawal, Rita / Baer, David J / O'Connor, Lauren E / Appleton, Katherine M

    Advances in nutrition (Bethesda, Md.)

    2022  Volume 13, Issue 6, Page(s) 2341–2356

    Abstract: Numerous governmental and health organizations recommend reduced intake of added sugars due to the health risks associated with excess intake, including the risk of obesity. Some organizations further recommend avoiding dietary sweetness, regardless of ... ...

    Abstract Numerous governmental and health organizations recommend reduced intake of added sugars due to the health risks associated with excess intake, including the risk of obesity. Some organizations further recommend avoiding dietary sweetness, regardless of the source. A scoping review and evidence map were completed to characterize the research that investigated associations between dietary sweetness and body weight. The aim was to identify and map published studies that have investigated total dietary sweetness, sweet food/beverages, sugar, or sweetener intake, and body weight-related outcomes and/or energy intake. Using preregistered search terms (osf.io/my7pb), 36,779 publications (duplicates removed) were identified from PubMed, Cochrane Library, and Scopus and screened for inclusion. Eligible studies were clinical trials, longitudinal cohorts, case-control studies, cross-sectional studies, and systematic reviews conducted among adults (age ≥18 y), which were performed to investigate associations between dietary sweetness, sweet foods/beverages, sugar, or sweetener (energetic or nonenergetic) intake and body weight, BMI, adiposity, and/or energy intake. A total of 833 eligible publications were identified, detailing 804 studies. Only 7 studies (0.9% of included studies; 2 clinical trials, 4 cross-sectional studies, and 1 with another design type) investigated associations between total dietary sweetness and body weight-related outcome and/or energy intake. An additional 608 (75.6%) studies investigated intakes of sweet foods/beverages, sugar, or sweetener, and body weight-related outcomes and/or energy intake, including 225 clinical trials, 81 longitudinal cohorts, 4 case-control studies, and 280 cross-sectional studies. Most studies (90.6%) did not measure the sweetness of the diet or individual foods consumed. Ninety-two (11.4%) publications reported data from studies on dietary patterns that included sweet foods/beverages alongside other dietary components and 97 (12.1%) systematic reviews addressed different but related research questions. Although there is a breadth of evidence from studies that have investigated associations between intakes of sweet foods and beverages, sugars, and sweeteners and body weight, there is a limited depth of evidence on the association between total dietary sweetness and body weight.
    MeSH term(s) Adult ; Humans ; Cross-Sectional Studies ; Body Weight ; Diet ; Obesity/etiology ; Energy Intake ; Sweetening Agents/adverse effects ; Beverages ; Sugars
    Chemical Substances Sweetening Agents ; Sugars
    Language English
    Publishing date 2022-08-27
    Publishing country United States
    Document type Review ; Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2583634-1
    ISSN 2156-5376 ; 2156-5376
    ISSN (online) 2156-5376
    ISSN 2156-5376
    DOI 10.1093/advances/nmac090
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Book: The measurement of sub-critical damping on the R.A.E. flutter simulator

    Appleton, J / Hicks, W. D

    (Current papers / Aeronautical Research Council ; 529)

    1961  

    Institution Aeronautical Research Council
    Author's details by J. Appleton and W. D. Hicks
    Series title Current papers / Aeronautical Research Council ; 529
    Language English
    Size 11 S., [3] Bl., Ill., graph. Darst., 33 cm
    Publisher HMSO
    Publishing place London
    Document type Book
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  9. Article ; Online: Adults with overweight or obesity use less efficient memory strategies compared to adults with healthy weight on a verbal list learning task modified with food words.

    Eichen, Dawn M / Kang Sim, Dong-Jin E / Appleton-Knapp, Sara L / Strong, David R / Boutelle, Kerri N

    Appetite

    2022  Volume 181, Page(s) 106402

    Abstract: Several studies suggest poorer episodic memory among adults with overweight (OW) relative to those with healthy weight (HW); however, few have used food stimuli. To understand the salience of food-related items when assessing memory, we adapted an ... ...

    Abstract Several studies suggest poorer episodic memory among adults with overweight (OW) relative to those with healthy weight (HW); however, few have used food stimuli. To understand the salience of food-related items when assessing memory, we adapted an episodic memory task, by replacing some non-food words with snack foods. Participants were 96 weight-loss seeking adults with OW compared to 48 adults with HW from the community matched on age, gender, ethnicity, and education. Overall memory ability was similar, although a trend showed the adults with HW performed better than adults with OW on immediate recall (d = 0.32, p = 0.07). However, there were clear differences in the use of learning strategies. Adults with HW utilized sematic clustering more effectively than adults with OW during all test phases (ds = 0.44-0.62; ps ≤ 0.01). Adults with HW also utilized serial clustering more effectively (d = 0.51; p < 0.01). Adults with HW showed better semantic clustering for both food and non-food words during immediate and short delay recall (ds = 0.42-0.78; ps ≤ 0.01) but semantic clustering was only better for the non-food category at long delay (d = 0.55; p < 0.01). These results show that adults with OW utilized less efficient learning strategies throughout the task and food-related content may impact learning. Clinically, these findings may suggest that weight-loss treatments should consider incorporating the teaching of learning and memory strategies to help increase utilization of new skills.
    MeSH term(s) Humans ; Adult ; Overweight/therapy ; Obesity/therapy ; Verbal Learning ; Learning ; Mental Recall ; Memory Disorders
    Language English
    Publishing date 2022-11-29
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1461347-5
    ISSN 1095-8304 ; 0195-6663
    ISSN (online) 1095-8304
    ISSN 0195-6663
    DOI 10.1016/j.appet.2022.106402
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Predictors and moderators of the response of adults with intellectual disabilities and depression to behavioural activation and guided self-help therapies.

    Melville, C A / Hatton, C / Beer, E / Hastings, R P / Cooper, S-A / McMeekin, N / Dagnan, D / Appleton, K / Scott, K / Fulton, L / Jones, R S P / McConnachie, A / Zhang, R / Knight, R / Knowles, D / Williams, C / Briggs, A / Jahoda, A

    Journal of intellectual disability research : JIDR

    2023  Volume 67, Issue 10, Page(s) 986–1002

    Abstract: ... attended and explained 35.3% of the variance in the total GDS-LD score at 12 months (R: Conclusions ...

    Abstract Background: No previous studies have reported predictors and moderators of outcome of psychological therapies for depression experienced by adults with intellectual disabilities (IDs). We investigated baseline variables as outcome predictors and moderators based on a randomised controlled trial where behavioural activation was compared with guided self-help.
    Methods: This study was an exploratory secondary data analysis of data collected during a randomised clinical trial. Participants (n = 161) were randomised to behavioural activation or guided self-help and followed up for 12 months. Pre-treatment variables were included if they have previously been shown to be associated with an increased risk of having depression in adults with IDs or have been reported as a potential predictor or moderator of outcome of treatment for depression with psychological therapies. The primary outcome measure, the Glasgow Depression Scale for Adults with Learning Disabilities (GDS-LD), was used as the dependant variable in mixed effects regression analyses testing for predictors and moderators of outcome, with baseline GDS-LD, treatment group, study centre and antidepressant use as fixed effects, and therapist as a random effect.
    Results: Higher baseline anxiety (mean difference in outcome associated with a 1 point increase in anxiety 0.164, 95% confidence interval [CI] 0.031, 0.297; P = 0.016), lower performance intelligence quotient (IQ) (mean difference in outcome associated with a 1 point increase in IQ 0.145, 95% CI 0.009, 0.280; P = 0.037) and hearing impairment (mean difference 3.449, 95% CI 0.466, 6.432; P = 0.024) were predictors of poorer outcomes, whilst greater severity of depressive symptoms at baseline (mean difference in outcome associated with 1 point increase in depression -0.160, 95% CI -0.806, -0.414; P < 0.001), higher expectation of change (mean difference in outcome associated with a 1 point increase in expectation of change -1.013, 95% CI -1.711, -0.314; p 0.005) and greater percentage of therapy sessions attended (mean difference in outcome with 1 point increase in percentage of sessions attended -0.058, 95% CI -0.099, -0.016; P = 0.007) were predictors of more positive outcomes for treatment after adjusting for randomised group allocation. The final model included severity of depressive and anxiety symptoms, lower WASI performance IQ subscale, hearing impairment, higher expectation of change and percentage of therapy sessions attended and explained 35.3% of the variance in the total GDS-LD score at 12 months (R
    Conclusions: Our results suggest that baseline variables may be useful predictors of outcomes of psychological therapies for adults with IDs. Further research is required to examine the value of these potential predictors. However, our findings suggest that therapists consider how baseline variables may enable them to tailor their therapeutic approach when using psychological therapies to treat depression experienced by adults with IDs.
    MeSH term(s) Adult ; Humans ; Depression/therapy ; Intellectual Disability/therapy ; Intellectual Disability/psychology ; Behavior Therapy/methods ; Anxiety ; Health Behavior
    Language English
    Publishing date 2023-06-21
    Publishing country England
    Document type Randomized Controlled Trial ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1103832-9
    ISSN 1365-2788 ; 0964-2633
    ISSN (online) 1365-2788
    ISSN 0964-2633
    DOI 10.1111/jir.13063
    Database MEDical Literature Analysis and Retrieval System OnLINE

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