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  1. Article ; Online: Implementation remains the biggest challenge to the effective use of PROMs and PREMs, so what can we do about it?

    Bull, Claudia / Pole, Jason D

    International journal for quality in health care : journal of the International Society for Quality in Health Care

    2024  Volume 36, Issue 2

    MeSH term(s) Humans ; Patient Reported Outcome Measures
    Language English
    Publishing date 2024-04-24
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 1194150-9
    ISSN 1464-3677 ; 1353-4505
    ISSN (online) 1464-3677
    ISSN 1353-4505
    DOI 10.1093/intqhc/mzae029
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    Zs.A 3052: Show issues Location:
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  2. Article ; Online: Long-term surgical consequences of childhood cancer.

    Youlden, Danny R / Pole, Jason D / Baxter, Nancy N / Aitken, Joanne F

    The Lancet. Oncology

    2023  Volume 24, Issue 6, Page(s) 582–583

    MeSH term(s) Child ; Humans ; Neoplasms/epidemiology ; Neoplasms/surgery ; Survivors
    Language English
    Publishing date 2023-05-11
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 2049730-1
    ISSN 1474-5488 ; 1470-2045
    ISSN (online) 1474-5488
    ISSN 1470-2045
    DOI 10.1016/S1470-2045(23)00166-3
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    Zs.A 5696: Show issues Location:
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  3. Article ; Online: Development and validation of thromboembolism diagnostic algorithms in children with cancer from real-world data.

    Athale, Uma / Halton, Jacqueline / Gayowsky, Anastasia / Chan, Anthony K C / Pole, Jason D

    Pediatric research

    2024  

    Abstract: Objective: To evaluate the accuracy of diagnostic algorithms developed using the International Classification of Diseases (ICD-9-CM and ICD-10-CA) diagnostic codes and physician billing codes for thromboembolism (TE) from health administrative data ... ...

    Abstract Objective: To evaluate the accuracy of diagnostic algorithms developed using the International Classification of Diseases (ICD-9-CM and ICD-10-CA) diagnostic codes and physician billing codes for thromboembolism (TE) from health administrative data compared to chart review diagnoses of TE in children with cancer.
    Methods: Using data linkage between the Pediatric Oncology Group of Ontario Network Information System (Ontario pediatric cancer registry) and various administrative data housed at ICES, eight algorithms were developed including a single reference to one of the billing codes, multiple references with varying time intervals, and combinations of various billing codes during primary cancer therapy for the whole cohort and, for early (<04/2002) and later (≥04/2002, solely ICD-10 codes) periods. Reference standard was chart review data from prior studies (from 1990 to 2016) among children (≤19 years) with cancer and radiologically confirmed TE.
    Results: Records of 2056 patients diagnosed with cancer at two participating sites during study period were reviewed; 112 had radiologically confirmed TE. The algorithm with addition of anticoagulation utilization codes was the best performing algorithm (sensitivity = 0.76;specificity = 0.85). With use of ICD-10 only codes, sensitivity of the same algorithm improved to 0.84 with specificity of 0.80.
    Conclusion: This study provides a valid approach for ascertaining pediatric TE using real-world data.
    Impact: Research in pediatric thrombosis, especially cancer-related thrombosis, is limited mainly due to small-sized studies. Real-world data provide ready access to large and diverse populations. However, there are no validated algorithms for identifying thrombosis in real-world data for children. An algorithm based on combination of thrombosis and anticoagulation utilization codes had 76% sensitivity and 85% specificity to identify diagnosis of thrombosis in children in administrative data. This study provides a valid approach for ascertaining pediatric thrombosis using real-world data and offers a good avenue to advance pediatric thrombosis research.
    Language English
    Publishing date 2024-02-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 4411-8
    ISSN 1530-0447 ; 0031-3998
    ISSN (online) 1530-0447
    ISSN 0031-3998
    DOI 10.1038/s41390-024-03082-x
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    Zs.A 564: Show issues Location:
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    Zs.MO 373: Show issues

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  4. Article ; Online: Immediate and Ongoing Impact of COVID-19 on Chlamydia Treatment in Australia.

    Engstrom, Teyl / Baliunas, Dolly / Smith, Angela / Dean, Judith A / Pole, Jason D

    Sexually transmitted diseases

    2023  Volume 50, Issue 6, Page(s) 363–369

    Abstract: Background: The COVID-19 pandemic has impacted the sexual health and well-being of individuals, directly through risk of contracting COVID-19, and indirectly through government lockdowns. Government restrictions were especially strict and long-lasting ... ...

    Abstract Background: The COVID-19 pandemic has impacted the sexual health and well-being of individuals, directly through risk of contracting COVID-19, and indirectly through government lockdowns. Government restrictions were especially strict and long-lasting in Australia, they also varied by state, offering an interesting opportunity to study the impacts of varying restrictions. This study compares the impact of the COVID-19 pandemic and resulting restrictions on chlamydia treatment prescriptions during 2020, through to July 2021 between different states and demographic groups in Australia.
    Methods: The rate of prescriptions per 100,000 population filled each month from January 2017 to July 2021 from Australia's Pharmaceutical Benefits Scheme for Azithromycin with a restricted indication to treat Chlamydia trachomatis was used to measure chlamydia treatment. The impact of COVID-19 lockdowns was modeled using an interrupted time-series Poisson regression model.
    Results: The data included 520,025 prescriptions to treat chlamydia, averaging 37.5 prescriptions per month per 100,000 population. Prescriptions declined 26% in April to May 2020 when initial COVID-19 lockdowns began in Australia; prescriptions increased in the following months but remained on average 21% below prepandemic (2017-2019) levels through to July 2021. Prescriptions declined the most in 1 Australian state, Victoria, both in the initial lockdown and the following period; generally, states with more COVID-19 cases saw bigger reductions in prescriptions.
    Conclusions: This is the first study to examine how treatment for chlamydia in Australia was impacted by the COVID-19 pandemic and restrictions not only in the immediate-term, but also ongoing up to July 2021, providing important information for planning for sexual health services in future pandemics.
    MeSH term(s) Humans ; Pandemics ; COVID-19/epidemiology ; Communicable Disease Control ; Victoria ; Azithromycin/therapeutic use
    Chemical Substances Azithromycin (83905-01-5)
    Language English
    Publishing date 2023-02-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 435191-5
    ISSN 1537-4521 ; 0148-5717
    ISSN (online) 1537-4521
    ISSN 0148-5717
    DOI 10.1097/OLQ.0000000000001785
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    Zs.A 1217: Show issues Location:
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  5. Article ; Online: Psychiatric disorders in childhood cancer survivors: A retrospective matched cohort study of inpatient hospitalisations and community-based mental health services utilisation in Western Australia.

    Abdalla, Tasnim / Preen, David B / Pole, Jason D / Walwyn, Thomas / Bulsara, Max / Ives, Angela / Choong, Catherine S / Ohan, Jeneva L

    The Australian and New Zealand journal of psychiatry

    2024  , Page(s) 48674241233871

    Abstract: Objective: We examined the impact of long-term mental health outcomes on healthcare services utilisation among childhood cancer survivors in Western Australia using linked hospitalisations and community-based mental healthcare records from 1987 to 2019.! ...

    Abstract Objective: We examined the impact of long-term mental health outcomes on healthcare services utilisation among childhood cancer survivors in Western Australia using linked hospitalisations and community-based mental healthcare records from 1987 to 2019.
    Method: The study cohort included 2977 childhood cancer survivors diagnosed with cancer at age < 18 years in Western Australia from 1982 to 2014 and a matched non-cancer control group of 24,994 individuals. Adjusted hazard ratios of recurrent events were estimated using the Andersen-Gill model. The cumulative burden of events over time was assessed using the method of mean cumulative count. The annual percentage change in events was estimated using the negative binomial regression model.
    Results: The results showed higher community-based service contacts (rate/100 person-years: 30.2, 95% confidence interval = [29.7-30.7] vs 22.8, 95% confidence interval = [22.6-22.9]) and hospitalisations (rate/1000 person-years: 14.8, 95% confidence interval = [13.6-16.0] vs 12.7, 95% confidence interval = [12.3-13.1]) in childhood cancer survivors compared to the control group. Childhood cancer survivors had a significantly higher risk of any event (adjusted hazard ratio = 1.5, 95% confidence interval = [1.1-2.0]). The cumulative burden of events increased with time since diagnosis and across age groups. The annual percentage change for hospitalisations and service contacts significantly increased over time (
    Conclusions: The elevated utilisation of healthcare services observed among childhood cancer survivors emphasises the need for periodic assessment of psychiatric disorders, particularly in high-risk survivors, to facilitate early management and optimise healthcare resources.
    Language English
    Publishing date 2024-02-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 221140-3
    ISSN 1440-1614 ; 0004-8674
    ISSN (online) 1440-1614
    ISSN 0004-8674
    DOI 10.1177/00048674241233871
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    Zs.A 856: Show issues Location:
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  6. Article ; Online: Financial toxicity among adolescent and young adult cancer survivors: A systematic review of educational attainment, employment, and income.

    Di Giuseppe, Giancarlo / Pagalan, Lief / Jetha, Arif / Pechlivanoglou, Petros / Pole, Jason D

    Critical reviews in oncology/hematology

    2023  Volume 183, Page(s) 103914

    Abstract: Purpose: To identify, evaluate and summarize the evidence on educational attainment, employment status and income of AYAs surviving cancer.: Methods: A search of six databases for articles published between 01/01/2010 and 03/31/2022 was performed. ... ...

    Abstract Purpose: To identify, evaluate and summarize the evidence on educational attainment, employment status and income of AYAs surviving cancer.
    Methods: A search of six databases for articles published between 01/01/2010 and 03/31/2022 was performed. Articles with an AYA survivorship population, quantitative design and a cancer-free comparator group were included. Data extraction was conducted, and quality appraisal was completed using ROBINS-I. Results were summarized using a narrative synthesis.
    Results: A total of 2801 articles were identified, of which 12 were included. Among the limited evidence, educational attainment did not differ from cancer-free peers. Survivors were more likely to be unemployed, have lower incomes and require social security for income supplementation. Evidence suggested that females, diagnosis of brain cancer and the presence of late-effects were among the risk factors for severe outcomes.
    Conclusions: Limited socioeconomic evidence exists for AYAs surviving cancer. Long-lasting financial toxicities occur and highlights a need for further investigation.
    MeSH term(s) Female ; Humans ; Adolescent ; Young Adult ; Cancer Survivors ; Financial Stress ; Employment ; Neoplasms/epidemiology ; Educational Status ; Brain Neoplasms
    Language English
    Publishing date 2023-01-25
    Publishing country Netherlands
    Document type Systematic Review ; Journal Article ; Review
    ZDB-ID 605680-5
    ISSN 1879-0461 ; 0737-9587 ; 1040-8428
    ISSN (online) 1879-0461
    ISSN 0737-9587 ; 1040-8428
    DOI 10.1016/j.critrevonc.2023.103914
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    Zs.A 1931: Show issues Location:
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  7. Article: A Comparison of Leximancer Semi-automated Content Analysis to Manual Content Analysis: A Healthcare Exemplar Using Emotive Transcripts of COVID-19 Hospital Staff Interactive Webcasts.

    Engstrom, Teyl / Strong, Jenny / Sullivan, Clair / Pole, Jason D

    International journal of qualitative methods

    2022  Volume 21, Page(s) 16094069221118993

    Abstract: Effective consumer centred healthcare incorporates consumer and clinician perspectives into decision making, in addition to traditional quantitative measures. This information is usually captured in qualitative data that requires manual analysis. ... ...

    Abstract Effective consumer centred healthcare incorporates consumer and clinician perspectives into decision making, in addition to traditional quantitative measures. This information is usually captured in qualitative data that requires manual analysis. Healthcare systems often lack resources to systematically incorporate qualitative feedback into decision making. Semi-automated content analysis tools, such as Leximancer, provide an efficient and objective alternative to time consuming manual content analysis (MCA). Literature on the validity of Leximancer in healthcare is sparse. This study seeks to validate Leximancer against MCA on a broad emotive conversational dataset gathered in a healthcare setting. At the outset of the COVID-19 pandemic, a large Australian hospital and health service conducted interactive webcasts with staff to provide updates and answer questions. A manual thematic analysis and a Leximancer content analysis were conducted independently on 20 webcast transcripts. The findings were compared, along with the time required to the complete each analysis. The Leximancer analysis identified nine concepts, while the manual analysis identified 12 concepts. The Leximancer concepts mapped to five of the concepts identified in the manual analysis, which accounted for 74% of mentions tagged in the text through the manual analysis. Leximancer missed concepts which required an emotional or contextual interpretation. The Leximancer analysis took 21 hours (excluding time to learn the program), compared to 73 hours for the manual analysis. Semi-automated content analysis provides an efficient alternative to manual qualitative data analysis, shifting it from a small-scale research activity to a more routine operational activity, albeit with some limitations. This is critical to be able to utilise at scale the rich narratives from consumers and clinicians in healthcare decision making.
    Language English
    Publishing date 2022-08-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2135788-2
    ISSN 1609-4069
    ISSN 1609-4069
    DOI 10.1177/16094069221118993
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  8. Article ; Online: Publicly subsidised smoking cessation medicines in times of COVID-19 in Australia: An interrupted time series analysis.

    Baliunas, Dolly / Gartner, Coral / Hollingworth, Samantha A / Sullivan, Clair / Comans, Tracy / Pole, Jason D

    Drug and alcohol review

    2022  Volume 42, Issue 1, Page(s) 225–232

    Abstract: Introduction: In Australia, the available published literature demonstrated a spike in dispensed prescription medicines after the onset of the COVID-19 pandemic that subsequently returned to expected levels. Smoking cessation medicines may not follow ... ...

    Abstract Introduction: In Australia, the available published literature demonstrated a spike in dispensed prescription medicines after the onset of the COVID-19 pandemic that subsequently returned to expected levels. Smoking cessation medicines may not follow this pattern because quit attempts are influenced by a range of factors. Knowledge of whether dispensing of these medicines has changed since the pandemic is lacking. We explored the change in dispensing of publicly subsidised smoking cessation medicines since the pandemic.
    Methods: Australia's universal health-care system provides access to government-subsidised medicines via the Pharmaceutical Benefits Scheme and records of dispensed medicines are publicly available on a nationally aggregated level. We retrieved Pharmaceutical Benefits Scheme data from January 2016 to January 2021. We used interrupted time series modelling to quantify the impact of COVID-19 on dispensing of nicotine replacement therapy (NRT) patches, varenicline and all smoking cessation treatments combined separately.
    Results: After an initial spike in medicines at the onset of the pandemic, the monthly rate of prescriptions dispensed for varenicline was predominantly within predicted ranges, while that of NRT patches was predominantly below predicted ranges.
    Discussion and conclusions: There has been a differential change in the number of subsidised smoking cessation medicines supplied in Australia since the COVID-19 pandemic, with varenicline prescriptions largely within, and NRT patches largely lower than, expected ranges. The reasons for the apparent change in dispensing of subsidised smoking cessation medicines are unclear.
    MeSH term(s) Humans ; Smoking Cessation ; Varenicline ; Nicotine ; Nicotinic Agonists ; Interrupted Time Series Analysis ; Bupropion ; Smoking ; Pandemics ; Tobacco Use Cessation Devices ; COVID-19 ; Pharmaceutical Preparations
    Chemical Substances Varenicline (W6HS99O8ZO) ; Nicotine (6M3C89ZY6R) ; Nicotinic Agonists ; Bupropion (01ZG3TPX31) ; Pharmaceutical Preparations
    Language English
    Publishing date 2022-09-29
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 1080442-0
    ISSN 1465-3362 ; 0959-5236
    ISSN (online) 1465-3362
    ISSN 0959-5236
    DOI 10.1111/dar.13557
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    Zs.A 5621: Show issues Location:
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  9. Article ; Online: Patient Reported Fatigue Among Adolescent and Young Adult Cancer Patients Compared to Non-Cancer Patients: A Systematic Review and Meta-Analysis.

    Forbes, Cheryl / Tanner, Sarah / Engstrom, Teyl / Lee, Wen Ray / Patel, Dhaval / Walker, Rick / Bradford, Natalie / Pole, Jason D

    Journal of adolescent and young adult oncology

    2023  Volume 13, Issue 2, Page(s) 242–250

    Abstract: Adolescent and young adult (AYA) cancer patients and survivors are a growing population due to more frequent diagnoses and improved survival. Fatigue is a common symptom experienced by cancer patients and it is often missed by health care professionals. ... ...

    Abstract Adolescent and young adult (AYA) cancer patients and survivors are a growing population due to more frequent diagnoses and improved survival. Fatigue is a common symptom experienced by cancer patients and it is often missed by health care professionals. Patient reported outcome measures (PROMs) can assist in evaluating patient reported fatigue. This systematic review aims to determine if AYA cancer patients report more fatigue than AYAs who have not been diagnosed with cancer. We used a subset of articles from a larger review that searched PubMed, EMBASE, CINAHL, and PsycINFO to determine which PROMs and domains are currently being used to evaluate AYA cancer. This study identified 175 articles related to PROMs in the AYA cancer population. Articles with PROMs reporting on fatigue/vitality were used in this review. From the original 175 articles, we identified 8 fatigue/vitality articles for this review. All eight articles found an increase in fatigue/decrease in vitality in the AYA cancer population compared to healthy controls. A meta-analysis was performed on four articles that used the same PROM tool (EORTC QLQ-C30). This found a statistically significant and clinically meaningful increase in mean fatigue of 12.5 95% confidence interval: 3.3-21.8 points (scale 0-100, higher number indicates more fatigue) in the AYA cancer group compared to healthy noncancer controls. Fatigue in the AYA cancer population is a significant issue, it is often undetected and underreported, and early interventions are needed to prevent the negative subsequent sequelae.
    MeSH term(s) Humans ; Adolescent ; Young Adult ; Quality of Life ; Neoplasms/complications ; Disease Progression ; Fatigue/etiology ; Patient Reported Outcome Measures
    Language English
    Publishing date 2023-10-30
    Publishing country United States
    Document type Meta-Analysis ; Systematic Review ; Journal Article ; Review
    ZDB-ID 2607978-1
    ISSN 2156-535X ; 2156-5333
    ISSN (online) 2156-535X
    ISSN 2156-5333
    DOI 10.1089/jayao.2023.0094
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  10. Article ; Online: Treatment patterns and outcomes in adolescents and young adults with nodular lymphocyte-predominant Hodgkin lymphoma: an IMPACT cohort study.

    Punnett, Angela / Baxter, Nancy N / Hodgson, David / Sutradhar, Rinku / Pole, Jason D / Lau, Cindy / Nathan, Paul C / Gupta, Sumit

    British journal of haematology

    2023  Volume 201, Issue 6, Page(s) 1081–1087

    Abstract: We leveraged population-based clinical and healthcare data to identify treatment patterns and long-term outcomes among adolescents and young adults (AYA) with nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL). All Ontario, Canada, AYA aged 15-21 ... ...

    Abstract We leveraged population-based clinical and healthcare data to identify treatment patterns and long-term outcomes among adolescents and young adults (AYA) with nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL). All Ontario, Canada, AYA aged 15-21 years at diagnosis with NLPHL between 1992 and 2012 were identified, and their detailed clinical data were collected. Linkage to healthcare databases identified additional events (subsequent malignant neoplasms [SMN], relapses and deaths). Event-free survival (EFS) and overall survival (OS) were compared by locus of care (adult vs. paediatric) and predictors of outcomes determined. Of 1014 AYA with Hodgkin lymphoma, 54 (5.3%) had NLPHL; 15 (27.8%) were treated at a paediatric centre. No paediatric centre patient received radiation only versus 16 (41.0%) of adult centre patients. Excision only was more common in paediatric centres (p < 0.001). The 20-year EFS and OS rates were 82.9% ± 5.2% and 100% respectively. Advanced stage (hazard ratio: 4.9, 95% CI: 1.3-18.4; p = 0.02) was associated with inferior EFS. Although the 25-year cumulative incidence of SMN was 19.3% ± 9.6% for the entire cohort, there were no SMN among the patients treated with excision only. AYA with NLPHL have outstanding long-term survival. Resection alone was rare outside of paediatric institutions but associated with excellent outcomes. Given substantial SMN risks, chemotherapy-sparing and radiation-sparing strategies for appropriate subsets of patients are warranted.
    MeSH term(s) Humans ; Adolescent ; Young Adult ; Child ; Hodgkin Disease/drug therapy ; Cohort Studies ; Neoplasm Recurrence, Local ; Lymphocytes/pathology ; Ontario/epidemiology
    Language English
    Publishing date 2023-04-04
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80077-6
    ISSN 1365-2141 ; 0007-1048
    ISSN (online) 1365-2141
    ISSN 0007-1048
    DOI 10.1111/bjh.18757
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