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  1. Book ; Online ; Conference proceedings: Examining the state of the science of mammalian embryo model systems

    Beachy, Sarah H. / Nicholson, Anna / Hackmann, Meredith / Addie, Siobhan

    proceedings of a workshop

    2020  

    Institution National Academies of Sciences, Engineering, and Medicine / Board on Health Sciences Policy
    Author's details Sarah H. Beachy, Anna Nicholson, Meredith Hackmann, Siobhan Addie, rapporteurs ; National Academies of Sciences, Engineering, and Medicine; Health and Medicine Division; Board on Health Sciences Policy
    Language English
    Size 1 Online-Ressource (XVI, 138 Seiten), figures, tables
    Publisher National Academies Press
    Publishing place Washington, DC
    Publishing country United States
    Document type Book ; Online ; Conference proceedings
    Note Kostenfreier Zugang nach Registrierung
    HBZ-ID HT020617684
    ISBN 978-0-309-67668-7 ; 0-309-67668-1
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

    Full text online

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  2. Book ; Online ; Conference proceedings: Exploring novel clinical trial designs for gene-based therapies

    Addie, Siobhan / Hackmann, Meredith / Alper, Joe / Beachy, Sarah H.

    proceedings of a workshop

    2020  

    Institution National Academies of Sciences, Engineering, and Medicine (U.S.) / Forum on Regenerative Medicine
    Author's details Siobhan Addie, Meredith Hackmann, Joe Alper, and Sarah H. Beachy, rapporteurs ; Forum on Regenerative Medicine, Board on Health Sciences Policy, Health and Medicine Division, the National Academies of Sciences, Engineering, Medicine
    Keywords Genetic Therapy ; Clinical Trials as Topic ; United States / https://id.nlm.nih.gov/mesh/D014481
    Language English
    Size 1 Online-Ressource (126 pages), figures, tables
    Publisher National Academies Press
    Publishing place Washington, D.C
    Publishing country United States
    Document type Book ; Online ; Conference proceedings
    Note Kostenfreier Zugang nach Registrierung
    HBZ-ID HT020887911
    ISBN 9780309672986 ; 0309672988
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Book ; Online ; Conference proceedings: An examination of emerging bioethical issues in biomedical research

    Addie, Siobhan / Hackmann, Meredith / Choi, Kelly / Wizemann, Theresa M. / Beachy, Sarah H.

    proceedings of a workshop

    2020  

    Institution National Academies of Sciences, Engineering, and Medicine / Health and Medicine Division
    Author's details Siobhan Addie, Meredith Hackmann, Kelly Choi, Theresa Wizemann, and Sarah H. Beachy, rapporteurs ; Board on Health Sciences Policy, Health and Medicine Division, National Academies of Sciences, Engineering, and Medicine
    Keywords Bioethical Issues ; Biomedical Research / ethics ; Medical Informatics Computing / ethics ; Information Dissemination / ethics
    Language English
    Size 1 Online-Ressource (XIII, 118 pages), illustrations, figures, tables
    Publisher National Academies Press
    Publishing place Washington, DC
    Publishing country United States
    Document type Book ; Online ; Conference proceedings
    Note Kostenfreier Zugang nach Registrierung
    HBZ-ID HT020805609
    ISBN 978-0-309-67663-2 ; 0-309-67663-0
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  4. Book ; Audio / Video ; Conference proceedings ; E-Book: Conflict of interest and medical innovation

    Beachy, Sarah H.

    ensuring integrity while facilitating innovation in medical research : workshop summary [Washington DC, June 5, 2013]

    2014  

    Abstract: Scientific advances such as the sequencing of the human genome have created great promise for improving human health by providing a greater understanding of disease biology and enabling the development of new drugs, diagnostics, and preventive services. ... ...

    Institution Roundtable on Translating Genomic Based Research for Health
    Author's details Sarah H. Beachy ... rapporteurs ; Roundtable on Translating Genomic-Based Research for Health, Board on Health Sciences Policy, Institute of Medicine of the National Academies
    Abstract Scientific advances such as the sequencing of the human genome have created great promise for improving human health by providing a greater understanding of disease biology and enabling the development of new drugs, diagnostics, and preventive services. However, the translation of research advances into clinical applications has so far been slower than anticipated. This is due in part to the complexity of the underlying biology as well as the cost and time it takes to develop a product. Pharmaceutical companies are adapting their business models to this new reality for product development by placing increasing emphasis on leveraging alliances, joint development efforts, early-phase research partnerships, and public-private partnerships.^
    Keywords Biomedical Research ; Conflict of Interest ; Cooperative Behavior ; Industry ; Diffusion of Innovation
    Language English
    Size XIX, 78 S. : Ill., graph. Darst.
    Publisher Nat. Acad. Pr
    Publishing place Washington, DC
    Publishing country United States
    Document type Book ; Audio / Video ; Conference proceedings ; E-Book
    Note Includes bibliographical references
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer ; Zugriff für angemeldete ZB MED-Nutzerinnen und –Nutzer
    HBZ-ID HT018832366
    ISBN 978-0-30930-169-5 ; 978-0-30930-168-8 ; 0-30930-168-8 ; 0-30930-169-6
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  5. Book ; Online ; Conference proceedings: Exploring sources of variability related to the clinical translation of regenerative engineering products

    Hackmann, Meredith / Wizemann, Theresa M. / Beachy, Sarah H.

    proceedings of a workshop

    2019  

    Institution Institute of Medicine / Board on Health Sciences Policy
    Author's details Meredith Hackmann, Theresa Wizemann, and Sarah H. Beachy, Rapporteurs ; Forum on Regenerative Medicine, Board on Health Sciences Policy, Health and Medicine Division ; the National Academies of Sciences, Engineering, Medicine
    Language English
    Size 1 Online-Ressource (xx, 111 pages), figures
    Publisher National Academies Press
    Publishing place Washington, DC
    Publishing country United States
    Document type Book ; Online ; Conference proceedings
    Note Kostenfreier Zugang nach Registrierung ; Open Access
    HBZ-ID HT020144611
    ISBN 978-0-309-48909-6 ; 0-309-48909-1
    DOI 10.17226/25371
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

    Full text online

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  6. Article ; Online: Implementing systems thinking and data science in the training of the regenerative medicine workforce.

    Plant, Anne L / Piscopo, Nicole / Saha, Krishanu / Zylberberg, Claudia / Roy, Krishnendu / Tsokas, Katherine / Schumm, Samantha N / Beachy, Sarah H

    NPJ Regenerative medicine

    2022  Volume 7, Issue 1, Page(s) 76

    Language English
    Publishing date 2022-12-24
    Publishing country United States
    Document type Journal Article
    ISSN 2057-3995
    ISSN (online) 2057-3995
    DOI 10.1038/s41536-022-00271-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: The National Academies' Roundtable on Genomics and Precision Health: Where we have been and where we are heading.

    Ginsburg, Geoffrey / Penny, Michelle / Feero, W Gregory / Miller, Mona / Addie, Siobhan / Beachy, Sarah H

    American journal of human genetics

    2021  Volume 108, Issue 10, Page(s) 1817–1822

    Abstract: The clinical application of genetics and genomics to advance precision health is one of the most dynamic and promising areas of medicine. In 2020, building on nearly 15 years of work, the Roundtable on Genomics and Precision Health of the National ... ...

    Abstract The clinical application of genetics and genomics to advance precision health is one of the most dynamic and promising areas of medicine. In 2020, building on nearly 15 years of work, the Roundtable on Genomics and Precision Health of the National Academies of Sciences, Engineering, and Medicine undertook a strategic planning process to assess its strengths, consider the current challenges facing the field, and set out new goals for its future work. As a result, the Roundtable has updated its vision and mission and prioritized four major areas of inquiry-innovation, dialogue, equity, and adoption-while keeping true to its founding goal of providing a neutral convening space for the diversity of stakeholders in genomics and precision health. The Roundtable is unique for its breadth of membership and is committed to fostering a new era for precision health built on decades of expanding knowledge and the emergence of new technologies. To achieve its goals, the Roundtable seeks to broaden its membership's diversity and to engage with new audiences. Roundtable members explore how evidence-based discoveries in genomics could be adopted and used in innovative ways to better serve human health, how equitable access to genomic and precision health technologies can be ensured, and how the Roundtable and broader genomics and precision health community can communicate more effectively to inform the public regarding genomics and precision health. As a first principle, the Roundtable is working to support the overall goal that all people benefit from genomics for precision health.
    MeSH term(s) Genomics/standards ; Humans ; National Academy of Sciences, U.S./organization & administration ; Precision Medicine ; Translational Research, Biomedical ; United States
    Language English
    Publishing date 2021-10-06
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 219384-x
    ISSN 1537-6605 ; 0002-9297
    ISSN (online) 1537-6605
    ISSN 0002-9297
    DOI 10.1016/j.ajhg.2021.08.015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 107: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Implementing Cancer Genomics in State Health Agencies: Mapping Activities to an Implementation Science Outcome Framework.

    Green, Ridgely Fisk / Kumerow, Marie T / Rodriguez, Juan L / Addie, Siobhan / Beachy, Sarah H / Senier, Laura

    Public health genomics

    2020  Volume 23, Issue 5-6, Page(s) 218–229

    Abstract: Objective: To show how state health agencies can plan and evaluate activities to strengthen the evidence base for public health genomics, we mapped state cancer genomics activities to the Doyle et al. [Genet Med. 2018;20(9):995-1003] implementation ... ...

    Abstract Objective: To show how state health agencies can plan and evaluate activities to strengthen the evidence base for public health genomics, we mapped state cancer genomics activities to the Doyle et al. [Genet Med. 2018;20(9):995-1003] implementation science outcome framework.
    Methods: We identified state health agency activities addressing hereditary breast and ovarian cancer and Lynch syndrome by reviewing project narratives from Centers for Disease Control and Prevention Cancer Genomics Program funding recipients, leading discussions with state health agencies, and conducting an environmental scan.
    Results: State health agencies' cancer genomics activities included developing or adding to state surveillance systems, developing educational materials, bidirectional reporting, promoting health plan policy change, training providers, and promoting recommendations and standards. To address health disparities, programs have tracked group differences, developed culturally appropriate educational materials, and promoted access to services for underserved populations.
    Conclusion: State health agencies can use the Doyle et al. [Genet Med. 2018;20(9):995-1003] performance objectives and outcome measures to evaluate proposed and ongoing activities. By demonstrating whether activities result in improved outcomes, state health agencies can build the evidence for the implementation of cancer genomics activities.
    MeSH term(s) Centers for Disease Control and Prevention, U.S. ; Colorectal Neoplasms, Hereditary Nonpolyposis/diagnosis ; Colorectal Neoplasms, Hereditary Nonpolyposis/genetics ; Genome, Human ; Genomics ; Health Policy ; Health Status Disparities ; Healthcare Disparities ; Humans ; Implementation Science ; Public Health ; United States
    Language English
    Publishing date 2020-09-17
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 2457023-0
    ISSN 1662-8063 ; 1662-4246
    ISSN (online) 1662-8063
    ISSN 1662-4246
    DOI 10.1159/000510336
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4908: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  9. Book ; Online ; Conference proceedings: Genomics-enabled learning health care systems

    Beachy, Sarah H / Olson, Steve / Berger, Adam C

    gathering and using genomic information to improve patient care and research

    2015  

    Abstract: The inclusion of genomic data in a knowledge-generating health care system infrastructure is one promising way to harness the full potential of that information to provide better patient care. In such a system, clinical practice and research influence ... ...

    Institution Institute of Medicine (U.S.). / Roundtable on Translating Genomic-Based Research for Health,
    Event/congress Genomics-enabled learning health care systems: gathering and using genomic information to improve patient care and research (Workshop) (2014, WashingtonD.C.)
    Author's details Roundtable on Translating Genomic-Based Research for Health, Board on Health Sciences Policy ; Sarah H. Beachy, Steve Olson and Adam C. Berger, rapporteurs ; Institute of Medicine of the National Academies
    Abstract The inclusion of genomic data in a knowledge-generating health care system infrastructure is one promising way to harness the full potential of that information to provide better patient care. In such a system, clinical practice and research influence each other with the goal of improving the efficiency and effectiveness of disease prevention, diagnosis, and treatment. To examine pragmatic approaches to incorporating genomics in learning health care systems, the Institute of Medicine Roundtable on Translating Genomic-Based Research for Health hosted a workshop which convened a variety of stakeholder groups, including commercial developers, health information technology professionals, clinical providers, academic researchers, patient groups, and government and health system representatives, to present their perspectives and participate in discussions on maximizing the value that can be obtained from genomic information. The workshop examined how a variety of systems are capturing and making use of genomic data to generate knowledge for advancing health care in the 21st century. It also sought to evaluate the challenges, opportunities, and best practices for capturing or using genomic information in knowledge-generating health care systems. Genomics-Enabled Learning Health Care Systems summarizes the presentations and discussion of the workshop.
    MeSH term(s) Delivery of Health Care/methods ; Genomics/methods ; Electronic Health Records
    Keywords United States
    Language English
    Size 1 online resource (1 PDF file (xx, 95 pages)) :, illustrations
    Document type Book ; Online ; Conference proceedings
    Note Title from PDF title page.
    ISBN 9780309371124 ; 0309371120
    Database Catalogue of the US National Library of Medicine (NLM)

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  10. Article ; Online: Toward establishment of temperature thresholds for immunological impact of heat exposure in humans.

    Beachy, Sarah H / Repasky, Elizabeth A

    International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group

    2011  Volume 27, Issue 4, Page(s) 344–352

    Abstract: There is interest in understanding the health impact of thermal effects as a result of exposure of humans to radiofrequency/microwave (RF/MW) fields. Immune cells and responses are affected by modest changes in temperature and it is important to quantify ...

    Abstract There is interest in understanding the health impact of thermal effects as a result of exposure of humans to radiofrequency/microwave (RF/MW) fields. Immune cells and responses are affected by modest changes in temperature and it is important to quantify these effects and establish safety thresholds similar to what has been done with other tissue targets. Since previous summaries of thresholds for thermal damage to normal tissues have not focused much attention to cells of the immune system, this summary highlights recent studies which demonstrate positive and some negative effects of temperature shifts on human immune cells. We emphasise literature reporting adverse immunological endpoints (such as cell damage, death and altered function) and provide the temperature at which these effects were noted. Whereas there have been many in vitro studies of adverse temperature effects on immune cells, there has been limited validation of these temperature effects in vivo. However, data from heat stress/stroke patients do provide some information regarding core temperatures (40°C) at which thermal damage to immunological processes can begin to occur. We conclude that there is considerable need for more quantitative time temperature assessments using relevant animal models, more complete kinetic analyses to determine how long immunological effects persist, and for analysis of whether frequency of exposure has impact on immune function. To date, no attempt to categorise effects by using cumulative thermal dose measurements (e.g. cumulative equivalent minutes at a given temperature) has been conducted for cells or tissues of the immune system, representing a major gap in this field.
    MeSH term(s) Exercise ; Fever/immunology ; HSP70 Heat-Shock Proteins/metabolism ; Heat-Shock Response/physiology ; Hot Temperature/adverse effects ; Humans ; Hyperthermia, Induced/adverse effects ; Immune System/cytology ; Immune System/physiology ; Microwaves ; Radio Waves
    Chemical Substances HSP70 Heat-Shock Proteins
    Language English
    Publishing date 2011-05-18
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 632526-9
    ISSN 1464-5157 ; 0265-6736
    ISSN (online) 1464-5157
    ISSN 0265-6736
    DOI 10.3109/02656736.2011.562873
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2051: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
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