LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Back to previous search Search history
Advanced search

Your last searches

  1. AU=Dupre Aude
  2. AU="Zafar, Junaid"
  3. AU="Norma Flores-Holguín"
  4. AU="Statuto, Teodora"
  5. AU="Wang, Po"
  6. AU="De Clercq, Erik"
  7. AU="Palamin, Nicola"
  8. AU="Sonego, Maura"
  9. AU="Short, Amanda"
  10. AU="Breukers, Jolien"
  11. AU="Marin, Daniele"
  12. AU="Silberg, Jonathan J"
  13. AU="Troy A Roepke"
  14. AU="Villena-Vargas, Jonathan"
  15. AU="Salvadori, Mirian G S S"
  16. AU="Biassoni M."
  17. AU="Tahir, Rizwan"
  18. AU="Shizuru, Judy"
  19. AU="Dogan, Özlem Yetmen"
  20. AU="Lui, Hiu-Tung"
  21. AU="Liu, Bilian"
  22. AU="Poling, R.L"
  23. AU="Shrem, Yosi"
  24. AU="Broodbakker, Jonno"
  25. AU=Pan Boyu
  26. AU="Chichelnitskiy, Evgeny"
  27. AU="Lin, I-Ling"
  28. AU="Tokarz, Ryan E"
  29. AU=Zarrilli Giovanni
  30. AU="Lipton, Stuart A."

Search results

Result 1 - 10 of total 65

Search options

  1. Article ; Online: La cycline B3, verrou de la méiose femelle en attendant la fécondation.

    Dupré, Aude / Wassmann, Katja

    Medecine sciences : M/S

    2023  Volume 39, Issue 3, Page(s) 289–292

    Title translation Cyclin B3: Locking female meiosis to await fertilization.
    MeSH term(s) Female ; Humans ; Fertilization ; Meiosis/genetics ; Oocytes ; Cyclin B/metabolism
    Chemical Substances Cyclin B
    Language French
    Publishing date 2023-03-21
    Publishing country France
    Document type News
    ZDB-ID 632733-3
    ISSN 1958-5381 ; 0767-0974
    ISSN (online) 1958-5381
    ISSN 0767-0974
    DOI 10.1051/medsci/2023019
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.B 2872: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article: The G2-to-M transition from a phosphatase perspective: a new vision of the meiotic division.

    Lemonnier, Tom / Dupré, Aude / Jessus, Catherine

    Cell division

    2020  Volume 15, Page(s) 9

    Abstract: Cell division is orchestrated by the phosphorylation and dephosphorylation of thousands of proteins. These post-translational modifications underlie the molecular cascades converging to the activation of the universal mitotic kinase, Cdk1, and entry into ...

    Abstract Cell division is orchestrated by the phosphorylation and dephosphorylation of thousands of proteins. These post-translational modifications underlie the molecular cascades converging to the activation of the universal mitotic kinase, Cdk1, and entry into cell division. They also govern the structural events that sustain the mechanics of cell division. While the role of protein kinases in mitosis has been well documented by decades of investigations, little was known regarding the control of protein phosphatases until the recent years. However, the regulation of phosphatase activities is as essential as kinases in controlling the activation of Cdk1 to enter M-phase. The regulation and the function of phosphatases result from post-translational modifications but also from the combinatorial association between conserved catalytic subunits and regulatory subunits that drive their substrate specificity, their cellular localization and their activity. It now appears that sequential dephosphorylations orchestrated by a network of phosphatase activities trigger Cdk1 activation and then order the structural events necessary for the timely execution of cell division. This review discusses a series of recent works describing the important roles played by protein phosphatases for the proper regulation of meiotic division. Many breakthroughs in the field of cell cycle research came from studies on oocyte meiotic divisions. Indeed, the meiotic division shares most of the molecular regulators with mitosis. The natural arrests of oocytes in G2 and in M-phase, the giant size of these cells, the variety of model species allowing either biochemical or imaging as well as genetics approaches explain why the process of meiosis has served as an historical model to decipher signalling pathways involved in the G2-to-M transition. The review especially highlights how the phosphatase PP2A-B55δ critically orchestrates the timing of meiosis resumption in amphibian oocytes. By opposing the kinase PKA, PP2A-B55δ controls the release of the G2 arrest through the dephosphorylation of their substrate, Arpp19. Few hours later, the inhibition of PP2A-B55δ by Arpp19 releases its opposing kinase, Cdk1, and triggers M-phase. In coordination with a variety of phosphatases and kinases, the PP2A-B55δ/Arpp19 duo therefore emerges as the key effector of the G2-to-M transition.
    Language English
    Publishing date 2020-05-25
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2236097-9
    ISSN 1747-1028
    ISSN 1747-1028
    DOI 10.1186/s13008-020-00065-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Translational Control of

    Meneau, Ferdinand / Dupré, Aude / Jessus, Catherine / Daldello, Enrico Maria

    Cells

    2020  Volume 9, Issue 6

    Abstract: The study of oocytes has made enormous contributions to the understanding of the ... ...

    Abstract The study of oocytes has made enormous contributions to the understanding of the G
    MeSH term(s) Animals ; Gene Expression Regulation, Developmental/genetics ; Gene Expression Regulation, Developmental/physiology ; Genomics ; Meiosis/genetics ; Meiosis/physiology ; Oocytes/metabolism ; Signal Transduction/physiology ; Xenopus laevis/genetics ; Xenopus laevis/metabolism
    Language English
    Publishing date 2020-06-19
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells9061502
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: Advanced prescription of injectable anticancer drugs: Safety assessment in a European Comprehensive Cancer Centre using the risk matrix approach.

    Acramel, Alexandre / Blondeel-Gomes, Sandy / Dupré, Mathilde / Kayembe, Ornella Tangila / Rochereau, Aude / Escalup, Laurence / Desmaris, Romain / Jourdan, Nathalie / Cordary, Adeline / Vaflard, Pauline / Cottu, Paul / Bellesoeur, Audrey

    British journal of clinical pharmacology

    2024  Volume 90, Issue 5, Page(s) 1333–1343

    Abstract: Aims: The purpose of this work was to assess failures in the advanced prescription of parenteral anticancer agents in an adult day oncology care unit with more than 100 patients per day.: Methods: An a priori descriptive analysis was carried out by ... ...

    Abstract Aims: The purpose of this work was to assess failures in the advanced prescription of parenteral anticancer agents in an adult day oncology care unit with more than 100 patients per day.
    Methods: An a priori descriptive analysis was carried out by using the risk matrix approach. After defining the scope in a multidisciplinary meeting, we determined at each step the failure modes (FMs), their effects (E) and their associated causes (C). A severity score (S) was assigned to all effects and a probability of occurrence (O) to all causes. These S and O indicators, were used to obtain a criticality index (CI) matrix. We assessed the risk control (RC) of each failure in order to define a residual criticality index (rCI) matrix.
    Results: During risk analysis, 14 FMs were detected, and 61 scenarios were identified considering all possible effects and causes. Nine situations (15%) were highlighted with the maximum CI, 18 (30%) with a medium CI, and 34 (55%) with a negligible CI. Nevertheless, among all these critical situations, only three (5%) had an rCI to process (i.e., missed dose adjustment, multiple prescriptions and abnormal biology data); the others required monitoring only. Clinicians' and pharmacists' knowledge of these critical situations enables them to manage the associated risks.
    Conclusions: Advanced prescription of injectable anticancer drugs appears to be a safe practice for patients when combined with risk management. The major risks identified concerned missed dose adjustment, prescription duplication and lack of consideration for abnormal biology data.
    MeSH term(s) Humans ; Antineoplastic Agents/administration & dosage ; Antineoplastic Agents/adverse effects ; Risk Assessment ; Medication Errors/prevention & control ; Medication Errors/statistics & numerical data ; Neoplasms/drug therapy ; Drug Prescriptions/statistics & numerical data ; Drug Prescriptions/standards ; Injections ; Cancer Care Facilities/statistics & numerical data ; Cancer Care Facilities/organization & administration ; Healthcare Failure Mode and Effect Analysis ; Adult
    Chemical Substances Antineoplastic Agents
    Language English
    Publishing date 2024-02-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 188974-6
    ISSN 1365-2125 ; 0306-5251 ; 0264-3774
    ISSN (online) 1365-2125
    ISSN 0306-5251 ; 0264-3774
    DOI 10.1111/bcp.16020
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1118: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: Aurora B/C-dependent phosphorylation promotes Rec8 cleavage in mammalian oocytes.

    Nikalayevich, Elvira / El Jailani, Safia / Dupré, Aude / Cladière, Damien / Gryaznova, Yulia / Fosse, Célia / Buffin, Eulalie / Touati, Sandra A / Wassmann, Katja

    Current biology : CB

    2022  Volume 32, Issue 10, Page(s) 2281–2290.e4

    Abstract: To generate haploid gametes, cohesin is removed in a stepwise manner from chromosome arms in meiosis I and the centromere region in meiosis II to segregate chromosomes and sister chromatids, respectively. Meiotic cohesin removal requires cleavage of the ... ...

    Abstract To generate haploid gametes, cohesin is removed in a stepwise manner from chromosome arms in meiosis I and the centromere region in meiosis II to segregate chromosomes and sister chromatids, respectively. Meiotic cohesin removal requires cleavage of the meiosis-specific kleisin subunit Rec8 by the protease separase.
    MeSH term(s) Animals ; Caenorhabditis elegans/genetics ; Caenorhabditis elegans/metabolism ; Cell Cycle Proteins/metabolism ; Centromere/metabolism ; Chromosomal Proteins, Non-Histone/metabolism ; Chromosome Segregation ; Mammals/genetics ; Meiosis ; Mice ; Oocytes/metabolism ; Phosphorylation ; Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae Proteins/metabolism ; Separase/metabolism
    Chemical Substances Cell Cycle Proteins ; Chromosomal Proteins, Non-Histone ; REC8 protein, S cerevisiae ; Saccharomyces cerevisiae Proteins ; Separase (EC 3.4.22.49)
    Language English
    Publishing date 2022-04-05
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1071731-6
    ISSN 1879-0445 ; 0960-9822
    ISSN (online) 1879-0445
    ISSN 0960-9822
    DOI 10.1016/j.cub.2022.03.041
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 3208: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article ; Online: Translational Control of Xenopus Oocyte Meiosis

    Ferdinand Meneau / Aude Dupré / Catherine Jessus / Enrico Maria Daldello

    Cells, Vol 9, Iss 1502, p

    Toward the Genomic Era

    2020  Volume 1502

    Abstract: The study of oocytes has made enormous contributions to the understanding of the G 2 /M transition. The complementarity of investigations carried out on various model organisms has led to the identification of the M-phase promoting factor (MPF) and to ... ...

    Abstract The study of oocytes has made enormous contributions to the understanding of the G 2 /M transition. The complementarity of investigations carried out on various model organisms has led to the identification of the M-phase promoting factor (MPF) and to unravel the basis of cell cycle regulation. Thanks to the power of biochemical approaches offered by frog oocytes, this model has allowed to identify the core signaling components involved in the regulation of M-phase. A central emerging layer of regulation of cell division regards protein translation. Oocytes are a unique model to tackle this question as they accumulate large quantities of dormant mRNAs to be used during meiosis resumption and progression, as well as the cell divisions during early embryogenesis. Since these events occur in the absence of transcription, they require cascades of successive unmasking, translation, and discarding of these mRNAs, implying a fine regulation of the timing of specific translation. In the last years, the Xenopus genome has been sequenced and annotated, enabling the development of omics techniques in this model and starting its transition into the genomic era. This review has critically described how the different phases of meiosis are orchestrated by changes in gene expression. The physiological states of the oocyte have been described together with the molecular mechanisms that control the critical transitions during meiosis progression, highlighting the connection between translation control and meiosis dynamics.
    Keywords Xenopus oocytes ; meiotic maturation ; translation ; mRNA polyadenylation ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2020-06-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  7. Article ; Online: Correction: The phosphorylation of ARPP19 by Greatwall renders the auto-amplification of MPF independently of PKA in

    Dupré, Aude / Buffin, Eulalie / Roustan, Chloé / Nairn, Angus C / Jessus, Catherine / Haccard, Olivier

    Journal of cell science

    2018  Volume 131, Issue 14

    Language English
    Publishing date 2018-07-30
    Publishing country England
    Document type Journal Article ; Published Erratum
    ZDB-ID 2993-2
    ISSN 1477-9137 ; 0021-9533
    ISSN (online) 1477-9137
    ISSN 0021-9533
    DOI 10.1242/jcs.222182
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1200: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 14: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article ; Online: The M-phase regulatory phosphatase PP2A-B55δ opposes protein kinase A on Arpp19 to initiate meiotic division

    Tom Lemonnier / Enrico Maria Daldello / Robert Poulhe / Tran Le / Marika Miot / Laurent Lignières / Catherine Jessus / Aude Dupré

    Nature Communications, Vol 12, Iss 1, Pp 1-

    2021  Volume 16

    Abstract: Mechanisms triggering meiotic divisions of oocytes remain unclear. Here, the authors report that meiosis resumption relies on the timely phosphorylation of Arpp19 protein at two distinct sites, which depends on two kinases (PKA and Gwl) and a single ... ...

    Abstract Mechanisms triggering meiotic divisions of oocytes remain unclear. Here, the authors report that meiosis resumption relies on the timely phosphorylation of Arpp19 protein at two distinct sites, which depends on two kinases (PKA and Gwl) and a single phosphatase (PP2A-B55δ).
    Keywords Science ; Q
    Language English
    Publishing date 2021-03-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  9. Article ; Online: The greatwall kinase is dominant over PKA in controlling the antagonistic function of ARPP19 in Xenopus oocytes.

    Dupré, Aude-Isabelle / Haccard, Olivier / Jessus, Catherine

    Cell cycle (Georgetown, Tex.)

    2017  Volume 16, Issue 15, Page(s) 1440–1452

    Abstract: The small protein ARPP19 plays a dual role during oocyte meiosis resumption. In Xenopus, ARPP19 phosphorylation at S109 by PKA is necessary for maintaining oocytes arrested in prophase of the first meiotic division. Progesterone downregulates PKA, ... ...

    Abstract The small protein ARPP19 plays a dual role during oocyte meiosis resumption. In Xenopus, ARPP19 phosphorylation at S109 by PKA is necessary for maintaining oocytes arrested in prophase of the first meiotic division. Progesterone downregulates PKA, leading to the dephosphorylation of ARPP19 at S109. This initiates a transduction pathway ending with the activation of the universal inducer of M-phase, the kinase Cdk1. This last step depends on ARPP19 phosphorylation at S67 by the kinase Greatwall. Hence, phosphorylated by PKA at S109, ARPP19 restrains Cdk1 activation while when phosphorylated by Greatwall at S67, ARPP19 becomes an inducer of Cdk1 activation. Here, we investigate the functional interplay between S109 and S67-phosphorylations of ARPP19. We show that both PKA and Gwl phosphorylate ARPP19 independently of each other and that Cdk1 is not directly involved in regulating the biological activity of ARPP19. We also show that the phosphorylation of ARPP19 at S67 that activates Cdk1, is dominant over the inhibitory S109 phosphorylation. Therefore our results highlight the importance of timely synchronizing ARPP19 phosphorylations at S109 and S67 to fully activate Cdk1.
    MeSH term(s) Animals ; Female ; Meiosis/genetics ; Meiosis/physiology ; Mitosis/genetics ; Mitosis/physiology ; Oocytes/metabolism ; Phosphoproteins/genetics ; Phosphoproteins/metabolism ; Phosphorylation/genetics ; Phosphorylation/physiology ; Xenopus Proteins/genetics ; Xenopus Proteins/metabolism ; Xenopus laevis/genetics ; Xenopus laevis/metabolism
    Chemical Substances Phosphoproteins ; Xenopus Proteins ; cyclic AMP-regulated phosphoprotein 19
    Language English
    Publishing date 2017-07-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2146183-1
    ISSN 1551-4005 ; 1538-4101 ; 1554-8627
    ISSN (online) 1551-4005
    ISSN 1538-4101 ; 1554-8627
    DOI 10.1080/15384101.2017.1338985
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 5881: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article ; Online: Correction: Control of Cdc6 accumulation by Cdk1 and MAPK is essential for completion of oocyte meiotic divisions in

    Daldello, Enrico M / Le, Tran / Poulhe, Robert / Jessus, Catherine / Haccard, Olivier / Dupré, Aude

    Journal of cell science

    2018  Volume 131, Issue 3

    Language English
    Publishing date 2018-02-01
    Publishing country England
    Document type Journal Article ; Published Erratum
    ZDB-ID 2993-2
    ISSN 1477-9137 ; 0021-9533
    ISSN (online) 1477-9137
    ISSN 0021-9533
    DOI 10.1242/jcs.215293
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1200: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 14: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top