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Article: A DNA damage and stress inducible G protein-coupled receptor blocks cells in G2/M.

Weng, Z / Fluckiger, A C / Nisitani, S / Wahl, M I / Le, L Q / Hunter, C A / Fernal, A A / Le Beau, M M / Witte, O N

Proceedings of the National Academy of Sciences of the United States of America

1998 Volume 95, Issue 21, Page(s) 12334–12339

Abstract: ... T and B lymphocyte progenitors and is a member of the seven membrane-spanning G protein-coupled ... and leads to accumulation of cells at G2/M independently of p53 and c-Abl. G2A can be induced ...

Abstract	Cell cycle progression is monitored by highly coordinated checkpoint machinery, which is activated to induce cell cycle arrest until defects like DNA damage are corrected. We have isolated an anti-proliferative cell cycle regulator named G2A (for G2 accumulation), which is predominantly expressed in immature T and B lymphocyte progenitors and is a member of the seven membrane-spanning G protein-coupled receptor family. G2A overexpression attenuates the transformation potential of BCR-ABL and other oncogenes, and leads to accumulation of cells at G2/M independently of p53 and c-Abl. G2A can be induced in lymphocytes and to a lesser extent in nonlymphocyte cell lines or tissues by multiple stimuli including different classes of DNA-damaging agents and serves as a response to damage and cellular stimulation which functions to slow cell cycle progression.
MeSH term(s)	3T3 Cells ; Amino Acid Sequence ; Animals ; Base Sequence ; Cell Cycle Proteins/chemistry ; Cell Cycle Proteins/genetics ; Cell Cycle Proteins/metabolism ; Cloning, Molecular ; DNA Damage ; DNA Primers ; DNA Replication ; G2 Phase ; GTP-Binding Proteins/metabolism ; Mice ; Mitosis ; Molecular Sequence Data ; Oxidative Stress ; Rats ; Receptors, G-Protein-Coupled ; Signal Transduction
Chemical Substances	Cell Cycle Proteins ; DNA Primers ; G2A receptor ; Receptors, G-Protein-Coupled ; GTP-Binding Proteins (EC 3.6.1.-)
Language	English
Publishing date	1998-10-13
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	209104-5
ISSN	1091-6490 ; 0027-8424
ISSN (online)	1091-6490
ISSN	0027-8424
DOI	10.1073/pnas.95.21.12334
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Article ; Conference proceedings: Hitzeassoziierte Mortalität und Morbidität von Herz-Kreislauf-Krankheiten in Sachsen-Anhalt

Keitel, M. / Wahl, G.

Das Gesundheitswesen

2024 Volume 86, Issue S 02

Event/congress	Der Öffentliche Gesundheitsdienst - Rückenwind für Gesundheit! 73. Wissenschaftlicher Kongress \| BVÖGD e.V., BZÖG e.V., DGÖG e.V., Hamburg, 2024-04-24
Language	German
Publishing date	2024-04-01
Publisher	Georg Thieme Verlag
Publishing place	Stuttgart ; New York
Document type	Article ; Conference proceedings
ZDB-ID	1101426-x
ISSN	1439-4421 ; 0941-3790 ; 0949-7013
ISSN (online)	1439-4421
ISSN	0941-3790 ; 0949-7013
DOI	10.1055/s-0044-1781910
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Article ; Conference proceedings: Verbreitung von Zahnversiegelungen bei Kindern und Jugendlichen in Sachsen-Anhalt – Bewertung des Prophylaxe-Potenzials und Ableitung eventueller Handlungsbedarfe

Nodurft, L. M. / Wahl, G. / Swart, E.

Das Gesundheitswesen

2023 Volume 85, Issue S 01

Event/congress	Der öffentliche Gesundheitsdienst — Wichtiger denn je! 72. Wissenschaftlicher Kongress des BVöGD e. V. und BZöG e. V., Potsdam, 2023-04-26
Language	German
Publishing date	2023-03-01
Publisher	Georg Thieme Verlag
Publishing place	Stuttgart ; New York
Document type	Article ; Conference proceedings
ZDB-ID	1101426-x
ISSN	1439-4421 ; 0941-3790 ; 0949-7013
ISSN (online)	1439-4421
ISSN	0941-3790 ; 0949-7013
DOI	10.1055/s-0043-1762785
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Article ; Online: Co-occurrence of native and invasive macroalgae might be facilitated under global warming.

Bommarito, C / Noè, S / Díaz-Morales, D M / Lukić, I / Hiebenthal, C / Rilov, G / Guy-Haim, T / Wahl, M

The Science of the total environment

2023 Volume 912, Page(s) 169087

Abstract: ... photosynthesis, respiration, and nutrients' uptake rates of mono- and co-cultured G. vermiculophylla while growth ... a growth reduction might result from increasing stress and energy demand of G. vermiculophylla under ... warming (RCP2.6 and RCP8.5 scenarios) treatments, both F. vesiculosus and G. vermiculophylla appear ...

Abstract	Climate change is driving compositional shifts in ecological communities directly by affecting species and indirectly through changes in species interactions. For example, competitive hierarchies can be inversed when competitive dominants are more susceptible to climate change. The brown seaweed Fucus vesiculosus is a foundation species in the Baltic Sea, experiencing novel interactions with the invasive red seaweed Gracilaria vermiculophylla, which is known for its high tolerance to environmental stress. We investigated the direct and interactive effects of warming and co-occurrence of the two algal species on their performance, by applying four climate change-relevant temperature scenarios: 1) cooling ) 2 °C below ambient - representing past conditions), 2) ambient summer temperature (18 °C), 3) IPCC RCP2.6 warming scenario (1 °C above ambient), and 4) RCP8.5 warming (3 °C above ambient) for 30 days and two compositional levels (mono and co-cultured algae) in a fully-crossed design. The RCP8.5 warming scenario increased photosynthesis, respiration, and nutrients' uptake rates of mono- and co-cultured G. vermiculophylla while growth was reduced. An increase in photosynthesis and essential nutrients' uptake and, at the same time, a growth reduction might result from increasing stress and energy demand of G. vermiculophylla under warming. In contrast, the growth of mono-cultured F. vesiculosus significantly increased in the highest warming treatment (+3 °C). The cooling treatment (-2 °C) exerted a slight negative effect only on co-cultured F. vesiculosus photosynthesis, compared to the ambient treatment. Interestingly, at ambient and warming (RCP2.6 and RCP8.5 scenarios) treatments, both F. vesiculosus and G. vermiculophylla appear to benefit from the presence of each other. Our results suggest that short exposure of F. vesiculosus to moderate or severe global warming scenarios may not directly affect or even slightly enhance its performance, while G. vermiculophylla net performance (growth) could be directly hampered by warming.
MeSH term(s)	Global Warming ; Seaweed ; Gracilaria ; Climate Change ; Temperature ; Fucus
Language	English
Publishing date	2023-12-04
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2023.169087
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Zs.A 949: Show issues

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Article ; Online: Analysis of vaccine messages on social media (Twitter) in Scandinavia.

Fues Wahl, H / Wikman Erlandson, B / Sahlin, C / Nyaku, M / Benĉina, G

Human vaccines & immunotherapeutics

2022 Volume 18, Issue 1, Page(s) 2026711

Abstract: Vaccine hesitancy is listed as one of the top 10 global health threats by the WHO. Existing studies investigating the relationship between vaccine hesitancy and social media have found that misinformation and vaccine concerns on social media can cause ... ...

Abstract	Vaccine hesitancy is listed as one of the top 10 global health threats by the WHO. Existing studies investigating the relationship between vaccine hesitancy and social media have found that misinformation and vaccine concerns on social media can cause significant declines in vaccine coverage rates. The objective of this study was to provide insight into the dynamics of vaccine messages on Twitter in Scandinavia (Denmark, Norway, Sweden), by analyzing tweets in local languages during 2019. A validated measure, the 5C scale, was used to map relevant predictors of vaccination behavior, capturing the factors
MeSH term(s)	Communication ; Humans ; Papillomavirus Vaccines ; Public Health ; Social Media ; Vaccination/psychology
Chemical Substances	Papillomavirus Vaccines
Language	English
Publishing date	2022-02-01
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2664176-8
ISSN	2164-554X ; 2164-5515
ISSN (online)	2164-554X
ISSN	2164-5515
DOI	10.1080/21645515.2022.2026711
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Zs.A 6967: Show issues

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Article ; Online: Co-occurrence of native and invasive macroalgae might be facilitated under global warming

Bommarito, Claudia / Noè, S. / Díaz-Morales, D.M. / Lukić, I. / Hiebenthal, Claas / Rilov, G. / Guy-Haim, Tamar / Wahl, Martin

2024

Abstract	Climate change is driving compositional shifts in ecological communities directly by affecting species and indirectly through changes in species interactions. For example, competitive hierarchies can be inversed when competitive dominants are more susceptible to climate change. The brown seaweed Fucus vesiculosus is a foundation species in the Baltic Sea, experiencing novel interactions with the invasive red seaweed Gracilaria vermiculophylla, which is known for its high tolerance to environmental stress. We investigated the direct and interactive effects of warming and co-occurrence of the two algal species on their performance, by applying four climate change-relevant temperature scenarios: 1) cooling ) 2 °C below ambient – representing past conditions), 2) ambient summer temperature (18 °C), 3) IPCC RCP2.6 warming scenario (1 °C above ambient), and 4) RCP8.5 warming (3 °C above ambient) for 30 days and two compositional levels (mono and co-cultured algae) in a fully-crossed design. The RCP8.5 warming scenario increased photosynthesis, respiration, and nutrients' uptake rates of mono- and co-cultured G. vermiculophylla while growth was reduced. An increase in photosynthesis and essential nutrients' uptake and, at the same time, a growth reduction might result from increasing stress and energy demand of G. vermiculophylla under warming. In contrast, the growth of mono-cultured F. vesiculosus significantly increased in the highest warming treatment (+3 °C). The cooling treatment (−2 °C) exerted a slight negative effect only on co-cultured F. vesiculosus photosynthesis, compared to the ambient treatment. Interestingly, at ambient and warming (RCP2.6 and RCP8.5 scenarios) treatments, both F. vesiculosus and G. vermiculophylla appear to benefit from the presence of each other. Our results suggest that short exposure of F. vesiculosus to moderate or severe global warming scenarios may not directly affect or even slightly enhance its performance, while G. vermiculophylla net performance (growth) could be directly ...
Subject code	580
Language	English
Publishing date	2024-02-20
Publisher	Elsevier
Publishing country	de
Document type	Article ; Online
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Article: Dynamic kinetic resolution of transient hemiketals: a strategy for the desymmetrisation of prochiral oxetanols.

Sandvoß, Alexander / Maag, Henning / Daniliuc, Constantin G / Schollmeyer, Dieter / Wahl, Johannes M

Chemical science

2022 Volume 13, Issue 21, Page(s) 6297–6302

Abstract: Identification of an electron poor trifluoroacetophenone allows the formation of uniquely stable hemiketals from prochiral oxetanols. When exposed to a cobalt(ii) catalyst, efficient ring-opening to densely functionalized dioxolanes is observed. ... ...

Abstract	Identification of an electron poor trifluoroacetophenone allows the formation of uniquely stable hemiketals from prochiral oxetanols. When exposed to a cobalt(ii) catalyst, efficient ring-opening to densely functionalized dioxolanes is observed. Mechanistic studies suggest an unprecedented redox process between the cobalt(ii) catalyst and the hemiketal that initiates the oxetane-opening. Based on this observation, a dynamic kinetic resolution of the transient hemiketals is explored that uses a Katsuki-type ligand for stereoinduction (up to 99 : 1 dr and 96 : 4 er) and allows a variety of 1,3-dioxolanes to be accessed (20 examples up to 98% yield).
Language	English
Publishing date	2022-05-04
Publishing country	England
Document type	Journal Article
ZDB-ID	2559110-1
ISSN	2041-6539 ; 2041-6520
ISSN (online)	2041-6539
ISSN	2041-6520
DOI	10.1039/d2sc01547a
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Article ; Online: A thrombin-driven neural net diagnoses the antiphospholipid syndrome without the need for interruption of anticoagulation.

de Laat-Kremers, Romy M W / Wahl, Denis / Zuily, Stéphane / Ninivaggi, Marisa / Regnault, Véronique / Musial, Jacek / de Groot, Philip G / Devreese, Katrien M J / de Laat, Bas

Blood advances

2024 Volume 8, Issue 4, Page(s) 936–946

Abstract: Abstract: Thrombosis is an important manifestation of the antiphospholipid syndrome (APS). The thrombin generation (TG) test is a global hemostasis assay, and increased TG is associated with thrombosis. APS is currently diagnosed based on clinical and ... ...

Abstract	Abstract: Thrombosis is an important manifestation of the antiphospholipid syndrome (APS). The thrombin generation (TG) test is a global hemostasis assay, and increased TG is associated with thrombosis. APS is currently diagnosed based on clinical and laboratory criteria, the latter defined as anti-cardiolipin, anti-β2-glycoprotein I antibodies, or lupus anticoagulant (LA). APS testing is often performed after a thrombotic episode and subsequent administration of anticoagulation, which might hamper the interpretation of clotting assays used for LA testing. We set out to develop an artificial neural network (NN) that can diagnose APS in patients who underwent vitamin K antagonist (VKA) treatment, based on TG test results. Five NNs were trained to diagnose APS in 48 VKA-treated patients with APS and 64 VKA-treated controls, using TG and thrombin dynamics parameters as inputs. The 2 best-performing NNs were selected (accuracy, 96%; sensitivity, 96%-98%; and specificity, 95%-97%) and further validated in an independent cohort of VKA-anticoagulated patients with APS (n = 33) and controls (n = 62). Independent clinical validation favored 1 of the 2 selected NNs, with a sensitivity of 88% and a specificity of 94% for the diagnosis of APS. In conclusion, the combined use of TG and NN methodology allowed for us to develop an NN that diagnoses APS with an accuracy of 92% in individuals with VKA anticoagulation (n = 95). After further clinical validation, the NN could serve as a screening and diagnostic tool for patients with thrombosis, especially because there is no need to interrupt anticoagulant therapy.
MeSH term(s)	Humans ; Antiphospholipid Syndrome/diagnosis ; Antiphospholipid Syndrome/drug therapy ; Thrombin/pharmacology ; Anticoagulants/adverse effects ; Blood Coagulation ; Lupus Coagulation Inhibitor ; Thrombosis/diagnosis ; Thrombosis/drug therapy ; Thrombosis/etiology
Chemical Substances	Thrombin (EC 3.4.21.5) ; Anticoagulants ; Lupus Coagulation Inhibitor
Language	English
Publishing date	2024-01-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	2915908-8
ISSN	2473-9537 ; 2473-9529
ISSN (online)	2473-9537
ISSN	2473-9529
DOI	10.1182/bloodadvances.2023011938
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Zs.A 7153: Show issues

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Article ; Online: Cone Density Is Correlated to Outer Segment Length and Retinal Thickness in the Human Foveola.

Domdei, Niklas / Ameln, Julius / Gutnikov, Aleksandr / Witten, Jenny L / Holz, Frank G / Wahl, Siegfried / Harmening, Wolf M

Investigative ophthalmology & visual science

2023 Volume 64, Issue 15, Page(s) 11

Abstract: Purpose: Assessment of the relationship between in vivo foveolar cone density, cone outer segment length (OSL), and foveal retinal thickness (RT).: Methods: Foveolar cone density maps covering the central ±300 µm of the retina were derived from ... ...

Abstract	Purpose: Assessment of the relationship between in vivo foveolar cone density, cone outer segment length (OSL), and foveal retinal thickness (RT). Methods: Foveolar cone density maps covering the central ±300 µm of the retina were derived from adaptive optics scanning laser ophthalmoscopy images. The corresponding maps of foveal cone OSL and RT were derived from high-resolution optical coherence tomography volume scans. Alignment of the two-dimensional maps containing OSL and RT with the cone density map was achieved by placing the location of maximum OSL on the cone density centroid (CDC). Results: Across 10 participants (27 ± 9 years; 6 female), cone density at the CDC was found to be between 147,038 and 215,681 cones/mm². The maximum OSL and minimum RT were found to lie between 31 and 40, and 193 and 226 µm, respectively. A significant correlation was observed between cone density at the CDC and maximum OSL (P = 0.001), as well as the minimal RT (P < 0.05). Across all participants, the best fit for the relationship between normalized cone density and normalized OSL within the central 300 µm was given by a quadratic function. Conclusions: Using optical coherence tomography-derived measurements of OSL enables to estimate CDC cone density and two-dimensional foveal cone density maps for example in patient eyes unsuitable for adaptive optics imaging. Furthermore, the observation of a fixed relationship between the normalized OSL and cone density points to a conserved mechanism shaping the foveal pit.
MeSH term(s)	Humans ; Female ; Visual Acuity ; Retina/diagnostic imaging ; Retinal Cone Photoreceptor Cells ; Fovea Centralis ; Ophthalmoscopy/methods ; Tomography, Optical Coherence/methods
Language	English
Publishing date	2023-12-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	391794-0
ISSN	1552-5783 ; 0146-0404
ISSN (online)	1552-5783
ISSN	0146-0404
DOI	10.1167/iovs.64.15.11
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Zs.A 45: Show issues

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Article ; Online: Antiaging Therapies, Cognitive Impairment, and Dementia.

Wahl, Devin / Anderson, Rozalyn M / Le Couteur, David G

The journals of gerontology. Series A, Biological sciences and medical sciences

2019 Volume 75, Issue 9, Page(s) 1643–1652

Abstract: Aging is a powerful risk factor for the development of many chronic diseases including dementia. Research based on disease models of dementia have yet to yield effective treatments, therefore it is opportune to consider whether the aging process itself ... ...

Abstract	Aging is a powerful risk factor for the development of many chronic diseases including dementia. Research based on disease models of dementia have yet to yield effective treatments, therefore it is opportune to consider whether the aging process itself might be a potential therapeutic target for the treatment and prevention of dementia. Numerous cellular and molecular pathways have been implicated in the aging process and compounds that target these processes are being developed to slow aging and delay the onset of age-associated conditions. A few particularly promising therapeutic agents have been shown to influence many of the main hallmarks of aging and increase life span in rodents. Here we discuss the evidence that some of these antiaging compounds may beneficially affect brain aging and thereby lower the risk for dementia.
MeSH term(s)	Aging/drug effects ; Aging/physiology ; Animals ; Cognitive Dysfunction/prevention & control ; Dementia/prevention & control ; Humans
Language	English
Publishing date	2019-10-16
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	1223643-3
ISSN	1758-535X ; 1079-5006
ISSN (online)	1758-535X
ISSN	1079-5006
DOI	10.1093/gerona/glz135
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