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Book ; Online: From PARIS to LE-PARIS

Chu, Jung-Mei / Lo, Hao-Cheng / Hsiang, Jieh / Cho, Chun-Chieh

Toward Patent Response Automation with Recommender Systems and Collaborative Large Language Models

2024

Abstract: ... its advanced version, the Large Language Model Enhanced PARIS (LE-PARIS). These systems are designed ... 5). Results demonstrate that both PARIS and LE-PARIS significantly meet key metrics and positively ...

Abstract	In patent prosecution, timely and effective responses to Office Actions (OAs) are crucial for acquiring patents, yet past automation and AI research have scarcely addressed this aspect. To address this gap, our study introduces the Patent Office Action Response Intelligence System (PARIS) and its advanced version, the Large Language Model Enhanced PARIS (LE-PARIS). These systems are designed to expedite the efficiency of patent attorneys in collaboratively handling OA responses. The systems' key features include the construction of an OA Topics Database, development of Response Templates, and implementation of Recommender Systems and LLM-based Response Generation. Our validation involves a multi-paradigmatic analysis using the USPTO Office Action database and longitudinal data of attorney interactions with our systems over six years. Through five studies, we examine the constructiveness of OA topics (studies 1 and 2) using topic modeling and the proposed Delphi process, the efficacy of our proposed hybrid recommender system tailored for OA (both LLM-based and non-LLM-based) (study 3), the quality of response generation (study 4), and the practical value of the systems in real-world scenarios via user studies (study 5). Results demonstrate that both PARIS and LE-PARIS significantly meet key metrics and positively impact attorney performance. Comment: 14 pages, 4 figures, summitted to a journal
Keywords	Computer Science - Computation and Language ; Computer Science - Human-Computer Interaction ; Computer Science - Information Retrieval ; Computer Science - Machine Learning
Subject code	004
Publishing date	2024-02-01
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Impact of the Different Types of Le Fort I Maxillary Surgical Movement on Nasal Width Changes: A Photogrammetric Analysis.

Lin, Yi-Yu / Denadai, Rafael / Chou, Pang-Yun / Yao, Chuan-Fong / Chen, Ying-An / Wang, Po-Fang / Lin, Clement Cheng-Hui / Chen, Yu-Ray

Annals of plastic surgery

2021 Volume 86, Issue 2S Suppl 1, Page(s) S64–S69

Abstract: Background: Le Fort I maxillary movements affect nasal width, but nasal width changes ... that the nasal width varies distinctly depending on the type of Le Fort I maxillary surgical movement. ...

Abstract	Background: Le Fort I maxillary movements affect nasal width, but nasal width changes with specific movement types have not been formally addressed to date. Objectives: The purpose of this study was to analyze and compare the changes in nasal width with different maxillary movements. Methods: A retrospective study was performed among consecutive patients who underwent bimaxillary orthognathic surgery (n = 138) and who were grouped based on the type of maxillary movement (ie, maxillary advancement with intrusion [MAI], maxillary advancement with extrusion [MAE], and maxillary setback with intrusion [MSI]). Preoperative and 12-month postoperative nasal widths were analyzed photogrammetrically by 2 blinded evaluators. Results: Maxillary advancement with intrusion and MAE presented a significantly (P < 0.05) higher alar base widening than MSI did, with no significant (P > 0.05) differences between MAI and MAE. Maxillary advancement movements (MAI and MAE) showed significantly (P < 0.05) higher alar base widening than maxillary setback movement (MSI). However, no significant (P > 0.05) difference was observed between maxillary intrusion (MAI and MSI) and maxillary extrusion (MAE) movements. Conclusions: This study shows that the nasal width varies distinctly depending on the type of Le Fort I maxillary surgical movement.
MeSH term(s)	Cephalometry ; Humans ; Maxilla/surgery ; Orthognathic Surgical Procedures ; Osteotomy, Le Fort ; Photogrammetry ; Retrospective Studies
Language	English
Publishing date	2021-01-11
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	423835-7
ISSN	1536-3708 ; 0148-7043
ISSN (online)	1536-3708
ISSN	0148-7043
DOI	10.1097/SAP.0000000000002658
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Article ; Online: Corrigendum to Zhang J, Cai J, Cui Y, Jiang S, Wei J, Kim YC, Chan J, Thalakola A, Le T, Xu L, Wang L, Jiang K, Wang X, Wang H, Cheng F, Buggs J, Koepsell H, Vallon V, Liu R. "Role of the macula densa sodium glucose cotransporter type 1-neuronal nitric oxide synthase-tubuloglomerular feedback pathway in diabetic hyperfiltration." Kidney Int. 2022;101:541-550.

Zhang, Jie / Cai, Jing / Cui, Yu / Jiang, Shan / Wei, Jin / Kim, Young Chul / Chan, Jenna / Thalakola, Anish / Le, Thanh / Xu, Lan / Wang, Lei / Jiang, Kun / Wang, Ximing / Wang, Haibo / Cheng, Feng / Buggs, Jacentha / Koepsell, Hermann / Vallon, Volker / Liu, Ruisheng

Kidney international

2022 Volume 102, Issue 2, Page(s) 448

Language	English
Publishing date	2022-07-20
Publishing country	United States
Document type	Published Erratum
ZDB-ID	120573-0
ISSN	1523-1755 ; 0085-2538
ISSN (online)	1523-1755
ISSN	0085-2538
DOI	10.1016/j.kint.2022.05.011
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Article: Effect of Le Fort I Maxillary Advancement and Clockwise Rotation on the Anteromedial Cheek Soft Tissue Change in Patients with Skeletal Class III Pattern and Midface Deficiency: A 3D Imaging-Based Prediction Study.

Lai, Hsin-Chih / Denadai, Rafael / Ho, Cheng-Ting / Lin, Hsiu-Hsia / Lo, Lun-Jou

Journal of clinical medicine

2020 Volume 9, Issue 1

Abstract: ... cheek region. Le Fort I maxillary advancement and rotational movements correct the problem ...

Abstract	Patients with a skeletal Class III deformity may present with a concave contour of the anteromedial cheek region. Le Fort I maxillary advancement and rotational movements correct the problem but information on the impact on the anteromedial cheek soft tissue change has been insufficient to date. This three-dimensional (3D) imaging-assisted study assessed the effect of surgical maxillary advancement and clockwise rotational movements on the anteromedial cheek soft tissue change. Two-week preoperative and 6-month postoperative cone-beam computed tomography scans were obtained from 48 consecutive patients who received 3D-guided two-jaw orthognathic surgery for the correction of Class III malocclusion associated with a midface deficiency and concave facial profile. Postoperative 3D facial bone and soft tissue models were superimposed on the corresponding preoperative models. The region of interest at the anteromedial cheek area was defined. The 3D cheek volumetric change (mm
Language	English
Publishing date	2020-01-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm9010262
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Article: [Comparison of three surgical techniques for controlling nasal width after Le Fort I osteotomy].

Wang, Zong-qi / Wang, Xiao-xia / Li, Zi-li / Yi, Biao / Liang, Cheng / Wang, Xin

Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences

2015 Volume 47, Issue 1, Page(s) 104–108

Abstract: Objective: To identify nasal width changes occurring after Le Fort I osteotomy and to compare ... In the study, 79 patients (22 male and 57 female, mean age 23.2 ± 3.4 years), who received Le ... for controlling nasal width widening after Le Fort I osteotomy. The postoperative nasal width-widening can't be ...

Abstract	Objective: To identify nasal width changes occurring after Le Fort I osteotomy and to compare prospectively the effect of three surgical techniques for controlling postoperative nasal width. Methods: In the study, 79 patients (22 male and 57 female, mean age 23.2 ± 3.4 years), who received Le Fort I osteotomy at Peking University Hospital of Stomatology from 2011 to 2014, were randomly divided into three groups. Group 1 was treated with traditional intraoral alar base cinch suture (ABCS); Group 2 with extraoral ABCS, and Group 3 with traditional ABCS plus an extra intraoral suture at points G.lat. All the patients had taken 3D photos using 3dMD camera before operation, and 3, and 6 months after operation. The nasal widths, which were indicated as distances between Sbal-Sbal, G.lat-G.lat and Al-Al, were measured by two examiners in the 3D photos three times with a time-interval of one week. SPSS 13.0 was used to do the statistic analysis. Results: At the end of the postoperative 6 months, the nasal widths lessened as compared with the postoperative 3 months. No significant differences were found between the three groups 6 months after the operation. The degree of the postoperative nasal width widening had positive correlation with that of the intraoperative nasal width widening, and had negative correlation with the initial nasal width and the amount of post-suture narrowing. Conclusion: There is no difference between three suturing techniques for controlling nasal width widening after Le Fort I osteotomy. The postoperative nasal width-widening can't be totally avoided, and the alteration might last at least 6 months after the operation. For patients with narrow nasal width and need to move maxilla forward, more overcorrection of ABCS is needed to control the postoperative nasal base widening.
MeSH term(s)	Adult ; Dental Materials ; Facial Bones ; Female ; Humans ; Male ; Maxilla ; Nose/anatomy & histology ; Osteotomy ; Osteotomy, Le Fort ; Postoperative Period ; Reconstructive Surgical Procedures ; Suture Techniques ; Young Adult
Chemical Substances	Dental Materials
Language	Chinese
Publishing date	2015-02-18
Publishing country	China
Document type	Comparative Study ; English Abstract ; Journal Article ; Randomized Controlled Trial
ISSN	1671-167X
ISSN	1671-167X
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Article: [Application of the cone beam computed tomography (CBCT) in Le Fort I osteotomy].

Hou, Min / Zhang, Lan-cheng / Zhang, Xi-zhong / Song, Da-li / Du, Qing-xiang / Liu, Chun-ming

Zhonghua zheng xing wai ke za zhi = Zhonghua zhengxing waike zazhi = Chinese journal of plastic surgery

2011 Volume 27, Issue 4, Page(s) 246–249

Abstract: Objective: To improve the accuracy and safety of the Le Fort I osteotomy.: Methods: Eighty-four ... could provide sufficient and valuable information in diagnosis and design for Le ... Fort I osteotomy.: Conclusions: CBCT imaging technology could provide precise anatomic images for Le ...

Abstract	Objective: To improve the accuracy and safety of the Le Fort I osteotomy. Methods: Eighty-four patients underwent CBCT scan before maxillary orthognathic surgery. The anatomic structures of maxilla were marked and measured. Results: In 84 cases, there were 3 cases with severe hypoplasia of maxillary sinus, 11 cases with impacted third molar, 8 cases with separation in maxillary sinus, 4 cases with the deviation of nasal septum, and 3 cases with cysts in maxillary sinus. Form CBCT images, the position of the pterygopalatine canal, the thickness of maxillary wall, hidden lesion of maxillary sinus, the location of Impacted molar, the deviation of nasal septum, and other anatomic structure could be accurately localized. CBCT could provide sufficient and valuable information in diagnosis and design for Le Fort I osteotomy. Conclusions: CBCT imaging technology could provide precise anatomic images for Le Fort I osteotomy. It improves the accuracy and safety of the Le Fort I osteotomy.
MeSH term(s)	Adolescent ; Adult ; Female ; Humans ; Male ; Osteotomy, Le Fort/methods ; Tomography, X-Ray Computed/methods ; Young Adult
Language	Chinese
Publishing date	2011-07
Publishing country	China
Document type	English Abstract ; Journal Article
ZDB-ID	2019799-8
ISSN	1009-4598 ; 1000-7806
ISSN	1009-4598 ; 1000-7806
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Article ; Online: Effect of Le Fort I Maxillary Advancement and Clockwise Rotation on the Anteromedial Cheek Soft Tissue Change in Patients with Skeletal Class III Pattern and Midface Deficiency

Hsin-Chih Lai / Rafael Denadai / Cheng-Ting Ho / Hsiu-Hsia Lin / Lun-Jou Lo

Journal of Clinical Medicine, Vol 9, Iss 1, p

A 3D Imaging-Based Prediction Study

2020 Volume 262

Abstract: ... cheek region. Le Fort I maxillary advancement and rotational movements correct the problem ... similar (all p > 0.05) to the 3D norm value (2.15 ± 1.2 mm). This study showed that both Le Fort ...

Abstract	Patients with a skeletal Class III deformity may present with a concave contour of the anteromedial cheek region. Le Fort I maxillary advancement and rotational movements correct the problem but information on the impact on the anteromedial cheek soft tissue change has been insufficient to date. This three-dimensional (3D) imaging-assisted study assessed the effect of surgical maxillary advancement and clockwise rotational movements on the anteromedial cheek soft tissue change. Two-week preoperative and 6-month postoperative cone-beam computed tomography scans were obtained from 48 consecutive patients who received 3D-guided two-jaw orthognathic surgery for the correction of Class III malocclusion associated with a midface deficiency and concave facial profile. Postoperative 3D facial bone and soft tissue models were superimposed on the corresponding preoperative models. The region of interest at the anteromedial cheek area was defined. The 3D cheek volumetric change (mm 3 postoperative minus preoperative models) and the preoperative surface area (mm 2 ) were computed to estimate the average sagittal movement (mm). The 3D cheek mass position from orthognathic surgery-treated patients was compared with published 3D normative data. Surgical maxillary advancement (all p < 0.001) and maxillary rotation (all p < 0.006) had a significant effect on the 3D anteromedial cheek soft tissue change. In total, 78.9%, 78.8%, and 78.8% of the variation in the cheek soft tissue sagittal movement was explained by the variation in the maxillary advancement and rotation movements for the right, left, and total cheek regions, respectively. The multiple linear regression models defined ratio values (relationship) between the 3D cheek soft tissue sagittal movement and maxillary bone advancement and rotational movements of 0.627 and 0.070, respectively. Maxillary advancements of 3−4 mm and >4 mm resulted in a 3D cheek mass position (1.91 ± 0.53 mm and 2.36 ± 0.72 mm, respectively) similar (all p > 0.05) to the 3D norm value (2.15 ± 1.2 mm). This study showed that both Le Fort I maxillary advancement and rotational movements affect the anteromedial cheek soft tissue change, with the maxillary advancement movement presenting a larger effect on the cheek soft tissue movement than the maxillary rotational movement. These findings can be applied in future multidisciplinary-based decision-making processes for planning and executing orthognathic surgery.
Keywords	maxilla advancement ; maxilla rotation ; cheek mass ; midface deficiency ; Medicine ; R
Subject code	616
Language	English
Publishing date	2020-01-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article ; Online: 3'-Sulfo-Le(x) is important for regulation of integrin subunit alphaV.

Zhang, Chun-Yi / Hu, Ping / Fu, Da / Wu, Wei / Jia, Cheng-You / Zhu, Xu Chao / Wu, Xing Zhong

Biochemistry

2010 Volume 49, Issue 36, Page(s) 7811–7820

Abstract: Carbohydrate structures with a 3'-sulfo betaGal linkage, such as 3'-sulfo-Le(x), can be synthesized ... in many biological processes. To investigate the role of Gal3ST-2 and its product 3'-sulfo-Le(x), we depleted Gal3ST-2 via ... Therefore, Gal3ST-2 and its product, 3'-sulfo-Le(x), were involved in regulation of integrin subunit alphaV and ...

Abstract	Carbohydrate structures with a 3'-sulfo betaGal linkage, such as 3'-sulfo-Le(x), can be synthesized by Gal:3-O-sulfotransferase-2 (Gal3ST-2) catalysis, but little is known about their roles in many biological processes. To investigate the role of Gal3ST-2 and its product 3'-sulfo-Le(x), we depleted Gal3ST-2 via siRNA and added exogenous Lewis-x trisaccharide 3'-sulfate sodium salt in human SMMC7721 hepatoma cells. After siRNA transfection, a striking morphological change in SMMC7721 hepatoma cells from polygon to shuttle shape and a significant decrease in the level of adhesion to sL-selectin, HUVEC, fibronectin, vitronectin, and fibrinogen were observed. The expression of integrin subunit alphaV was markedly downregulated, and 3'-sulfated subunit alphaV almost disappeared in the transfectants. The level of cell surface integrin alphaVbeta3 was reduced simultaneously, although total subunit beta3 underwent almost no change. After treatment with exogenous Lewis-x 3'-sulfate, cellular integrin subunit alphaV was upregulated and the level of cell surface integrin alphaVbeta3 was elevated. Interestingly, knockdown of Gal3ST-2 expression effectively inhibited cell proliferation, and the result was significantly correlated with the decrease in the levels of ILK, phosphorylated AKT, and ERK. On the other hand, treatment with Lewis-x trisaccharide 3'-sulfate sodium salt greatly upregulated the phosphorylation of AKT and ERK. Our results also indicated that downregulation of Gal3ST-2 via siRNA transfection was associated with the decrease in the level of expression of anti-apoptotic protein, Bcl-2, with a consequent decrease in the ratios for Bcl-2 to Bax. By exposure to Lewis-x trisaccharide 3'-sulfate sodium salt, the apoptotic response of cells was inhibited. Therefore, Gal3ST-2 and its product, 3'-sulfo-Le(x), were involved in regulation of integrin subunit alphaV and might be associated with cancer cell regulation.
MeSH term(s)	Cell Line, Tumor ; Cell Proliferation ; Down-Regulation ; Humans ; Integrin alphaV/chemistry ; Integrin alphaV/metabolism ; Oligosaccharides/pharmacology ; Oligosaccharides/physiology ; RNA, Small Interfering/metabolism ; Sulfotransferases/antagonists & inhibitors ; Sulfotransferases/genetics ; Sulfotransferases/metabolism ; Transfection ; Trisaccharides/chemistry
Chemical Substances	3-sulfated Lewis x ; Integrin alphaV ; Oligosaccharides ; RNA, Small Interfering ; Trisaccharides ; galactosyl-(1,4)-fucopyranosyl-(1,3)-N-acetylglucosamine ; Sulfotransferases (EC 2.8.2.-) ; galactose-3-O-sulfotransferase 3 (EC 2.8.2.-)
Language	English
Publishing date	2010-09-14
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1108-3
ISSN	1520-4995 ; 0006-2960
ISSN (online)	1520-4995
ISSN	0006-2960
DOI	10.1021/bi101040k
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Article: [Comparative analysis of two surgical techniques for controlling nasal width after Le Fort I osteotomy].

Wang, Miao-Zhen / Wang, Xiao-Xia / Li, Zi-Li / Y I, Biao / Liang, Cheng / Wang, Xing

Zhonghua zheng xing wai ke za zhi = Zhonghua zhengxing waike zazhi = Chinese journal of plastic surgery

2013 Volume 29, Issue 3, Page(s) 184–188

Abstract: ... Le Fort I osteotomy.: Methods: Fifty-five patients who received the Le Fort I osteotomy have been included ... control the alar base widening after Le Fort I osteotomy. ...

Abstract	Objective: To compare the efficacy of two surgical techniques for controllong nasal width after Le Fort I osteotomy. Methods: Fifty-five patients who received the Le Fort I osteotomy have been included in this study. They were randomly divided into 2 groups. The experimental group received extraoral ABS, and the control group received traditional intraoral ABS. 3D photos of the patient's face were taken before operation and at postoperative 3 months. Alar width was measured on the 3D photos. Data was reported as means and standard deviations, and statistic analysis was done by using student t test. Results: Compared with presurgical data, G. lat-G. lat increased by (2.66 +/- 1.47) mm, Al-Al increased by (2.20 +/- 1.22) mm and Sbal-Sbal increased by (1.30 +/- 1.33) mm in experimental group. G. lat-G. lat increased by (1.38 +/- 1.29) mm, Al-Al increased by (1.06 +/- 0.95) mm and Sbal-Sbal increased by (0.36 +/- 1.33) mm in the control group. There was significant difference between two groups. Conclusions: The surgical technique of ABS is the most important factor for determining the postoperative alar width. Both techniques have better effect on the Sbal-Sbal width control than the G. lat-G. lat and Al-Al width control. Traditional intraoral ABS can more effectively control the alar width. Both techniques cannot completely control the alar base widening after Le Fort I osteotomy.
MeSH term(s)	Face ; Humans ; Nose/anatomy & histology ; Nose Deformities, Acquired/surgery ; Osteotomy, Le Fort/adverse effects ; Photography
Language	Chinese
Publishing date	2013-05
Publishing country	China
Document type	Comparative Study ; English Abstract ; Journal Article ; Randomized Controlled Trial
ZDB-ID	2019799-8
ISSN	1009-4598 ; 1000-7806
ISSN	1009-4598 ; 1000-7806
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Article ; Online: Simultaneous Le Fort I, II, and III osteotomies for correction of midface deficiency in Apert disease.

Dai, Jiewen / Wang, Xudong / Yu, Hongbo / Cheng, Jie / Yuan, Hao / Gui, Haijun / Shen, Shunyao / Shen, Guofang

The Journal of craniofacial surgery

2012 Volume 23, Issue 5, Page(s) 1391–1395

Abstract: Le Fort III osteotomy was usually applied to correct midface hypoplasia in Apert syndrome, and ... the simultaneous Le Fort I, II, and III osteotomies for segmental advancement of midface deficiency involving ... and right zygoma, with simultaneous Le Fort I, Le Fort II, and Le Fort III osteotomies, and ...

Abstract	Le Fort III osteotomy was usually applied to correct midface hypoplasia in Apert syndrome, and various surgical modifications have been developed in recent years. In this article, we reported the simultaneous Le Fort I, II, and III osteotomies for segmental advancement of midface deficiency involving nasal bones, zygoma, inferior orbital rims, and maxilla in an adult Chinese patient with Apert syndrome. To achieve the ideal advancement of different parts of midface simultaneously, we divided the midface into 4 segments, including nasal bone combined with upper portion of maxilla, lower portion of maxilla, and left and right zygoma, with simultaneous Le Fort I, Le Fort II, and Le Fort III osteotomies, and each segment was repositioned as required respectively to obtain ideal facial aesthetics and favorable occlusion. The long-term stability of bony segment advancements also was observed during 7-year follow-up. Compared with segmental distraction osteogenesis or multiple-stage surgery, which mainly applied to younger patients with more severe midface hypoplasia, this single-stage strategy offered a reliable surgical alternative for treating adult patient with midface hypoplasia that should be corrected in different levels.
MeSH term(s)	Acrocephalosyndactylia/diagnostic imaging ; Acrocephalosyndactylia/surgery ; Facial Bones/diagnostic imaging ; Facial Bones/surgery ; Humans ; Male ; Orthodontics, Corrective ; Osteotomy, Le Fort/methods ; Tomography, X-Ray Computed ; Young Adult
Language	English
Publishing date	2012-09
Publishing country	United States
Document type	Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1159501-2
ISSN	1536-3732 ; 1049-2275
ISSN (online)	1536-3732
ISSN	1049-2275
DOI	10.1097/SCS.0b013e3182565a5d
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