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Article ; Online: Artificial Biosynthetic Pathway for Efficient Synthesis of Vanillin, a Feruloyl-CoA-Derived Natural Product from Eugenol.

Zhu, Xiaochong / Wu, Jieyuan / Li, Shizhong / Xiang, La / Jin, Jian-Ming / Liang, Chaoning / Tang, Shuang-Yan

Journal of agricultural and food chemistry

2024 Volume 72, Issue 12, Page(s) 6463–6470

Abstract: Eugenol, the main component of essential oil from ... ...

Abstract	Eugenol, the main component of essential oil from the
MeSH term(s)	Eugenol/metabolism ; Biosynthetic Pathways ; Acyl Coenzyme A ; Benzaldehydes ; Coumaric Acids
Chemical Substances	ferulic acid (AVM951ZWST) ; Eugenol (3T8H1794QW) ; vanillin (CHI530446X) ; feruloyl-CoA ; Acyl Coenzyme A ; Benzaldehydes ; Coumaric Acids
Language	English
Publishing date	2024-03-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	241619-0
ISSN	1520-5118 ; 0021-8561
ISSN (online)	1520-5118
ISSN	0021-8561
DOI	10.1021/acs.jafc.3c08723
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Zs.A 1172: Show issues

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Article ; Online: Task specific monolith for magnetic field-reinforced in-tube solid phase microextraction of mercury species in waters prior to online HPLC quantification.

Song, Xiaochong / Wu, Jiangyi / Pang, Jinling / Wu, Yuanfei / Huang, Xiaojia

Journal of hazardous materials

2021 Volume 411, Page(s) 125141

Abstract: In this study, a novel sorbent based on task specific monolith doped with ... ...

Abstract	In this study, a novel sorbent based on task specific monolith doped with Fe
Language	English
Publishing date	2021-01-15
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1491302-1
ISSN	1873-3336 ; 0304-3894
ISSN (online)	1873-3336
ISSN	0304-3894
DOI	10.1016/j.jhazmat.2021.125141
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Article ; Online: Fabrication of functional group-rich monoliths for magnetic field-assisted in-tube solid phase microextraction of inorganic selenium species in water samples followed by online chromatographic determination.

Song, Xiaochong / Luo, Siyu / Liu, Jun / Wu, Yuanfei / Huang, Xiaojia

The Analyst

2022 Volume 147, Issue 7, Page(s) 1499–1508

Abstract: Efficient separation and enrichment is a crucial step in the analysis of Se(IV) and Se(VI). In the present study, for the first time, online monolith-based magnetic field-assisted in-tube solid phase microextraction (MFA/IT-SPME) was applied to capture ... ...

Abstract	Efficient separation and enrichment is a crucial step in the analysis of Se(IV) and Se(VI). In the present study, for the first time, online monolith-based magnetic field-assisted in-tube solid phase microextraction (MFA/IT-SPME) was applied to capture inorganic selenium species in water samples. To this aim, porous monoliths mixed with magnetic nanoparticles were synthesized in a silica capillary and employed as a microextraction column (MEC) for MFA/IT-SPME. After that, a magnetic coil utilized to induce variable magnetic fields in adsorption and desorption steps was entwined around the MEC. Se(IV) was coordinated with
MeSH term(s)	Magnetic Fields ; Reproducibility of Results ; Selenium/chemistry ; Solid Phase Microextraction/methods ; Water/chemistry ; Water Pollutants, Chemical/analysis
Chemical Substances	Water Pollutants, Chemical ; Water (059QF0KO0R) ; Selenium (H6241UJ22B)
Language	English
Publishing date	2022-03-28
Publishing country	England
Document type	Journal Article
ZDB-ID	210747-8
ISSN	1364-5528 ; 0003-2654
ISSN (online)	1364-5528
ISSN	0003-2654
DOI	10.1039/d1an02097h
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Zs.A 2423: Show issues

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Article ; Online: DEHP exposure elevated cardiovascular risk in obese mice by disturbing the arachidonic acid metabolism of gut microbiota

Chai, Xuyang / Wen, Luyao / Song, Yuanyuan / He, Xiaochong / Yue, Jingxian / Wu, Jianlin / Chen, Xin / Cai, Zongwei / Qi, Zenghua

Science of the Total Environment. 2023 June, v. 875 p.162615-

2023

Abstract: Phthalate esters (PAEs) are one of the significant classes of emerging contaminants that are increasingly detected in environmental and human samples. Nevertheless, the current toxicity studies rarely report how PAEs affect the cardiovascular system, ... ...

Abstract	Phthalate esters (PAEs) are one of the significant classes of emerging contaminants that are increasingly detected in environmental and human samples. Nevertheless, the current toxicity studies rarely report how PAEs affect the cardiovascular system, especially in obese individuals. In this study, diet-induced obese mice and corresponding normal mice were exposed to di(2-ethylhexyl) phthalate (DEHP) by oral gavage at environmentally relevant concentrations and key characteristics of cardiovascular risk were examined. The 16S rRNA and high-resolution mass spectrometry were used to investigate the alterations in the gut microbial profile and metabolic homeostasis. The results indicated that the cardiovascular system of fat individuals was more susceptible to DEHP exposure than mice in the lean group. 16S rRNA-based profiling and correlation analysis collectively suggested DEHP-induced gut microbial remodeling in fed a high-fat diet mice, represented by the abundance of the genus Faecalibaculum. Using metagenomic approaches, Faecalibaculum rodentium was identified as the top-ranked candidate bacterium. Additionally, metabolomics data revealed that DEHP exposure altered the gut metabolic homeostasis of arachidonic acid (AA), which is associated with adverse cardiovascular events. Finally, cultures of Faecalibaculum rodentium were treated with AA in vitro to verify the role of Faecalibaculum rodentium in altering AA metabolism. Our findings provide novel insights into DEHP exposure induced cardiovascular damage in obese individuals and suggest that AA could be used as a potential modulator of gut microbiota to prevent related diseases.
Keywords	arachidonic acid ; bacteria ; cardiovascular system ; digestive system ; environment ; high fat diet ; homeostasis ; humans ; intestinal microorganisms ; mass spectrometry ; metabolism ; metabolomics ; metagenomics ; phthalates ; risk ; toxicity ; Cardiovascular damage ; DEHP exposure ; Faecalibaculum rodentium ; Obesity
Language	English
Dates of publication	2023-06
Publishing place	Elsevier B.V.
Document type	Article ; Online
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2023.162615
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Article ; Online: DEHP exposure elevated cardiovascular risk in obese mice by disturbing the arachidonic acid metabolism of gut microbiota.

Chai, Xuyang / Wen, Luyao / Song, Yuanyuan / He, Xiaochong / Yue, Jingxian / Wu, Jianlin / Chen, Xin / Cai, Zongwei / Qi, Zenghua

The Science of the total environment

2023 Volume 875, Page(s) 162615

Abstract	Phthalate esters (PAEs) are one of the significant classes of emerging contaminants that are increasingly detected in environmental and human samples. Nevertheless, the current toxicity studies rarely report how PAEs affect the cardiovascular system, especially in obese individuals. In this study, diet-induced obese mice and corresponding normal mice were exposed to di(2-ethylhexyl) phthalate (DEHP) by oral gavage at environmentally relevant concentrations and key characteristics of cardiovascular risk were examined. The 16S rRNA and high-resolution mass spectrometry were used to investigate the alterations in the gut microbial profile and metabolic homeostasis. The results indicated that the cardiovascular system of fat individuals was more susceptible to DEHP exposure than mice in the lean group. 16S rRNA-based profiling and correlation analysis collectively suggested DEHP-induced gut microbial remodeling in fed a high-fat diet mice, represented by the abundance of the genus Faecalibaculum. Using metagenomic approaches, Faecalibaculum rodentium was identified as the top-ranked candidate bacterium. Additionally, metabolomics data revealed that DEHP exposure altered the gut metabolic homeostasis of arachidonic acid (AA), which is associated with adverse cardiovascular events. Finally, cultures of Faecalibaculum rodentium were treated with AA in vitro to verify the role of Faecalibaculum rodentium in altering AA metabolism. Our findings provide novel insights into DEHP exposure induced cardiovascular damage in obese individuals and suggest that AA could be used as a potential modulator of gut microbiota to prevent related diseases.
MeSH term(s)	Mice ; Humans ; Animals ; Diethylhexyl Phthalate/toxicity ; Diethylhexyl Phthalate/metabolism ; Gastrointestinal Microbiome ; Mice, Obese ; RNA, Ribosomal, 16S ; Arachidonic Acid ; Cardiovascular Diseases/chemically induced ; Risk Factors ; Obesity/metabolism ; Heart Disease Risk Factors
Chemical Substances	phthalic acid (6O7F7IX66E) ; Diethylhexyl Phthalate (C42K0PH13C) ; RNA, Ribosomal, 16S ; Arachidonic Acid (27YG812J1I)
Language	English
Publishing date	2023-03-04
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2023.162615
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Zs.A 949: Show issues

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Article ; Online: The IFT80/Hedgehog Pathway Regulates the Osteogenic-adipogenic Differentiation of Bone Marrow Mesenchymal Stem Cells.

Jiang, Mingyang / Zhang, Ke / Hu, Yang / Lu, Shenyi / Wei, Guiqing / Liu, Kaicheng / Chen, Chuanliang / Zou, Xiaochong / Dai, Yongheng / Gui, Ying / Wu, Jing / Bo, Huan / Bo, Zhandong

Current medicinal chemistry

2024

Abstract: Background: Steroid-induced avascular necrosis of the femoral head (SANFH) is a typical refractory disease that often progresses irreversibly and has a high disability rate. Numerous studies have confirmed that abnormal osteogenic-adipogenic ... ...

Abstract	Background: Steroid-induced avascular necrosis of the femoral head (SANFH) is a typical refractory disease that often progresses irreversibly and has a high disability rate. Numerous studies have confirmed that abnormal osteogenic-adipogenic differentiation of bone marrow mesenchymal stem cells (BM-MSCs) is one of the major factors of SANFH. However, the mechanism remains to be elucidated. Objectives: This study aimed to investigate the function of the IFT80/Hedgehog pathway in the osteogenic-adipogenic differentiation of BM-MSCs. Methods: Femoral head specimens of SANFH patients and femoral neck fractures (FNFs) patients were collected to detect the expression of IFT80, Shh and osteogenic-adipogenic differentiation-related genes by immunohistochemistry (IHC), western blot (WB) and Reverse Transcription Quantitative Polymerase Chain Reaction (RT-qPCR). Based on the rabbit SANFH model, the mRNA expression and protein level of IFT80 and Shh were detected by RT-qPCR and WB. After the osteogenic-adipogenic differentiation based on rabbit BM-MSCs, the IFT80, Gli, PPAR-γ, and Runx2 expression were detected. Differences in alkaline phosphodiesterase activity, calcium nodule, quantification/distribution of lipid droplets, expression of IFT80/Hedgehog axis, and the level of osteogenic- adipogenic associated factors were determined after IFT80 overexpression. Results: RT-qPCR, WB and IHC revealed that IFT80 was highly expressed in the osteoblasts and intra-trabecular osteocytes at the edge of trabeculae and in the intercellular matrix of the bone marrow lumen; Shh was highly expressed in the osteoblasts and intra- trabecular osteocytes at the edge of trabeculae. The Runx2 expression was low, while the PPAR-γ expression was high in both human specimens and animal models of SANFH, suggesting that the balance of osteogenic-adipogenic differentiation was dysregulated. Rabbit BM-MSCs with stable overexpression of IFT80 showed increased alkaline phosphatase activity after induction of osteogenic differentiation, increased calcium nodule production, and decreased adipogenesis after induction of adipogenic differentiation. Conclusion: There is a dysregulation of the balance of osteogenic-adipogenic differentiation in SANFH. IFT80 may inhibit adipogenic differentiation while promoting osteogenic differentiation in rabbit BM-MSCs by activating the Hedgehog pathway.
Language	English
Publishing date	2024-04-18
Publishing country	United Arab Emirates
Document type	Journal Article
ZDB-ID	1319315-6
ISSN	1875-533X ; 0929-8673
ISSN (online)	1875-533X
ISSN	0929-8673
DOI	10.2174/0109298673300113240418050128
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Zs.A 4432: Show issues

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Article ; Online: Corrigendum to "Circular RNA ciRS-7 accelerates ESCC progression through acting as a miR-876-5p sponge to enhance MAGE-A family expression" [Cancer Lett. 426 (2018) 37-46].

Sang, Meixiang / Meng, Lingjiao / Sang, Yang / Liu, Shina / Ding, Pingan / Ju, Yingchao / Liu, Fei / Gu, Lina / Lian, Yishui / Li, Juan / Wu, Yunyan / Zhang, Xiaochong / Shan, Baoen

Cancer letters

2021 Volume 526, Page(s) 364–365

Language	English
Publishing date	2021-12-10
Publishing country	Ireland
Document type	Published Erratum
ZDB-ID	195674-7
ISSN	1872-7980 ; 0304-3835
ISSN (online)	1872-7980
ISSN	0304-3835
DOI	10.1016/j.canlet.2021.12.001
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Zs.A 1177: Show issues

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Article: Rapid computation of set boundaries of multi-scale grids and its application in coverage analysis of remote sensing images

Wu, Xiangyu / Tong, Xiaochong / Lei, Yi / Li, He / Guo, Congzhou / Zhang, Yongsheng / Lai, Guangling / Zhou, Shengxiong

Computers & geosciences. 2021 Jan., v. 146

2021

Abstract: With the rapid development of remote sensing technology, the amount of remote sensing data is increasing, service objects are increasingly extensive, and requests from users to query the coverage of remote sensing images under specific conditions have ... ...

Abstract	With the rapid development of remote sensing technology, the amount of remote sensing data is increasing, service objects are increasingly extensive, and requests from users to query the coverage of remote sensing images under specific conditions have also increased. These conditions have increased efficiency and precision requirements for concurrent access and response. Remote sensing images provide multiple coverages of the same area, and the nested and overlapping relationships among data are complex. Therefore, calculating the range of multiple overlaps of images becomes increasingly difficult as the number of images increases. To query the range of a coverage area of multiple images is to calculate its boundary, which is an important part of spatial overlay analysis. Traditional vector methods are inefficient in processing many spatial objects or complex shapes. The overlay of traditional spatial grids is mostly addressed via single-scale methods, which have low computational efficiency and low boundary fitting precision. Combined with the current gridding management method for multi-source remote sensing images, we proposed a new algorithm for rapid computation of the set boundaries of multi-scale grids and applied it to coverage analysis of remote sensing images. The algorithm can effectively trace the boundaries of multi-scale grids formed in the regions covered by remote sensing images, and it can solve all types of complex boundaries, such as convex and concave boundaries, holes and islands. The experiments in this study show that the new algorithm greatly improves computational efficiency and boundary fitting precision compared with the single-scale grid methods. Compared with the vector algorithms of ArcGIS and other commercial software, this study's algorithm can greatly improve calculation efficiency while ensuring a precision above 99%. The new algorithm is suitable for rapid calculations of large areas and widespread coverage of remote sensing images.
Keywords	algorithms ; application coverage ; area ; computer software ; computers ; exhibitions ; image analysis ; islands ; remote sensing ; shape ; spatial data
Language	English
Dates of publication	2021-01
Publishing place	Elsevier Ltd
Document type	Article
Note	NALT-AP-4-rerunAP2-fuzzy
ISSN	0098-3004
DOI	10.1016/j.cageo.2020.104573
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Article ; Online: Neutrophil autophagy and NETosis in COVID-19: perspectives.

Zhang, Ruoyu / Sun, Chen / Han, Yunze / Huang, Leo / Sheng, Honghui / Wang, Jing / Zhang, Yuqing / Lai, Jonathan / Yuan, Jiahao / Chen, Xuemei / Jiang, Chao / Wu, Fuyuan / Wang, Junmin / Fan, Xiaochong / Wang, Jian

Autophagy

2022 Volume 19, Issue 3, Page(s) 758–767

Abstract: The COVID-19 pandemic has caused substantial losses worldwide in people's lives, health, and property. Currently, COVID-19 is still prominent worldwide without any specific drug treatment. The SARS-CoV-2 pathogen is the cause of various systemic diseases, ...

Abstract	The COVID-19 pandemic has caused substantial losses worldwide in people's lives, health, and property. Currently, COVID-19 is still prominent worldwide without any specific drug treatment. The SARS-CoV-2 pathogen is the cause of various systemic diseases, mainly acute pneumonia. Within the pathological process, neutrophils are recruited to infected sites, especially in the lungs, for the first stage of removing invading SARS-CoV-2 through a range of mechanisms. Macroautophagy/autophagy, a conserved autodegradation process in neutrophils, plays a crucial role in the neutrophil phagocytosis of pathogens. NETosis refers to neutrophil cell death, while auto-inflammatory factors and antigens release NETs. This review summarizes the latest research progress and provides an in-depth explanation of the underlying mechanisms of autophagy and NETosis in COVID-19. Furthermore, after exploring the relationship between autophagy and NETosis, we discuss potential targets and treatment options. This review keeps up with the latest research on COVID-19 from neutrophil autophagy and NETosis with a new perspective, which can guide the urgent development of antiviral drugs and provide guidance for the clinical treatment of COVID-19.
MeSH term(s)	Humans ; Autophagy/physiology ; Neutrophils/metabolism ; Pandemics ; COVID-19 ; SARS-CoV-2 ; Class III Phosphatidylinositol 3-Kinases/metabolism
Chemical Substances	Class III Phosphatidylinositol 3-Kinases (EC 2.7.1.137)
Language	English
Publishing date	2022-08-11
Publishing country	United States
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2454135-7
ISSN	1554-8635 ; 1554-8627
ISSN (online)	1554-8635
ISSN	1554-8627
DOI	10.1080/15548627.2022.2099206
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Zs.A 6741: Show issues

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Article: Formation of Hexagonal PdSe₂ for Electronics and Catalysis

Wu, Zhenhua / Lu, Lei / Liang, Xiaochong / Dun, Chaochao / Yan, Shicheng / Mu, Erzhen / Liu, Yang / Hu, Zhiyu

Journal of physical chemistry. 2020 Apr. 28, v. 124, no. 20

2020

Abstract: Palladium diselenide (PdSe₂), a novel but scarcely studied transition metal dichalcogenide (TMD), usually presents a pentagonal structure rather than a hexagonal one like other traditional TMDs. In this work, we successfully design and fabricate ... ...

Abstract	Palladium diselenide (PdSe₂), a novel but scarcely studied transition metal dichalcogenide (TMD), usually presents a pentagonal structure rather than a hexagonal one like other traditional TMDs. In this work, we successfully design and fabricate hexagonal PdSe₂ that has only been predicted in theory. PdSe₂ composed of an octahedral phase, which is one type of hexagonal phase, was prepared through a two-step method of selenizing the predeposited Pd. Interestingly, octahedral PdSe₂ with great air stability presents intrinsic nanotubes. Moreover, fine structures including octahedral–pentagonal heterostructures are also detected in these nanotubes, which offer huge opportunities beyond traditional TMDs. The experimental band gap, valence band, and work function of the as-fabricated PdSe₂ nanotubes are 0.7, 4.45, and 5.586 eV, respectively. Finally, a preliminary exploration of hexagonal PdSe₂ nanotubes related to the selector device and photoelectrochemical water splitting indicates their potential for further applications in electronics and catalysis.
Keywords	air ; catalytic activity ; electronics ; nanotubes ; palladium ; physical chemistry
Language	English
Dates of publication	2020-0428
Size	p. 10935-10940.
Publishing place	American Chemical Society
Document type	Article
Note	NAL-AP-2-clean
ISSN	1932-7455
DOI	10.1021/acs.jpcc.0c00521
Database	NAL-Catalogue (AGRICOLA)

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