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Article ; Online: Conformational Changes in Herpes Simplex Virus Glycoprotein C.

Gianopulos, Katrina A / Komala Sari, Tri / Weed, Darin J / Pritchard, Suzanne M / Nicola, Anthony V

2022 Volume 96, Issue 16, Page(s) e0016322

Abstract: Low endosomal pH facilitates herpesvirus entry in a cell-specific manner. Herpes simplex virus 1 (HSV-1) causes significant morbidity and death in humans worldwide. HSV-1 enters cells by low-pH and neutral-pH pathways. Low-pH-induced conformational ... ...

Abstract	Low endosomal pH facilitates herpesvirus entry in a cell-specific manner. Herpes simplex virus 1 (HSV-1) causes significant morbidity and death in humans worldwide. HSV-1 enters cells by low-pH and neutral-pH pathways. Low-pH-induced conformational changes in the HSV envelope glycoprotein B (gB) may mediate membrane fusion during viral entry. HSV-1 gC, a 511-amino acid, type I integral membrane glycoprotein, mediates HSV-1 attachment to host cell surface glycosaminoglycans, but this interaction is not essential for viral entry. We previously demonstrated that gC regulates low-pH viral entry independent of its known role in cell attachment. Low-pH-triggered conformational changes in gB occur at a lower pH when gC is absent, suggesting that gC positively regulates gB conformational changes. Here, we demonstrate that mildly acidic pH triggers conformational changes in gC itself. Low-pH treatment of virions induced antigenic changes in distinct gC epitopes, and those changes were reversible. One of these gC epitopes is recognized by a monoclonal antibody that binds to a linear sequence that includes residues within gC amino acids 33 to 123. This antibody inhibited low-pH entry of HSV, suggesting that its gC N-terminal epitope is particularly important. We propose that gC plays a critical role in HSV entry through a low-pH endocytosis pathway, which is a major entry route in human epithelial cells.
MeSH term(s)	Antibodies, Monoclonal ; Epitopes/metabolism ; Herpes Simplex/virology ; Herpesvirus 1, Human/physiology ; Humans ; Viral Envelope Proteins/chemistry ; Virus Internalization
Chemical Substances	Antibodies, Monoclonal ; Epitopes ; Viral Envelope Proteins ; glycoprotein gC, herpes simplex virus type 1
Language	English
Publishing date	2022-08-01
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	80174-4
ISSN	1098-5514 ; 0022-538X
ISSN (online)	1098-5514
ISSN	0022-538X
DOI	10.1128/jvi.00163-22
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Article ; Online: Extracellular matrix complexity in biomarker studies: a novel assay detecting total serum tenascin-C reveals different distribution to isoform-specific assays.

Ozanne, James / Lewis, Mel / Schwenzer, Anja / Kurian, Dominic / Brady, Jeff / Pritchard, David / McLachlan, Gerry / Farquharson, Colin / Midwood, Kim S

Frontiers in immunology

2023 Volume 14, Page(s) 1275361

Abstract: ... studies. Tenascin-C is a pro-inflammatory matrix protein expressed at low levels in most healthy tissues ... cancer. Analysis of circulating tenascin-C has been widely explored as a disease biomarker. Hundreds ... of different tenascin-C isoforms can be generated by alternative splicing, and this protein is also modified ...

Abstract	Serum biomarkers are the gold standard in non-invasive disease diagnosis and have tremendous potential as prognostic and theranostic tools for patient stratification. Circulating levels of extracellular matrix molecules are gaining traction as an easily accessible means to assess tissue pathology. However, matrix molecules are large, multimodular proteins that are subject to a vast array of post-transcriptional and post-translational modifications. These modifications often occur in a tissue- and/or disease-specific manner, generating hundreds of different variants, each with distinct biological roles. Whilst this complexity can offer unique insight into disease processes, it also has the potential to confound biomarker studies. Tenascin-C is a pro-inflammatory matrix protein expressed at low levels in most healthy tissues but elevated in, and associated with the pathogenesis of, a wide range of autoimmune diseases, fibrosis, and cancer. Analysis of circulating tenascin-C has been widely explored as a disease biomarker. Hundreds of different tenascin-C isoforms can be generated by alternative splicing, and this protein is also modified by glycosylation and citrullination. Current enzyme-linked immunosorbent assays (ELISA) are used to measure serum tenascin-C using antibodies, recognising sites within domains that are alternatively spliced. These studies, therefore, report only levels of specific isoforms that contain these domains, and studies on the detection of total tenascin-C are lacking. As such, circulating tenascin-C levels may be underestimated and/or biologically relevant isoforms overlooked. We developed a highly specific and sensitive ELISA measuring total tenascin-C down to 0.78ng/ml, using antibodies that recognise sites in constitutively expressed domains. In cohorts of people with different inflammatory and musculoskeletal diseases, levels of splice-specific tenascin-C variants were lower than and distributed differently from total tenascin-C. Neither total nor splice-specific tenascin-C levels correlated with the presence of autoantibodies to citrullinated tenascin-C in rheumatoid arthritis (RA) patients. Elevated tenascin-C was not restricted to any one disease and levels were heterogeneous amongst patients with the same disease. These data confirm that its upregulation is not disease-specific, instead suggest that different molecular endotypes or disease stages exist in which pathology is associated with, or independent of, tenascin-C. This immunoassay provides a novel tool for the detection of total tenascin-C that is critical for further biomarker studies. Differences between the distribution of tenascin-C variants and total tenascin-C have implications for the interpretation of studies using isoform-targeted assays. These data highlight the importance of assay design for the detection of multimodular matrix molecules and reveal that there is still much to learn about the intriguingly complex biological roles of distinct matrix proteoforms.
MeSH term(s)	Humans ; Tenascin/metabolism ; Extracellular Matrix/metabolism ; Protein Isoforms ; Biomarkers ; Autoantibodies
Chemical Substances	Tenascin ; Protein Isoforms ; Biomarkers ; Autoantibodies
Language	English
Publishing date	2023-11-22
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2023.1275361
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Article ; Online: Endothelial protein C receptor is increased in preterm preeclampsia and fetal growth restriction.

Andres, Faith / Hannan, Natalie J / Walker, Susan P / MacDonald, Teresa M / Wong, Georgia P / Murphy, Ciara / Cannon, Ping / Kandel, Manju / Masci, Joshua / Nguyen, Tuong-Vi / Abboud, Alison / Idzes, Danica / Kyritsis, Valerie / Pritchard, Natasha / Tong, Stephen / Kaitu'u-Lino, Tu'uhevaha J

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

2022 Volume 36, Issue 12, Page(s) e22651

Abstract: ... This study aimed to characterize endothelial protein C receptor (EPCR) in preterm preeclampsia, term ... elevated (p = .01) in established preterm preeclampsia while its substrate, protein C (PC) was ...

Abstract	Placental dysfunction is the leading cause of both preeclampsia and fetal growth restriction. This study aimed to characterize endothelial protein C receptor (EPCR) in preterm preeclampsia, term preeclampsia, and fetal growth restriction (defined by delivery of a small for gestational age [SGA] infant [<10% birthweight centile]) and examine its regulation in primary syncytiotrophoblast. Placental EPCR mRNA and protein were significantly increased in patients with preterm preeclampsia (<34 weeks gestation) compared to gestation-matched controls (p < .0001). In the plasma, EPCR was also significantly elevated (p = .01) in established preterm preeclampsia while its substrate, protein C (PC) was significantly reduced (p = .0083). Placentas from preterm small for gestational age (SGA) cases, had elevated EPCR mRNA expression (p < .0001) relative to controls. At 36 weeks, no significant changes in plasma EPCR were detected in samples from patients destined to develop preeclampsia or deliver an SGA infant at term. In terms of syncytiotrophoblast, hypoxia significantly increased EPCR mRNA expression (p = .008), but Tumor Necrosis Factor Alpha (TNF-α) decreased EPCR mRNA. Interleukin-6 (IL-6) had no significant effect on EPCR mRNA expression. When isolated syncytiotrophoblast was treated with metformin under hypoxia (1% O
MeSH term(s)	Infant, Newborn ; Humans ; Female ; Pregnancy ; Pre-Eclampsia/metabolism ; Fetal Growth Retardation/metabolism ; Endothelial Protein C Receptor/metabolism ; Placenta/metabolism ; Hypoxia/metabolism ; RNA, Messenger/genetics ; RNA, Messenger/metabolism
Chemical Substances	Endothelial Protein C Receptor ; RNA, Messenger
Language	English
Publishing date	2022-11-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	639186-2
ISSN	1530-6860 ; 0892-6638
ISSN (online)	1530-6860
ISSN	0892-6638
DOI	10.1096/fj.202201150R
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Zs.A 2266: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Client resistance to hepatitis C treatment initiation in opioid agonist treatment clinics in Sydney, Australia: A qualitative study.

Coupland, Heidi / Day, Carolyn / Haber, Paul / Pritchard-Jones, Janice / McKee, Kristen / George, Jacob / McCaughan, Geoff

Drug and alcohol review

2021 Volume 41, Issue 3, Page(s) 706–714

Abstract: ... of hepatitis C virus (HCV) globally. Previous research has identified barriers to HCV treatment uptake in OAT clinics ... using constant comparative methods.: Results: Despite progress in integrating hepatitis C care ...

Abstract	Introduction: Opioid agonist treatment (OAT) clinics play a key role in achieving elimination of hepatitis C virus (HCV) globally. Previous research has identified barriers to HCV treatment uptake in OAT clinics; however, most studies were conducted prior to the introduction of direct-acting antiviral treatments (DAA). It remains unclear whether progress has been made in responding to barriers and what challenges persist in this setting. Methods: Semi-structured in-depth interviews were conducted with staff (n = 20) and clients (n = 15) in two OAT clinics in Sydney, Australia. Interviews were transcribed verbatim and analysed using constant comparative methods. Results: Despite progress in integrating hepatitis C care in the clinics, competing priorities, concerns about side-effects, distrust of staff, health problems and difficulties accessing testing and medication persisted as key reasons why clients had not initiated treatment. Most clients preferred to postpone treatment and focus on other priorities and some highlighted lack of medical evidence for urgent treatment. Pressure on services to achieve elimination targets within set time frames was a primary driver of repeated offers of treatment by staff and the framing of clients' preferences for postponing treatment, as a barrier. Discussion and conclusion: Current timelines for HCV elimination targets may have galvanised services into action but may have also created tensions at the coalface due to disparities between staff and clients' priorities. The involvement of peer workers and mechanisms to ensure continued follow up with clients about DAA treatments is required. Public health timelines for HCV elimination need to be informed by affected communities' priorities.
MeSH term(s)	Analgesics, Opioid/therapeutic use ; Antiviral Agents/therapeutic use ; Australia ; Hepatitis C/drug therapy ; Hepatitis C, Chronic/drug therapy ; Humans ; Substance Abuse, Intravenous
Chemical Substances	Analgesics, Opioid ; Antiviral Agents
Language	English
Publishing date	2021-11-28
Publishing country	Australia
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1080442-0
ISSN	1465-3362 ; 0959-5236
ISSN (online)	1465-3362
ISSN	0959-5236
DOI	10.1111/dar.13414
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Article ; Online: Setting foot in private spaces: extending the hepatitis C cascade of care to automatic needle/syringe dispensing machines, a mixed methods study.

Coupland, Heidi / Henderson, Charles / Pritchard-Jones, Janice / Kao, Shih-Chi / Sheils, Sinead / Nagy, Regina / O'Donnell, Martin / Haber, Paul S / Day, Carolyn A

Harm reduction journal

2022 Volume 19, Issue 1, Page(s) 56

Abstract: Background: Global commitment to achieving hepatitis C virus (HCV) elimination has enhanced ...

Abstract	Background: Global commitment to achieving hepatitis C virus (HCV) elimination has enhanced efforts in improving access to direct-acting antiviral (DAA) treatments for people who inject drugs (PWID). Scale-up of efforts to engage hard-to-reach groups of PWID in HCV testing and treatment is crucial to success. Automatic needle/syringe dispensing machines (ADMs) have been used internationally to distribute sterile injecting equipment. ADMs are a unique harm reduction service, affording maximum anonymity to service users. This paper explores the feasibility and acceptability of extending the HCV cascade of care to sites where ADMs are located. Methods: The ADM users into Treatment (ADMiT) study was undertaken in a metropolitan region in Sydney, Australia. This mixed methods study involved analysis of closed-circuit television footage, ethnographic methods (fieldwork observation and in-depth interviews) and structured surveys. Researchers and peers conducted fieldwork and data collection over 10 weeks at one ADM site, including offering access to HCV testing and treatment. Results: Findings from 10 weeks of fieldwork observations, 70 survey participants and 15 interviews highlighted that there is scope for engaging with this population at the time they use the ADM, and enhanced linkage to HCV testing and treatment may be warranted. Most survey participants reported prior HCV testing, 61% in the last 12 months and 38% had received HCV treatment. However, fieldwork revealed that most people observed using the ADM were not willing to engage with the researchers. Field work data and interviews suggested that extending the HCV cascade of care to ADMs may encroach on what is a private space for many PWID, utilized specifically to avoid engagement. Discussion: Enhanced linkage to HCV testing and treatment for people who use ADMs may be warranted. However, data suggested that extending the HCV cascade of care to ADMs may encroach on what is a private space for many PWID, utilized specifically to avoid engagement. The current study raises important public health questions about the need to ensure interventions reflect the needs of affected communities, including their right to remain anonymous.
MeSH term(s)	Antiviral Agents/therapeutic use ; Hepacivirus ; Hepatitis C/epidemiology ; Hepatitis C, Chronic/drug therapy ; Humans ; Substance Abuse, Intravenous/epidemiology ; Syringes
Chemical Substances	Antiviral Agents
Language	English
Publishing date	2022-05-28
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2146691-9
ISSN	1477-7517 ; 1477-7517
ISSN (online)	1477-7517
ISSN	1477-7517
DOI	10.1186/s12954-022-00640-6
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Article ; Online: Observation of B_{c}^{+}→D^{0}K^{+} Decays.

Aaij, R / Adeva, B / Adinolfi, M / Ajaltouni, Z / Akar, S / Albrecht, J / Alessio, F / Alexander, M / Ali, S / Alkhazov, G / Alvarez Cartelle, P / Alves, A A / Amato, S / Amerio, S / Amhis, Y / An, L / Anderlini, L / Andreassi, G / Andreotti, M /

Andrews, J E / Appleby, R B / Archilli, F / d'Argent, P / Arnau Romeu, J / Artamonov, A / Artuso, M / Aslanides, E / Auriemma, G / Baalouch, M / Babuschkin, I / Bachmann, S / Back, J J / Badalov, A / Baesso, C / Baker, S / Balagura, V / Baldini, W / Barlow, R J / Barschel, C / Barsuk, S / Barter, W / Baryshnikov, F / Baszczyk, M / Batozskaya, V / Batsukh, B / Battista, V / Bay, A / Beaucourt, L / Beddow, J / Bedeschi, F / Bediaga, I / Bel, L J / Bellee, V / Belloli, N / Belous, K / Belyaev, I / Ben-Haim, E / Bencivenni, G / Benson, S / Berezhnoy, A / Bernet, R / Bertolin, A / Betancourt, C / Betti, F / Bettler, M-O / van Beuzekom, M / Bezshyiko, Ia / Bifani, S / Billoir, P / Bird, T / Birnkraut, A / Bitadze, A / Bizzeti, A / Blake, T / Blanc, F / Blouw, J / Blusk, S / Bocci, V / Boettcher, T / Bondar, A / Bondar, N / Bonivento, W / Bordyuzhin, I / Borgheresi, A / Borghi, S / Borisyak, M / Borsato, M / Bossu, F / Boubdir, M / Bowcock, T J V / Bowen, E / Bozzi, C / Braun, S / Britsch, M / Britton, T / Brodzicka, J / Buchanan, E / Burr, C / Bursche, A / Buytaert, J / Cadeddu, S / Calabrese, R / Calvi, M / Calvo Gomez, M / Camboni, A / Campana, P / Campora Perez, D H / Capriotti, L / Carbone, A / Carboni, G / Cardinale, R / Cardini, A / Carniti, P / Carson, L / Carvalho Akiba, K / Casse, G / Cassina, L / Castillo Garcia, L / Cattaneo, M / Cavallero, G / Cenci, R / Chamont, D / Charles, M / Charpentier, Ph / Chatzikonstantinidis, G / Chefdeville, M / Chen, S / Cheung, S-F / Chobanova, V / Chrzaszcz, M / Cid Vidal, X / Ciezarek, G / Clarke, P E L / Clemencic, M / Cliff, H V / Closier, J / Coco, V / Cogan, J / Cogneras, E / Cogoni, V / Cojocariu, L / Collazuol, G / Collins, P / Comerma-Montells, A / Contu, A / Cook, A / Coombs, G / Coquereau, S / Corti, G / Corvo, M / Costa Sobral, C M / Couturier, B / Cowan, G A / Craik, D C / Crocombe, A / Cruz Torres, M / Cunliffe, S / Currie, R / D'Ambrosio, C / Da Cunha Marinho, F / Dall'Occo, E / Dalseno, J / David, P N Y / Davis, A / De Bruyn, K / De Capua, S / De Cian, M / De Miranda, J M / De Paula, L / De Serio, M / De Simone, P / Dean, C T / Decamp, D / Deckenhoff, M / Del Buono, L / Demmer, M / Dendek, A / Derkach, D / Deschamps, O / Dettori, F / Dey, B / Di Canto, A / Dijkstra, H / Dordei, F / Dorigo, M / Dosil Suárez, A / Dovbnya, A / Dreimanis, K / Dufour, L / Dujany, G / Dungs, K / Durante, P / Dzhelyadin, R / Dziurda, A / Dzyuba, A / Déléage, N / Easo, S / Ebert, M / Egede, U / Egorychev, V / Eidelman, S / Eisenhardt, S / Eitschberger, U / Ekelhof, R / Eklund, L / Ely, S / Esen, S / Evans, H M / Evans, T / Falabella, A / Farley, N / Farry, S / Fay, R / Fazzini, D / Ferguson, D / Fernandez Prieto, A / Ferrari, F / Ferreira Rodrigues, F / Ferro-Luzzi, M / Filippov, S / Fini, R A / Fiore, M / Fiorini, M / Firlej, M / Fitzpatrick, C / Fiutowski, T / Fleuret, F / Fohl, K / Fontana, M / Fontanelli, F / Forshaw, D C / Forty, R / Franco Lima, V / Frank, M / Frei, C / Fu, J / Funk, W / Furfaro, E / Färber, C / Gallas Torreira, A / Galli, D / Gallorini, S / Gambetta, S / Gandelman, M / Gandini, P / Gao, Y / Garcia Martin, L M / García Pardiñas, J / Garra Tico, J / Garrido, L / Garsed, P J / Gascon, D / Gaspar, C / Gavardi, L / Gazzoni, G / Gerick, D / Gersabeck, E / Gersabeck, M / Gershon, T / Ghez, Ph / Gianì, S / Gibson, V / Girard, O G / Giubega, L / Gizdov, K / Gligorov, V V / Golubkov, D / Golutvin, A / Gomes, A / Gorelov, I V / Gotti, C / Graciani Diaz, R / Granado Cardoso, L A / Graugés, E / Graverini, E / Graziani, G / Grecu, A / Griffith, P / Grillo, L / Gruberg Cazon, B R / Grünberg, O / Gushchin, E / Guz, Yu / Gys, T / Göbel, C / Hadavizadeh, T / Hadjivasiliou, C / Haefeli, G / Haen, C / Haines, S C / Hamilton, B / Han, X / Hansmann-Menzemer, S / Harnew, N / Harnew, S T / Harrison, J / Hatch, M / He, J / Head, T / Heister, A / Hennessy, K / Henrard, P / Henry, L / van Herwijnen, E / Heß, M / Hicheur, A / Hill, D / Hombach, C / Hopchev, H / Hulsbergen, W / Humair, T / Hushchyn, M / Hutchcroft, D / Idzik, M / Ilten, P / Jacobsson, R / Jaeger, A / Jalocha, J / Jans, E / Jawahery, A / Jiang, F / John, M / Johnson, D / Jones, C R / Joram, C / Jost, B / Jurik, N / Kandybei, S / Karacson, M / Kariuki, J M / Karodia, S / Kecke, M / Kelsey, M / Kenzie, M / Ketel, T / Khairullin, E / Khanji, B / Khurewathanakul, C / Kirn, T / Klaver, S / Klimaszewski, K / Koliiev, S / Kolpin, M / Komarov, I / Koopman, R F / Koppenburg, P / Kosmyntseva, A / Kozachuk, A / Kozeiha, M / Kravchuk, L / Kreplin, K / Kreps, M / Krokovny, P / Kruse, F / Krzemien, W / Kucewicz, W / Kucharczyk, M / Kudryavtsev, V / Kuonen, A K / Kurek, K / Kvaratskheliya, T / Lacarrere, D / Lafferty, G / Lai, A / Lanfranchi, G / Langenbruch, C / Latham, T / Lazzeroni, C / Le Gac, R / van Leerdam, J / Leflat, A / Lefrançois, J / Lefèvre, R / Lemaitre, F / Lemos Cid, E / Leroy, O / Lesiak, T / Leverington, B / Li, T / Li, Y / Likhomanenko, T / Lindner, R / Linn, C / Lionetto, F / Liu, X / Loh, D / Longstaff, I / Lopes, J H / Lucchesi, D / Lucio Martinez, M / Luo, H / Lupato, A / Luppi, E / Lupton, O / Lusiani, A / Lyu, X / Machefert, F / Maciuc, F / Maev, O / Maguire, K / Malde, S / Malinin, A / Maltsev, T / Manca, G / Mancinelli, G / Manning, P / Maratas, J / Marchand, J F / Marconi, U / Marin Benito, C / Marinangeli, M / Marino, P / Marks, J / Martellotti, G / Martin, M / Martinelli, M / Martinez Santos, D / Martinez Vidal, F / Martins Tostes, D / Massacrier, L M / Massafferri, A / Matev, R / Mathad, A / Mathe, Z / Matteuzzi, C / Mauri, A / Maurice, E / Maurin, B / Mazurov, A / McCann, M / McNab, A / McNulty, R / Meadows, B / Meier, F / Meissner, M / Melnychuk, D / Merk, M / Merli, A / Michielin, E / Milanes, D A / Minard, M-N / Mitzel, D S / Mogini, A / Molina Rodriguez, J / Monroy, I A / Monteil, S / Morandin, M / Morawski, P / Mordà, A / Morello, M J / Morgunova, O / Moron, J / Morris, A B / Mountain, R / Muheim, F / Mulder, M / Mussini, M / Müller, D / Müller, J / Müller, K / Müller, V / Naik, P / Nakada, T / Nandakumar, R / Nandi, A / Nasteva, I / Needham, M / Neri, N / Neubert, S / Neufeld, N / Neuner, M / Nguyen, T D / Nguyen-Mau, C / Nieswand, S / Niet, R / Nikitin, N / Nikodem, T / Nogay, A / Novoselov, A / O'Hanlon, D P / Oblakowska-Mucha, A / Obraztsov, V / Ogilvy, S / Oldeman, R / Onderwater, C J G / Otalora Goicochea, J M / Otto, A / Owen, P / Oyanguren, A / Pais, P R / Palano, A / Palutan, M / Papanestis, A / Pappagallo, M / Pappalardo, L L / Parker, W / Parkes, C / Passaleva, G / Pastore, A / Patel, G D / Patel, M / Patrignani, C / Pearce, A / Pellegrino, A / Penso, G / Pepe Altarelli, M / Perazzini, S / Perret, P / Pescatore, L / Petridis, K / Petrolini, A / Petrov, A / Petruzzo, M / Picatoste Olloqui, E / Pietrzyk, B / Pikies, M / Pinci, D / Pistone, A / Piucci, A / Placinta, V / Playfer, S / Plo Casasus, M / Poikela, T / Polci, F / Poluektov, A / Polyakov, I / Polycarpo, E / Pomery, G J / Popov, A / Popov, D / Popovici, B / Poslavskii, S / Potterat, C / Price, E / Price, J D / Prisciandaro, J / Pritchard, A / Prouve, C / Pugatch, V / Puig Navarro, A / Punzi, G / Qian, W / Quagliani, R / Rachwal, B / Rademacker, J H / Rama, M / Ramos Pernas, M / Rangel, M S / Raniuk, I / Ratnikov, F / Raven, G / Redi, F / Reichert, S / Dos Reis, A C / Remon Alepuz, C / Renaudin, V / Ricciardi, S / Richards, S / Rihl, M / Rinnert, K / Rives Molina, V / Robbe, P / Rodrigues, A B / Rodrigues, E / Rodriguez Lopez, J A / Rodriguez Perez, P / Rogozhnikov, A / Roiser, S / Rollings, A / Romanovskiy, V / Romero Vidal, A / Ronayne, J W / Rotondo, M / Rudolph, M S / Ruf, T / Ruiz Valls, P / Saborido Silva, J J / Sadykhov, E / Sagidova, N / Saitta, B / Salustino Guimaraes, V / Sanchez Mayordomo, C / Sanmartin Sedes, B / Santacesaria, R / Santamarina Rios, C / Santimaria, M / Santovetti, E / Sarti, A / Satriano, C / Satta, A / Saunders, D M / Savrina, D / Schael, S / Schellenberg, M / Schiller, M / Schindler, H / Schlupp, M / Schmelling, M / Schmelzer, T / Schmidt, B / Schneider, O / Schopper, A / Schubert, K / Schubiger, M / Schune, M-H / Schwemmer, R / Sciascia, B / Sciubba, A / Semennikov, A / Sergi, A / Serra, N / Serrano, J / Sestini, L / Seyfert, P / Shapkin, M / Shapoval, I / Shcheglov, Y / Shears, T / Shekhtman, L / Shevchenko, V / Siddi, B G / Silva Coutinho, R / Silva de Oliveira, L / Simi, G / Simone, S / Sirendi, M / Skidmore, N / Skwarnicki, T / Smith, E / Smith, I T / Smith, J / Smith, M / Snoek, H / Soares Lavra, L / Sokoloff, M D / Soler, F J P / Souza De Paula, B / Spaan, B / Spradlin, P / Sridharan, S / Stagni, F / Stahl, M / Stahl, S / Stefko, P / Stefkova, S / Steinkamp, O / Stemmle, S / Stenyakin, O / Stevens, H / Stevenson, S / Stoica, S / Stone, S / Storaci, B / Stracka, S / Straticiuc, M / Straumann, U / Sun, L / Sutcliffe, W / Swientek, K / Syropoulos, V / Szczekowski, M / Szumlak, T / T'Jampens, S / Tayduganov, A / Tekampe, T / Tellarini, G / Teubert, F / Thomas, E / van Tilburg, J / Tilley, M J / Tisserand, V / Tobin, M / Tolk, S / Tomassetti, L / Tonelli, D / Topp-Joergensen, S / Toriello, F / Tournefier, E / Tourneur, S / Trabelsi, K / Traill, M / Tran, M T / Tresch, M / Trisovic, A / Tsaregorodtsev, A / Tsopelas, P / Tully, A / Tuning, N / Ukleja, A / Ustyuzhanin, A / Uwer, U / Vacca, C / Vagnoni, V / Valassi, A / Valat, S / Valenti, G / Vazquez Gomez, R / Vazquez Regueiro, P / Vecchi, S / van Veghel, M / Velthuis, J J / Veltri, M / Veneziano, G / Venkateswaran, A / Vernet, M / Vesterinen, M / Viana Barbosa, J V / Viaud, B / Vieira, D / Vieites Diaz, M / Viemann, H / Vilasis-Cardona, X / Vitti, M / Volkov, V / Vollhardt, A / Voneki, B / Vorobyev, A / Vorobyev, V / Voß, C / de Vries, J A / Vázquez Sierra, C / Waldi, R / Wallace, C / Wallace, R / Walsh, J / Wang, J / Ward, D R / Wark, H M / Watson, N K / Websdale, D / Weiden, A / Whitehead, M / Wicht, J / Wilkinson, G / Wilkinson, M / Williams, M / Williams, M P / Williams, T / Wilson, F F / Wimberley, J / Wishahi, J / Wislicki, W / Witek, M / Wormser, G / Wotton, S A / Wraight, K / Wyllie, K / Xie, Y / Xing, Z / Xu, Z / Yang, Z / Yao, Y / Yin, H / Yu, J / Yuan, X / Yushchenko, O / Zarebski, K A / Zavertyaev, M / Zhang, L / Zhang, Y / Zhelezov, A / Zheng, Y / Zhu, X / Zhukov, V / Zucchelli, S

Physical review letters

2017 Volume 118, Issue 11, Page(s) 111803

Abstract: ... recorded by the LHCb detector at center-of-mass energies of 7 and 8 TeV, the B_{c}^{+}→D^{0}K^{+} decay is ... π^{+} decays, a measurement of the branching fraction multiplied by the production rates for B_{c ... relative to B^{+} mesons in the LHCb acceptance is obtained, R_{D^{0}K}=(f_{c}/f_{u})×B(B_{c}^{+}→D^{0}K^ ...

Abstract	Using proton-proton collision data corresponding to an integrated luminosity of 3.0 fb^{-1}, recorded by the LHCb detector at center-of-mass energies of 7 and 8 TeV, the B_{c}^{+}→D^{0}K^{+} decay is observed with a statistical significance of 5.1 standard deviations. By normalizing to B^{+}→D[over ¯]^{0}π^{+} decays, a measurement of the branching fraction multiplied by the production rates for B_{c}^{+} relative to B^{+} mesons in the LHCb acceptance is obtained, R_{D^{0}K}=(f_{c}/f_{u})×B(B_{c}^{+}→D^{0}K^{+})=(9.3_{-2.5}^{+2.8}±0.6)×10^{-7}, where the first uncertainty is statistical and the second is systematic. This decay is expected to proceed predominantly through weak annihilation and penguin amplitudes, and is the first B_{c}^{+} decay of this nature to be observed.
Language	English
Publishing date	2017-03-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.118.111803
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Article: Etanercept and hepatitis C.

Pritchard, C

Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases

2008 Volume 5, Issue 3, Page(s) 179

Language	English
Publishing date	2008-08-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	1283266-2
ISSN	1076-1608
ISSN	1076-1608
DOI	10.1097/00124743-199906000-00015
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Article ; Online: Herpes Simplex Virus Glycoprotein C Regulates Low-pH Entry.

Komala Sari, Tri / Gianopulos, Katrina A / Weed, Darin J / Schneider, Seth M / Pritchard, Suzanne M / Nicola, Anthony V

mSphere

2020 Volume 5, Issue 1

Abstract: Herpes simplex viruses (HSVs) cause significant morbidity and mortality in humans worldwide. Herpesviruses mediate entry by a multicomponent virus-encoded machinery. Herpesviruses enter cells by endosomal low-pH and pH-neutral mechanisms in a cell- ... ...

Abstract	Herpes simplex viruses (HSVs) cause significant morbidity and mortality in humans worldwide. Herpesviruses mediate entry by a multicomponent virus-encoded machinery. Herpesviruses enter cells by endosomal low-pH and pH-neutral mechanisms in a cell-specific manner. HSV mediates cell entry via the envelope glycoproteins gB and gD and the heterodimer gH/gL regardless of pH or endocytosis requirements. Specifics concerning HSV envelope proteins that function selectively in a given entry pathway have been elusive. Here, we demonstrate that gC regulates cell entry and infection by a low-pH pathway. Conformational changes in the core herpesviral fusogen gB are critical for membrane fusion. The presence of gC conferred a higher pH threshold for acid-induced antigenic changes in gB. Thus, gC may selectively facilitate low-pH entry by regulating conformational changes in the fusion protein gB. We propose that gC modulates the HSV fusion machinery during entry into pathophysiologically relevant cells, such as human epidermal keratinocytes.
MeSH term(s)	Animals ; Chlorocebus aethiops ; Herpes Simplex/virology ; Herpesvirus 1, Human/physiology ; Humans ; Hydrogen-Ion Concentration ; Protein Domains ; Vero Cells ; Viral Envelope Proteins/chemistry ; Viral Envelope Proteins/physiology ; Virus Internalization
Chemical Substances	Viral Envelope Proteins ; glycoprotein gC, herpes simplex virus type 1
Language	English
Publishing date	2020-02-05
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ISSN	2379-5042
ISSN (online)	2379-5042
DOI	10.1128/mSphere.00826-19
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Article ; Online: Impact of CD4+ T-cell count on sustained virologic response to direct-acting antivirals in hepatitis C virus monoinfected cancer patients: a prospective observational study.

Angelidakis, Georgios / Pritchard, Haley / Yibirin, Marcel / Jiang, Ying / Mustafayev, Khalis / Torres, Harrys A

Diagnostic microbiology and infectious disease

2022 Volume 103, Issue 3, Page(s) 115719

Abstract: ... to direct-acting antiviral (DAA) treatment outside the hepatitis C virus (HCV)-HIV coinfected population ...

Abstract	Limited data are available on the use of CD4+ T-cell count and percentage to predict response to direct-acting antiviral (DAA) treatment outside the hepatitis C virus (HCV)-HIV coinfected population. We sought to determine the impact of CD4+ T-cell count and percentage on response to DAAs in cancer patients with HCV monoinfection. Patients treated with DAAs were enrolled in a prospective observational study. CD4+ T-cell count and percentage was measured at baseline, end of treatment (EOT), and 12 weeks after the EOT (SVR12). A total of 174 patients were enrolled. Most patients (155/174, 89%) achieved an SVR12. A multivariate logistic regression model found that patients with hepatocellular carcinoma, HCV-3 and previous DAA treatment were more likely to develop treatment failure. Neither univariate analysis nor multivariate logistic regression analysis did show any association between CD4+ T-cell count or percentage and SVR12. CD4 T-cell count or percentage does not appear to impact SVR rates in cancer patients with HCV monoinfection receiving DAAs.
MeSH term(s)	Antiviral Agents/therapeutic use ; CD4-Positive T-Lymphocytes ; HIV Infections/complications ; HIV Infections/drug therapy ; HIV Infections/epidemiology ; Hepacivirus ; Hepatitis C ; Hepatitis C, Chronic/complications ; Hepatitis C, Chronic/drug therapy ; Humans ; Neoplasms/complications ; Neoplasms/drug therapy ; Sustained Virologic Response ; Treatment Outcome
Chemical Substances	Antiviral Agents
Language	English
Publishing date	2022-05-04
Publishing country	United States
Document type	Journal Article ; Observational Study
ZDB-ID	604920-5
ISSN	1879-0070 ; 0732-8893
ISSN (online)	1879-0070
ISSN	0732-8893
DOI	10.1016/j.diagmicrobio.2022.115719
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Article ; Online: Ground Displacements in NY Using Persistent Scatterer Interferometric Synthetic Aperture Radar and Comparison of X- and C-Band Data

Yusuf Eshqi Molan / Rowena Lohman / Matthew Pritchard

Remote Sensing, Vol 15, Iss 1815, p

2023 Volume 1815

Abstract: ... X-band, 3.1 cm radar wavelength) as well as the European Space Agency’s Sentinel-1 satellite (C-band ... found in the full-resolution X-band data, which was followed by the C-band data and ...

Abstract	In this study, we investigated the quality of Interferometric Synthetic Aperture Radar (InSAR) data to measure surface displacements in upstate New York, an area with dense vegetation, snowy winters, and strong seasonal signals. We used data from the German Space Agency’s TerraSAR-X and TanDEM-X satellites (X-band, 3.1 cm radar wavelength) as well as the European Space Agency’s Sentinel-1 satellite (C-band, 5.6 cm radar wavelength); both datasets covered a ~3-year time period from 2018 to 2021. Using persistent scatterer interferometry (PSI), we were able to observe several deforming features in the region with sub-centimeter/year deformation rates. We also examined a version of the X-band data that we spatially averaged to the same pixel size as the Sentinel-1 imagery in order to separate out the effects of wavelength and pixel size on PSI accuracy and coverage. Overall, the largest number of stable PS points was found in the full-resolution X-band data, which was followed by the C-band data and then by the downsampled X-band data. Our analysis also included a subset of snow-free imagery so that we could assess the effect that snow-covered images had on the distribution and accuracy of PS points and the resulting time series. This analysis revealed that PS populations increased by 50–60% for the snow-free data when compared with analyses using the full datasets. The average deformation rates inferred from the time series generated using only snow-free images were nearly identical to those estimated from the full time series. We assessed the accuracy of the inferred rates through comparisons between the results of different datasets and with limited ground survey data. We found that all of the inferred deformation rates from each of the datasets agreed with in situ measurements in an area of known ground subsidence above an underground salt mine in Lansing, NY. The S1 datasets, however, had higher levels of noise.
Keywords	persistent scatterer ; surface displacements ; Science ; Q
Subject code	333
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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