Article ; Online: Fast and accurate population admixture inference from genotype data from a few microsatellites to millions of SNPs.
2022 Volume 129, Issue 2, Page(s) 79–92
Abstract: Model-based (likelihood and Bayesian) and non-model-based (PCA and K-means clustering) methods were developed to identify populations and assign individuals to the identified populations using marker genotype data. Model-based methods are favoured ... ...
| Abstract | Model-based (likelihood and Bayesian) and non-model-based (PCA and K-means clustering) methods were developed to identify populations and assign individuals to the identified populations using marker genotype data. Model-based methods are favoured because they are based on a probabilistic model of population genetics with biologically meaningful parameters and thus produce results that are easily interpretable and applicable. Furthermore, they often yield more accurate structure inferences than non-model-based methods. However, current model-based methods either are computationally demanding and thus applicable to small problems only or use simplified admixture models that could yield inaccurate results in difficult situations such as unbalanced sampling. In this study, I propose new likelihood methods for fast and accurate population admixture inference using genotype data from a few multiallelic microsatellites to millions of diallelic SNPs. The methods conduct first a clustering analysis of coarse-grained population structure by using the mixture model and the simulated annealing algorithm, and then an admixture analysis of fine-grained population structure by using the clustering results as a starting point in an expectation maximisation algorithm. Extensive analyses of both simulated and empirical data show that the new methods compare favourably with existing methods in both accuracy and running speed. They can analyse small datasets with just a few multiallelic microsatellites but can also handle in parallel terabytes of data with millions of markers and millions of individuals. In difficult situations such as many and/or lowly differentiated populations, unbalanced or very small samples of individuals, the new methods are substantially more accurate than other methods. |
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| MeSH term(s) | Algorithms ; Bayes Theorem ; Genetics, Population ; Genotype ; Humans ; Microsatellite Repeats ; Polymorphism, Single Nucleotide |
| Language | English |
| Publishing date | 2022-05-04 |
| Publishing country | England |
| Document type | Journal Article |
| ZDB-ID | 2423-5 |
| ISSN | 1365-2540 ; 0018-067X |
| ISSN (online) | 1365-2540 |
| ISSN | 0018-067X |
| DOI | 10.1038/s41437-022-00535-z |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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