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Article ; Online: Sequential Multilocus Repetitive Transcranial Magnetic Stimulation for Treatment of Tinnitus With and Without Comorbid Major Depressive Disorder.

Berman, Zoe R / Citrenbaum, Cole / Corlier, Juliana / Leuchter, Andrew F / Folmer, Robert L / Leuchter, Michael K

Neuromodulation : journal of the International Neuromodulation Society

2024

Abstract: Objective: Repetitive transcranial magnetic stimulation (rTMS) is a promising treatment for tinnitus, although outcomes are highly variable. We previously described a multilocus sequential rTMS treatment protocol for tinnitus involving stimulation of ... ...

Abstract	Objective: Repetitive transcranial magnetic stimulation (rTMS) is a promising treatment for tinnitus, although outcomes are highly variable. We previously described a multilocus sequential rTMS treatment protocol for tinnitus involving stimulation of both prefrontal and auditory targets. In this study, we report results using this approach in an open-label treatment study of tinnitus with and without comorbid major depressive disorder (MDD). Materials and methods: Forty patients with chronic tinnitus (mean age 56 years, ten female) and with (n = 17) or without (n = 23) MDD received multilocus rTMS administered sequentially to 1) left dorsolateral prefrontal cortex, followed by 2) auditory cortex (Heschel's gyrus). Patients completed weekly self-report ratings using the Tinnitus Functional Index (TFI) and Tinnitus Handicap Inventory, and patients with MDD completed the Inventory of Depressive Symptomatology Self-Report 30-item. Results: Patients showed significant mean improvement in tinnitus at sessions 5 (mean TFI improvement 6.8 points ± 12.2, p = 0.002) and 10 (mean improvement 9.2 points ± 14.1, p = 0.002), with 48% of patients responding within ten treatment sessions. Responders were significantly older than nonresponders (61.5 ± 15 years vs 51.3 ± 16 years), and there was a trend toward decreased likelihood of response in subjects with comorbid MDD compared with subjects without comorbidity (odds ratio = 0.28, p = 0.06). Patients with comorbid MDD reported significantly less improvement after ten sessions than did those with tinnitus alone (4.3 ± 10.3 vs 14.7 ± 15.0 points, p = 0.04). Post hoc analyses suggested that the comorbid group achieved improvement comparable to that of the tinnitus-only group after 30 treatments. Conclusions: Patients showed significant improvement in tinnitus from multilocus sequential rTMS treatment, and those with tinnitus alone improved more quickly. Those with depression who continued rTMS through a full 30-session course further improved, indicating that tinnitus with comorbid MDD may respond with extended treatment.
Language	English
Publishing date	2024-02-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	1500372-3
ISSN	1525-1403 ; 1094-7159
ISSN (online)	1525-1403
ISSN	1094-7159
DOI	10.1016/j.neurom.2024.01.001
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Article: Allopregnanolone Improves Locomotor Activity and Arousal in the Aged CGG Knock-in Mouse Model of Fragile X-Associated Tremor/Ataxia Syndrome.

Schwartzer, Jared J / Garcia-Arocena, Dolores / Jamal, Amanda / Izadi, Ali / Willemsen, Rob / Berman, Robert F

Frontiers in neuroscience

2021 Volume 15, Page(s) 752973

Abstract: Carriers of the fragile X premutation (PM) can develop a variety of early neurological symptoms, including depression, anxiety and cognitive impairment as well as being at risk for developing the late-onset fragile X-associated tremor/ataxia syndrome ( ... ...

Abstract	Carriers of the fragile X premutation (PM) can develop a variety of early neurological symptoms, including depression, anxiety and cognitive impairment as well as being at risk for developing the late-onset fragile X-associated tremor/ataxia syndrome (FXTAS). The absence of effective treatments for FXTAS underscores the importance of developing efficacious therapies to reduce the neurological symptoms in elderly PM carriers and FXTAS patients. A recent preliminary study reported that weekly infusions of Allopregnanolone (Allop) may improve deficits in executive function, learning and memory in FXTAS patients. Based on this study we examined whether Allop would improve neurological function in the aged CGG knock-in (CGG KI) dutch mouse, B6.129P2(Cg)-Fmr1
Language	English
Publishing date	2021-12-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2411902-7
ISSN	1662-453X ; 1662-4548
ISSN (online)	1662-453X
ISSN	1662-4548
DOI	10.3389/fnins.2021.752973
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Article ; Online: Ultramassive transfusion and adjunctive therapies in a case of blood bank depletion.

Jackson, Max / Berman, Spencer / Rueda, Mario / Borrego, Robert / Lottenberg, Lawrence / Azar, Faris

Trauma case reports

2023 Volume 48, Page(s) 100955

Abstract: Background: We present the case of a patient who presents with a high velocity thoracoabdominal gunshot wound requiring ultramassive transfusion who exhausted the county blood bank requiring adjunctive therapies to balanced blood product transfusion ... ...

Abstract	Background: We present the case of a patient who presents with a high velocity thoracoabdominal gunshot wound requiring ultramassive transfusion who exhausted the county blood bank requiring adjunctive therapies to balanced blood product transfusion while additional blood products could be obtained. Summary: Thoracoabdominal gunshot wounds carry a high mortality of 14-37 % because of the risk to produce cardiopulmonary, solid organ as well as major vascular injuries (Mandal and Oparah (1989) [1]). Ultramassive transfusion (>20 units of blood product transfusion) also carries high morbidity and mortality and management has generally centered on balanced transfusion (Matthay et al. (2021) [2]). Conclusion: Balanced blood product transfusion reduces mortality for patients requiring ultramassive transfusion but when this is not possible utilization of adjuncts to blood products may temporize resuscitation until additional blood products can be obtained.
Language	English
Publishing date	2023-10-18
Publishing country	Netherlands
Document type	Case Reports
ZDB-ID	2835433-3
ISSN	2352-6440 ; 2352-6440
ISSN (online)	2352-6440
ISSN	2352-6440
DOI	10.1016/j.tcr.2023.100955
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Article ; Online: Diagnostic and prognostic implications of a three-antibody molecular subtyping algorithm for non-muscle invasive bladder cancer.

Jackson, Chelsea L / Chen, Lina / Hardy, Céline Sc / Ren, Kevin Ym / Visram, Kash / Bratti, Vanessa F / Johnstone, Jeannette / Sjödahl, Gottfrid / Siemens, David Robert / Gooding, Robert J / Berman, David M

The journal of pathology. Clinical research

2021 Volume 8, Issue 2, Page(s) 143–154

Abstract: Intrinsic molecular subtypes may explain marked variation between bladder cancer patients in prognosis and response to therapy. Complex testing algorithms and little attention to more prevalent, early-stage (non-muscle invasive) bladder cancers (NMIBCs) ... ...

Abstract	Intrinsic molecular subtypes may explain marked variation between bladder cancer patients in prognosis and response to therapy. Complex testing algorithms and little attention to more prevalent, early-stage (non-muscle invasive) bladder cancers (NMIBCs) have hindered implementation of subtyping in clinical practice. Here, using a three-antibody immunohistochemistry (IHC) algorithm, we identify the diagnostic and prognostic associations of well-validated proteomic features of basal and luminal subtypes in NMIBC. By IHC, we divided 481 NMIBCs into basal (GATA3
MeSH term(s)	Algorithms ; Biomarkers, Tumor/metabolism ; Humans ; Prognosis ; Proteomics ; Urinary Bladder Neoplasms/diagnosis ; Urinary Bladder Neoplasms/pathology
Chemical Substances	Biomarkers, Tumor
Language	English
Publishing date	2021-10-26
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2814357-7
ISSN	2056-4538 ; 2056-4538
ISSN (online)	2056-4538
ISSN	2056-4538
DOI	10.1002/cjp2.245
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Article ; Online: Left ventricular morphologic progression in apical hypertrophic cardiomyopathy.

Lee, Mirae / Shechter, Alon / Han, Donghee / Nguyen, Long-Co / Kim, Min Sun / Berman, Daniel S / Rader, Florian / Siegel, Robert J

International journal of cardiology

2023 Volume 381, Page(s) 62–69

Abstract: Background: Left ventricular (LV) morphologic progression in apical hypertrophic cardiomyopathy (AHC) has not been well studied. We evaluated serial echocardiographic changes in LV morphology.: Methods: Serial echocardiograms in AHC patients were ... ...

Abstract	Background: Left ventricular (LV) morphologic progression in apical hypertrophic cardiomyopathy (AHC) has not been well studied. We evaluated serial echocardiographic changes in LV morphology. Methods: Serial echocardiograms in AHC patients were assessed. LV morphology was categorized according to the presence of an apical pouch or aneurysm, and LV hypertrophic severity and extent; relative, pure, and apical-mid type defined as mild (<15 mm thickness) apical hypertrophy, significant (≥15 mm) apical hypertrophy, and both apical and midventricular hypertrophy, respectively. Adverse clinical events and late gadolinium enhancement (LGE) extent on cardiac magnetic resonance were evaluated for each morphologic type. Results: In 41 patients, 165 echocardiograms (maximal interval: 4.2 [IQR, 2.3-11.8] years) were evaluated. Morphologic changes were observed in 19 (46%) patients. Eleven (27%) patients displayed the progression of LV hypertrophy toward pure or apical-mid type. Five (12%) and 6 (15%) patients developed new pouches and aneurysms. Patients with progression tended to be younger (50 ± 15.6 vs 59 ± 14.4 years, P = 0.058) and had a longer period of follow-up (12 [5-14] vs 3 [2-4] years, P < 0.001). During a follow-up of 7.6 (IQR 3.0-12.1) years, 21 (51%) experienced clinical events. The relative, pure, and apical-mid types showed different LGE extents (2%, 6%, and 19%, P = 0.004). Patients with severe hypertrophic and apical involvement showed higher clinical event rates. Conclusions: About half of AHC patients had a progression of LV morphology to more hypertrophic involvement and/or an apical pouch or aneurysm formation. Advanced AHC morphologic types were associated with higher event rates and scar burdens.
MeSH term(s)	Humans ; Cardiomyopathy, Hypertrophic/complications ; Apical Hypertrophic Cardiomyopathy ; Contrast Media ; Gadolinium ; Hypertrophy, Left Ventricular/diagnostic imaging ; Hypertrophy, Left Ventricular/complications
Chemical Substances	Contrast Media ; Gadolinium (AU0V1LM3JT)
Language	English
Publishing date	2023-04-05
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	779519-1
ISSN	1874-1754 ; 0167-5273
ISSN (online)	1874-1754
ISSN	0167-5273
DOI	10.1016/j.ijcard.2023.04.006
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Zs.A 1673: Show issues

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Article ; Online: What has been learned from mouse models of the Fragile X Premutation and Fragile X-associated tremor/ataxia syndrome?

Foote, Molly M / Careaga, Milo / Berman, Robert F

The Clinical neuropsychologist

2016 Volume 30, Issue 6, Page(s) 960–972

Abstract: Objective: To describe in this review how research using mouse models developed to study the Fragile X premutation (PM) and Fragile X-associated tremor/ataxia syndrome (FXTAS) have contributed to understanding these disorders. PM carriers bear an ... ...

Abstract	Objective: To describe in this review how research using mouse models developed to study the Fragile X premutation (PM) and Fragile X-associated tremor/ataxia syndrome (FXTAS) have contributed to understanding these disorders. PM carriers bear an expanded CGG trinucleotide repeat on the Fragile X Mental Retardation 1 (FMR1) gene, and are at risk for developing the late onset neurodegenerative disorder FXTAS. Conclusions: Much has been learned about these genetic disorders from the development and study of mouse models. This includes new insights into the early cellular and molecular events that occur in PM carriers and in FXTAS, the presence of multiorgan pathology beyond the CNS, immunological dysregulation, unexpected synthesis of a potentially toxic peptide in FXTAS (i.e., FMRpolyG), and evidence that the disease process may be halted or reversed by appropriate molecular therapies given early in the course of disease.
MeSH term(s)	Animals ; Ataxia/genetics ; Ataxia/pathology ; Disease Models, Animal ; Fragile X Mental Retardation Protein/genetics ; Fragile X Syndrome/genetics ; Fragile X Syndrome/pathology ; Humans ; Male ; Mice ; Mutation/genetics ; Neuropsychological Tests ; Tremor/genetics ; Tremor/pathology ; Trinucleotide Repeat Expansion/genetics
Chemical Substances	Fragile X Mental Retardation Protein (139135-51-6)
Language	English
Publishing date	2016-08
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	639080-8
ISSN	1744-4144 ; 0920-1637 ; 1385-4046
ISSN (online)	1744-4144
ISSN	0920-1637 ; 1385-4046
DOI	10.1080/13854046.2016.1158254
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Article ; Online: Evaluation of Microsatellite Typing, ITS Sequencing, AFLP Fingerprinting, MALDI-TOF MS, and Fourier-Transform Infrared Spectroscopy Analysis of

Vatanshenassan, Mansoureh / Boekhout, Teun / Mauder, Norman / Robert, Vincent / Maier, Thomas / Meis, Jacques F / Berman, Judith / Then, Euníce / Kostrzewa, Markus / Hagen, Ferry

Journal of fungi (Basel, Switzerland)

2020 Volume 6, Issue 3

Abstract: ... Candida ... ...

Abstract	Candida auris
Language	English
Publishing date	2020-08-25
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2784229-0
ISSN	2309-608X ; 2309-608X
ISSN (online)	2309-608X
ISSN	2309-608X
DOI	10.3390/jof6030146
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Article ; Online: Increased CT angiography-derived extracellular volume fraction predicts less benefit in left ventricular remodeling and ejection fraction after transcatheter edge to edge repair for severe mitral regurgitation.

Malhotra, Pankaj / Han, Donghee / Chakravarty, Tarun / Thomson, Louise / Dey, Damini / Nakamura, Mamoo / Patel, Dhairya / Harutyunyan, Izabela / Tamarappoo, Balaji / Skaf, Sabah / Singh, Siddharth / Rader, Florian / Siegel, Robert / Friedman, John / Makkar, Raj / Berman, Daniel

Journal of cardiovascular computed tomography

2024 Volume 18, Issue 2, Page(s) 217–218

MeSH term(s)	Humans ; Mitral Valve Insufficiency/diagnostic imaging ; Mitral Valve Insufficiency/surgery ; Stroke Volume ; Ventricular Remodeling ; Computed Tomography Angiography ; Predictive Value of Tests ; Ventricular Function, Left ; Treatment Outcome ; Heart Valve Prosthesis Implantation
Language	English
Publishing date	2024-02-01
Publishing country	United States
Document type	Letter
ZDB-ID	2394360-9
ISSN	1876-861X ; 1934-5925
ISSN (online)	1876-861X
ISSN	1934-5925
DOI	10.1016/j.jcct.2024.01.002
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Zs.A 6761: Show issues

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Article ; Online: The fitness costs and benefits of trisomy of each Candida albicans chromosome.

Yang, Feng / Todd, Robert T / Selmecki, Anna / Jiang, Yuan-Ying / Cao, Yong-Bing / Berman, Judith

Genetics

2021 Volume 218, Issue 2

Abstract: Candida albicans is a prevalent human fungal pathogen. Rapid genomic change, due to aneuploidy, is a common mechanism that facilitates survival from multiple types of stresses including the few classes of available antifungal drugs. The stress survival ... ...

Abstract	Candida albicans is a prevalent human fungal pathogen. Rapid genomic change, due to aneuploidy, is a common mechanism that facilitates survival from multiple types of stresses including the few classes of available antifungal drugs. The stress survival of aneuploids occurs despite the fitness costs attributed to most aneuploids growing under idealized lab conditions. Systematic study of the aneuploid state in C. albicans has been hindered by the lack of a comprehensive collection of aneuploid strains. Here, we describe a collection of diploid C. albicans aneuploid strains, each carrying one extra copy of each chromosome, all from the same genetic background. We tested the fitness of this collection under several physiological conditions including shifts in pH, low glucose, oxidative stress, temperature, high osmolarity, membrane stress, and cell wall stress. We found that most aneuploids, under most conditions, were less fit than their euploid parent, yet there were specific conditions under which specific aneuploid isolates provided a fitness benefit relative to the euploid parent strain. Importantly, this fitness benefit was attributable to the change in the copy number of specific chromosomes. Thus, C. albicans can tolerate aneuploidy of each chromosome and some aneuploids confer improved growth under conditions that the yeast encounters in its host niches.
MeSH term(s)	Antifungal Agents/pharmacology ; Antifungal Agents/therapeutic use ; Candida albicans/genetics ; Candidiasis/drug therapy ; Candidiasis/microbiology ; Chromosomes, Fungal/genetics ; Drug Resistance, Fungal/genetics ; Genetic Fitness ; Genome, Fungal ; Host Microbial Interactions/genetics ; Humans ; Trisomy
Chemical Substances	Antifungal Agents
Language	English
Publishing date	2021-04-09
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2167-2
ISSN	1943-2631 ; 0016-6731
ISSN (online)	1943-2631
ISSN	0016-6731
DOI	10.1093/genetics/iyab056
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Article ; Online: Altered behavior, brain structure, and neurometabolites in a rat model of autism-specific maternal autoantibody exposure.

Bruce, Matthew R / Couch, Amalie C M / Grant, Simone / McLellan, Janna / Ku, Katherine / Chang, Christina / Bachman, Angelica / Matson, Matthew / Berman, Robert F / Maddock, Richard J / Rowland, Douglas / Kim, Eugene / Ponzini, Matthew D / Harvey, Danielle / Taylor, Sandra L / Vernon, Anthony C / Bauman, Melissa D / Van de Water, Judy

Molecular psychiatry

2023 Volume 28, Issue 5, Page(s) 2136–2147

Abstract: Maternal immune dysregulation is a prenatal risk factor for autism spectrum disorder (ASD). Importantly, a clinically relevant connection exists between inflammation and metabolic stress that can result in aberrant cytokine signaling and autoimmunity. In ...

Abstract	Maternal immune dysregulation is a prenatal risk factor for autism spectrum disorder (ASD). Importantly, a clinically relevant connection exists between inflammation and metabolic stress that can result in aberrant cytokine signaling and autoimmunity. In this study we examined the potential for maternal autoantibodies (aAbs) to disrupt metabolic signaling and induce neuroanatomical changes in the brains of exposed offspring. To accomplish this, we developed a model of maternal aAb exposure in rats based on the clinical phenomenon of maternal autoantibody-related ASD (MAR-ASD). Following confirmation of aAb production in rat dams and antigen-specific immunoglobulin G (IgG) transfer to offspring, we assessed offspring behavior and brain structure longitudinally. MAR-ASD rat offspring displayed a reduction in pup ultrasonic vocalizations and a pronounced deficit in social play behavior when allowed to freely interact with a novel partner. Additionally, longitudinal in vivo structural magnetic resonance imaging (sMRI) at postnatal day 30 (PND30) and PND70, conducted in a separate cohort of animals, revealed sex-specific differences in total and regional brain volume. Treatment-specific effects by region appeared to converge on midbrain and cerebellar structures in MAR-ASD offspring. Simultaneously, in vivo
MeSH term(s)	Humans ; Male ; Pregnancy ; Female ; Rats ; Animals ; Autistic Disorder/metabolism ; Autism Spectrum Disorder/metabolism ; Autoantibodies ; Prenatal Exposure Delayed Effects/metabolism ; Brain/metabolism ; Maternal Exposure
Chemical Substances	Autoantibodies
Language	English
Publishing date	2023-03-27
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1330655-8
ISSN	1476-5578 ; 1359-4184
ISSN (online)	1476-5578
ISSN	1359-4184
DOI	10.1038/s41380-023-02020-3
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