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  1. Article ; Online: Robert U. Muller-in memory.

    Kubie, John L / Fenton, André A

    Hippocampus

    2014  Volume 24, Issue 6, Page(s) 611–614

    MeSH term(s) Animals ; Hippocampus/physiology ; History, 20th Century ; History, 21st Century ; Humans ; Learning/physiology ; Memory/physiology ; Neurons/physiology ; Neurosciences/history ; Rats ; Space Perception/physiology
    Language English
    Publishing date 2014-03-18
    Publishing country United States
    Document type Biography ; Historical Article ; Journal Article ; Portrait
    ZDB-ID 1074352-2
    ISSN 1098-1063 ; 1050-9631
    ISSN (online) 1098-1063
    ISSN 1050-9631
    DOI 10.1002/hipo.22269
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    Zs.A 3227: Show issues Location:
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  2. Article ; Online: 2024 Carl W. Gottschalk Distinguished Lectureship of the American Physiological Society Renal Section.

    Fenton, Robert A / Ellison, David H

    American journal of physiology. Renal physiology

    2024  

    Language English
    Publishing date 2024-03-28
    Publishing country United States
    Document type Editorial
    ZDB-ID 603837-2
    ISSN 1522-1466 ; 0363-6127
    ISSN (online) 1522-1466
    ISSN 0363-6127
    DOI 10.1152/ajprenal.00086.2024
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  3. Article ; Online: Perspective on G protein-coupled receptors in renal physiology.

    Pluznick, Jennifer L / Fenton, Robert A

    American journal of physiology. Renal physiology

    2023  Volume 325, Issue 6, Page(s) F683–F684

    MeSH term(s) Receptors, G-Protein-Coupled ; Signal Transduction ; Urinary Tract Physiological Phenomena
    Chemical Substances Receptors, G-Protein-Coupled
    Language English
    Publishing date 2023-10-12
    Publishing country United States
    Document type Editorial
    ZDB-ID 603837-2
    ISSN 1522-1466 ; 0363-6127
    ISSN (online) 1522-1466
    ISSN 0363-6127
    DOI 10.1152/ajprenal.00307.2023
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  4. Article ; Online: Regulation of the water channel Aquaporin-2 by Cullin E3 ubiquitin ligases.

    Murali, Sathish K / McCormick, James A / Fenton, Robert A

    American journal of physiology. Renal physiology

    2024  

    Abstract: Aquaporin 2 (AQP2) is a vasopressin (VP) regulated water channel in the renal collecting duct. Phosphorylation and ubiquitylation of AQP2 play essential roles in controlling the cellular abundance of AQP2 and its accumulation on the plasma membrane in ... ...

    Abstract Aquaporin 2 (AQP2) is a vasopressin (VP) regulated water channel in the renal collecting duct. Phosphorylation and ubiquitylation of AQP2 play essential roles in controlling the cellular abundance of AQP2 and its accumulation on the plasma membrane in response to VP. Cullin-RING ubiquitin ligases (CRLs) are multi-subunit E3 ligases involved in ubiquitylation and degradation of their target proteins, eight of which are expressed in the collecting duct. Here, we utilized an established cell model of the collecting duct (mpkCCD14 cells) to study the role of Cullins in modulating AQP2. Western blotting identified Cul-1 to -5 in mpkCCD14 cells. Treatment of cells for 4 h with a pan-cullin inhibitor (MLN4924) decreased AQP2 abundance, prevented a VP-induced reduction in AQP2 Ser
    Language English
    Publishing date 2024-03-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 603837-2
    ISSN 1522-1466 ; 0363-6127
    ISSN (online) 1522-1466
    ISSN 0363-6127
    DOI 10.1152/ajprenal.00049.2024
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  5. Article ; Online: Urinary proteomics for kidney dysfunction: insights and trends.

    Wu, Qi / Fenton, Robert A

    Expert review of proteomics

    2021  Volume 18, Issue 6, Page(s) 437–452

    Abstract: ... ...

    Abstract Introduction
    MeSH term(s) Biomarkers ; Humans ; Kidney ; Kidney Diseases/diagnosis ; Mass Spectrometry ; Proteomics
    Chemical Substances Biomarkers
    Language English
    Publishing date 2021-07-13
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2299100-1
    ISSN 1744-8387 ; 1478-9450
    ISSN (online) 1744-8387
    ISSN 1478-9450
    DOI 10.1080/14789450.2021.1950535
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    Zs.A 6686: Show issues Location:
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  6. Article ; Online: Urinary Prostaglandin E2 Excretion and the Risk of Cardiovascular and Kidney Disease.

    Geurts, Frank / Chaker, Layal / van der Burgh, Anna C / Cronin-Fenton, Deirdre / Fenton, Robert A / Hoorn, Ewout J

    Journal of the American Heart Association

    2024  Volume 13, Issue 4, Page(s) e032835

    Abstract: Background: Inhibition of prostaglandin synthesis by nonsteroidal anti-inflammatory drugs is associated with cardiovascular mortality and kidney disease. This study hypothesizes that urinary prostaglandin E2 (PGE2) and PGE2 metabolite (PGEM) excretions ... ...

    Abstract Background: Inhibition of prostaglandin synthesis by nonsteroidal anti-inflammatory drugs is associated with cardiovascular mortality and kidney disease. This study hypothesizes that urinary prostaglandin E2 (PGE2) and PGE2 metabolite (PGEM) excretions are markers of cardiovascular and kidney health, because they reflect both systemic and kidney-derived PGE2 production.
    Methods and results: PGE2 and PGEM were measured in spot urine samples from 2291 participants (≥55 years old) of the population-based Rotterdam Study. Urinary PGE2 and PGEM excretions were analyzed using linear regression analyses to identify cross-sectional associations with cardiovascular risk factors and baseline estimated glomerular filtration rate (eGFR). Longitudinal associations with cardiovascular mortality and kidney outcomes (eGFR <60 or <45 mL/min per 1.73 m
    Conclusions: Urinary PGE2 and PGEM excretions are novel markers for the presence and progression of cardiovascular and kidney disease. Future studies should address whether these associations are causal and can be targeted to improve cardiovascular and kidney outcomes.
    MeSH term(s) Humans ; Middle Aged ; Dinoprostone ; Cardiovascular Diseases/diagnosis ; Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/etiology ; Cross-Sectional Studies ; Kidney Diseases/diagnosis ; Kidney Diseases/epidemiology ; Kidney Diseases/complications ; Kidney ; Glomerular Filtration Rate/physiology ; Albuminuria/urine ; Risk Factors
    Chemical Substances Dinoprostone (K7Q1JQR04M)
    Language English
    Publishing date 2024-02-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 2653953-6
    ISSN 2047-9980 ; 2047-9980
    ISSN (online) 2047-9980
    ISSN 2047-9980
    DOI 10.1161/JAHA.123.032835
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Proteomic approaches in kidney disease biomarker discovery.

    Fenton, Robert A

    American journal of physiology. Renal physiology

    2018  Volume 315, Issue 6, Page(s) F1817–F1821

    Abstract: Biomarkers have the potential to greatly facilitate diagnosis and treatment of patients with various forms of kidney disease. State-of-the-art mass spectrometry-based methods possess the capability, on a proteome scale and in an unbiased manner, to ... ...

    Abstract Biomarkers have the potential to greatly facilitate diagnosis and treatment of patients with various forms of kidney disease. State-of-the-art mass spectrometry-based methods possess the capability, on a proteome scale and in an unbiased manner, to detect alterations in protein abundances and/or posttranslational modifications in plasma, urine, or tissue. Such approaches can provide a large, unbiased database to facilitate identification of potential biomarkers. In the diagnosis of kidney diseases, urine is usually a more favorable specimen than plasma and kidney tissue due to its noninvasive collection and simplicity of processing. However, whether analysis of proteins in urine faithfully reflects their changes in the kidney tissue remains unclear. The use of proteomics to analyze kidney tissue samples collected during late-stage kidney diseases has also recently gathered pace. The goal of this minireview is to provide an overview of the proteomic technologies currently applied to studies of kidney and their limitations, present existing kidney and urine proteome databases, and highlight a few applications of such approaches in kidney disease biomarker discovery.
    MeSH term(s) Animals ; Biomarkers/metabolism ; Biomarkers/urine ; Humans ; Kidney/metabolism ; Kidney/pathology ; Kidney Diseases/diagnosis ; Kidney Diseases/metabolism ; Kidney Diseases/urine ; Predictive Value of Tests ; Prognosis ; Proteomics/methods ; Urinalysis
    Chemical Substances Biomarkers
    Language English
    Publishing date 2018-09-19
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 603837-2
    ISSN 1522-1466 ; 0363-6127
    ISSN (online) 1522-1466
    ISSN 0363-6127
    DOI 10.1152/ajprenal.00421.2018
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  8. Article: Dissecting the Effects of Aldosterone and Hypokalemia on the Epithelial Na

    Kristensen, Mathias / Fenton, Robert A / Poulsen, Søren B

    Frontiers in physiology

    2022  Volume 13, Page(s) 800055

    Abstract: Primary hyperaldosteronism (PA) is characterized by aldosterone excess and hypertension. This may be linked to increased renal ... ...

    Abstract Primary hyperaldosteronism (PA) is characterized by aldosterone excess and hypertension. This may be linked to increased renal Na
    Language English
    Publishing date 2022-04-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2022.800055
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  9. Article ; Online: Potassium-Switch Signaling Pathway Dictates Acute Blood Pressure Response to Dietary Potassium.

    Welling, Paul A / Little, Robert / Al-Qusairi, Lama / Delpire, Eric / Ellison, David H / Fenton, Robert A / Grimm, P Richard

    Hypertension (Dallas, Tex. : 1979)

    2024  Volume 81, Issue 5, Page(s) 1044–1054

    Abstract: Background: Potassium (K: Methods: To test the hypothesis that small, physiological changes in plasma K: Results: As P: Conclusions: Low ... ...

    Abstract Background: Potassium (K
    Methods: To test the hypothesis that small, physiological changes in plasma K
    Results: As P
    Conclusions: Low K
    MeSH term(s) Animals ; Mice ; Potassium/metabolism ; Protein Serine-Threonine Kinases/metabolism ; Potassium, Dietary/metabolism ; Blood Pressure/physiology ; Sodium Chloride/metabolism ; Solute Carrier Family 12, Member 3/metabolism ; Signal Transduction ; Phosphorylation ; Kidney Tubules, Distal/metabolism ; Hydrochlorothiazide ; Sodium/metabolism ; Alanine/metabolism ; Proline/metabolism
    Chemical Substances Potassium (RWP5GA015D) ; Protein Serine-Threonine Kinases (EC 2.7.11.1) ; Potassium, Dietary ; Sodium Chloride (451W47IQ8X) ; Solute Carrier Family 12, Member 3 ; Hydrochlorothiazide (0J48LPH2TH) ; Sodium (9NEZ333N27) ; Alanine (OF5P57N2ZX) ; Proline (9DLQ4CIU6V)
    Language English
    Publishing date 2024-03-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 423736-5
    ISSN 1524-4563 ; 0194-911X ; 0362-4323
    ISSN (online) 1524-4563
    ISSN 0194-911X ; 0362-4323
    DOI 10.1161/HYPERTENSIONAHA.123.22546
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    Zs.A 1488: Show issues Location:
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  10. Article ; Online: USE OF A STATEWIDE SOLID ORGAN INJURY PROCOTCOL TO OPTIMIZE TRIAGE, TREATMENT, AND TRANSFER FOR PEDIATRIC ABDOMINAL TRAUMA.

    Swendiman, Robert A / Russell, Katie W / Larsen, Kezlyn / Eyre, Matthew / Fenton, Stephen J

    The journal of trauma and acute care surgery

    2024  

    Abstract: Background: The Utah Pediatric Trauma Network (UPTN) is a non-competitive collaboration of all 51 hospitals in the state of Utah with the purpose of improving pediatric trauma care. Created in 2019, UPTN has implemented evidence-based guidelines based ... ...

    Abstract Background: The Utah Pediatric Trauma Network (UPTN) is a non-competitive collaboration of all 51 hospitals in the state of Utah with the purpose of improving pediatric trauma care. Created in 2019, UPTN has implemented evidence-based guidelines based on hospital resources and capabilities with quarterly review of data collected in a network-specific database. A blunt solid organ injury (SOI) protocol was developed to optimize treatment of these injuries statewide. The purpose of this study was to review the effectiveness of the SOI guideline.
    Methods: The UPTN REDCap® database was retrospectively reviewed from 2021 through 2022. We compared admissions from the Level 1 pediatric trauma center (PED1) to non-pediatric hospitals (non-PED1) of children with low grade (I-II) and high grade (III-V) SOIs.
    Results: In 2 years, 172 patients were treated for blunt SOI, with or without concomitant injuries. There were 48 (28%) low grade and 124 (72%) high grade SOIs. 33 (69%) patients were triaged with low grade SOI injuries at a non-PED1 center, and 17 (35%) were transferred to the PED1 hospital. Most had multiple injuries, but 7 (44%) were isolated, and none required a transfusion or any procedure/operation at either hospital. Of the 124 patients with high grade injuries, 41 (33%) primarily presented to the PED1 center, and 44 (35%) were transferred there. Of these, 2 required a splenectomy and none required angiography. 39 children were treated at non-PED1 centers without transfer, and 4 required splenectomy and 6 underwent angiography/embolization procedures. No patient with an isolated SOI died.
    Conclusions: Implementation of SOI guidelines across UPTN successfully allowed non-pediatric hospitals to safely admit children with low grade isolated SOI, keeping families closer to home, while standardizing pediatric triage for blunt abdominal trauma in the state.
    Level of evidence: III - Retrospective study.
    Language English
    Publishing date 2024-01-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2651070-4
    ISSN 2163-0763 ; 2163-0755
    ISSN (online) 2163-0763
    ISSN 2163-0755
    DOI 10.1097/TA.0000000000004261
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