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Article: Rôle des N-glycanes dans les fonctions des protéines d’enveloppe du virus de l’hépatite C.

Helle, François / Dubuisson, Jean

2022 Volume 13, Issue 5, Page(s) 271–282

Abstract: During their passage through endoplasmic reticulum and Golgi complex, proteins are subjected to modifications such as N-glycosylation. N-glycans play a pivotal role in protein folding and quality control of glycoproteins. Most of viral envelope proteins ... ...

Title translation	N-glycans as contributors in the biological properties of the hepatitis C virus envelope proteins.
Abstract	During their passage through endoplasmic reticulum and Golgi complex, proteins are subjected to modifications such as N-glycosylation. N-glycans play a pivotal role in protein folding and quality control of glycoproteins. Most of viral envelope proteins are N-glycosylated and use the cellular glycosylation machinery. The presence of glycans on envelope proteins gives several advantages to viruses. First it enables a correct folding of viral proteins. Moreover, glycans associated to envelope proteins can play a role the in viral entry process and help viruses to evade from the host immune system. Hepatits C Virus (HCV) E1 and E2 envelope proteins are highly N-glycosylated. Studies using retroviral particles pseudotyped with HCV envelope proteins and native virus produced in cell culture have shown that these glycans play an essential role in HCV life cycle. Furthermore, since these glycans are highly conserved and play a pivotal role, they constitute an interesting target for the development of new therapeutic strategies. This review summarizes the knowledge on the role of HCVenvelope.
Language	French
Publishing date	2022-09-19
Publishing country	France
Document type	English Abstract ; Journal Article
ZDB-ID	2118387-9
ISSN	1950-6961 ; 1267-8694
ISSN (online)	1950-6961
ISSN	1267-8694
DOI	10.1684/13-5.2011.271-282-article-1
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Article ; Online: Contrary to ultra-processed foods, the consumption of unprocessed or minimally processed foods is associated with favorable patterns of protein intake, diet quality and lower cardiometabolic risk in French adults (INCA3).

Salomé, Marion / Arrazat, Laura / Wang, Juhui / Dufour, Ariane / Dubuisson, Carine / Volatier, Jean-Luc / Huneau, Jean-François / Mariotti, François

European journal of nutrition

2021 Volume 60, Issue 7, Page(s) 4055–4067

Abstract: Purpose: While the consumption of ultra-processed foods is steadily increasing, there is a growing interest in more sustainable diets that would include more plant protein. We aimed to study associations between the degree of food processing, patterns ... ...

Abstract	Purpose: While the consumption of ultra-processed foods is steadily increasing, there is a growing interest in more sustainable diets that would include more plant protein. We aimed to study associations between the degree of food processing, patterns of protein intake, diet quality and cardiometabolic risk. Methods: Using the NOVA classification, we assessed the proportion of energy from unprocessed/minimally processed foods (MPFp), processed foods (PFp) and ultra-processed foods (UPFp) in the diets of 1774 adults (18-79 years) from the latest cross-sectional French national survey (INCA3, 2014-2015). We studied the associations between MPFp, PFp and UPFp with protein intakes, diet quality (using the PANDiet scoring system, the global (PDI), healthful (hPDI) and unhealthful (uPDI) plant-based diet indices) and risk of cardiometabolic death (using the EpiDiet model). Results: MPFp was positively associated with animal protein intake and plant protein diversity, whereas PFp was positively associated with plant protein intake and negatively with plant protein diversity. The PANDiet was positively associated with MPFp (β = 0.14, P < 0.0001) but negatively with UPFp (β = - 0.05, P < 0.0001). These associations were modified by adjustment for protein intakes and plant protein diversity. As estimated with comparative risk assessment modeling between extreme tertiles of intake, mortality from cardiometabolic diseases would be decreased with higher MPFp (e.g. by 31% for ischemic heart diseases) and increased with higher UPFp (by 42%) and PFp (by 11%). Conclusions: In the French population, in contrast with UPFp, higher MPFp was associated with higher animal protein intake, better plant protein diversity, higher diet quality and markedly lower cardiometabolic risk.
MeSH term(s)	Animals ; Cardiovascular Diseases/epidemiology ; Cross-Sectional Studies ; Diet ; Energy Intake ; Fast Foods ; Food Handling
Language	English
Publishing date	2021-05-08
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1466536-0
ISSN	1436-6215 ; 1436-6207
ISSN (online)	1436-6215
ISSN	1436-6207
DOI	10.1007/s00394-021-02576-2
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Article: Contrary to ultra-processed foods, the consumption of unprocessed or minimally processed foods is associated with favorable patterns of protein intake, diet quality and lower cardiometabolic risk in French adults (INCA3)

Salomé, Marion / Arrazat, Laura / Wang, Juhui / Dufour, Ariane / Dubuisson, Carine / Volatier, Jean-Luc / Huneau, Jean-François / Mariotti, François

European journal of nutrition. 2021 Oct., v. 60, no. 7

2021

Abstract: PURPOSE: While the consumption of ultra-processed foods is steadily increasing, there is a growing interest in more sustainable diets that would include more plant protein. We aimed to study associations between the degree of food processing, patterns of ...

Abstract	PURPOSE: While the consumption of ultra-processed foods is steadily increasing, there is a growing interest in more sustainable diets that would include more plant protein. We aimed to study associations between the degree of food processing, patterns of protein intake, diet quality and cardiometabolic risk. METHODS: Using the NOVA classification, we assessed the proportion of energy from unprocessed/minimally processed foods (MPFp), processed foods (PFp) and ultra-processed foods (UPFp) in the diets of 1774 adults (18–79 years) from the latest cross-sectional French national survey (INCA3, 2014–2015). We studied the associations between MPFp, PFp and UPFp with protein intakes, diet quality (using the PANDiet scoring system, the global (PDI), healthful (hPDI) and unhealthful (uPDI) plant-based diet indices) and risk of cardiometabolic death (using the EpiDiet model). RESULTS: MPFp was positively associated with animal protein intake and plant protein diversity, whereas PFp was positively associated with plant protein intake and negatively with plant protein diversity. The PANDiet was positively associated with MPFp (β = 0.14, P < 0.0001) but negatively with UPFp (β = − 0.05, P < 0.0001). These associations were modified by adjustment for protein intakes and plant protein diversity. As estimated with comparative risk assessment modeling between extreme tertiles of intake, mortality from cardiometabolic diseases would be decreased with higher MPFp (e.g. by 31% for ischemic heart diseases) and increased with higher UPFp (by 42%) and PFp (by 11%). CONCLUSIONS: In the French population, in contrast with UPFp, higher MPFp was associated with higher animal protein intake, better plant protein diversity, higher diet quality and markedly lower cardiometabolic risk.
Keywords	animal proteins ; comparative risk assessment ; death ; energy ; food quality ; heart ; models ; mortality ; national surveys ; plant proteins ; plant-based diet ; protein intake ; risk
Language	English
Dates of publication	2021-10
Size	p. 4055-4067.
Publishing place	Springer Berlin Heidelberg
Document type	Article
ZDB-ID	1466536-0
ISSN	1436-6215 ; 1436-6207
ISSN (online)	1436-6215
ISSN	1436-6207
DOI	10.1007/s00394-021-02576-2
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Article ; Online: Plant-Protein Diversity Is Critical to Ensuring the Nutritional Adequacy of Diets When Replacing Animal With Plant Protein: Observed and Modeled Diets of French Adults (INCA3).

Salomé, Marion / de Gavelle, Erwan / Dufour, Ariane / Dubuisson, Carine / Volatier, Jean-Luc / Fouillet, Hélène / Huneau, Jean-François / Mariotti, François

The Journal of nutrition

2019 Volume 150, Issue 3, Page(s) 536–545

Abstract: Background: There is a current trend in Western countries toward increasing the intake of plant protein. A higher plant-protein intake has been associated with nutritional and health benefits, but these may depend on the pattern of plant-protein sources. ...

Abstract	Background: There is a current trend in Western countries toward increasing the intake of plant protein. A higher plant-protein intake has been associated with nutritional and health benefits, but these may depend on the pattern of plant-protein sources. Objective: We hypothesized that the diversity of plant foods could be important to nutrient adequacy when increasing plant-protein intake in the diet. Methods: Using data on 1341 adults (aged 18-64 y) from a representative French national dietary survey conducted in 2014-2015 (the third Individual and National Study on Food Consumption Survey-INCA3), we studied the links between plant-protein intake, dietary diversity (using various dimensions), and nutrient adequacy [assessed using the PANDiet (Probability of Adequate Nutrient Intake) scoring system, comprising adequacy (AS) and moderation (MS) subscores]. We simulated substituting plant-protein foods for animal-protein foods using different models of plant-protein diversity. Results: We found that overall diet quality was weakly associated with total and protein diversity and more strongly with plant-protein diversity. Plant-protein intake was inversely associated with animal-protein intake, and positively with the PANDiet and MS, but not with the AS. Plant-protein intake displayed little diversity, mostly taking the form of grains (61% of plant-protein intake), and this diversity was even less marked under a higher plant-protein intake. Finally, modeled substitutions showed that reducing animal-protein intake increased the MS (by 32%) in a similar manner whichever plant protein was used for substitution, whereas it decreased the AS (by 20%) unless using a highly diversified plant-protein mix. These simulated improvements in overall adequacy included marked decreases in adequacy regarding certain nutrients that are typically of animal origin. Conclusions: We conclude that in French adults the current pattern of plant-protein intake is hindering the nutritional benefits of a transition toward more plant protein, indicating that the consumption of plant-protein-based foods other than refined grains should be encouraged.
MeSH term(s)	Adult ; Animals ; Dietary Proteins/administration & dosage ; France ; Humans ; Nutrition Policy ; Plant Proteins/administration & dosage ; Plant Proteins/chemistry
Chemical Substances	Dietary Proteins ; Plant Proteins
Language	English
Publishing date	2019-10-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	218373-0
ISSN	1541-6100 ; 0022-3166
ISSN (online)	1541-6100
ISSN	0022-3166
DOI	10.1093/jn/nxz252
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Article: Correction: Bilyy et al. Rapid Generation of Coronaviral Immunity Using Recombinant Peptide Modified Nanodiamonds.

Bilyy, Rostyslav / Pagneux, Quentin / François, Nathan / Bila, Galyna / Grytsko, Roman / Lebedin, Yuri / Barras, Alexandre / Dubuisson, Jean / Belouzard, Sandrine / Séron, Karin / Boukherroub, Rabah / Szunerits, Sabine

Pathogens (Basel, Switzerland)

2023 Volume 12, Issue 12

Abstract: In the original publication [ ... ]. ...

Abstract	In the original publication [...].
Language	English
Publishing date	2023-11-30
Publishing country	Switzerland
Document type	Published Erratum
ZDB-ID	2695572-6
ISSN	2076-0817
ISSN	2076-0817
DOI	10.3390/pathogens12121411
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Article: Et s'il fallait convaincre...

Dubuisson, Jean-Bernard / Delaloye, Jean-François

Revue medicale suisse

2007 Volume 3, Issue 130, Page(s) 2379

Title translation	And if it was necessary to convince....
MeSH term(s)	Adult ; Aged ; Breast Neoplasms/diagnostic imaging ; Female ; Humans ; Mammography/utilization ; Middle Aged
Language	French
Publishing date	2007-10-24
Publishing country	Switzerland
Document type	Editorial
ZDB-ID	2177010-4
ISSN	1660-9379
ISSN	1660-9379
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Article ; Online: Major Metabolites From Hypericum perforatum L., Hyperforin And Hypericin, Are Both Active Against Human Coronaviruses

Raczkiewicz, Imelda / Rivière, Céline / Bouquet, Peggy / Desmarets, Lowiese / Tarricone, Audrey / Camuzet, Charline / François, Nathan / Lefèvre, Gabriel / Samaillie, Jennifer / Silva Angulo, Fabiola / Robil, Cyril / Trottein, François / Sahpaz, Sevser / Dubuisson, Jean D. / Belouzard, Sandrine / Goffard, Anne / Séron, Karin

bioRxiv

Abstract: COVID-19 pandemic has highlighted the need of antiviral molecules against coronaviruses. Plants are an endless source of active compounds. In the current study, we investigated the potential antiviral effects of Hypericum perforatum L. Its extract ... ...

Abstract	COVID-19 pandemic has highlighted the need of antiviral molecules against coronaviruses. Plants are an endless source of active compounds. In the current study, we investigated the potential antiviral effects of Hypericum perforatum L. Its extract contained two major metabolites belonging to distinct chemical classes, hypericin (HC) and hyperforin (HF). First, we demonstrated that HC inhibited HCoV-229E at the entry step by directly targeting the viral particle in a light-dependent manner. While antiviral properties have already been described for HC, the study here showed for the first time that HF has pan-coronavirus antiviral capacity. Indeed, HF was highly active against Alphacoronavirus HCoV-229E (IC<sub>50</sub> value of 1.10 μM), and Betacoronaviruses SARS-CoV-2 (IC<sub>50</sub> value of of 0.24 to 0.98 μM), SARS-CoV (IC<sub>50</sub> value of 1.01 μM) and MERS-CoV (IC<sub>50</sub> value of 2.55 μM). Unlike HC, HF was active at a post-entry step, most likely the replication step. Antiviral activity of HF on HCoV-229E and SARS-CoV-2 was confirmed in primary human respiratory epithelial cells. Furthermore, in vitro combination assay of HF with remdesivir showed that their association was additive, which was encouraging for a potential therapeutical association. As HF was active on both Alpha- and Betacoronaviruses, a cellular target was hypothesized. Heme oxygenase 1 (HO-1) pathway, a potential target of HF, has been investigated but the results showed that HF antiviral activity against HCoV-229E was not dependent on HO-1. Collectively, HF is a promising antiviral candidate in view of our results and pharmacokinetics studies already published in animal models or in human.
Keywords	covid19
Language	English
Publishing date	2024-04-17
Publisher	Cold Spring Harbor Laboratory
Document type	Article ; Online
DOI	10.1101/2024.04.09.588755
Database	COVID19

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Article ; Online: Correction

Rostyslav Bilyy / Quentin Pagneux / Nathan François / Galyna Bila / Roman Grytsko / Yuri Lebedin / Alexandre Barras / Jean Dubuisson / Sandrine Belouzard / Karin Séron / Rabah Boukherroub / Sabine Szunerits

Pathogens, Vol 12, Iss 12, p

Bilyy et al. Rapid Generation of Coronaviral Immunity Using Recombinant Peptide Modified Nanodiamonds. Pathogens 2021, 10 , 861

2023 Volume 1411

Abstract: In the original publication [.] ...

Abstract	In the original publication [.]
Keywords	n/a ; Medicine ; R
Language	English
Publishing date	2023-11-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Virology and cell biology of the hepatitis C virus life cycle: an update.

Dubuisson, Jean / Cosset, François-Loïc

Journal of hepatology

2014 Volume 61, Issue 1 Suppl, Page(s) S3–S13

Abstract: Hepatitis C virus (HCV) is an important human pathogen that causes hepatitis, liver cirrhosis and hepatocellular carcinoma. It imposes a serious problem to public health in the world as the population of chronically infected HCV patients who are at risk ... ...

Abstract	Hepatitis C virus (HCV) is an important human pathogen that causes hepatitis, liver cirrhosis and hepatocellular carcinoma. It imposes a serious problem to public health in the world as the population of chronically infected HCV patients who are at risk of progressive liver disease is projected to increase significantly in the next decades. However, the arrival of new antiviral molecules is progressively changing the landscape of hepatitis C treatment. The search for new anti-HCV therapies has also been a driving force to better understand how HCV interacts with its host, and major progresses have been made on the various steps of the HCV life cycle. Here, we review the most recent advances in the fast growing knowledge on HCV life cycle and interaction with host factors and pathways.
MeSH term(s)	Cell Biology/trends ; Hepacivirus/genetics ; Hepacivirus/growth & development ; Hepacivirus/pathogenicity ; Hepatitis C/pathology ; Hepatitis C/physiopathology ; Hepatocytes/pathology ; Hepatocytes/virology ; Humans ; Life Cycle Stages/physiology ; Lipid Metabolism/physiology ; RNA, Viral/physiology ; Virology/trends ; Virus Replication/physiology
Chemical Substances	RNA, Viral
Language	English
Publishing date	2014-11
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	605953-3
ISSN	1600-0641 ; 0168-8278
ISSN (online)	1600-0641
ISSN	0168-8278
DOI	10.1016/j.jhep.2014.06.031
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Article: Mouse infection by Legionella, a model to analyze autophagy.

Dubuisson, Jean-François / Swanson, Michele S

Autophagy

2006 Volume 2, Issue 3, Page(s) 179–182

Abstract: Autophagy is a conserved membrane traffic pathway that equips eukaryotic cells to capture cytoplasmic components within a double-membrane vacuole, or autophagosome, for delivery to lysosomes. Although best known as a mechanism to survive starvation, ... ...

Abstract	Autophagy is a conserved membrane traffic pathway that equips eukaryotic cells to capture cytoplasmic components within a double-membrane vacuole, or autophagosome, for delivery to lysosomes. Although best known as a mechanism to survive starvation, autophagy is now recognized to combat infection by a variety of microbes.(1-3) Not surprisingly, to establish a replication niche in host cells, some intracellular pathogens have acquired mechanisms either to evade or subvert the autophagic pathway. Because they are amenable to genetic manipulation, these microbes can be exploited as experimental tools to investigate the contribution of autophagy to immunity. Here we discuss the mouse macrophage response to L. pneumophila, the facultative intracellular bacterium responsible for an acute form of pneumonia, Legionnaire's disease.
MeSH term(s)	Animals ; Apoptosis/physiology ; Autophagy/physiology ; Disease Models, Animal ; Inflammation/microbiology ; Legionella pneumophila/pathogenicity ; Legionnaires' Disease/microbiology ; Macrophages/physiology ; Mice ; Mice, Inbred C57BL ; Models, Biological ; Vacuoles/microbiology
Language	English
Publishing date	2006-07-17
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Review
ZDB-ID	2454135-7
ISSN	1554-8635 ; 1554-8627
ISSN (online)	1554-8635
ISSN	1554-8627
DOI	10.4161/auto.2831
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