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Article ; Online: Rapid alterations in neuroimmune gene expression after acute ethanol: Timecourse, sex differences and sensitivity to cranial surgery.

Gano, Anny / Mondello, Jamie E / Doremus-Fitzwater, Tamara L / Deak, Terrence

2019 Volume 337, Page(s) 577083

Abstract: Prior work has established that that an acute ethanol challenge mimicking high intensity alcohol consumption increased IL-6 and suppressed IL-1β and TNFα mRNA in intoxication, with the opposite pattern seen in withdrawal. These experiments utilized ... ...

Abstract	Prior work has established that that an acute ethanol challenge mimicking high intensity alcohol consumption increased IL-6 and suppressed IL-1β and TNFα mRNA in intoxication, with the opposite pattern seen in withdrawal. These experiments utilized Sprague-Dawley rats to further extend these results across time course (from 45 min to 6 h after ethanol), sex, and central versus peripheral expression. Furthermore, these data show that cannulation surgery may selectively modify the central neuroimmune response to ethanol. These findings highlight a unique plasticity of IL-6 that is specific to central structures and responsive to alterations by environmental factors.
MeSH term(s)	Animals ; Catheterization/methods ; Ethanol/administration & dosage ; Ethanol/toxicity ; Female ; Gene Expression ; Interleukin-1beta/biosynthesis ; Interleukin-1beta/immunology ; Interleukin-6/biosynthesis ; Interleukin-6/immunology ; Male ; Rats ; Rats, Sprague-Dawley ; Sex Characteristics ; Skull/surgery ; Time Factors ; Tumor Necrosis Factor-alpha/biosynthesis ; Tumor Necrosis Factor-alpha/immunology
Chemical Substances	IL1B protein, rat ; Il6 protein, rat ; Interleukin-1beta ; Interleukin-6 ; Tumor Necrosis Factor-alpha ; Ethanol (3K9958V90M)
Language	English
Publishing date	2019-10-15
Publishing country	Netherlands
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	8335-5
ISSN	1872-8421 ; 0165-5728
ISSN (online)	1872-8421
ISSN	0165-5728
DOI	10.1016/j.jneuroim.2019.577083
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Article ; Online: A cross-sectional comparison of ethanol-related cytokine expression in the hippocampus of young and aged Fischer 344 rats.

Gano, Anny / Doremus-Fitzwater, Tamara L / Deak, Terrence

Neurobiology of aging

2017 Volume 54, Page(s) 40–53

Abstract: Our work in Sprague Dawley rats has shown rapid alterations in neuroimmune gene expression (RANGE) in the hippocampus and paraventricular nucleus of the hypothalamus (PVN). These manifest as increased interleukin (IL)-6 and IκBα, and suppressed IL-1β and ...

Abstract	Our work in Sprague Dawley rats has shown rapid alterations in neuroimmune gene expression (RANGE) in the hippocampus and paraventricular nucleus of the hypothalamus (PVN). These manifest as increased interleukin (IL)-6 and IκBα, and suppressed IL-1β and tumor necrosis factor alpha during acute ethanol intoxication. The present studies tested these effects across the lifespan (young adulthood at 2-3 months; senescence at 18 and 24 months), as well as across strain (Fischer 344) and sex. The hippocampus revealed age-dependent shifts in cytokine expression (IL-6, IL-1β, and monocyte chemoattractant protein 1), but no changes were observed in the PVN at baseline or following ethanol. RANGE in adults was similar across sex and comparable with effects seen in Sprague Dawley rats. Plasma corticosterone levels increased with age, whereas the blood ethanol concentrations and loss of righting reflex were similar in all groups older than 2 months. These findings indicate that the RANGE effect is largely conserved across strain and is durable across age, even in the face of a shifting neuroimmune profile that emerges during immunosenescence.
MeSH term(s)	Aging/genetics ; Aging/immunology ; Aging/metabolism ; Animals ; Chemokine CCL2/genetics ; Chemokine CCL2/metabolism ; Corticosterone/blood ; Cross-Sectional Studies ; Cytokines/genetics ; Cytokines/metabolism ; Ethanol/poisoning ; Female ; Gene Expression ; Hippocampus/metabolism ; Immunosenescence/genetics ; Immunosenescence/immunology ; Male ; Neuroimmunomodulation/genetics ; Rats, Inbred F344 ; Rats, Sprague-Dawley ; Sex Characteristics
Chemical Substances	Chemokine CCL2 ; Cytokines ; Ethanol (3K9958V90M) ; Corticosterone (W980KJ009P)
Language	English
Publishing date	2017-03-17
Publishing country	United States
Document type	Comparative Study ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	604505-4
ISSN	1558-1497 ; 0197-4580
ISSN (online)	1558-1497
ISSN	0197-4580
DOI	10.1016/j.neurobiolaging.2017.01.025
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Zs.A 1685: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Reward-centricity and attenuated aversions: An adolescent phenotype emerging from studies in laboratory animals.

Doremus-Fitzwater, Tamara L / Spear, Linda P

Neuroscience and biobehavioral reviews

2016 Volume 70, Page(s) 121–134

Abstract: Adolescence is an evolutionarily conserved developmental period, with neural circuits and behaviors contributing to the detection, procurement, and receipt of rewards bearing similarity across species. Studies with laboratory animals suggest that ... ...

Abstract	Adolescence is an evolutionarily conserved developmental period, with neural circuits and behaviors contributing to the detection, procurement, and receipt of rewards bearing similarity across species. Studies with laboratory animals suggest that adolescence is typified by a "reward-centric" phenotype-an increased sensitivity to rewards relative to adults. In contrast, adolescent rodents are reportedly less sensitive to the aversive properties of many drugs and naturally aversive stimuli. Alterations within the mesocorticolimbic dopamine and endocannabinoid systems likely contribute to an adolescent reward-sensitive, yet aversion-resistant, phenotype. Although early hypotheses postulated that developmental changes in dopaminergic circuitry would result in a "reward deficiency" syndrome, evidence now suggests the opposite: that adolescents are uniquely poised to seek out hedonic stimuli, experience greater "pleasure" from rewards, and consume rewarding stimuli in excess. Future studies that more clearly define the role of specific brain regions and neurotransmitter systems in the expression of behaviors toward reward- and aversive-related cues and stimuli are necessary to more fully understand an adolescent-proclivity for and vulnerability to rewards and drugs of potential abuse.
MeSH term(s)	Adolescent ; Animals ; Animals, Laboratory ; Brain ; Dopamine ; Humans ; Phenotype ; Reward
Chemical Substances	Dopamine (VTD58H1Z2X)
Language	English
Publishing date	2016-08-11
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	282464-4
ISSN	1873-7528 ; 0149-7634
ISSN (online)	1873-7528
ISSN	0149-7634
DOI	10.1016/j.neubiorev.2016.08.015
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Article ; Online: Sustained alterations in neuroimmune gene expression after daily, but not intermittent, alcohol exposure.

Gano, Anny / Doremus-Fitzwater, Tamara L / Deak, Terrence

Brain research

2016 Volume 1646, Page(s) 62–72

Abstract: Acute ethanol intoxication is associated with Rapid Alterations in Neuroimmune Gene Expression (RANGE), including increased Interleukin (IL)-6 and Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha (IκBα), and suppressed ... ...

Abstract	Acute ethanol intoxication is associated with Rapid Alterations in Neuroimmune Gene Expression (RANGE), including increased Interleukin (IL)-6 and Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha (IκBα), and suppressed IL-1β and Tumor necrosis factor (TNF) α, yet little is known about adaptations in cytokines across the first few ethanol exposures. Thus, the present studies examined central cytokines during intoxication (3h post-ethanol) following 2, 4 or 6 intragastric ethanol challenges (4g/kg) delivered either daily or every-other-day (EOD). Subsequent analyses of blood ethanol concentrations (BECs) and corticosterone were performed to determine whether the schedule of ethanol delivery would alter the pharmacokinetics of, or general sensitivity to, subacute ethanol exposure. As expected, ethanol led to robust increases in IL-6 and IκBα gene expression in hippocampus, amygdala and bed nucleus of the stria terminalis (BNST), whereas IL-1β and TNFα were suppressed, thereby replicating our prior work. Ethanol-dependent increases in IL-6 and IκBα remained significant in all structures - even after 6 days of ethanol. When these doses were administered EOD, modest IL-6 increases in BNST were observed, with TNFα and IL-1β suppressed exclusively in the hippocampus. Analysis of BECs revealed a small but significant reduction in ethanol after 4 EOD exposures - an effect which was not observed when ethanol was delivered after 6 daily intubations. These findings suggest that ethanol-induced RANGE effects are not simply a function of ethanol load per se, and underscore the critical role that ethanol dosing interval plays in determining the neuroimmune consequences of alcohol.
MeSH term(s)	Amygdala/drug effects ; Amygdala/immunology ; Amygdala/metabolism ; Animals ; Brain/drug effects ; Brain/immunology ; Brain/metabolism ; Corticosterone/blood ; Cytokines/metabolism ; Ethanol/administration & dosage ; Ethanol/blood ; Gene Expression/drug effects ; Hippocampus/drug effects ; Hippocampus/immunology ; Hippocampus/metabolism ; Male ; Neuroimmunomodulation/drug effects ; Rats ; Rats, Sprague-Dawley ; Septal Nuclei/drug effects ; Septal Nuclei/immunology ; Septal Nuclei/metabolism
Chemical Substances	Cytokines ; Ethanol (3K9958V90M) ; Corticosterone (W980KJ009P)
Language	English
Publishing date	2016-05-18
Publishing country	Netherlands
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	1200-2
ISSN	1872-6240 ; 0006-8993
ISSN (online)	1872-6240
ISSN	0006-8993
DOI	10.1016/j.brainres.2016.05.027
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Article: Lingering Effects of Prenatal Alcohol Exposure on Basal and Ethanol-Evoked Expression of Inflammatory-Related Genes in the CNS of Adolescent and Adult Rats.

Doremus-Fitzwater, Tamara L / Youngentob, Steven L / Youngentob, Lisa / Gano, Anny / Vore, Andrew S / Deak, Terrence

Frontiers in behavioral neuroscience

2020 Volume 14, Page(s) 82

Abstract: Emerging data suggest that alcohol's effects on central inflammatory factors are not uniform across the lifespan. In particular, prenatal alcohol exposure (PAE) significantly alters steady-state levels of neuroimmune factors, as well as subsequent ... ...

Abstract	Emerging data suggest that alcohol's effects on central inflammatory factors are not uniform across the lifespan. In particular, prenatal alcohol exposure (PAE) significantly alters steady-state levels of neuroimmune factors, as well as subsequent reactivity to later immune challenge. Thus, the current experiment investigated developmental sensitivities to, and long-lasting consequences of, PAE on ethanol-evoked cytokine expression in male and female adolescent and adult rats. Pregnant dams received either an
Language	English
Publishing date	2020-06-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2452960-6
ISSN	1662-5153
ISSN	1662-5153
DOI	10.3389/fnbeh.2020.00082
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Article ; Online: Conditioned effects of ethanol on the immune system.

Gano, Anny / Pautassi, Ricardo Marcos / Doremus-Fitzwater, Tamara L / Deak, Terrence

Experimental biology and medicine (Maywood, N.J.)

2017 Volume 242, Issue 7, Page(s) 718–730

Abstract: Several studies indicate that the immune system can be subjected to classical conditioning. Acute ethanol intoxication significantly modulates several pro-inflammatory cytokines (e.g. interleukins-1 and 6 [IL-1β and IL-6, respectively] and tumor necrosis ...

Abstract	Several studies indicate that the immune system can be subjected to classical conditioning. Acute ethanol intoxication significantly modulates several pro-inflammatory cytokines (e.g. interleukins-1 and 6 [IL-1β and IL-6, respectively] and tumor necrosis factor alpha [TNFα])) in several brain areas, including amygdala (AMG), paraventricular nucleus (PVN), and hippocampus (HPC). It is unknown, however, whether cues associated with ethanol can elicit conditioned alterations in cytokine expression. The present study analyzed, in male Sprague-Dawley rats, whether ethanol-induced changes in the central cytokine response may be amenable to conditioning. In Experiments 1 and 2, the rats were given one or two pairings between a distinctive odor (conditional stimulus, CS) and the post-absorptive effects of a high (3.0 or 4.0 g/kg, Experiments 1 and 2, respectively) ethanol dose. Neither of these experiments revealed conditioning of IL-6, IL-1β, or TNFα, as measured via mRNA levels. Yet, re-exposure to the lemon-odor CS in Experiment 1 significantly increased C-Fos levels in the PVN. In Experiment 3, the rats were given four pairings between an odor CS and a moderate ethanol dose (2.0 g/kg), delivered intraperitoneally (i.p.) or intragastrically (i.g.). Re-exposure to the odor CS significantly increased IL-6 levels in HPC and AMG, an effect only evident in paired rats administered ethanol i.p. Overall, this study suggests that ethanol exposure can regulate the levels of IL-6 at HPC and AMG via classical conditioning mechanisms. These ethanol-induced, conditioned alterations in cytokine levels may ultimately affect the intake and motivational effects of ethanol. Impact statement This study examines, across three experiments, whether odor cues associated with ethanol exposure can condition changes in cytokine expression. The analysis of ethanol-induced conditioning of immune responses is a novel niche that can help understand the transition from social drinking to alcohol abuse and dependence. Ethanol-induced conditioning of the immune system could likely exacerbate neuroinflammation and drug-related toxicity, which in turn may facilitate further engagement in ethanol intake. The main new finding of the present study was that, after four pairings of ethanol's unconditioned effects and a distinctive odor, the latter CS increased IL-6 levels in HPC and AMG. This suggests that ethanol's effects upon IL-6 in HPC and AMG may come under conditioned control, particularly after repeated pairings between distinctive odor cues and ethanol's effects. This article advances our knowledge of conditioned increases in cytokine responses, which should help understand the mechanisms underlying alcohol use, abuse, and relapse.
MeSH term(s)	Amygdala/drug effects ; Amygdala/metabolism ; Animals ; Conditioning, Classical/drug effects ; Ethanol/pharmacology ; Hippocampus/drug effects ; Hippocampus/metabolism ; Immune System/drug effects ; Interleukin-1beta/metabolism ; Interleukin-6/metabolism ; Male ; Odorants ; Paraventricular Hypothalamic Nucleus/drug effects ; Paraventricular Hypothalamic Nucleus/metabolism ; Rats ; Rats, Sprague-Dawley ; Real-Time Polymerase Chain Reaction ; Tumor Necrosis Factor-alpha/metabolism
Chemical Substances	Interleukin-1beta ; Interleukin-6 ; Tumor Necrosis Factor-alpha ; Ethanol (3K9958V90M)
Language	English
Publishing date	2017-04
Publishing country	England
Document type	Journal Article
ZDB-ID	4015-0
ISSN	1535-3699 ; 1525-1373 ; 0037-9727
ISSN (online)	1535-3699 ; 1525-1373
ISSN	0037-9727
DOI	10.1177/1535370217694097
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Article ; Online: Differential effects of acute versus chronic stress on ethanol sensitivity: Evidence for interactions on both behavioral and neuroimmune outcomes.

Doremus-Fitzwater, Tamara L / Paniccia, Jacqueline E / Gano, Anny / Vore, Andrew S / Deak, Terrence

Brain, behavior, and immunity

2018 Volume 70, Page(s) 141–156

Abstract: Acute alcohol intoxication induces significant alterations in brain cytokines. Since stress challenges also profoundly impact central cytokine expression, these experiments examined the influence of acute and chronic stress on ethanol-induced brain ... ...

Abstract	Acute alcohol intoxication induces significant alterations in brain cytokines. Since stress challenges also profoundly impact central cytokine expression, these experiments examined the influence of acute and chronic stress on ethanol-induced brain cytokine responses. In Experiment 1, adult male rats were exposed to acute footshock. After a post-stress recovery interval of 0, 2, 4, or 24 h, rats were administered ethanol (4 g/kg; intragastric), with trunk blood and brains collected 3 h later. In non-stressed controls, acute ethanol increased expression of Il-6 and IκBα in the hippocampus. In contrast, rats exposed to footshock 24 h prior to ethanol demonstrated potentiation of hippocampal Il-6 and IκBα expression relative to ethanol-exposed non-stressed controls. Experiment 2 subsequently examined the effects of chronic stress on ethanol-related cytokine expression. Following a novel chronic escalating stress procedure, rats were intubated with ethanol. As expected, acute ethanol increased Il-6 expression in all structures examined, yet the Il-6 response was attenuated exclusively in the hippocampus in chronically stressed rats. Later experiments determined that neither acute nor chronic stress affected ethanol pharmacokinetics. When ethanol hypnosis was examined, however, rats exposed to chronic stress awoke at significantly lower blood ethanol levels compared to acutely stressed rats, despite similar durations of ethanol-induced sedation. These data indicate that chronic stress may increase sensitivity to ethanol hypnosis. Together, these experiments demonstrate an intriguing interaction between recent stress history and ethanol-induced increases in hippocampal Il-6, and may provide insight into novel pharmacotherapeutic targets for prevention and treatment of alcohol-related health outcomes based on stress susceptibility.
MeSH term(s)	Animals ; Brain/metabolism ; Chronic Disease ; Corticosterone/blood ; Cytokines/metabolism ; Ethanol/metabolism ; Ethanol/pharmacokinetics ; Ethanol/pharmacology ; Hippocampus/metabolism ; I-kappa B Proteins/drug effects ; Interleukin-1beta/drug effects ; Interleukin-6/metabolism ; Male ; Rats ; Rats, Sprague-Dawley ; Stress, Psychological/metabolism ; Stress, Psychological/physiopathology
Chemical Substances	Cytokines ; I-kappa B Proteins ; Il6 protein, rat ; Interleukin-1beta ; Interleukin-6 ; Ethanol (3K9958V90M) ; Corticosterone (W980KJ009P)
Language	English
Publishing date	2018-02-17
Publishing country	Netherlands
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	639219-2
ISSN	1090-2139 ; 0889-1591
ISSN (online)	1090-2139
ISSN	0889-1591
DOI	10.1016/j.bbi.2018.02.009
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Zs.A 2276: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Conditioning the neuroimmune response to ethanol using taste and environmental cues in adolescent and adult rats.

Gano, Anny / Pautassi, Ricardo M / Doremus-Fitzwater, Tamara L / Barney, Thaddeus M / Vore, Andrew S / Deak, Terrence

Experimental biology and medicine (Maywood, N.J.)

2019 Volume 244, Issue 5, Page(s) 362–371

Abstract: Impact statement: A combined odor and taste cue was paired with a binge-like ethanol exposure (4 g/kg intraperitoneal) using a single-trial learning paradigm. Re-exposure to the CS alone was sufficient to evoke a conditioned Interleukin (IL)-6 elevation ...

Abstract	Impact statement: A combined odor and taste cue was paired with a binge-like ethanol exposure (4 g/kg intraperitoneal) using a single-trial learning paradigm. Re-exposure to the CS alone was sufficient to evoke a conditioned Interleukin (IL)-6 elevation in the amygdala in adolescents, an effect that was not observed in young adults. This demonstrates a particular sensitivity of adolescents to alcohol-associated cues and neuroimmune learning, whereas prior work indicated that adults require multiple pairings of ethanol to the CS in order to achieve a conditioned amygdala IL-6 response. While the role of immune conditioning has been studied in other drugs of abuse, these findings highlight a previously unknown aspect of alcohol-related learning. Given the emergent importance of the neuroimmune system in alcohol abuse, these findings may be important for understanding cue-induced reinstatement of alcohol intake among problem drinkers.
MeSH term(s)	Age Factors ; Alcohol Drinking/immunology ; Alcohol Drinking/metabolism ; Alcoholism ; Amygdala/immunology ; Amygdala/metabolism ; Animals ; Conditioning, Classical/physiology ; Cues ; Interleukin-6/biosynthesis ; Interleukin-6/immunology ; Male ; Neuroimmunomodulation/physiology ; Rats ; Rats, Sprague-Dawley
Chemical Substances	Interleukin-6
Language	English
Publishing date	2019-02-26
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	4015-0
ISSN	1535-3699 ; 1525-1373 ; 0037-9727
ISSN (online)	1535-3699 ; 1525-1373
ISSN	0037-9727
DOI	10.1177/1535370219831709
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Article ; Online: Male adolescent rats display blunted cytokine responses in the CNS after acute ethanol or lipopolysaccharide exposure.

Doremus-Fitzwater, Tamara L / Gano, Anny / Paniccia, Jacqueline E / Deak, Terrence

Physiology & behavior

2015 Volume 148, Page(s) 131–144

Abstract: Alcohol induces widespread changes in cytokine expression, with recent data from our laboratory having demonstrated that, during acute ethanol intoxication, adult rats exhibit consistent increases in interleukin (IL)-6 mRNA expression in several brain ... ...

Abstract	Alcohol induces widespread changes in cytokine expression, with recent data from our laboratory having demonstrated that, during acute ethanol intoxication, adult rats exhibit consistent increases in interleukin (IL)-6 mRNA expression in several brain regions, while showing reductions in IL-1 and TNFα expression. Given evidence indicating that adolescence may be an ontogenetic period in which some neuroimmune processes and cells may not yet have fully matured, the purpose of the current experiments was to examine potential age differences in the central cytokine response of adolescent (P31-33days of age) and adult (69-71days of age) rats to either an acute immune (lipopolysaccharide; LPS) or non-immune challenge (ethanol). In Experiment 1, male Sprague-Dawley rats were given an intraperitoneal (i.p.) injection of either sterile saline, LPS (250μg/kg), or ethanol (4-g/kg), and then trunk blood and brain tissue were collected 3h later for measurement of blood ethanol concentrations (BECs), plasma endotoxin, and central mRNA expression of several immune-related gene targets. In Experiment 2, the response to intragastrically (i.g.) administered ethanol was examined and compared to animals given tap water (i.g.). Results showed that LPS stimulated robust increases in expression of IL-1, IL-6, TNFα, and IκBα in the hippocampus, PVN, and amygdala, and that these increases were generally less pronounced in adolescents relative to adults. Following an i.p. ethanol challenge, IL-6 and IκBα expression was significantly increased in both ages in the PVN and amygdala, and adults exhibited even greater increases in IκBα than adolescents. I.g. administration of ethanol also increased IL-6 and IκBα expression in all three brain regions, with hippocampal IL-6 elevated even more so in adults compared to adolescents. Furthermore, assessment of plasma endotoxin concentrations revealed (i) whereas robust increases in plasma endotoxin were observed in adults injected with LPS, no corresponding elevations were seen in adolescents after LPS; and (ii) neither adolescents nor adults demonstrated increases in plasma endotoxin concentrations following i.p. or i.g. ethanol administration. Analysis of BECs indicated that, for both routes of exposure, adolescents exhibited lower BECs than adults. Taken together, these data suggest that categorically different mechanisms are involved in the central cytokine response to antigen exposure versus ethanol administration. Furthermore, these findings confirm once again that acute ethanol intoxication is a potent activator of brain cytokines, and calls for future studies to identify the mechanisms underlying age-related differences in the cytokine response observed during ethanol intoxication.
MeSH term(s)	Aging/drug effects ; Animals ; Central Nervous System/anatomy & histology ; Central Nervous System/drug effects ; Central Nervous System/metabolism ; Central Nervous System Depressants/pharmacology ; Corticosterone/blood ; Cytokines/metabolism ; Endotoxins/blood ; Ethanol/blood ; Ethanol/pharmacology ; Factor Analysis, Statistical ; Lipopolysaccharides/pharmacology ; Male ; Oncogene Proteins v-fos/genetics ; Oncogene Proteins v-fos/metabolism ; RNA, Messenger ; Rats ; Rats, Sprague-Dawley
Chemical Substances	Central Nervous System Depressants ; Cytokines ; Endotoxins ; Lipopolysaccharides ; Oncogene Proteins v-fos ; RNA, Messenger ; Ethanol (3K9958V90M) ; Corticosterone (W980KJ009P)
Language	English
Publishing date	2015-09-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	3907-x
ISSN	1873-507X ; 0031-9384
ISSN (online)	1873-507X
ISSN	0031-9384
DOI	10.1016/j.physbeh.2015.02.032
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Article ; Online: Age-related differences in impulsivity among adolescent and adult Sprague-Dawley rats.

Doremus-Fitzwater, Tamara L / Barreto, Michelle / Spear, Linda P

Behavioral neuroscience

2012 Volume 126, Issue 5, Page(s) 735–741

Abstract: Adolescence is an ontogenetic period characterized by numerous hormonal, neural, and behavioral changes. In animal models, adolescents exhibit greater levels of novelty-seeking behavior and risk-taking relative to adults, behaviors associated in humans ... ...

Abstract	Adolescence is an ontogenetic period characterized by numerous hormonal, neural, and behavioral changes. In animal models, adolescents exhibit greater levels of novelty-seeking behavior and risk-taking relative to adults, behaviors associated in humans with increases in impulsivity and elevated propensities to engage in drug and alcohol seeking behaviors. The current series of experiments sought to explore possible age-related differences in impulsivity when indexed using delay discounting in adolescent (postnatal day [P] 25-27) and adult (P68-71) female (Experiment 1) and male (Experiment 2) Sprague-Dawley rats. In both experiments, adolescents exhibited significantly greater levels of impulsive-like behavior in this test relative to adults-even when data were adjusted to account for baseline differences in activity levels (i.e., general nose-poking behavior) across age. Taken together, these results extend to both sexes previous findings of adolescent-associated elevations in impulsivity observed among male mice using delay discounting, as well as among male rats using other procedures to index impulsivity. That these age differences were observed among both male and female rats suggests that impulsivity may be a pervasive feature of adolescence, and contributes to the expression of risky behaviors during this ontogenetic period.
MeSH term(s)	Age Factors ; Animals ; Behavior, Animal/physiology ; Female ; Impulsive Behavior/physiopathology ; Male ; Rats ; Rats, Sprague-Dawley ; Reward ; Risk-Taking
Language	English
Publishing date	2012-08-13
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	230159-3
ISSN	1939-0084 ; 0735-7044
ISSN (online)	1939-0084
ISSN	0735-7044
DOI	10.1037/a0029697
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In stock of ZB MED Cologne/Königswinter

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In stock of ZB MED Cologne/Königswinter

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In stock of ZB MED Cologne/Königswinter

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In stock of ZB MED Cologne/Königswinter

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