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Article ; Online: Emergent superconductivity in TaO

Li, Wenjing / Li, Xing / Zhang, Xiaohua / Yu, Hong / Han, Fanjunjie / Bergara, Aitor / Lin, Jianyan / Wu, Jinhui / Yang, Guochun

Physical chemistry chemical physics : PCCP

2023 Volume 25, Issue 35, Page(s) 23502–23509

Abstract: Tantalum (Ta) is an interesting transition metal that exhibits superconductivity in its elemental states. Additionally, several Ta chalcogenides (S and Se) have also demonstrated superconducting properties. In this work, we propose the existence of five ... ...

Abstract	Tantalum (Ta) is an interesting transition metal that exhibits superconductivity in its elemental states. Additionally, several Ta chalcogenides (S and Se) have also demonstrated superconducting properties. In this work, we propose the existence of five high-pressure metallic Ta-O compounds (
Language	English
Publishing date	2023-09-13
Publishing country	England
Document type	Journal Article
ZDB-ID	1476244-4
ISSN	1463-9084 ; 1463-9076
ISSN (online)	1463-9084
ISSN	1463-9076
DOI	10.1039/d3cp03094f
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Article ; Online: A TSHR-Targeting Aptamer in Monocytes Correlating with Clinical Activity in TAO.

Cao, Jiamin / Zhang, Feng / Chen, Haiyan / Wu, Bingxuan / Yin, Jiayang / Chenzhao, Changci / Xiong, Wei

International journal of nanomedicine

2024 Volume 19, Page(s) 3577–3588

Abstract: Background: Manifestations of thyroid-associated ophthalmopathy (TAO) vary greatly. Few tools and ... indicators are available to assess TAO, restricting personalized diagnosis and treatment.: Aim ... to evaluate clinical activity in patients with TAO.: Methods: An aptamer targeting TSHR was developed ...

Abstract	Background: Manifestations of thyroid-associated ophthalmopathy (TAO) vary greatly. Few tools and indicators are available to assess TAO, restricting personalized diagnosis and treatment. Aim: To identify an aptamer targeting thyroid-stimulating hormone receptor (TSHR) and utilize this aptamer to evaluate clinical activity in patients with TAO. Methods: An aptamer targeting TSHR was developed by exponential enrichment and systematic evaluation of TSHR ligands. After truncation and optimization, the affinity, equilibrium dissociation constant, and serum stability of this aptamer were evaluated. The affinity of the TSHR-targeting aptamer to isolated fibrocytes was assessed, as was aptamer internalization by fibrocytes. The mechanism of binding was determined by molecular docking. The correlation between disease manifestations and the percentage of TSHR-positive cells was assessed by correlation analysis. Results: The aptamer TSHR-21-42 was developed to bind to TSHR, with the equilibrium dissociation constant being 71.46 Kd. Isolated fibrocytes were shown to bind TSHR-21-42 through TSHR, with its affinity maintained at various temperatures and ion concentrations. TSHR-21-42 could compete with anti-TSHR antibody, both for binding site to TSHR and uptake by cells after binding. In addition, TSHR-21-42 could bind to leukocytes in peripheral blood, with this binding differing in patients with TAO and healthy control subjects. The percentage of TSHR-positive monocytes, as determined by binding of TSHR-21-42, correlated positively with clinical activity score in patients with TAO, indicating that TSHR-21-42 binding could assess the severity of TAO. Conclusion: This aptamer targeting TSHR may be used to objectively assess disease activity in patients with TAO, by evaluating the percentages of TSHR positive cells in peripheral blood.
Language	English
Publishing date	2024-04-17
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2364941-0
ISSN	1178-2013 ; 1176-9114
ISSN (online)	1178-2013
ISSN	1176-9114
DOI	10.2147/IJN.S446656
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Article ; Online: A dual-functional Ta/TaO

Wang, Rui / Shi, Tuo / Zhang, Xumeng / Wu, Zuheng / Liu, Qi

RSC advances

2021 Volume 11, Issue 30, Page(s) 18241–18245

Abstract: In this work, we demonstrate that a Ta/TaO ...

Abstract	In this work, we demonstrate that a Ta/TaO
Language	English
Publishing date	2021-05-20
Publishing country	England
Document type	Journal Article
ISSN	2046-2069
ISSN (online)	2046-2069
DOI	10.1039/d1ra02350k
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Article ; Online: Infrared Spectroscopy of Solvation in the TaO

Jian, Xianhui / Xin, Ke / Hu, Jin / Zhang, Luning / Wang, Xuefeng / Wang, Guanjun

The journal of physical chemistry. A

2021 Volume 125, Issue 23, Page(s) 5054–5060

Abstract: The solvent effect of the TaO ...

Abstract	The solvent effect of the TaO
Language	English
Publishing date	2021-06-04
Publishing country	United States
Document type	Journal Article
ISSN	1520-5215
ISSN (online)	1520-5215
DOI	10.1021/acs.jpca.1c03185
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Book ; Online: TAO Conceptual Design Report

JUNO Collaboration / Abusleme, Angel / Adam, Thomas / Ahmad, Shakeel / Aiello, Sebastiano / Akram, Muhammad / Ali, Nawab / An, Fengpeng / An, Guangpeng / An, Qi / Andronico, Giuseppe / Anfimov, Nikolay / Antonelli, Vito / Antoshkina, Tatiana / Asavapibhop, Burin / de André, João Pedro Athayde Marcondes / Auguste, Didier / Babic, Andrej / Baldini, Wander /

Barresi, Andrea / Baussan, Eric / Bellato, Marco / Bergnoli, Antonio / Bernieri, Enrico / Biare, David / Birkenfeld, Thilo / Blin, Sylvie / Blum, David / Blyth, Simon / Bolshakova, Anastasia / Bongrand, Mathieu / Bordereau, Clément / Breton, Dominique / Brigatti, Augusto / Brugnera, Riccardo / Budano, Antonio / Buscemi, Mario / Busto, Jose / Butorov, Ilya / Cabrera, Anatael / Cai, Hao / Cai, Xiao / Cai, Yanke / Cai, Zhiyan / Cammi, Antonio / Campeny, Agustin / Cao, Chuanya / Cao, Guofu / Cao, Jun / Caruso, Rossella / Cerna, Cédric / Chakaberia, Irakli / Chang, Jinfan / Chang, Yun / Chen, Pingping / Chen, Po-An / Chen, Shaomin / Chen, Shenjian / Chen, Xurong / Chen, Yi-Wen / Chen, Yixue / Chen, Yu / Chen, Zhang / Cheng, Jie / Cheng, Yaping / Chepurnov, Alexander / Chiesa, Davide / Chimenti, Pietro / Chukanov, Artem / Chuvashova, Anna / Claverie, Gérard / Clementi, Catia / Clerbaux, Barbara / Di Lorenzo, Selma Conforti / Corti, Daniele / Costa, Salvatore / Corso, Flavio Dal / De La Taille, Christophe / Deng, Jiawei / Deng, Zhi / Deng, Ziyan / Depnering, Wilfried / Diaz, Marco / Ding, Xuefeng / Ding, Yayun / Dirgantara, Bayu / Dmitrievsky, Sergey / Dohnal, Tadeas / Donchenko, Georgy / Dong, Jianmeng / Dornic, Damien / Doroshkevich, Evgeny / Dracos, Marcos / Druillole, Frédéric / Du, Shuxian / Dusini, Stefano / Dvorak, Martin / Enqvist, Timo / Enzmann, Heike / Fabbri, Andrea / Fajt, Lukas / Fan, Donghua / Fan, Lei / Fang, Can / Fang, Jian / Fatkina, Anna / Fedoseev, Dmitry / Fekete, Vladko / Feng, Li-Cheng / Feng, Qichun / Ford, Richard / Formozov, Andrey / Fournier, Amélie / Gan, Haonan / Gao, Feng / Garfagnini, Alberto / Göttel, Alexandre / Genster, Christoph / Giammarchi, Marco / Giaz, Agnese / Giudice, Nunzio / Giuliani, Franco / Gonchar, Maxim / Gong, Guanghua / Gong, Hui / Gorchakov, Oleg / Gornushkin, Yuri / Grassi, Marco / Grewing, Christian / Gromov, Maxim / Gromov, Vasily / Gu, Minghao / Gu, Xiaofei / Gu, Yu / Guan, Mengyun / Guardone, Nunzio / Gul, Maria / Guo, Cong / Guo, Jingyuan / Guo, Wanlei / Guo, Xinheng / Guo, Yuhang / Haacke, Michael / Hackspacher, Paul / Hagner, Caren / Han, Ran / Han, Yang / He, Miao / He, Wei / Heinz, Tobias / Hellmuth, Patrick / Heng, Yuekun / Herrera, Rafael / Hong, Daojin / Hou, Shaojing / Hsiung, Yee / Hu, Bei-Zhen / Hu, Hang / Hu, Jianrun / Hu, Jun / Hu, Shouyang / Hu, Tao / Hu, Zhuojun / Huang, Chunhao / Huang, Guihong / Huang, Hanxiong / Huang, Qinhua / Huang, Wenhao / Huang, Xingtao / Huang, Yongbo / Hui, Jiaqi / Huo, Lei / Huo, Wenju / Huss, Cédric / Hussain, Safeer / Insolia, Antonio / Ioannisian, Ara / Isocrate, Roberto / Jen, Kuo-Lun / Ji, Xiaolu / Ji, Xingzhao / Jia, Huihui / Jia, Junji / Jian, Siyu / Jiang, Di / Jiang, Xiaoshan / Jin, Ruyi / Jing, Xiaoping / Jollet, Cécile / Joutsenvaara, Jari / Jungthawan, Sirichok / Kalousis, Leonidas / Kampmann, Philipp / Kang, Li / Karagounis, Michael / Kazarian, Narine / Khan, Amir / Khan, Waseem / Khosonthongkee, Khanchai / Kinz, Patrick / Korablev, Denis / Kouzakov, Konstantin / Krasnoperov, Alexey / Krokhaleva, Svetlana / Krumshteyn, Zinovy / Kruth, Andre / Kutovskiy, Nikolay / Kuusiniemi, Pasi / Lachenmaier, Tobias / Landini, Cecilia / Leblanc, Sébastien / Lefevre, Frederic / Lei, Liping / Lei, Ruiting / Leitner, Rupert / Leung, Jason / Li, Chao / Li, Demin / Li, Fei / Li, Fule / Li, Haitao / Li, Huiling / Li, Jiaqi / Li, Jin / Li, Kaijie / Li, Mengzhao / Li, Nan / Li, Qingjiang / Li, Ruhui / Li, Shanfeng / Li, Shuaijie / Li, Tao / Li, Teng / Li, Weidong / Li, Weiguo / Li, Xiaomei / Li, Xiaonan / Li, Xinglong / Li, Yi / Li, Yufeng / Li, Zhibing / Li, Ziyuan / Liang, Hao / Liang, Jingjing / Liebau, Daniel / Limphirat, Ayut / Limpijumnong, Sukit / Lin, Guey-Lin / Lin, Shengxin / Lin, Tao / Ling, Jiajie / Lippi, Ivano / Liu, Fang / Liu, Haidong / Liu, Hongbang / Liu, Hongjuan / Liu, Hongtao / Liu, Hu / Liu, Hui / Liu, Jianglai / Liu, Jinchang / Liu, Min / Liu, Qian / Liu, Qin / Liu, Runxuan / Liu, Shuangyu / Liu, Shubin / Liu, Shulin / Liu, Xiaowei / Liu, Yan / Lokhov, Alexey / Lombardi, Paolo / Lombardo, Claudio / Loo, Kai / Lu, Chuan / Lu, Haoqi / Lu, Jingbin / Lu, Junguang / Lu, Shuxiang / Lu, Xiaoxu / Lubsandorzhiev, Bayarto / Lubsandorzhiev, Sultim / Ludhova, Livia / Luo, Fengjiao / Luo, Guang / Luo, Pengwei / Luo, Shu / Luo, Wuming / Lyashuk, Vladimir / Ma, Qiumei / Ma, Si / Ma, Xiaoyan / Ma, Xubo / Maalmi, Jihane / Malyshkin, Yury / Mantovani, Fabio / Manzali, Francesco / Mao, Xin / Mao, Yajun / Mari, Stefano M. / Marini, Filippo / Marium, Sadia / Martellini, Cristina / Martin-Chassard, Gisele / Martini, Agnese / Mayilyan, Davit / Müller, Axel / Meng, Yue / Meregaglia, Anselmo / Meroni, Emanuela / Meyhöfer, David / Mezzetto, Mauro / Miller, Jonathan / Miramonti, Lino / Monforte, Salvatore / Montini, Paolo / Montuschi, Michele / Morozov, Nikolay / Muralidharan, Pavithra / Nastasi, Massimiliano / Naumov, Dmitry V. / Naumova, Elena / Nemchenok, Igor / Nikolaev, Alexey / Ning, Feipeng / Ning, Zhe / Nunokawa, Hiroshi / Oberauer, Lothar / Ochoa-Ricoux, Juan Pedro / Olshevskiy, Alexander / Orestano, Domizia / Ortica, Fausto / Pan, Hsiao-Ru / Paoloni, Alessandro / Parkalian, Nina / Parmeggiano, Sergio / Payupol, Teerapat / Pei, Yatian / Pelliccia, Nicomede / Peng, Anguo / Peng, Haiping / Perrot, Frédéric / Petitjean, Pierre-Alexandre / Petrucci, Fabrizio / Rico, Luis Felipe Piñeres / Popov, Artyom / Poussot, Pascal / Pratumwan, Wathan / Previtali, Ezio / Qi, Fazhi / Qi, Ming / Qian, Sen / Qian, Xiaohui / Qiao, Hao / Qin, Zhonghua / Qiu, Shoukang / Rajput, Muhammad / Ranucci, Gioacchino / Raper, Neill / Re, Alessandra / Rebber, Henning / Rebii, Abdel / Ren, Bin / Ren, Jie / Rezinko, Taras / Ricci, Barbara / Robens, Markus / Roche, Mathieu / Rodphai, Narongkiat / Romani, Aldo / Roskovec, Bedřich / Roth, Christian / Ruan, Xiangdong / Ruan, Xichao / Rujirawat, Saroj / Rybnikov, Arseniy / Sadovsky, Andrey / Saggese, Paolo / Salamanna, Giuseppe / Sanfilippo, Simone / Sangka, Anut / Sanguansak, Nuanwan / Sawangwit, Utane / Sawatzki, Julia / Sawy, Fatma / Schever, Michaela / Schuler, Jacky / Schwab, Cédric / Schweizer, Konstantin / Selivanov, Dmitry / Selyunin, Alexandr / Serafini, Andrea / Settanta, Giulio / Settimo, Mariangela / Shahzad, Muhammad / Shi, Gang / Shi, Jingyan / Shi, Yongjiu / Shutov, Vitaly / Sidorenkov, Andrey / Simkovic, Fedor / Sirignano, Chiara / Siripak, Jaruchit / Sisti, Monica / Slupecki, Maciej / Smirnov, Mikhail / Smirnov, Oleg / Sogo-Bezerra, Thiago / Songwadhana, Julanan / Soonthornthum, Boonrucksar / Sotnikov, Albert / Sramek, Ondrej / Sreethawong, Warintorn / Stahl, Achim / Stanco, Luca / Stankevich, Konstantin / Stefanik, Dus / Steiger, Hans / Steinmann, Jochen / Sterr, Tobias / Stock, Matthias Raphael / Strati, Virginia / Studenikin, Alexander / Sun, Gongxing / Sun, Shifeng / Sun, Xilei / Sun, Yongjie / Sun, Yongzhao / Suwonjandee, Narumon / Szelezniak, Michal / Tang, Jian / Tang, Qiang / Tang, Quan / Tang, Xiao / Tietzsch, Alexander / Tkachev, Igor / Tmej, Tomas / Treskov, Konstantin / Triossi, Andrea / Troni, Giancarlo / Trzaska, Wladyslaw / Tuve, Cristina / van Waasen, Stefan / Boom, Johannes Vanden / Vanroyen, Guillaume / Vassilopoulos, Nikolaos / Vedin, Vadim / Verde, Giuseppe / Vialkov, Maxim / Viaud, Benoit / Volpe, Cristina / Vorobel, Vit / Votano, Lucia / Walker, Pablo / Wang, Caishen / Wang, Chung-Hsiang / Wang, En / Wang, Guoli / Wang, Jian / Wang, Jun / Wang, Kunyu / Wang, Lu / Wang, Meifen / Wang, Meng / Wang, Ruiguang / Wang, Siguang / Wang, Wei / Wang, Wenshuai / Wang, Xi / Wang, Xiangyue / Wang, Yangfu / Wang, Yaoguang / Wang, Yi / Wang, Yifang / Wang, Yuanqing / Wang, Yuman / Wang, Zhe / Wang, Zheng / Wang, Zhimin / Wang, Zongyi / Watcharangkool, Apimook / Wei, Lianghong / Wei, Wei / Wei, Yadong / Wen, Liangjian / Wiebusch, Christopher / Wong, Steven Chan-Fai / Wonsak, Bjoern / Wu, Diru / Wu, Fangliang / Wu, Qun / Wu, Wenjie / Wu, Zhi / Wurm, Michael / Wurtz, Jacques / Wysotzki, Christian / Xi, Yufei / Xia, Dongmei / Xie, Yuguang / Xie, Zhangquan / Xing, Zhizhong / Xu, Benda / Xu, Donglian / Xu, Fanrong / Xu, Jilei / Xu, Jing / Xu, Meihang / Xu, Yin / Xu, Yu / Yan, Baojun / Yan, Xiongbo / Yan, Yupeng / Yang, Anbo / Yang, Changgen / Yang, Huan / Yang, Jie / Yang, Lei / Yang, Xiaoyu / Yang, Yifan / Yao, Haifeng / Yasin, Zafar / Ye, Jiaxuan / Ye, Mei / Yegin, Ugur / Yermia, Frédéric / Yi, Peihuai / Yin, Xiangwei / You, Zhengyun / Yu, Boxiang / Yu, Chiye / Yu, Chunxu / Yu, Hongzhao / Yu, Miao / Yu, Xianghui / Yu, Zeyuan / Yuan, Chengzhuo / Yuan, Ying / Yuan, Zhenxiong / Yuan, Ziyi / Yue, Baobiao / Zafar, Noman / Zambanini, Andre / Zeng, Pan / Zeng, Shan / Zeng, Tingxuan / Zeng, Yuda / Zhan, Liang / Zhang, Feiyang / Zhang, Guoqing / Zhang, Haiqiong / Zhang, Honghao / Zhang, Jiawen / Zhang, Jie / Zhang, Jingbo / Zhang, Peng / Zhang, Qingmin / Zhang, Shiqi / Zhang, Tao / Zhang, Xiaomei / Zhang, Xuantong / Zhang, Yan / Zhang, Yinhong / Zhang, Yiyu / Zhang, Yongpeng / Zhang, Yuanyuan / Zhang, Yumei / Zhang, Zhenyu / Zhang, Zhijian / Zhao, Fengyi / Zhao, Jie / Zhao, Rong / Zhao, Shujun / Zhao, Tianchi / Zheng, Dongqin / Zheng, Hua / Zheng, Minshan / Zheng, Yangheng / Zhong, Weirong / Zhou, Jing / Zhou, Li / Zhou, Nan / Zhou, Shun / Zhou, Xiang / Zhu, Jiang / Zhu, Kejun / Zhuang, Honglin / Zong, Liang / Zou, Jiaheng

A Precision Measurement of the Reactor Antineutrino Spectrum with Sub-percent Energy Resolution

2020

Abstract: The Taishan Antineutrino Observatory (TAO, also known as JUNO-TAO) is a satellite experiment ...

Abstract	The Taishan Antineutrino Observatory (TAO, also known as JUNO-TAO) is a satellite experiment of the Jiangmen Underground Neutrino Observatory (JUNO). A ton-level liquid scintillator detector will be placed at about 30 m from a core of the Taishan Nuclear Power Plant. The reactor antineutrino spectrum will be measured with sub-percent energy resolution, to provide a reference spectrum for future reactor neutrino experiments, and to provide a benchmark measurement to test nuclear databases. A spherical acrylic vessel containing 2.8 ton gadolinium-doped liquid scintillator will be viewed by 10 m^2 Silicon Photomultipliers (SiPMs) of >50% photon detection efficiency with almost full coverage. The photoelectron yield is about 4500 per MeV, an order higher than any existing large-scale liquid scintillator detectors. The detector operates at -50 degree C to lower the dark noise of SiPMs to an acceptable level. The detector will measure about 2000 reactor antineutrinos per day, and is designed to be well shielded from cosmogenic backgrounds and ambient radioactivities to have about 10% background-to-signal ratio. The experiment is expected to start operation in 2022. Comment: 134 pages, 114 figures
Keywords	Physics - Instrumentation and Detectors ; High Energy Physics - Experiment ; Nuclear Experiment
Subject code	660
Publishing date	2020-05-18
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Nano-metal diborides-supported anode catalyst with strongly coupled TaO

Wang, Yuannan / Zhang, Mingcheng / Kang, Zhenye / Shi, Lei / Shen, Yucheng / Tian, Boyuan / Zou, Yongcun / Chen, Hui / Zou, Xiaoxin

Nature communications

2023 Volume 14, Issue 1, Page(s) 5119

Abstract: The sluggish kinetics of oxygen evolution reaction (OER) and high iridium loading in catalyst coated membrane (CCM) are the key challenges for practical proton exchange membrane water electrolyzer (PEMWE). Herein, we demonstrate high-surface-area nano- ... ...

Abstract	The sluggish kinetics of oxygen evolution reaction (OER) and high iridium loading in catalyst coated membrane (CCM) are the key challenges for practical proton exchange membrane water electrolyzer (PEMWE). Herein, we demonstrate high-surface-area nano-metal diborides as promising supports of iridium-based OER nanocatalysts for realizing efficient, low-iridium-loading PEMWE. Nano-metal diborides are prepared by a novel disulphide-to-diboride transition route, in which the entropy contribution to the Gibbs free energy by generation of gaseous sulfur-containing products plays a crucial role. The nano-metal diborides, TaB
Language	English
Publishing date	2023-08-23
Publishing country	England
Document type	Journal Article
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-023-40912-8
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Article ; Online: The Tao Hong Si Wu Decoction ameliorates diabetes-associated cognitive dysfunction by inhibiting the formation of amyloid plaques.

Cai, Ming / Chen, Zhen / Zhang, Mengling / Xia, Wenwen / Dai, Wentao / Zhao, Mengdie / Xie, Ruonan / Ji, Zhaojie / Han, Lan / Peng, Daiyin

International journal of geriatric psychiatry

2024 Volume 39, Issue 3, Page(s) e6076

Abstract: Objectives: The herbs in Tao Hong Si Wu Decoction (THSWD) are beneficial in the treatment ...

Abstract	Objectives: The herbs in Tao Hong Si Wu Decoction (THSWD) are beneficial in the treatment of cognitive impairment. However, the underlying mechanisms of THSWD in treating diabetes-associated cognitive dysfunction (DACD) are not entirely explored. This study is aimed to investigate the therapeutic effects of THSWD in DACD model rats and the underlying mechanism. Methods: Ultra-high-phase liquid chromatography was employed to identify the main compounds contained in the THSWD extract. DACD rat model was induced by feeding with a high-sugar and high-fat diet and injecting streptozotocin (35 mg/kg). DACD rats were gavaged with THSWD for 1 week. The learning and memory abilities of the rats were measured by using the Morris water maze. Western blotting was used to detect the changes in DACD rat targets. Statistical methods were used to evaluate the correlation between proteins. Results: The results show that THSWD effectively reduced the escape latency, hippocampal neuron damage, glycosylated hemoglobin, type A1C, and blood lipid levels in DACD rats. Furthermore, DACD rats showed significantly increased amyloid precursor protein, β-secretase, Aβ Conclusions: THSWD can improve the learning and memory abilities of DACD rats by inhibiting the expression of AEGs-AGE receptors pathway, which provides an experimental basis for the clinical application of THSWD. In addition, the experiment combines pharmacological and statistical methods, which offers a new perspective for the study of Chinese herbal medicine.
MeSH term(s)	Humans ; Rats ; Animals ; Drugs, Chinese Herbal/therapeutic use ; Drugs, Chinese Herbal/pharmacology ; Plaque, Amyloid ; Cognitive Dysfunction/drug therapy ; Cognitive Dysfunction/etiology ; Diabetes Mellitus
Chemical Substances	Taohong Siwu decoction II ; Drugs, Chinese Herbal
Language	English
Publishing date	2024-03-04
Publishing country	England
Document type	Journal Article
ZDB-ID	806736-3
ISSN	1099-1166 ; 0885-6230
ISSN (online)	1099-1166
ISSN	0885-6230
DOI	10.1002/gps.6076
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Article: Anticolon Cancer Targets and Molecular Mechanisms of Tao-He-Cheng-Qi Formula.

Zhang, Zexin / Lin, Siqi / Liu, Zifeng / Han, Jun / Li, Jing / Yu, Yi

Evidence-based complementary and alternative medicine : eCAM

2022 Volume 2022, Page(s) 7998664

Abstract: Background: Tao-He-Cheng-Qi Formula (THCQF) is a traditional Chinese medicine that has been proven ...

Abstract	Background: Tao-He-Cheng-Qi Formula (THCQF) is a traditional Chinese medicine that has been proven to have antitumor effects. The aim of this study was to elucidate the molecular targets and mechanisms of THCQF against colon cancer and construct a prognostic model based on network pharmacology, bioinformatics analysis, and in vitro experiments. Methods: Potential THCQF compounds and targets were retrieved from the Traditional Chinese Medicine Systems Pharmacology and Bioinformatics Analysis Tool for Molecular Mechanism of Traditional Chinese Medicine databases. Differentially expressed genes for colon cancer were screened in The Cancer Genome Atlas and Gene Expression Omnibus databases. The anticolon cancer mechanisms of THCQF were explored using Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses. Molecular docking simulations and molecular dynamics analysis were used to evaluate the binding between target proteins and active compounds. Finally, the identified compounds were used to treat colon cancer cells from the HCT116 cell line, and expression of mRNA and protein after relevant posttreatment were tested using real-time polymerase chain reaction and western blotting. Results: A total of 27 anticolon cancer targets of THCQF were selected, among which four genes ( Conclusions: Taken together, the results indicate that AE and QR are the pivotal active compounds of THCQF, and
Language	English
Publishing date	2022-04-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	2171158-6
ISSN	1741-4288 ; 1741-427X
ISSN (online)	1741-4288
ISSN	1741-427X
DOI	10.1155/2022/7998664
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Article ; Online: Protective effect of Tao Hong Si Wu Decoction against inflammatory injury caused by intestinal flora disorders in an ischemic stroke mouse model.

Zhang, Lijuan / Xue, Sujun / Fei, Changyi / Yu, Chao / Li, Jingjing / Li, Yumeng / Wang, Ni / Chu, Furui / Pan, Lingyu / Duan, Xianchun / Peng, Daiyin

BMC complementary medicine and therapies

2024 Volume 24, Issue 1, Page(s) 124

Abstract: ... Tao Hong Si Wu Decoction (THSWD), against inflammatory injury after IS and its underlying mechanisms ...

Abstract	Background and aims: Recent studies have shown that intestinal flora are involved in the pathological process of ischemic stroke (IS). The potential protective effect of the traditional Chinese prescription, Tao Hong Si Wu Decoction (THSWD), against inflammatory injury after IS and its underlying mechanisms of action were investigated in the current study. Methods: Fifty SPF(Specefic pathogen Free) male C57 mice were randomly assigned to sham operation, model, THSWD low-dose (6.5 g/kg), medium-dose (13 g/kg) and high-dose (26 g/kg) groups (10 mice per group). Mouse models of transient middle cerebral artery occlusion were prepared via thread embolism. Neurological function score, hematoxylin-eosin (HE) staining, immunohistochemistry, enzyme-linked immunosorbent assay (ELISA), 16S ribosomal DNA (rDNA) sequencing, quantitative reverse transcription PCR (qRT-PCR) and other methods were employed to elucidate the underlying molecular mechanisms. Results: Notably, THSWD induced a reduction in the neurological function score (P < 0.01) and neuronal injury in brain tissue, increase in protein expression of Claudin-5 and zonula occludens-1 (ZO-1) in brain tissue(P < 0.01), and decrease in serum lipopolysaccharide (LPS)(P < 0.01), diamine oxidase (DAO)(P < 0.01) and D-lactic acid(P < 0.01, P < 0.05) levels to a significant extent. THSWD also inhibited the levels of tumor necrosis factor-α (TNF-α)(P < 0.01) and interleukin - 1β (IL-1β)(P < 0.01) in brain tissue, and increased alpha and beta diversity in ischemic stroke mice, along with a certain reversal effect on different microflora. Finally, THSWD inhibited the polarization of microglia cells(P < 0.01) and decreased the protein and gene expression of toll-like receptor-4 (TLR-4)(P < 0.01, P < 0.05) and nuclear factor kappa B (NF-κB)(P < 0.01) in brain tissue. Conclusion: Our data indicate that THSWD may interfere with inflammatory response in ischemic stroke by regulating intestinal flora and promoting intestinal barrier repair.
MeSH term(s)	Mice ; Male ; Animals ; Ischemic Stroke ; Gastrointestinal Microbiome ; Drugs, Chinese Herbal/pharmacology ; NF-kappa B/metabolism
Chemical Substances	Taohong Siwu decoction II ; Drugs, Chinese Herbal ; NF-kappa B
Language	English
Publishing date	2024-03-18
Publishing country	England
Document type	Journal Article
ISSN	2662-7671
ISSN (online)	2662-7671
DOI	10.1186/s12906-024-04417-1
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Article ; Online: Sustainable Development Evaluation on the Landscape Design of Industrial Heritage Park: A Case Study of Tao Sichuan, China.

Meng, Lei / Lin, Bao-Gang / Zhang, Hui-Zhong / Bu, Rui

Journal of environmental and public health

2023 Volume 2023, Page(s) 1564614

Abstract: ... to ensure both sustainable development and social justice. In this study, the Tao Sichuan Creative ...

Abstract	The sustainable development of the urban environmental landscape is a process that integrates resource utilization, ecological benefit, economy, and society and involves elements of culture, society, politics, economy, and individual residents. Citizen participation is increasingly important for the urban landscape design, and therefore, urban environmental landscape studies must be evaluated objectively by the public to ensure both sustainable development and social justice. In this study, the Tao Sichuan Creative Industry Park (the former "Universe Porcelain Factory") in Jingdezhen, Jiangxi province, China, was taken as example, and the implemented landscape reconstruction was evaluated. The analytical hierarchy process was used to collect both expert and public opinions regarding the cultural landscape; then, the weight coefficient of the value index layer of the industrial heritage park was obtained. A comparison of the two groups (experts and the public) showed that the experts do not exactly agree with the perspective of the public: experts prefer the artistic value far more than any other factors, while the public prefers the artistic value, social value, and economic value. Each group prefers different values of the landscape, suggesting that environmental justice should not be biased toward one of these perspectives. Finally, a design optimization principle is proposed according to the results of this study. This principle strengthens the sustainable development concept in the landscape reconstruction of industrial heritage parks, and suggestions are provided for optimizing the allocation of urban public landscape resources.
MeSH term(s)	Conservation of Natural Resources ; Sustainable Development ; China ; Public Opinion ; Industry
Language	English
Publishing date	2023-07-07
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2526611-1
ISSN	1687-9813 ; 1687-9813
ISSN (online)	1687-9813
ISSN	1687-9813
DOI	10.1155/2023/1564614
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